Patient adherence to medical treatment: a review of reviews
Open accessAbstract
Background: Patients' non-adherence to medical treatment remains a persistent problem. Many interventions to improve patient adherence are unsuccessful and sound theoretical foundations are lacking. Innovations in theory and practice are badly needed. A new and promising way could be to review the existing reviews of adherence to interventions and identify the underlying theories for effective interventions. That is the aim of our study. Methods: The study is a review of 38 systematic reviews of the effectiveness of adherence interventions published between 1990 and 2005. Electronic literature searches were conducted in Medline, Psychinfo, Embase and the Cochrane Library. Explicit inclusion and exclusion criteria were applied. The scope of the study is patient adherence to medical treatment in the cure and care sector. Results: Significant differences in the effectiveness of adherence interventions were found in 23 of the 38 systematic reviews. Effective interventions were found in each of four theoretical approaches to adherence interventions: technical, behavioural, educational and multi-faceted or complex interventions. Technical solutions, such as a simplification of the regimen, were often found to be effective, although that does not count for every therapeutic regimen. Overall, our results show that, firstly, there are effective adherence interventions without an explicit theoretical explanation of the operating mechanisms, for example technical solutions. Secondly, there are effective adherence interventions, which clearly stem from the behavioural theories, for example incentives and reminders. Thirdly, there are other theoretical models that seem plausible for explaining non-adherence, but not very effective in improving adherence behaviour. Fourthly, effective components within promising theories could not be identified because of the complexity of many adherence interventions and the lack of studies that explicitly compare theoretical components. Conclusion: There is a scarcity of comparative studies explicitly contrasting theoretical models or their components. The relative weight of these theories and the effective components in the interventions designed to improve adherence, need to be assessed in future studies.
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Ongoing contact has been demonstrated to improve long-term adherence to behavior change.
“ongoing contact that has been demonstrated so often to improve long-term adherence to behavior change [55–58].”
From SMART trial: A randomized clinical trial of self-monitoring in behavioral weight management-design and baseline findings (2009) · cites this paper as [57]
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Self-efficacy: Toward a unifying theory of behavioral change
Bandura, A. (1977) · Psychological Review · doi:10.1037/0033-295x.84.2.191 · Cited by 43,925 · see citing works
Self-efficacy: Toward a unifying theory of behavioral change
Bandura, A. (1978) · Advances in Behaviour Research and Therapy · doi:10.1016/0146-6402(78)90002-4 · Cited by 10,586 · see citing works
Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,274 · see citing works
Kirk, J. M. W., MacDonald, A., Lavender, P., Dean, J. M., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,901 · see citing works
Adherence to Long‐Term Therapies: Evidence for Action
Burkhart, P. V., & Sabaté, E. (2003) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2003.tb00001.x · Cited by 2,526 · see citing works
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388 · see citing works
DiMatteo, M. R. (2004) · Medical Care · doi:10.1097/01.mlr.0000114908.90348.f9 · Cited by 2,169 · see citing works
Social support and patient adherence to medical treatment: a meta-analysis.
DiMatteo, M. R. (2004) · Health Psychology · doi:10.1037/0278-6133.23.2.207 · Cited by 2,107 · cited 3× · see citing works
“A meta-analysis of 122 studies, conducted by DiMatteo, aimed at assessing which type of social support, either practical, emotional or undifferentiated, has the strongest relationship with adherence [52].”
Patient adherence to treatment: three decades of research. A comprehensive review
Vermeire, E., Hearnshaw, H., Royen, P. V., & Denekens, J. (2001) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1046/j.1365-2710.2001.00363.x · Cited by 1,833 · see citing works
Lacro, J. P., Dunn, L. B., Dolder, C. R., Leckband, S. G., & Jeste, D. V. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n1007 · Cited by 1,383 · cited 1× · see citing works
“Overviews of the number of non-adherent patients can be found in various reviews [10-14].”
Self-management education and regular practitioner review for adults with asthma
Gibson, P. G., Powell, H. A., Wilson, A., Abramson, M. J., Haywood, P., Bauman, A. E., Hensley, M., Walters, E. H., & Roberts, J. J. (2002) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001117 · Cited by 1,373 · see citing works
A systematic review of adherence with medications for diabetes
Cramer, J. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1218 · Cited by 1,203 · see citing works
Interventions to Enhance Patient Adherence to Medication Prescriptions: Scientific Review
McDonald, H. P., Garg, A. X., & Haynes, R. B. (2002) · JAMA · doi:10.1001/jama.288.22.2868 · Cited by 1,176 · see citing works
Effectiveness of Interventions to Improve Patient Compliance
ROTER, D. L., Hall, J. A., Merisca, R., Nordstrom, B. L., Cretin, D., & Svarstad, B. L. (1998) · Medical Care · doi:10.1097/00005650-199808000-00004 · Cited by 998 · see citing works
Social cognition models and health behaviour: A structured review
Armitage, C. J., & Conner, M. (2000) · Psychology & Health · doi:10.1080/08870440008400299 · Cited by 797 · see citing works
Self-regulation, health, and behavior: A perceptual-cognitive approach
Leventhal, H., Leventhal, E. A., & Contrada, R. J. (1998) · Psychology and Health · doi:10.1080/08870449808407425 · Cited by 726 · see citing works
Compliance With Medication Regimens for Mental and Physical Disorders
Cramer, J. A., & Rosenheck, R. (1998) · Psychiatric Services · doi:10.1176/ps.49.2.196 · Cited by 725 · see citing works
Grace, S. L., Abbey, S. E., Shnek, Z. M., Irvine, J., Franche, R., & Stewart, D. E. (2002) · General Hospital Psychiatry · doi:10.1016/s0163-8343(02)00179-2 · Cited by 685 · see citing works
How to read a paper: Papers that summarise other papers (systematic reviews and meta-analyses)
Greenhalgh, T. (1997) · BMJ · doi:10.1136/bmj.315.7109.672 · Cited by 574 · see citing works
Interventions to Improve Medication Adherence in Schizophrenia
Zygmunt, A., Olfson, M., Boyer, C. A., & Mechanic, D. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.10.1653 · Cited by 541 · see citing works
Drug-Related Hospital Admissions
Einarson, T. R. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700702 · Cited by 520 · see citing works
Interventions for enhancing medication adherence
Haynes, R. B., Yao, X., Degani, A., Kripalani, S. B., Garg, A. X., & McDonald, H. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub2 · Cited by 512 · see citing works
Behavioral theories and the problem of compliance
Leventhal, H., & Cameron, L. D. (1987) · Patient Education and Counseling · doi:10.1016/0738-3991(87)90093-0 · Cited by 503 · see citing works
Ammassari, A., Trotta, M. P., Murri, R., Castelli, F., Narciso, P., Noto, P., Vecchiet, J., Monforte, A. D., Wu, A. W., & Antinori, A. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200212153-00007 · Cited by 480 · see citing works
Meta-analysis of trials of interventions to improve medication adherence
Peterson, A. M., Takiya, L., & Finley, R. S. (2003) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/60.7.657 · Cited by 446 · see citing works
Arthritis self-management studies: a twelve-year review.
Lorig, K., & Holman, H. (1993) · Health Education Quarterly · doi:10.1177/109019819302000104 · Cited by 434 · see citing works
Inhaled Corticosteroids for Asthma Therapy
Cochrane, M., BALA, M. M., Downs, K. E., Mauskopf, J., & Ben-Joseph, R. H. (2000) · CHEST Journal · doi:10.1378/chest.117.2.542 · Cited by 427 · see citing works
An Overview of Interventions to Improve Compliance With Appointment Keeping for Medical Services
Macharia, W. (1992) · JAMA · doi:10.1001/jama.1992.03480130129038 · Cited by 369 · see citing works
Studies of educational interventions and outcomes in diabetic adults: A meta-analysis revisited
Brown, S. A. (1990) · Patient Education and Counseling · doi:10.1016/0738-3991(90)90070-2 · Cited by 366 · see citing works
Should we pay the patient? Review of financial incentives to enhance patient compliance
Giuffrida, A., & Torgerson, D. J. (1997) · BMJ · doi:10.1136/bmj.315.7110.703 · Cited by 337 · see citing works
Interventions to improve adherence to lipid-lowering medication
van Driel, M. L., Morledge, M. D., Ulep, R., Shaffer, J. P., Davies, P., & Deichmann, R. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004371.pub4 · Cited by 333 · see citing works
Non-Compliance in Patients with Heart Failure; How can we Manage it?
van der Wal, M. H. L., Jaarsma, T., & van Veldhuisen, D. J. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.04.007 · Cited by 333 · see citing works
Hampson, S., Skinner, T. C., Hart, J., Storey, L., Gage, H., FOXCROFT, D. R., Kimber, A., Shaw, K. M., & Walker, J. (2001) · Health Technology Assessment · doi:10.3310/hta5100 · Cited by 311 · see citing works
Iskedjian, M., Einarson, T. R., MacKeigan, L. D., Shear, N. H., Addis, A., Mittmann, N., & Ilersich, A. L. T. (2002) · Clinical Therapeutics · doi:10.1016/s0149-2918(02)85026-3 · Cited by 302 · see citing works
Rueda, S., Park‐Wyllie, L. Y., Bayoumi, A. M., Tynan, A., Antoniou, T., Rourke, S. B., & Glazier, R. H. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001442.pub2 · Cited by 299 · see citing works
Schroeder, K., Fahey, T. P., & Ebrahim, S. B. J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004804 · Cited by 291 · see citing works
Patient adherence in the treatment of depression
Pampallona, S., Bollini, P., Tibaldi, G., Kupelnick, B., & Munizza, C. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.2.104 · Cited by 291 · see citing works
Compliance with cardiovascular disease prevention strategies: A review of the research
Burke, L. E., Dunbar-Jacob, J. M., & Hill, M. N. (1997) · Annals of Behavioral Medicine · doi:10.1007/bf02892289 · Cited by 286 · see citing works
Vermeire, E., Wens, J., Royen, P. V., Biot, Y., Hearnshaw, H., & Lindenmeyer, A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003638.pub2 · Cited by 284 · see citing works
The impact of reducing dose frequency on health outcomes
Richter, A., Anton, S., Koch, P., & Dennett, S. L. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80222-9 · Cited by 271 · see citing works
Provider–patient interaction in diabetes care: effects on patient self-care and outcomes
van Dam, H. A., van der Horst, F. G., van den Borne, B. H. P., Ryckman, R., & Crebolder, H. F. J. M. (2002) · Patient Education and Counseling · doi:10.1016/s0738-3991(02)00122-2 · Cited by 264 · see citing works
Loghman‐Adham, M. (2003) · PubMed · Cited by 244 · see citing works
Bunzel, B., & Laederach, K. (2000) · Transplantation · doi:10.1097/00007890-200009150-00001 · Cited by 237 · see citing works
Interventions to Improve Antipsychotic Medication Adherence: Review of Recent Literature
Dolder, C. R., Lacro, J. P., Leckband, S. G., & Jeste, D. V. (2003) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000085413.08426.41 · Cited by 236 · see citing works
A meta-analysis of controlled trials of cardiac patient education
Mullen, P. D., Mains, D. A., & Vélez, R. (1992) · Patient Education and Counseling · doi:10.1016/0738-3991(92)90194-n · Cited by 212 · see citing works
Clinical interventions for treatment non-adherence in psychosis: Meta-analysis
Nosè, M., Barbui, C., Gray, R. J., & Tansella, M. (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.183.3.197 · Cited by 185 · see citing works
van Eijken, M., Tsang, S., Wensing, M., de Smet, P. A. G. M., & Grol, R. P. T. M. (2003) · Drugs & Aging · doi:10.2165/00002512-200320030-00006 · Cited by 184 · see citing works
Improving Adherence to Antidepressants
Vergouwen, A. C. M., Bakker, A., Katon, W. J., Verheij, T. J., & Koerselman, F. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n1203 · Cited by 178 · see citing works
Do fixed-dose combination pills or unit-of-use packaging improve adherence? A systematic review.
CONNOR, J. L., Rafter, N., & Rodgers, A. (2004) · Europe PMC (PubMed Central) · Cited by 155 · see citing works
Adherence Intervention Research What have We Learned and What do We do Next?
Bender, B. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(03)01718-4 · Cited by 150 · see citing works
Sluijs, E. M., & Knibbe, J. J. (1991) · Patient Education and Counseling · doi:10.1016/0738-3991(91)90060-i · Cited by 136 · see citing works
Self-citationCompliance in Healthcare and Research
Burke, E. P. L. E., Ockene, S., & Sauleda, J. S. (2001) · Revista Española de Cardiología · doi:10.1016/s0300-8932(01)76488-3 · Cited by 119 · see citing works
Meta-analysis of the effects of psychoeducational care in adults with asthma
Devine, E. C. (1996) · Research in Nursing & Health · doi:10.1002/(sici)1098-240x(199610)19:5 · Cited by 118 · see citing works
Compliance With Antihypertensive Regimen: A Review of the Research in the 1980s
Dunbar‐Jacob, J. M., Dwyer, K. A., & Dunning, E. J. (1991) · Annals of Behavioral Medicine · doi:10.1093/abm/13.1.31 · Cited by 97 · see citing works
Higgins, N. (2004) · Age and Ageing · doi:10.1093/ageing/afh072 · Cited by 95 · see citing works
Patient education in schizophrenia: a review
Merinder, L. (2000) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2000.102002098.x · Cited by 86 · see citing works
Treatment Compliance and the Therapeutic Alliance
Munetz, M. R. (1998) · Psychiatric Services · doi:10.1176/ps.49.11.1496 · Cited by 82 · see citing works
A Meta-Analysis of the Effects Of Psychoeducational Care in Adults with Hypertension
Devine, E. C., & REIFSCHNEIDER, E. (1995) · Nursing Research · doi:10.1097/00006199-199507000-00009 · Cited by 80 · see citing works
Treatment Compliance and the Therapeutic Alliance
Blackwell, B. (1997) · Cited by 78 · see citing works
Meta-Analysis of Interventions for Medication Adherence to Antihypertensives
Takiya, L., Peterson, A. M., & Finley, R. S. (2004) · Annals of Pharmacotherapy · doi:10.1345/aph.1d268 · Cited by 71 · see citing works
Suspected Nafcillin-Induced Interstitial Nephritis
Guharoy, S. R., Kar, S., & McGalliard, J. N. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700206 · Cited by 61 · see citing works
Sharp, J., Wild, M. R., & Gumley, A. I. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.09.010 · Cited by 60 · see citing works
Antipsychotic medications: compliance and attitudes towards treatment
Awad, A. G. (2004) · Current Opinion in Psychiatry · doi:10.1097/00001504-200403000-00002 · Cited by 58 · see citing works
Newell, S., Bowman, J., & Cockburn, J. (1999) · Preventive Medicine · doi:10.1006/pmed.1999.0579 · Cited by 57 · see citing works
An overview of interventions to improve compliance with appointment keeping for medical services
Macharia, W. M. (1992) · JAMA · doi:10.1001/jama.267.13.1813 · Cited by 54 · see citing works
Haddad, M., Inch, C., Glazier, R. H., Wilkins, A., Bayoumi, A. M., & Rourke, S. B. (2000) · doi:10.1002/14651858.cd001442 · Cited by 44 · see citing works
Interventions to improve antihypertensive drug adherence: a quantitative review of trials
Morrison, A., Ai, W., & Berger, M. (2000) · Cited by 43 · see citing works
Dinnes, J., Kleijnen, J., Leitner, M., & Thompson, D. R. (1999) · BMJ Quality & Safety · doi:10.1136/qshc.8.1.65 · Cited by 37 · see citing works
Meta‐Analysis of Interventions To Improve Drug Adherence in Patients with Hyperlipidemia
Peterson, A. M., Takiya, L., & Finley, R. S. (2003) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.23.1.80.31921 · Cited by 32 · see citing works
Discontinuation Rates of Helicobacter pylori Treatment Regimens: A Meta‐Analysis
Buring, S. M., Winner, L. H., Hatton, R. C., & Doering, P. L. (1999) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.19.4.324.30939 · Cited by 31 · see citing works
Interventions to improve adherence to lipid lowering medication
Schedlbauer, A., Schroeder, K., Peters, T., & Fahey, T. P. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004371.pub2 · Cited by 31 · see citing works
Newell, S., Bowman, J., & Cockburn, J. (2000) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(99)00157-9 · Cited by 30 · see citing works
Dodds, F., Rebair-Brown, A., & Parsons, S. (2000) · Clinical Effectiveness in Nursing · doi:10.1054/cein.2000.0110 · Cited by 21 · see citing works
Rates of study completion with single versus split daily dosing of antidepressants: a meta-analysis
Yıldız, A., Ankerst, D. P., & Sachs, G. S. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00300-2 · Cited by 20 · see citing works
Patient compliance then and now
Haynes, R. B. (1987) · Patient Education and Counseling · doi:10.1016/0738-3991(87)90091-7 · Cited by 17 · see citing works
Treatment Compliance and the Therapeutic Alliance
Mai, F. (2000) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945 · see citing works
Authors Task Force Members, Rydén, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht108 · Cited by 1,958 · see citing works
Allcott, H., & Rogers, T. (2014) · American Economic Review · doi:10.1257/aer.104.10.3003 · Cited by 1,340 · see citing works
Adherence in Internet Interventions for Anxiety and Depression
Christensen, H., Griffiths, K. M., & Farrer, L. (2009) · Journal of Medical Internet Research · doi:10.2196/jmir.1194 · Cited by 1,133 · see citing works
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244 · see citing works
Determinants of patient adherence: a review of systematic reviews
Kardas, P., Lewek, P., & Matyjaszczyk, M. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00091 · Cited by 809 · see citing works
Getting to the Top of Mind: How Reminders Increase Saving
Karlan, D., McConnell, M. A., Stephen, S., Welch, K., & Kuzmova, V. (2016) · AEA Randomized Controlled Trials · doi:10.1257/rct.1350-1.0 · Cited by 628 · see citing works
Rydén, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H., Huikuri, H., et al. (2014) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2013.10.013 · Cited by 609 · see citing works
Interventions to improve adherence to exercise for chronic musculoskeletal pain in adults.
Jordan, J. L., Holden, M., Mason, E. E., & Foster, N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005956.pub2 · Cited by 166 · see citing works
THE WORLD MEDICINES SITUATION 2011
Milani, B. (2011) · Cited by 427 · see citing works
Hugtenburg, J. G., Vervloet, M., van Dijk, L., Timmers, L., & Elders, P. J. M. (2013) · Patient Preference and Adherence · doi:10.2147/ppa.s29549 · Cited by 402 · see citing works
Titov, N., Dear, B. F., Johnston, L., Lorian, C., Zou, J., Wootton, B., Spence, J., McEvoy, P. M., & Rapee, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062873 · Cited by 364 · see citing works
Medication adherence outcomes of 771 intervention trials: Systematic review and meta-analysis
Conn, V. S., & Ruppar, T. M. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.03.008 · Cited by 367 · see citing works
Nilsen, P., Roback, K., Broström, A., & Ellström, P.-E. (2012) · Implementation Science · doi:10.1186/1748-5908-7-53 · Cited by 284 · see citing works
Interventional tools to improve medication adherence: review of literature
Costa, E. M., Pecorelli, S. L., Giardini, A., Savin, M., Menditto, E., Lehane, E. A., Laosa, O., Monaco, A., & Marengoni, A. (2015) · Patient Preference and Adherence · doi:10.2147/ppa.s87551 · Cited by 297 · see citing works
Improving patient adherence: a three-factor model to guide practice
DiMatteo, M. R., Haskard-Zolnierek, K. B., & Martin, L. R. (2012) · Health Psychology Review · doi:10.1080/17437199.2010.537592 · Cited by 288 · see citing works
Type 2 Diabetes in the Real World: The Elusive Nature of Glycemic Control
Edelman, S. V., & Polonsky, W. H. (2017) · Diabetes Care · doi:10.2337/dc16-1974 · Cited by 289 · see citing works
Ryan, R. E., Santesso, N., Lowe, D., Hill, S., Grimshaw, J. M., Prictor, M., Kaufman, C., Cowie, G., & Taylor, M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007768.pub3 · Cited by 273 · see citing works
Being surveyed can change later behavior and related parameter estimates
Zwane, A. P., Zinman, J., Dusen, E. V., Parienté, W., Null, C., Miguel, E. A., Kremer, M. R., Karlan, D., Hornbeck, R. A., Xavier Giné, A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000776108 · Cited by 268 · see citing works
What’s in a name? Compliance, adherence and concordance in chronic psychiatric disorders
Chakrabarti, S. (2014) · World Journal of Psychiatry · doi:10.5498/wjp.v4.i2.30 · Cited by 257 · see citing works
Behavioral Hazard in Health Insurance *
Baicker, K., Mullainathan, S., & Schwartzstein, J. (2015) · The Quarterly Journal of Economics · doi:10.1093/qje/qjv029 · Cited by 247 · see citing works
Self-Regulatory Processes and Exercise Adherence in Older Adults
McAuley, E., Mullen, S. P., Szabo‐Reed, A. N., White, S. M., Wójcicki, T. R., Mailey, E. L., Gothe, N. P., Olson, E. A., Voss, M. W., Erickson, K. I., et al. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2011.04.014 · Cited by 237 · see citing works
pre-diabetes Task Force on diabetes (2014) · Diabetes and Vascular Disease Research · doi:10.1177/1479164114525548 · Cited by 236 · see citing works
Vervloet, M., van Dijk, L., Santen-Reestman, J., van Vlijmen, B., van Wingerden, P., Bouvy, M. L., & de Bakker, D. H. (2012) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2012.05.005 · Cited by 215 · see citing works
Effective Discharge Communication in the Emergency Department
Samuels‐Kalow, M. E., Stack, A. M., & Porter, S. C. (2012) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2011.10.023 · Cited by 219 · see citing works
Taking healthcare interventions from trial to practice
Glasziou, P., Chalmers, I., Altman, D. G., Bastian, H., Boutron, I., Brice, A., Jamtvedt, G., Farmer, A., Ghersi, D., Groves, T., et al. (2010) · BMJ · doi:10.1136/bmj.c3852 · Cited by 209 · see citing works
Dean, A. J., Walters, J., & Hall, A. (2010) · Archives of Disease in Childhood · doi:10.1136/adc.2009.175125 · Cited by 205 · see citing works
McHorney, C. A. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802619425 · Cited by 192 · see citing works
Brundisini, F. K., Vanstone, M. G., Hulan, D., DeJean, D., & Giacomini, M. K. (2015) · BMC Health Services Research · doi:10.1186/s12913-015-1174-8 · Cited by 167 · see citing works
Room, J., Hannink, E., Dawes, H., & Barker, K. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-019221 · Cited by 163 · see citing works
Neil, A. L., Batterham, P., Christensen, H., Bennett, K., & Griffiths, K. M. (2009) · Journal of Medical Internet Research · doi:10.2196/jmir.1050 · Cited by 152 · see citing works
Antiretroviral Therapy Adherence Among Transgender Women Living With HIV
Sevelius, J. M., Carrico, A. W., & Johnson, M. O. (2010) · Journal of the Association of Nurses in AIDS Care · doi:10.1016/j.jana.2010.01.005 · Cited by 155 · see citing works
Lambert, K., Mullan, J., & Mansfield, K. J. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0734-z · Cited by 156 · see citing works
Predictors of adherence among community users of a cognitive behavior therapy website.
(2008) · PubMed Central · Cited by 142 · see citing works
Effects of eHealth Interventions on Medication Adherence: A Systematic Review of the Literature
Linn, A. J., Vervloet, M., van Dijk, L., Smit, E. G., & van Weert, J. C. M. (2011) · Journal of Medical Internet Research · doi:10.2196/jmir.1738 · Cited by 136 · see citing works
Holden, M. A., Nicholls, E. E., Young, J., Hay, E. M., & Foster, N. E. (2009) · Arthritis Care & Research · doi:10.1002/art.24829 · Cited by 131 · see citing works
International consensus on hereditary and acquired angioedema
Lang, D. M., Aberer, W., Bernstein, J. A., Chng, H. H., Grumach, A. S., Hide, M., Maurer, M., Weber, R. W., & Zuraw, B. L. (2012) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2012.10.008 · Cited by 130 · see citing works
Getting to the Top of Mind: How Reminders Increase SavingPreprint
Karlan, D., McConnell, M. A., Mullainathan, S., & Zinman, J. (2010) · SSRN Electronic Journal · doi:10.2139/ssrn.1652784 · Cited by 130 · see citing works
Burke, L. E., Styn, M. A., Glanz, K., Ewing, L. J., Elci, O. U., Conroy, M. B., Sereika, S. M., Acharya, S. D., Music, E., Keating, A. L., et al. (2009) · Contemporary Clinical Trials · doi:10.1016/j.cct.2009.07.003 · Cited by 121 · see citing works
Griva, K., Davenport, A., Harrison, M. J., & Newman, S. P. (2012) · Annals of Behavioral Medicine · doi:10.1007/s12160-012-9359-4 · Cited by 129 · see citing works
Wong, A., Plasek, J. M., Montecalvo, S. P., & Zhou, L. (2018) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2151 · Cited by 127 · see citing works
Sismondo, S. (2018) · Mattering Press eBooks · doi:10.28938/9780995527775 · Cited by 127 · see citing works
Interventions for improving adherence to ocular hypotensive therapy
Waterman, H. A., Evans, J. R., Gray, T. A., Henson, D. B., & Harper, R. A. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006132.pub3 · Cited by 127 · see citing works
The shifting landscape of health care: toward a model of health care empowerment.
Johnson, M. O. (2011) · American Journal of Public Health · doi:10.2105/ajph.2009.189829 · Cited by 134 · see citing works
Patel, S., Jacobus-Kantor, L., Marshall, L., Ritchie, C., Kaplinski, M., Khurana, P., & Katz, R. J. (2013) · Journal of Diabetes Science and Technology · doi:10.1177/193229681300700307 · Cited by 122 · see citing works
Patton, D., Hughes, C. M., Cadogan, C. A., & Ryan, C. A. (2016) · Drugs & Aging · doi:10.1007/s40266-016-0426-6 · Cited by 119 · see citing works
A Review of Barriers to Medication Adherence: A Framework for Driving Policy Options
Gellad, W. F., Grenard, J. L., & McGlynn, E. A. (2009) · Scholarship @ Claremont (The Claremont Colleges) · Cited by 115 · see citing works
Adherencia y persistencia terapéutica: causas, consecuencias y estrategias de mejora
Dilla, T., Valladares, A., Lizán, L., & Sacristán, J. A. (2009) · Atención Primaria · doi:10.1016/j.aprim.2008.09.031 · Cited by 114 · see citing works
Homko, C. J., Deeb, L. C., Rohrbacher, K., Mulla, W. R., Mastrogiannis, D., Gaughan, J., Santamore, W. P., & Bové, A. A. (2012) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0010 · Cited by 110 · see citing works
Goldberg, S. B., Imhoff-Smith, T., Bolt, D. M., Wilson-Mendenhall, C. D., Dahl, C. J., Davidson, R. J., & Rosenkranz, M. A. (2020) · JMIR Mental Health · doi:10.2196/23825 · Cited by 97 · see citing works
Vervloet, M., van Dijk, L., Santen-Reestman, J., van Vlijmen, B., Bouvy, M. L., & de Bakker, D. H. (2011) · BMC Health Services Research · doi:10.1186/1472-6963-11-5 · Cited by 106 · see citing works
Getting to the Top of Mind: How Reminders Increase Saving
Karlan, D., McConnell, M. A., Mullainathan, S., & Zinman, J. (2010) · National Bureau of Economic Research · doi:10.3386/w16205 · Cited by 106 · see citing works
Digital interventions to improve adherence to maintenance medication in asthma
Chan, A., De Simoni, A., Wileman, V., Holliday, L., Newby, C. J., Chisari, C., Ali, S., Zhu, N., Padakanti, P., Pinprachanan, V., et al. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013030.pub2 · Cited by 105 · see citing works
Armitage, C. J., Harris, P. R., & Arden, M. A. (2011) · Health Psychology · doi:10.1037/a0023738 · Cited by 128 · see citing works
Incentives and enablers to improve adherence in tuberculosis
Lutge, E. E., Wiysonge, C. S., Knight, S. E., Sinclair, D., & Volmink, J. A. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007952.pub3 · Cited by 105 · see citing works
Adherence to 7-Day Primaquine Treatment for the Radical Cure of P. vivax in the Peruvian Amazon
Grietens, K. P., Soto, V., Erhart, A., Ribera, J. M., Toomer, E., Tenorio, A., Grande-Montalvo, T., Rodriguez, H., Llanos‐Cuentas, A., D’Alessandro, U., et al. (2010) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2010.09-0521 · Cited by 105 · see citing works
The Challenges of Oral Agents as Antineoplastic Treatments
Given, B. A., Spoelstra, S., & GRANT, M. M. (2011) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2011.02.003 · Cited by 103 · see citing works
Nicolson, P. J. A., Hinman, R. S., Wrigley, T. V., Stratford, P. W., & Bennell, K. L. (2018) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2018.8275 · Cited by 100 · see citing works
Phillips, L. A., Cohen, J., Burns, E. A., Abrams, J., & Renninger, S. (2016) · Journal of Behavioral Medicine · doi:10.1007/s10865-016-9732-z · Cited by 99 · see citing works
Contraceptive discontinuation: Reasons challenges and solutions.2016
Castle, S., & Askew, I. (2015) · Cited by 96 · see citing works
Mendes, R., Martins, S. P. V., & Fernandes, L. P. N. S. (2019) · Journal of Clinical Medicine Research · doi:10.14740/jocmr3894 · Cited by 100 · see citing works
An online lifestyle diary with a persuasive computer assistant providing feedback on self-management
Blanson Henkemans, O. A., van der Boog, P. J. M., Lindenberg, J., van der Mast, C. A. P. G., Neerincx, M. A., & Zwetsloot-Schonk, B. J. H. M. (2009) · Technology and Health Care · doi:10.3233/thc-2009-0545 · Cited by 96 · see citing works
Factors affecting children's adherence to regular dental attendance
Badri, P., Saltaji, H., Flores‐Mir, C., & Amin, M. S. (2014) · The Journal of the American Dental Association · doi:10.14219/jada.2014.49 · Cited by 94 · see citing works
Patient Adherence to Dysphagia Recommendations: A Systematic Review
Krekeler, B. N., Broadfoot, C., Johnson, S., Connor, N., & Rogus-Pulia, N. (2017) · Dysphagia (New York. Print) · doi:10.1007/s00455-017-9852-9 · Cited by 52 · see citing works
Getting to the Top of Mind: How Reminders Increase Saving
Karlan, D., McConnell, M. A., Stephen, S., Welch, K., & Kuzmova, V. (2016) · AEA Randomized Controlled Trials · doi:10.1257/rct.1350 · Cited by 93 · see citing works
Ryan, R. E., Santesso, N. A., Hill, S., Lowe, D. B., Kaufman, C., & Grimshaw, J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007768.pub2 · Cited by 92 · see citing works
Valenstein, M. M., Kavanagh, J., Lee, T. A., Reilly, P., Dalack, G. W., Grabowski, J., Smelson, D. A., Ronis, D. L., Ganoczy, D. A., Woltmann, E. M., et al. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp121 · Cited by 91 · see citing works
Bekker, H. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2010.01.002 · Cited by 89 · see citing works
mHealth SMS text messaging interventions and to promote medication adherence: an integrative review
DeKoekkoek, T., Given, B. A., Given, C. W., Ridenour, K., Schueller, M., & Spoelstra, S. (2015) · Journal of Clinical Nursing · doi:10.1111/jocn.12918 · Cited by 89 · see citing works
Adherence, T. I. E. F. O. P., van Dulmen, S., Sluijs, E. M., van Dijk, L., de Ridder, D. T. D., Heerdink, E. R., & Bensing, J. M. (2008) · BMC Health Services Research · doi:10.1186/1472-6963-8-47 · Cited by 89 · see citing works
Self-citationBurg, M. M., Schwartz, J. E., Kronish, I. M., Diaz, K. M., Alcántara, C., Duer-Hefele, J., & Davidson, K. W. (2017) · Annals of Behavioral Medicine · doi:10.1007/s12160-017-9902-4 · Cited by 91 · see citing works
Non-adherence to medication regimens among older African-American adults
Bazargan, M., Smith, J. P., Yazdanshenas, H., Movassaghi, M., Martins, D., & Orum, G. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0558-5 · Cited by 90 · see citing works
Healthcare non-adherence decisions and internet health information
Weaver, J. B., Thompson, N. J., Weaver, S. S., & Hopkins, G. L. (2009) · Computers in Human Behavior · doi:10.1016/j.chb.2009.05.011 · Cited by 89 · see citing works
Compliance with supportive periodontal/peri‐implant therapy: A systematic review
Amerio, E., Mainas, G., Petrova, D., Giner Tarrida, L., Nart, J., & Monje, A. (2020) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13204 · Cited by 87 · see citing works
The effectiveness of various robotic technologies in assisting older adults
Shishehgar, M., Kerr, D. V., & Blake, J. (2017) · Health Informatics Journal · doi:10.1177/1460458217729729 · Cited by 88 · see citing works
Mail-order pharmacy use and adherence to diabetes-related medications.
Duru, O. K., Schmittdiel, J. A., Dyer, W. T., Parker, M. M., Uratsu, C. S., Chan, J., & Karter, A. J. (2010) · PubMed · Cited by 87 · see citing works
Schmid‐Mohler, G., Thut, M. P., Wuthrich, R. P., Denhaerynck, K., & Geest, S. D. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.01056.x · Cited by 87 · see citing works
Cahir, C., Guinan, E., Dombrowski, S. U., Sharp, L., & Bennett, K. (2015) · Patient Education and Counseling · doi:10.1016/j.pec.2015.05.013 · Cited by 84 · see citing works
Klein, A., Otto, G., & Krämer, I. (2009) · Transplantation · doi:10.1097/tp.0b013e318199d122 · Cited by 84 · see citing works
Adherence to antiretroviral treatment in patients with HIV in the UK: a study of complexity
Sherr, L., Lampe, F. C., Norwood, S., Date, H. L., Harding, R., Johnson, M. A., Edwards, S., Fisher, M., Arthur, G., Zetler, S., et al. (2008) · AIDS Care · doi:10.1080/09540120701867032 · Cited by 81 · see citing works
Factors Associated with First-Fill Adherence Rates for Diabetic Medications: A Cohort Study
Shah, N. R., Hirsch, A. G., Zacker, C., Taylor, S. D., Wood, G. C., & Stewart, W. F. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0870-z · Cited by 81 · see citing works
Combating inappropriate use of medicines
Holloway, K. (2011) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.11.14 · Cited by 80 · see citing works
Lai, J. W. M., & Bower, M. (2020) · Journal of Computer Assisted Learning · doi:10.1111/jcal.12412 · Cited by 92 · see citing works
Interventional Therapies for Chronic Low Back Pain: A Focused Review (Efficacy and Outcomes)
Patel, V. B., Wasserman, R. A., & Imani, F. (2015) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.29716 · Cited by 78 · see citing works
Holloway, K., & van Dijk, L. (2011) · Data Archiving and Networked Services (DANS) · Cited by 77 · see citing works
Brennan, C. W., Daly, B. J., & Jones, K. R. (2013) · Western Journal of Nursing Research · doi:10.1177/0193945913476577 · Cited by 77 · see citing works
Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework
Allemann, S. S., Nieuwlaat, R., van den Bemt, B. J. F., Hersberger, K. E., & Arnet, I. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00429 · Cited by 79 · see citing works
A Study Assessing Public Knowledge, Belief and Behavior of Antibiotic Use in an Omani Population
José, J., Jimmy, B., AlSabahi, A. G. M. S., & Sabei, G. A. A. (2013) · Oman Medical Journal · doi:10.5001/omj.2013.95 · Cited by 73 · see citing works
Yeung, D., Alvarez, K., Quinones, M. E., Clark, C. A., Oliver, G. R., Álvarez, C., & Jaiyeola, A. O. (2016) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2016.08.012 · Cited by 76 · see citing works
Social support and immunosuppressant therapy adherence among adult renal transplant recipients
Chisholm‐Burns, M. A., Spivey, C. A., & Wilks, S. E. (2009) · Clinical Transplantation · doi:10.1111/j.1399-0012.2009.01060.x · Cited by 72 · see citing works
Sheridan, S., Draeger, L. B., Pignone, M., Keyserling, T., Simpson, R. J. J., Rimer, B., Bangdiwala, S., Cai, J.-W., & Gizlice, Z. (2011) · BMC Health Services Research · doi:10.1186/1472-6963-11-331 · Cited by 71 · see citing works
Low-Dose Aspirin Therapy for Cardiovascular Prevention
Herlitz, J. D., Toth, P. P., & Næsdal, J. (2010) · American Journal of Cardiovascular Drugs · doi:10.2165/11318440-000000000-00000 · Cited by 70 · see citing works
A mobile application improves therapy-adherence rates in elderly patients undergoing rehabilitation
Mertens, A., Brandl, C., Miron-Shatz, T., Schlick, C., Neumann, T., Kribben, A., Meister, S., Diamantidis, C., Albrecht, U., Horn, P., et al. (2016) · Medicine · doi:10.1097/md.0000000000004446 · Cited by 65 · see citing works
Long-term adherence to inhaled corticosteroids in children with asthma: Observational study
Klok, T., Kaptein, A. A., Duiverman, E. J., & Brand, P. L. P. (2015) · Respiratory Medicine · doi:10.1016/j.rmed.2015.07.016 · Cited by 67 · see citing works
Müller, S., Kohlmann, T., & Wilke, T. (2015) · BMC Health Services Research · doi:10.1186/s12913-015-0809-0 · Cited by 68 · see citing works
Education in patient–physician communication: How to improve effectiveness?
Wouda, J. C., & van de Wiel, H. B. M. (2012) · Patient Education and Counseling · doi:10.1016/j.pec.2012.09.005 · Cited by 66 · see citing works
Toward appropriate criteria in medication adherence assessment in older persons: Position Paper
Giardini, A., Martin, M. T., Cahir, C., Lehane, E. A., Menditto, E., Strano, M., Pecorelli, S., Monaco, A., & Marengoni, A. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0435-z · Cited by 65 · see citing works
Vervloet, M., van Dijk, L., de Bakker, D. H., Souverein, P. C., Santen-Reestman, J., van Vlijmen, B., van Aarle, M. C. W., van der Hoek, L. S., & Bouvy, M. L. (2014) · Diabetic Medicine · doi:10.1111/dme.12439 · Cited by 65 · see citing works
Jansà, M., Hernández, C., Vidal, M., Nuñez, M., Bertran, M. J., Sanz, S., Castell, C., & Sanz, G. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2009.12.012 · Cited by 61 · see citing works
Adherence and medication management by the elderly
Henriques, M. A., Costa, M. A. R., & Cabrita, J. (2012) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2012.04144.x · Cited by 61 · see citing works
- Authors
- van Dulmen, S., Sluijs, E., van Dijk, L., de Ridder, D., Heerdink, R., & Bensing, J.
- Affiliations
- Netherlands Institute for Health Services Research (NL)
- Venue
- BMC Health Services Research
- Published
- 2007-04-17
- Volume
- 7
- Issue
- 1
- Pages
- 55-55
- ISSN
- 1472-6963 (ISSN-L)
- PMC
- PMC1955829
- OpenAlex
- W2000801086
- Cited by
- 627
- References
- 77
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 19 · 2023: 19 · 2022: 18 · 2021: 23 · 2020: 24 · 2019: 26 · 2018: 43 · 2017: 41 · 2016: 43 · 2015: 75 · 2014: 48 · 2013: 51 · 2012: 27
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Health Services Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- ZonMw
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Keywords
- medication adherence, treatment adherence interventions, behavioral theory, educational intervention, technical solutions, regimen simplification, incentives, reminders, complex interventions
- MeSH terms
- Humans, Patient Compliance, Patient Education as Topic, Severity of Illness Index, Social Support, Meta-Analysis as Topic, Reminder Systems
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