The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
Open accessAbstract
Background: Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome. Results: We investigated colon cancer samples (23 characterized by microsatellite stability, MSS, and 16 by high microsatellite instability, MSI-H) for genome-wide expression of microRNA (miRNA) and mRNA. Based on combined miRNA and mRNA gene expression, a molecular signature consisting of twenty seven differentially expressed genes, inclusive of 8 miRNAs, could correctly distinguish MSI-H versus MSS colon cancer samples. Among the differentially expressed miRNAs, various members of the oncogenic miR-17-92 family were significantly up-regulated in MSS cancers. The majority of protein coding genes were also up-regulated in MSS cancers. Their functional classification revealed that they were most frequently associated with cell cycle, DNA replication, recombination, repair, gastrointestinal disease and immune response. Conclusion: This is the first report that indicates the existence of differences in miRNA expression between MSS versus MSI-H colorectal cancers. In addition, the work suggests that the combination of mRNA/miRNA expression signatures may represent a general approach for improving bio-molecular classification of human cancer.
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MicroRNA expression profiles classify human cancers
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Self-citationRAS Is Regulated by the let-7 MicroRNA Family
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Cited by
Molecular Genetics of Colorectal Cancer
Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805
microRNAs in cancer management
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A network-biology perspective of microRNA function and dysfunction in cancer
Bracken, C. P., Scott, H. S., & Goodall, G. J. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.134 · Cited by 668
Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
Colussi, D., Brandi, G., Bazzoli, F., & Ricciardiello, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816365 · Cited by 429
Enjoy the Trip: Calcium in Mitochondria Back and Forth
De Stefani, D., Rizzuto, R., & Pozzan, T. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034216 · Cited by 423
Metadata
- Authors
- Lanza, G., Ferracin, M., Gafà, R., Veronese, A., Spizzo, R., Pichiorri, F., Liu, C.-G., Calin, G. A., Croce, C. M., & Negrini, M.
- Venue
- Molecular Cancer
- Published
- 2007-08-23
- Volume
- 6
- Issue
- 1
- Pages
- 54-54
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2123099342
- Cited by
- 285
- References
- 46
- FWCI
- 14.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lanza, G., Ferracin, M., Gafà, R., Veronese, A., Spizzo, R., Pichiorri, F., Liu, C.-G., Calin, G. A., Croce, C. M., & Negrini, M. (2007). mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer. Molecular Cancer. https://doi.org/10.1186/1476-4598-6-54
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