Microglia and Alzheimer's disease pathogenesis

Neuropathological stageing of Alzheimer-related changes.

Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works

Amyloid deposition as the central event in the aetiology of Alzheimer’s disease

Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538 · see citing works

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works

Reactive microgliosis

Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096 · see citing works

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works

Microglia as neuroprotective, immunocompetent cells of the CNS

Streit, W. J. (2002) · Glia · doi:10.1002/glia.10154 · Cited by 919 · see citing works

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836 · see citing works

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works

Amyloid β-Protein and the Genetics of Alzheimer's Disease

Selkoe, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18295 · Cited by 798 · see citing works

The Pathogenesis of Senile Plaques

DICKSON, D. W. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199704000-00001 · Cited by 753 · see citing works

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743 · see citing works

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works

Dystrophic microglia in the aging human brain

Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705 · see citing works

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

Dickson, D. W., Crystal, H. A., Mattiace, L. A., Masur, D. M., Blau, A. D., Davies, P., Yen, S.-H., & Aronson, M. K. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90027-u · Cited by 643 · see citing works

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

Barger, S. W., & Harmon, A. D. (1997) · Nature · doi:10.1038/42257 · Cited by 622 · see citing works

Microglial response to amyloid plaques in APPsw transgenic mice.

Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B. T., Saido, T. C., Hsiao, K., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 592 · see citing works

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway

Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546 · see citing works

A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation

Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works

Ameboid microglia as effectors of inflammation in the central nervous system

Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482 · see citing works

Inflammation, autotoxicity and Alzheimer disease

McGeer, P. L. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00289-5 · Cited by 474 · see citing works

Immune System Response in Alzheimer's Disease

McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029863 · Cited by 460 · see citing works

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

Lassmann, H., Bancher, C., Breitschopf, H., Węgiel, J., Bobinski, M., Jellinger, K. A., & Wı́sniewski, H. M. (1995) · Acta Neuropathologica · doi:10.1007/bf00294257 · Cited by 458 · see citing works

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Yan, S. D., Zhu, H., Fu, J., Yan, S. F., Roher, A. E., Tourtellotte, W. W., Rajavashisth, T. B., Chen, X., Godman, G. C., Stern, D. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5296 · Cited by 427 · see citing works

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., van Gool, W. A., Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Williams, A. (2002) · Glia · doi:10.1002/glia.10146 · Cited by 402 · see citing works

Microglia and inflammatory mechanisms in the clearance of amyloid β peptide

Rogers, J., Strohmeyer, R., Kovelowski, C. J., & Li, R. (2002) · Glia · doi:10.1002/glia.10153 · Cited by 381 · see citing works

Altered antigen expression of microglia in the aged rodent CNS

Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364 · see citing works

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS<i>In Vivo</i>

Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348 · see citing works

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

Stalder, M., Phinney, A., Probst, A., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65423-5 · Cited by 345 · see citing works

Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy

Graeber, M. B., Tetzlaff, W., Streit, W. J., & Kreutzberg, G. W. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90585-x · Cited by 333 · see citing works

Amyloid Fibrils Activate Tyrosine Kinase-Dependent Signaling and Superoxide Production in Microglia

McDonald, D. R., Brunden, K. R., & Landreth, G. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02284.1997 · Cited by 308 · see citing works

Microglia enhance β‐amyloid peptide‐induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species

Qin, L., Liu, Y., Cooper, C. L., Liu, B., Wilson, B. C., & Hong, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01210.x · Cited by 290 · see citing works

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

Haga, S., Akai, K., & Ishii, T. (1989) · Acta Neuropathologica · doi:10.1007/bf00687883 · Cited by 284 · see citing works

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce ?-amyloid fibrils

Frackowiak, J., Wisniewski, H. M., Wegiel, J., Merz, G. S., Iqbal, K., & Wang, K. C. (1992) · Acta Neuropathologica · doi:10.1007/bf00227813 · Cited by 276 · see citing works

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

Sparks, D. L., Hunsaker, J. C., Scheff, S. W., Kryscio, R. J., Henson, J. L., & Markesbery, W. R. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90024-t · Cited by 271 · see citing works

Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells

Paresce, D. M., Chung, H., & Maxfield, F. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.29390 · Cited by 269 · see citing works

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

Giulian, D., Haverkamp, L. J., Yu, J., Karshin, W. L., Tom, D., Li, J., Kirkpatrick, J. B., Kuo, Y., & Roher, A. E. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06021.1996 · Cited by 266 · see citing works

THE ASSOCIATION BETWEEN HEAD TRAUMA AND ALZHEIMER'S DISEASE

Graves, A. B., White, E., Koepsell, T. D., Reifler, B. V., van Belle, G., Larson, E. B., & Raskind, M. A. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115523 · Cited by 257 · see citing works

Complement and cytokine gene expression in cultured microglia derived from postmortem human brains

Walker, D. G., Kim, S. U., & McGeer, P. L. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490400407 · Cited by 248 · see citing works

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease.

Yang, F., Sun, X., Beech, W. K., Teter, B., Wu, S. S. H., Sigel, J. J., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 245 · see citing works

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

Wisniewski, H. M., Węgiel, J., WANG, K. C., Kujawa, M., & Lach, B. (1989) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100029887 · Cited by 244 · see citing works

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

Perlmutter, L. S., Barron, E., & Chui, H. C. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90748-x · Cited by 240 · see citing works

Microglial Expression of MHC Class II Increases in Normal Aging of Nonhuman Primates

Sheffield, L. G., & Berman, N. E. J. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00168-1 · Cited by 234 · see citing works

MHC class II‐positive microglia in human brain: Association with alzheimer lesions

Perlmutter, L. S., Scott, S. A., Barrón, E., & Chui, H. C. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330407 · Cited by 228 · see citing works

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

Wisniewski, H. M., Wegiel, J., Wang, K. C., & Lach, B. (1992) · Acta Neuropathologica · doi:10.1007/bf00311383 · Cited by 221 · see citing works

Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors.

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Peptides released by ameboid microglia regulate astroglial proliferation.

Giulian, D., & Baker, T. J. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.6.2411 · Cited by 208 · see citing works

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, S. L., Burgess, L. H., Kocsis‐Angle, J., Antal, J. M., Dority, M. D., Embury, P. B., Piotrkowski, A. M., & Brunden, K. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741017.x · Cited by 202 · see citing works

Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain

Styren, S. D., Civin, W. H., & Rogers, J. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90054-v · Cited by 191 · see citing works

Effects of ageing on microglia in the normal rat brain: immunohistochemical observations

Ogura, K., Ogawa, M., & Yoshida, M. (1994) · Neuroreport · doi:10.1097/00001756-199406020-00016 · Cited by 181 · see citing works

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

Tooyama, I., Kimura, H., Akiyama, H., & McGeer, P. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)91496-4 · Cited by 180 · see citing works

Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family

Rozemüller, A. J. M., Eikelenboom, P., Pals, S. T., & Stam, F. C. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90547-8 · Cited by 173 · see citing works

Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits

Streit, W. J., & Sparks, D. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050097 · Cited by 168 · see citing works

Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes

Flanary, B. E., & Streit, W. J. (2004) · Glia · doi:10.1002/glia.10301 · Cited by 167 · see citing works

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid.

Frautschy, S. A., Cole, G. M., & Baird, A. (1992) · PubMed Central · Cited by 157 · see citing works

Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia

Walker, D. G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00306-2 · Cited by 155 · see citing works

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles

Iqbal, K., Alonso, A. D. C., Gong, C., Khatoon, S., Pei, J. ‐., Wang, J. Z., & Grundke, I. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_15 · Cited by 140 · see citing works

CD45 Opposes β-Amyloid Peptide-Induced Microglial Activation via Inhibition of p44/42 Mitogen-Activated Protein Kinase

Tan, J. R., Town, T., Mori, T., Wu, Y., Saxe, M., Crawford, F., & Mullan, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-20-07587.2000 · Cited by 138 · see citing works

Lack of alzheimer pathology after β-amyloid protein injections in rat brain

Games, D., Khan, K., Soriano, F., Keim, P., Davis, D., Bryant, K., & Lieberburg, I. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90057-5 · Cited by 123 · see citing works

Activation of nuclear factor-κB by β-amyloid peptides and interferon-γ in murine microglia

Bonaiuto, C., McDonald, P. P., Rossi, F., & Cassatella, M. A. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00054-4 · Cited by 113 · see citing works

Phagocytosis of ?/A4 amyloid fibrils of the neuritic neocortical plaques

Wisniewski, H. M., Barcikowska, M., & Kida, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00310142 · Cited by 109 · see citing works

Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons

Wu, Q. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00219-0 · Cited by 93 · see citing works

Expression of ?2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells

Marzolo, M., Rommy von Bernhardi, M., Bu, G., & Inestrosa, N. C. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3 · Cited by 87 · see citing works

β-Amyloid peptides induce degeneration of cultured rat microglia

Korotzer, A. R., Pike, C. J., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90068-x · Cited by 82 · see citing works

The enigma of cell death in neurodegenerative disorders

Jellinger, K. A., & Stadelmann, C. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6301-6_2 · Cited by 57 · see citing works

Predicting the failure of amyloid-β vaccine

Smith, M. A., Atwood, C., Joseph, J. A., & Perry, G. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08695-6 · Cited by 49 · see citing works

Alzheimer's vaccine: a cure as dangerous as the disease?

Münch, G. W., & Robinson, S. R. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200044 · Cited by 44 · see citing works

Ethanol metabolism and striatal dopamine turnover

Barbaccia, M. L., Bosio, A., Spano, P., & Trabucchi, M. (1982) · Journal of Neural Transmission · doi:10.1007/bf01243408 · Cited by 44 · see citing works

Potential neurotoxic inflammatory responses to Aβ vaccination in humans

Münch, G. W., & Robinson, S. R. (2002) · Journal of Neural Transmission · doi:10.1007/s007020200091 · Cited by 40 · see citing works

NSAIDs and Alzheimer's disease: how far to generalise from trials?

Breitner, J. C. S. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00498-8 · Cited by 26 · see citing works

Microglial signaling by amyloid β protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS

Hasegawa, H., Nakai, M., Tanimukai, S., Taniguchi, T., Terashima, A., Kawamata, T., Fukunaga, K., Miyamoto, E., Misaki, K., Mukai, H., et al. (2001) · Neuroreport · doi:10.1097/00001756-200108080-00055 · Cited by 20 · see citing works

Physiology and Pathophysiology of Microglial Cell Function

Streit, W. J. (2002) · Springer eBooks · doi:10.1007/978-1-4757-4139-1_1 · Cited by 14 · see citing works

Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells

Beczkowska, I. W., Gracy, K. N., Pickel, V. M., & Inturrisi, C. E. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970101)47:1 · Cited by 11 · see citing works

Untitled work

Ard (1996) · doi:10.1002/(sici)1097-4547(19960115)43:2

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046 · see citing works

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039 · see citing works

Review: Activation patterns of microglia and their identification in the human brain

Boche, D., Perry, V. H., & Nicoll, J. A. R. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 911 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Alzheimer's Disease: From Pathology to Therapeutic Approaches

Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626 · see citing works

Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

Townsend, M., Shankar, G. M., Mehta, T., Walsh, D. M., & Selkoe, D. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103754 · Cited by 619 · see citing works

Microglial dysfunction in brain aging and Alzheimer's disease

Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

Tynan, R. J., Naicker, S., Hinwood, M., Nalivaiko, E., Buller, K. M., Pow, D. V., Day, T. A., & Walker, F. R. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.02.001 · Cited by 531 · see citing works

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.001 · Cited by 513 · see citing works

NOX Enzymes in the Central Nervous System: From Signaling to Disease

Sorce, S., & Krause, K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2578 · Cited by 472 · see citing works

Ageing, Cellular Senescence and Neurodegenerative Disease

Kritsilis, M., V. Rizou, S., Koutsoudaki, P. N., Evangelou, K., Gorgoulis, V. G., & Papadopoulos, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102937 · Cited by 448 · see citing works

Microglial phenotype: is the commitment reversible?

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Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

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