Sex differences in rheumatoid arthritis: more than meets the eye
Open accessAbstract
Sex differences in the prevalence of autoimmune diseases such as rheumatoid arthritis (RA) are well described, but the literature is not as clear about sex differences in RA disease course and prognosis. A recent study from a very large cross-sectional international cohort demonstrated slightly worse levels of disease activity and function in female patients with RA, compared with men. These findings are discussed in the context of our evolving knowledge of sex differences in the expression of this prototypic autoimmune disease, both in terms of the actual disease activity level, the effects that the disease has on physical function, and our ability accurately to measure these aspects.
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The sample size of included studies consisted mostly of female participants, which is generally reflective of prevalence rates in rheumatic conditions.
“Besides, the sample size of included studies consisted mostly of female participants, which is generally reflective of prevalence rates in rheumatic conditions (Van Vollenhoven, 2009).”
From Guided internet-based cognitive-behavioral therapy for patients with rheumatic conditions: A systematic review (2021) · cites this paper as Van Vollenhoven, 2009
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- Authors
- van Vollenhoven, R. F.
- Venue
- BMC Medicine
- Published
- 2009-03-30
- Volume
- 7
- Issue
- 1
- Pages
- 12-12
- ISSN
- 1741-7015 (ISSN-L)
- PMC
- PMC2670321
- OpenAlex
- W2090929542
- Cited by
- 326
- References
- 33
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 35 · 2023: 33 · 2022: 38 · 2021: 43 · 2020: 39 · 2019: 31 · 2018: 25 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 1 · 2012: 5
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- rheumatoid arthritis, sex differences, disease activity, physical function, prognosis, autoimmune disease, clinical course, sex differences in disease expression
- MeSH terms
- Arthritis, Rheumatoid, Cross-Sectional Studies, Female, Humans, Male, Severity of Illness Index, Sex Characteristics, Cohort Studies, Prevalence
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