The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Microglia and neuroinflammation: a pathological perspective
Open accessAbstract
Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. Their role in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses. Specific reference is made also to their involvement in Alzheimer's disease where microglial cell activation is thought to be critically important in the neurodegenerative process.
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“After acute inflammatory damage, the brain glial cells respond to repair the tissue. If the stimulus persists, it produces an inflammatory chronic state that leads to neuronal dysfunction, injury, and loss (Streit et al., 2004; Calsolaro and Edison, 2016).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Streit et al., 2004
In the citing paper
“It is vital to determine pathways of persistent activation in microglia since this underpins the chronic inflammatory state in neurological diseases with an inflammatory aspect [151].”
From ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease (2020) · cites this paper as [151]
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Cited by
Sorted by citations
Neuroinflammation in Alzheimer's disease: current evidence and future directions
Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726
Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.
(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288
Microglial signatures and their role in health and disease
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Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044
Kwon, Y. H., Fingert, J. H., Kuehn, M. H., & Alward, W. L. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804630 · Cited by 892
Metadata
- Authors
- Streit
- Venue
- Journal of Neuroinflammation
- Published
- 2004
- Volume
- 1
- Issue
- 1
- Pages
- 14
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC509427
- OpenAlex
- W1563590122
- Cited by
- 1,039
- References
- 26
- Citations by year
- 2026: 25 · 2025: 41 · 2024: 73 · 2023: 71 · 2022: 70 · 2021: 78 · 2020: 82 · 2019: 62 · 2018: 62 · 2017: 54 · 2016: 45 · 2015: 49 · 2014: 51 · 2013: 49 · 2012: 41
- FWCI
- 16.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Brain Research Foundation
- McKnight Foundation
- Evelyn F. McKnight Brain Research Foundation
- University of Florida
- National Institutes of Health
- National Institute on Aging (P30AG019606, P01AG012411)
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microglia, neuroinflammation, central nervous system infection, Alzheimer's disease, microglial activation, neurodegeneration
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