A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue
Open accessAbstract
Muscle fatigue and cognitive disturbances persist in patients after recovery from acute COVID-19 disease. However, there are no specific treatments for post-COVID fatigue. Objective: To evaluate the efficacy and safety of the health supplements ImmunoSEB (systemic enzyme complex) and ProbioSEB CSC3 (probiotic complex) in patients suffering from COVID-19 induced fatigue. A randomized, multicentric, double blind, placebo-controlled trial was conducted in 200 patients with a complaint of post-COVID fatigue. The test arm (n = 100) received the oral supplements for 14 days and the control arm (n = 100) received a placebo. Treatment efficacy was compared using the Chalder Fatigue scale (CFQ-11), at various time points from days 1 to 14. The supplemental treatment resulted in resolution of fatigue in a greater percentage of subjects in the test vs. the control arm (91% vs. 15%) on day 14. Subjects in the test arm showed a significantly greater reduction in total as well as physical and mental fatigue scores at all time points vs. the control arm. The supplements were well tolerated with no adverse events reported. This study demonstrates that a 14 days supplementation of ImmunoSEB + ProbioSEB CSC3 resolves post-COVID-19 fatigue and can improve patients’ functional status and quality of life.
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In a study, 91/100 SARS-CoV-2 patients who received probiotics (Bacillus coagulans, Bacillus subtilis, Bacillus clausii) showed diminished physical and mental fatigue compared with 15/100 placebo patients on day 14.
“A study by [151] reported improvements in patients who received probiotics and enzyme supplements, as 91/100 patients with SARS-CoV-2 who received the treatment with probiotics (Bacillus coagulans, Bacillus subtilis and Bacillus clausii) showed diminished physical and mental fatigue compared with 15/100 placebo patients on day 14 of the treatment.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [151]
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- [7]Kedor C. Freitag H. Meyer-Arndt L.A. Wittke K. Steinbeis F. Haffke M. Gordon R. Heidecker B. Volk H.D. Skurk C. Chronic COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) following the first pandemic wave in Germany—A first analysis of a prospective observational study medRxiv 2021 10.1101/2021.02.06.21249256 · DOI
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The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
- Authors
- Rathi, A., Jadhav, S. B., & Shah, N.
- Affiliations
- Advanced Enzyme Technologies Limited (India) (IN)
- Cystic Fibrosis Canada (CA)
- Corresponding author
- Rathi, Abhijit
- Venue
- Medicines
- Publisher
- MDPI AG
- Published
- 2021-08-30
- Volume
- 8
- Issue
- 9
- Pages
- 47
- ISSN
- 2305-6320 (ISSN-L)
- PMC
- PMC8472462
- OpenAlex
- W3198559038
- Cited by
- 65
- References
- 58
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 25 · 2023: 9 · 2022: 12 · 2021: 1
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicines (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- post-COVID-19 fatigue, probiotics, dietary supplements, Chalder Fatigue Questionnaire, physical and mental fatigue, functional status, quality of life, COVID-19 recovery
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