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Cited by 37Malaria Research and ControlPregnancy and preeclampsia studiesBirth, Development, and Health

Maternal malaria status and metabolic profiles in pregnancy and in cord blood: relationships with birth size in Nigerian infants

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Ayoola, Omolola O, Whatmore, Andrew, Balogun, Williams O, Jarrett, Olatokunbo O, Cruickshank, John K, Clayton, Peter E·2012·Malaria Journal
DOI 10.1186/1475-2875-11-75PMC PMC3325162
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Abstract

BACKGROUND: Malaria is more common in pregnant than in non-pregnant Nigerian women, and is associated with small birth size and the attendant short- and long-term health risks. The influence of malaria on maternal metabolic status in pregnancy and in cord blood and how this relates to birth size has not been studied. The study objective was to define relationships between maternal and cord serum metabolic markers, maternal malaria status and birth size. METHODS: During pregnancy, anthropometric measurements, blood film for malaria parasites and assays for lipids, glucose, insulin and TNF were obtained from 467 mothers and these analytes and insulin-like growth factor-I (IGF-I) were obtained from cord blood of 187 babies. RESULTS: Overall prevalence of maternal malaria was 52%, associated with younger age, anaemia and smaller infant birth size. Mothers with malaria had significantly lower cholesterol (total, HDL and LDL) and higher TNF, but no difference in triglyceride. In contrast, there was no effect of maternal malaria on cord blood lipids, but the median (range) cord IGF-I was significantly lower in babies whose mothers had malaria: 60.4 (24, 145) μg/L, versus no malaria: 76.5 (24, 150) μg/L, p = 0.03. On regression analysis, the key determinants of birth weight included maternal total cholesterol, malarial status and cord insulin and IGF-I. CONCLUSIONS: Malaria in pregnancy was common and associated with reduced birth size, lower maternal lipids and higher TNF. In the setting of endemic malaria, maternal total cholesterol during pregnancy and cord blood insulin and IGF-I levels are potential biomarkers of foetal growth and birth size.

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Crossref · 10.1186/1475-2875-11-75

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  • Younger women, particularly adolescents, are at higher risk of malaria infection than older women, independent of parity.

    “It is well established that younger women (primigravidae and multigravidae), particularly adolescents, are at higher risk of malaria infection than older women,18–20 and this is independent of parity.20–22”

    From Malaria in pregnancy. (2013) · cites this paper as [19]

    The Results section reports that malaria was associated with younger maternal age, supporting the general age-related claim. It also reports an association with primigravidity, but does not establish that the age association is independent of parity or specifically elevated among adolescents (no page number available in our copy). (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In stable transmission settings, most malaria infections in pregnancy are asymptomatic but increase substantially the risk of anaemia.

    “Where transmission is stable, such as in most of sub-Saharan Africa, most infections are asymptomatic but increase substantially the risk of anaemia.19,26,30–31”

    From Malaria in pregnancy. (2013) · cites this paper as [19]

    The Results section reports that most women in the Nigerian study were asymptomatic and that malaria was associated with lower packed cell volume; the Discussion also associates malaria with maternal anaemia. The paper does not establish that this pattern holds across stable-transmission settings or quantify a substantial increase in anaemia risk. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Malaria increases the risk of low birth weight, particularly in primigravidae, and this risk seems higher for infections in the first or second trimester.

    “Malaria increases the risk of low birth weight (LBW),19,23,30,49–51 particularly in primigravidae, and this risk seems to be higher for infections in first or second trimester,23–24,30,49 though in one study this was true also for infections occurring late in pregnancy.49”

    From Malaria in pregnancy. (2013) · cites this paper as [19]

    The Background links malaria in pregnancy to low birth weight, and the Discussion (Effect of maternal malarial on birth indices) reports lower mean birth weight among babies of mothers with malaria. The Discussion also associates malaria with first pregnancy, but does not show that its effect on birth weight is greater in primigravidae. Our copy does not establish a higher low-birth-weight risk for infections in the first or second trimester. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Primigravidae are at higher risk of malaria than multigravidae, though less in low transmission settings, while in epidemic areas the risk is not affected by parity.

    “Parity also affects the risk of malaria as primigravidae are at higher risk than multigravidae,18–20, 23–24 though less in low transmission settings,15 while in epidemic areas, the risk is not affected by parity.25”

    From Malaria in pregnancy. (2013) · cites this paper as [19]

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1 of the 61 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Ong K Kratzsch J Kiess W Costello M Scott C Dunger D Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood J Clin Endocrinol Metab 2000 85 4266 4269 10.1210/jc.85.11.4266 11095465 · DOI

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Authors
Ayoola, O. O., Whatmore, A., Balogun, W. O., Jarrett, O. O., Cruickshank, J. K., & Clayton, P. E.
Affiliations
  • Manchester Academic Health Science Centre (GB)
  • University of Ibadan (NG)
Corresponding author
Ayoola, Omolola O
ORCID
Venue
Malaria Journal
Publisher
Springer Science and Business Media LLC
Published
2012-03-19
Volume
11
Issue
1
Pages
75-75
ISSN
1475-2875 (ISSN-L)
DOI
10.1186/1475-2875-11-75
PMC
PMC3325162
OpenAlex
W2156296281
Cited by
37
References
61
Citations by year
2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 4
FWCI
2.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Malaria Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Funders
  • Wellcome Trust (080723/Z/06/Z)
  • NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
  • National Institutes of Health
  • Manchester Biomedical Research Centre
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
malaria in pregnancy, maternal malaria, birth size, birth weight, umbilical cord blood, cord blood insulin, insulin-like growth factor I, cord blood lipids, total cholesterol, TNF-α, fetal growth, biomarkers, Nigerian women
MeSH terms
Adolescent, Adult, Blood Glucose, Female, Fetal Blood, Humans, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Insulin-Like Growth Factor I, Lipoproteins, Middle Aged, Nigeria, Plasmodium falciparum, Pregnancy, Tumor Necrosis Factor-alpha, Biomarkers, Pregnancy Complications, Parasitic, Malaria, Falciparum

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