Targeting hypoxic tumour cells to overcome metastasis
Open accessAbstract
The microenvironment within solid tumours can influence the metastatic dissemination of tumour cells, and recent evidence suggests that poorly oxygenated (hypoxic) cells in primary tumours can also affect the survival and proliferation of metastatic tumour cells in distant organs. Hypoxic tumour cells have been historically targeted during radiation therapy in attempts to improve loco-regional control rates of primary tumours since hypoxic cells are known to be resistant to ionizing radiation-induced DNA damage. There are, therefore, a number of therapeutic strategies to directly target hypoxic cells in primary (and metastatic) tumours, and several compounds are becoming available to functionally inhibit hypoxia-induced proteins that are known to promote metastasis. This mini-review summarizes several established and emerging experimental strategies to target hypoxic cells in primary tumours with potential clinical application to the treatment of patients with tumour metastases or patients at high risk of developing metastatic disease. Targeting hypoxic tumour cells to reduce metastatic disease represents an important advance in the way scientists and clinicians view the influence of tumour hypoxia on therapeutic outcome.
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Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.
“Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [3]
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- Authors
- Bennewith, K. L., & Dedhar, S.
- Affiliations
- BC Cancer Agency (CA)
- Corresponding author
- Dedhar, Shoukat
- Venue
- BMC Cancer
- Published
- 2011-11-30
- Volume
- 11
- Issue
- 1
- Pages
- 504-504
- ISSN
- 1471-2407 (ISSN-L)
- PMC
- PMC3247198
- OpenAlex
- W2046325076
- Cited by
- 109
- References
- 69
- Citations by year
- 2026: 2 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 11 · 2019: 10 · 2018: 10 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 14 · 2013: 16 · 2012: 8
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Michael Smith Health Research BC
- Terry Fox Foundation (020395)
- Canadian Institutes of Health Research
- Canadian Cancer Society Research Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Keywords
- tumor hypoxia, metastasis, hypoxic tumor cells, hypoxia-targeted therapy, hypoxia-inducible factor, radioresistance (biology), ionizing radiation, tumor microenvironment
- MeSH terms
- Humans, Neoplasm Metastasis, Cell Hypoxia, Patient Selection
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