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Cited by 133Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesSchizophrenia research and treatment

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study [ISRCTN83050762]

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Carey, Paul D, Vythilingum, Bavanisha, Seedat, Soraya, Muller, Jacqueline E, van Ameringen, Michael, Stein, Dan J·2005·BMC Psychiatry
DOI 10.1186/1471-244x-5-5PMC PMC547907
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Abstract

Background: Although serotonin reuptake inhibitors are effective in the treatment of OCD, many patients fail to respond to these agents. Growing evidence from open-label and placebo-controlled trials suggests a role for augmentation of SRIs with atypical antipsychotics in OCD. Quetiapine is generally well tolerated and previous open-label data has produced mixed results in OCD and additional controlled data is needed. Methods: We undertook a double-blind, randomised, parallel-group, flexible-dose, placebo-controlled study of quetiapine augmentation in subjects who had responded inadequately to open-label treatment with an SRI for 12 weeks. Following informed consent and screening, forty-two subjects were randomised to either placebo or quetiapine for six weeks. Results: There was significant improvement from baseline to endpoint on the Yale-Brown Obsessive-Compulsive Scale in both the quetiapine and placebo groups (quetiapine, n = 20, p < 0.0001; placebo, n = 21, p = 0.001) with 40% (n = 8) of quetiapine and 47.6% (n = 10) of placebo treated subjects being classified as responders. Quetiapine did not demonstrate a significant benefit over placebo at the end of the six-week treatment period (p = .636). Similarly quetiapine failed to separate from placebo in the subgroup of subjects (n = 10) with co-morbid tics. Quetiapine was generally well tolerated. Conclusions: In this study, quetiapine augmentation was no more effective than placebo augmentation of SRIs. A number of limitations in study design make comparisons with previous studies in this area difficult and probably contributed to our negative findings. Future work in this important clinical area should address these limitations.

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Figure 1 YBOCS change for treatment groups Quetiapine and placebo groups improved significantly, without significant between group differences (F = 0.19; p = 0.636)
Figure 1 YBOCS change for treatment groups Quetiapine and placebo groups improved significantly, without significant between group differences (F = 0.19; p = 0.636)CC BY · PubMed Central

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Research works printed but not linked: 2

  1. Diagnostic and Statistical Manual for Mental Disorders Fourth Edition TR: . 2002, Washington, D.C., American Psychiatric Association
  2. Guy W: ECDU Assessment Manual for Psychopharmacology. 1976, National Institute of Mental Health, Research Branch, 313-331.

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Metadata

Authors
Carey, P. D., Vythilingum, B., Seedat, S., Muller, J. E., van Ameringen, M., & Stein, D. J.
Affiliations
Stellenbosch University (ZA)
Corresponding author
Carey, Paul D
ORCID
Venue
BMC Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2005-01-24
Volume
5
Issue
1
Pages
5-5
ISSN
1471-244X (ISSN-L)
DOI
10.1186/1471-244x-5-5
PMC
PMC547907
OpenAlex
W2128853507
Cited by
133
References
37
Citations by year
2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 1 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 9 · 2013: 4 · 2012: 8
FWCI
15.04
Type
journal article
Language
en
Update notices
erratum (2005-11-30)
Open access
Licence
Locations
  • BMC Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • SUNScholar (Stellenbosch University) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
quetiapine, obsessive-compulsive disorder, treatment-refractory OCD, serotonin reuptake inhibitors, drug augmentation, atypical antipsychotics, Yale-Brown Obsessive Compulsive Scale, drug tolerability
MeSH terms
Quetiapine Fumarate, Adolescent, Adult, Dibenzothiazepines, Double-Blind Method, Drug Administration Schedule, Drug Resistance, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Placebos, Psychiatric Status Rating Scales, Antipsychotic Agents, Treatment Outcome, Treatment Failure, Selective Serotonin Reuptake Inhibitors

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