The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913)
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BACKGROUND: The aim of this paper is to evaluate the effect of antipsychotics for the treatment of schizophrenia in a community based study on sexual function and prolactin levels comparing the use of aripiprazole and standard of care (SOC), which was a limited choice of three widely used and available antipsychotics (olanzapine, quetiapine or risperidone) (The Schizophrenia Trial of Aripiprazole [STAR] study [NCT00237913]). METHOD: This open-label, 26-week, multi-centre, randomised study compared aripiprazole to SOC (olanzapine, quetiapine or risperidone) in patients with schizophrenia (DSM-IV-TR criteria). The primary effectiveness variable was the mean total score of the Investigator Assessment Questionnaire (IAQ) at Week 26. The outcome research variables included the Arizona Sexual Experience scale (ASEX). This along with the data collected on serum prolactin levels at week 4, 8, 12, 18 and 26 will be the focus of this paper. RESULTS: A total of 555 patients were randomised to receive aripiprazole (n = 284) or SOC (n = 271). Both treatment groups experienced improvements in sexual function from baseline ASEX assessments. However at 8 weeks the aripiprazole treatment group reported significantly greater improvement compared with the SOC group (p = 0.007; OC). Although baseline mean serum prolactin levels were similar in the two treatment groups (43.4 mg/dL in the aripiprazole group and 42.3 mg/dL in the SOC group, p = NS) at Week 26 OC, mean decreases in serum prolactin were 34.2 mg/dL in the aripiprazole group, compared with 13.3 mg/dL in the SOC group (p < 0.001). CONCLUSION: The study findings suggest that aripiprazole has the potential to reduce sexual dysfunction, which in turn might improve patient compliance.
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The relative impact of antipsychotics on sexual dysfunction can be summarized as: paliperidone = risperidone > haloperidol > olanzapine ≥ ziprasidone > clozapine ≥ quetiapine > aripiprazole.
“These studies suggest that the relative impact of AP on sexual dysfunction can be summarized as: paliperidone = risperidone > haloperidol > olanzapine ≥ ziprasidone > clozapine ≥ quetiapine > aripiprazole (503,520,536).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [536]
Only few studies have directly compared the sexual functioning associated with different atypical antipsychotics.
“To date, only few studies (534-547) have directly compared the sexual functioning associated with different atypical AP.”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [536]
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- Authors
- Hanssens, L., L'Italien, G., Loze, J.-Y., Marcus, R. N., Pans, M., & Kerselaers, W.
- Affiliations
- Bristol-Myers Squibb (Belgium) (BE)
- Bristol-Myers Squibb (United States) (US)
- Otsuka (France) (FR)
- Corresponding author
- Hanssens, Linda
- ORCID
- L'Italien, Gilbert
- Venue
- BMC Psychiatry
- Published
- 2008-12
- Volume
- 8
- Issue
- 1
- Pages
- 95-95
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC2637262
- OpenAlex
- W1987902149
- Cited by
- 85
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 14
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Otsuka Pharmaceutical
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- aripiprazole, schizophrenia, sexual dysfunction, serum prolactin, antipsychotic drugs, olanzapine, quetiapine, risperidone, community-based treatment, Arizona Sexual Experience Scale, medication adherence
- MeSH terms
- Aripiprazole, Quetiapine Fumarate, Olanzapine, Adult, Benzodiazepines, Dibenzothiazepines, Female, Humans, Male, Piperazines, Prolactin, Quality of Life, Schizophrenia, Schizophrenic Psychology, Sexual Behavior, Antipsychotic Agents, Quinolones, Treatment Outcome, Patient Satisfaction, Risperidone
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