Complementary and alternative medicine use in adolescents with inflammatory bowel disease and juvenile idiopathic arthritis
Open accessAbstract
BACKGROUND: The use of complementary alternative medicine (CAM) is potentially prevalent among paediatric patients with chronic diseases but with variable rates among different age groups, diseases and countries. There are no recent reports on CAM use among paediatric patients with inflammatory bowel disease (IBD) and juvenile idiopathic arthritis (JIA) in Europe. We hypothesized that CAM use associates with a more severe disease in paediatric IBD and JIA. METHODS: A cross-sectional questionnaire study among adolescent outpatients with IBD and JIA addressing the frequency and type of CAM use during the past year. The patients were recruited at the Children's Hospital, University of Helsinki, Finland. RESULTS: Of the 147 respondents, 97 had IBD (Crohn's disease: n = 46; median age 15.5, disease duration 3.4 years) and 50 had JIA (median age 13.8, disease duration 6.9 years). During the past 12 months, 48% regularly used CAM while 81% reported occasional CAM use. Compared to patients with JIA, the use of CAM in IBD patients tended to be more frequent. The most commonly used CAM included probiotics, multivitamins, and mineral and trace element supplements. Self-imposed dietary restrictions were common, involving 27.6% of the non-CAM users but 64.8% of all CAM users. Disease activity was associated with CAM use in JIA but not in IBD. CONCLUSIONS: CAM use is frequent among adolescents with IBD and JIA and associates with self-imposed dietary restrictions. Reassuringly, adherence to disease modifying drugs is good in young CAM users. In JIA, patients with active disease used more frequently CAM than patients with inactive disease. As CAM use is frequent, physicians should familiarise themselves with the basic concepts of CAM. The potential pharmacological interaction or the toxicity of certain CAM products warrants awareness and hence physicians should actively ask their patients about CAM use.
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Use of complementary and alternative medicine (CAM), including nutritional supplements, probiotics, and diets, among families affected by IBD is well reported.
“The use of complementary and alternative medicine (CAM), including nutritional supplements, probiotics, and diets among families affected by IBD is well reported [19,20,21].”
From Online Acceptance and Commitment Therapy and Nutrition Workshop for Parents of Children with Inflammatory Bowel Disease: Feasibility, Acceptability, and Initial Effectiveness. (2021) · cites this paper as [19]
The Results report CAM use among adolescents with IBD, including probiotics and nutritional supplements, and separately report frequent use of special diets. The Methods (Questionnaire) explicitly state that dietary modifications were not treated as CAM in this study, so the source does not support classifying diets as CAM here. (LLM, conf=0.86)
Experimental — accuracy not yet measuredInterest and use of CAM is common in pediatric IBD.
“This interest and use of CAM is common in pediatric IBD, despite being limited evidence for the role of diet and other types of CAMs in inducing and maintaining disease remission in IBD (excluding exclusive enteral nutrition in pediatric Crohn’s disease) [22,23,24].”
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Cites
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Pediatric Integrative Medicine
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“[30], the use of complementary and alternative medicine (CAM) was found to be relatively frequent among adolescents with JIA: 81% reported occasional use.”
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“A 2014 survey study of adolescent patients with IBD showed that during the preceding 12 months, 48% regularly used CAM, while 81% reported occasional CAM use [25].”
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“In IBD, a special subgroup of the above, it varies between 20% and 60%, and occasional CAM use might be as high as 81% [3, 4, 6, 7, 13].”
BackgroundCannabidiol (CBD) Use among children with juvenile idiopathic arthritis
Failing, C., Boehnke, K. F., & Riebschleger, M. P. (2021) · Pediatric Rheumatology · doi:10.1186/s12969-021-00656-5 · Cited by 8 · see citing works
“These findings are consistent with other studies showing that children with JIA use CIM more frequently if they have more active disease and longer disease duration, and that use of immunosuppressive or biologic medications is not a factor related to CIM use among children with JIA [6, 25].”
ResultThe Use of Complementary and Alternative Medicine is Frequent in Patients With Pancreatic Disorders
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Use of complementary and alternative therapies in infants under 3 months in Jordan
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“The use of complementary and alternative medicine is considerably higher in children with special health care needs: the use of such medicine is most common in children with asthma (5), epilepsy (6), attention-deficit hyperactivity disorder (7), autism (8), cerebral palsy (9), cystic fibrosis (10), inflammatory bowel…”
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Katsaus suomalaiseen CAM-tutkimukseen
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“analysed paediatric patients in Finland and evaluated the frequency of CAM use among them at 54% [7].”
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Complementary and Alternative Therapies
Panganiban, J. A., Erlichman, J., & Mascarenhas, M. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-49215-5_39 · Cited by 2 · see citing works
General Nutrition and Fitness for the Child with Rheumatic Disease
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“In the work of other authors [45], it was found that among adolescents with IBD, complementary alternative medicine (CAM), which includes dietary supplements, was more frequently used in the inactive and mild disease state, without any division into CD and UC.”
BackgroundResultComplementary and alternative therapies for inflammatory bowel diseases in children
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Malnutrition in Juvenile Idiopathic Arthritis
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Integrative Health Therapies for Pediatric IBD
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Complementary and alternative medicine in children with inflammatory bowel disease
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Методы альтернативной и комплементарной медицины в педиатрической ревматологии
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Additional file 1 of Cannabidiol (CBD) Use among children with juvenile idiopathic arthritis
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Perspektivenwechsel – Ziele kinderrheumatologischer Therapie
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- Authors
- Nousiainen, P., Merras-Salmio, L., Aalto, K., & Kolho, K.-L.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Kolho, Kaija-Leena
- Venue
- BMC Complementary and Alternative Medicine
- Published
- 2014-04-04
- Volume
- 14
- Issue
- 1
- Pages
- 124-124
- ISSN
- 1472-6882 (ISSN-L)
- PMC
- PMC4101821
- OpenAlex
- W2017972937
- Cited by
- 42
- References
- 37
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 3 · 2018: 4 · 2017: 5 · 2016: 3 · 2014: 2
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- Helsingin ja Uudenmaan Sairaanhoitopiiri
- Signe ja Ane Gyllenbergin Säätiö
- Sigrid Juséliuksen Säätiö
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
- Keywords
- complementary and alternative medicine, inflammatory bowel disease, juvenile idiopathic arthritis, adolescents, Crohn's disease, probiotics, dietary restriction, disease activity, drug interactions, self-medication
- MeSH terms
- Adolescent, Complementary Therapies, Arthritis, Juvenile, Child, Cross-Sectional Studies, Diet, Female, Finland, Humans, Male, Surveys and Questionnaires, Self Care, Severity of Illness Index, Inflammatory Bowel Diseases, Micronutrients, Dietary Supplements, Probiotics
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