The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The secret life of kinases: functions beyond catalysis
Open accessAbstract
Protein phosphorylation participates in the regulation of all fundamental biological processes, and protein kinases have been intensively studied. However, while the focus was on catalytic activities, accumulating evidence suggests that non-catalytic properties of protein kinases are essential, and in some cases even sufficient for their functions. These non-catalytic functions include the scaffolding of protein complexes, the competition for protein interactions, allosteric effects on other enzymes, subcellular targeting, and DNA binding. This rich repertoire often is used to coordinate phosphorylation events and enhance the specificity of substrate phosphorylation, but also can adopt functions that do not rely on kinase activity. Here, we discuss such kinase independent functions of protein and lipid kinases focussing on kinases that play a role in the regulation of cell proliferation, differentiation, apoptosis, and motility.
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Cites
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Induced protein degradation: an emerging drug discovery paradigm
Lai, A. C., & Crews, C. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.211 · Cited by 1,486
Dual‐specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling
Caunt, C. J., & Keyse, S. M. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08716.x · Cited by 535
Kinase inhibition in autoimmunity and inflammation
Zarrin, A. A., Bao, K., Lupardus, P., & Vucic, D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0082-8 · Cited by 431
Ten things you should know about protein kinases: IUPHAR R eview 14
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Fang, Z., Grütter, C., & Rauh, D. (2013) · ACS Chemical Biology · doi:10.1021/cb300663j · Cited by 197
Metadata
- Authors
- Rauch, J., Volinsky, N., Romano, D., & Kolch, W.
- Venue
- Cell Communication and Signaling
- Published
- 2011
- Volume
- 9
- Issue
- 1
- Pages
- 23
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2061324224
- Cited by
- 196
- References
- 16
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- gold
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