Malarial infection and birthweight in urban Zanzibar, Tanzania
Abstract
In urban Zanzibar, Tanzania, 389 women with full-term pregnancies were studied to see what effect their infection with malaria (at delivery) had on the birthweight (BW) of their infants. The overall prevalence of low birthweight (LBW) (i.e. < 2500 g) was 3.9% (15 out of 389). Overall, 21.3% (82/384) of the women only had peripheral parasitaemias at delivery, 17.6% (58/329) only had active placental infections and 47.9% (157/328) had both. The youngest women (< 20 years), the primiparae and those with Plasmodium infection gave birth to neonates with relatively low mean BW. The lowest mean BW (2967 g) was found among the offspring of women with active placental infection (N = 58). The women with past/chronic infection (N = 73) or no infection (N = 201) generally produced heavier infants, with mean BW of 3242 and 3338 g, respectively. The women with active placental infection were also far more likely to have babies of LBW (15.5%) than those with past/chronic infection (1.4%) or no infection (1.5%). Multivariate analysis indicated that the highest relative risk of LBW (10.1, with a 95% confidence interval of 2.9-35.4) was associated with active placental infection, with no significant difference between primiparae and multiparae. In the study population, therefore, with its low prevalence of LBW, malaria infection increased the risk of LBW in full-term neonates by about 10-fold, with a population-attributable proportion of 55.4%.
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Other reviews suggest the same statistically significant association between malaria in pregnancy and low birthweight.
“This is validated by other reviews conducted that suggest the same statistically significant association between malaria in pregnancy and low birthweight of the baby [25].”
From Malaria in pregnancy: Meta-analyses of prevalence and associated complications (2024) · cites this paper as [25]
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- Authors
- Matteelli, A., Donato, F., Shein, A., Muchi, J. A., Abass, A. K., Mariani, M., Leopardi, O., Maxwell, C. A., & Carosi, G.
- Affiliations
- University of Brescia (IT)
- Ospedale Maggiore di Lodi (IT)
- Venue
- Annals of Tropical Medicine & Parasitology
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 90
- Issue
- 2
- Pages
- 125-134
- ISSN
- 0003-4983 (ISSN-L)
- 1364-8594
- OpenAlex
- W2255401135
- Cited by
- 36
- References
- 22
- Citations by year
- 2024: 2 · 2022: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Tropical Medicine and Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- malaria, birth weight, low birth weight, placental malaria, pregnancy, neonatal outcomes, primiparous women, chronic malaria infection
- MeSH terms
- Adult, Age Factors, Anemia, Birth Weight, Cross-Sectional Studies, Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Malaria, Parity, Placenta Diseases, Pregnancy, Tanzania, Urban Health, Pregnancy Complications, Parasitic, Prevalence, Multivariate Analysis, Parasitemia
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