Effect of supplement with lactic-acid producing bacteria on fatigue and physical activity in patients with chronic fatigue syndrome
Open accessAbstract
Disturbances in intestinal microbial ecology and in the immune system of the host have been implicated as a part of the pathogenesis in chronic fatigue syndrome. Probiotic lactic acid producing bacteria have been shown to prevent and alleviate gastrointestinal disturbances and to normalize the cytokine profile which might be of an advantage for patients suffering from chronic fatigue syndrome. The aim of the study was to evaluate the effect of Lactobacillus paracasei ssp. paracasei F19, Lactobacillus acidophilus NCFB 1748 and Bifidobacterium lactis Bb12 on fatigue and physical activity in CFS patients. Fifteen patients fulfilling the criteria set by international researchers in the field at the US Centre for Disease Control and Prevention in 1994 for chronic fatigue syndrome, were included in the study. The patients had high fatigue severity scores and high disability scores. During the first two weeks baseline observations without treatment were assessed, succeeded by four weeks of intake of a probiotic product and a four-week follow-up period. The fatigue, health and physical activity was assessed by the use of the Visual Analogue Scales and the SF-12 Health Survey. Faecal samples were collected and the normal microflora was analysed. Neurocognitive functions improved during the study period while there were no significant changes in fatigue and physical activity scores. No major changes occurred in the gastrointestinal microflora. At the end of the study 6 of 15 patients reported that they had improved according to the assessment described. The findings in this study that improvement of health is possible to achieve should encourage further studies with interventions with probiotics in patients with CFS.
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In 15 patients with chronic fatigue syndrome, 4 weeks of a probiotic mixture improved memory and concentration but not fatigue or physical activity.
“Patients reported improvement in memory and concentration but not in fatigue or physical activity.132”
From The Gut Microbiome and the Brain (2014) · cites this paper as [132]
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- Authors
- Sullivan, Å., Nord, C. E., & Evengård, B.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Evengård, Birgitta
- ORCID
- Evengård, Birgitta
- Venue
- Nutrition Journal
- Published
- 2009-01-26
- Volume
- 8
- Issue
- 1
- Pages
- 4-4
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC2642862
- OpenAlex
- W2072411472
- Cited by
- 80
- References
- 35
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Stockholms Läns Landsting
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- chronic fatigue syndrome, probiotics, lactic acid bacteria, Bifidobacterium animalis subsp. lactis BB-12, fatigue, physical activity, gut microbiota, neurocognitive function, disability
- MeSH terms
- Adult, Bifidobacterium, Fatigue, Feces, Female, Humans, Lactobacillus, Lactobacillus acidophilus, Male, Middle Aged, Motor Activity, Pilot Projects, Fatigue Syndrome, Chronic, Dietary Supplements, Probiotics, Leukocyte L1 Antigen Complex
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