Microglia and neuroinflammation: a pathological perspective

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Innate Immunity

Medzhitov, R. M., & Janeway, C. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008033430506 · Cited by 1,827

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

IRIZARRY, M. C., MCNAMARA, M., FEDORCHAK, K., HSIAO, K., & HYMAN, B. T. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199709000-00002 · Cited by 649

Microglial response to amyloid plaques in APPsw transgenic mice.

Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B. T., Saido, T. C., Hsiao, K., & Cole, G. M. (1998) · Europe PMC (PubMed Central) · Cited by 592

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., van Gool, W. A., Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Williams, A. (2002) · Glia · doi:10.1002/glia.10146 · Cited by 412

Rats and mice exhibit distinct inflammatory reactions after spinal cord injury

Sroga, J. M., Jones, T. B., Kigerl, K. A., McGaughy, V. M., & Popovich, P. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10736 · Cited by 369

Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo

Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.

(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288

Microglial signatures and their role in health and disease

Butovsky, O., & Weiner, H. L. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0057-5 · Cited by 1,046

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044

Primary Open-Angle Glaucoma

Kwon, Y. H., Fingert, J. H., Kuehn, M. H., & Alward, W. L. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804630 · Cited by 892

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

Gao, H., & Hong, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.05.002 · Cited by 852

The role of microglia in amyloid clearance from the AD brain

Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

Reed-Geaghan, E. G., Savage, J. C., Hise, A. G., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-09.2009 · Cited by 591

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Cai, Z., Hussain, M. D., & Yan, L.-J. (2014) · International Journal of Neuroscience · doi:10.3109/00207454.2013.833510 · Cited by 583

Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage

Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556

A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 555

Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice

Shan, S., Zhang, Y., Zhao, H., Zeng, T., & Zhao, X. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.134261 · Cited by 556

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

Kim, H.-J., Cho, M.-H., Shim, W. H., Kim, J. K., Jeon, E.-Y., Kim, D.-H., & Yoon, S.-Y. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.103 · Cited by 475

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Morales, I., Guzmán-Martínez, L., Cerda-Troncoso, C., Farías, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466

Microglial Phagocytosis of Fibrillar β-Amyloid through a β1Integrin-Dependent Mechanism

Koenigsknecht-Talboo, J., & Landreth, G. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2557-04.2004 · Cited by 457

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

Wang, S., Yuan, Y., Chen, N., & Wang, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.12.019 · Cited by 452

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

Cho, M.-H., Cho, K., Kang, H.-J., Jeon, E.-Y., Kim, H.-S., Kwon, H.-J., Kim, H.-M., Kim, D.-H., & Yoon, S.-Y. (2014) · Autophagy · doi:10.4161/auto.29647 · Cited by 395

The P2X 7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X 7 R Pore

Monif, M., Reid, C. A., Powell, K. L., Smart, M. L., & Williams, D. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5512-08.2009 · Cited by 374

Critical role of TLR4 response in the activation of microglia induced by ethanol

Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373

Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients

Yachou, Y., Idrissi, A. E., Belapasov, V., & BenAli, S. A. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04575-3 · Cited by 386

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego, C. M., Gallezot, J.-D., Pittman, B., Nabulsi, N., Lim, K., Lin, S.-F., Matuskey, D., Lee, J.-Y., O’Connor, K. C., Huang, Y., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511003112 · Cited by 356

Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy

Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

Njie, E. G., Boelen, E., Stassen, F. R., Steinbusch, H. W. M., Borchelt, D. R., & Streit, W. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.008 · Cited by 335

Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function

Walker, F. R., Nilsson, M., & Jones, K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990208 · Cited by 336

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

Paudel, Y. N., Shaikh, M. F., Chakraborti, A., Kumari, Y., Aledo-Serrano, Á., Aleksovska, K., Alvim, M. K. M., & Othman, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00628 · Cited by 311

Oxidative Stress in Autism Spectrum Disorder

Bjørklund, G., Meguid, N. A., El-Bana, M. A., Tinkov, A. A., Saad, K., Dadar, M., Hemimi, M., Skalny, A. V., Hosnedlová, B., Kizek, R., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01742-2 · Cited by 323

Neuroinflammation and white matter pathology in schizophrenia: systematic review

Najjar, S., & Pearlman, D. M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.04.041 · Cited by 321

Privileged Structures: Efficient Chemical “Navigators” toward Unexplored Biologically Relevant Chemical Spaces

Kim, J., Kim, H., & Park, S. B. (2014) · Journal of the American Chemical Society · doi:10.1021/ja508343a · Cited by 309

Postoperative cognitive dysfunction – current preventive strategies

Kotekar, N., Shenkar, A., & Nagaraj, R. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s133896 · Cited by 319

The effects of microglia-associated neuroinflammation on Alzheimer’s disease

Wang, C., Zong, S., Cui, X., Wang, X., Wu, S., Wang, L., Liu, Y., & Lu, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1117172 · Cited by 331

Excessive Extracellular Volume Reveals a Neurodegenerative Pattern in Schizophrenia Onset

Pasternak, O., Westin, C., Sylvain Bouix, A., Seidman, L. J., Goldstein, J. M., Woo, T.-U. W., Petryshen, T. L., Mesholam‐Gately, R. I., McCarley, R. W., Kikinis, R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2904-12.2012 · Cited by 306

Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease

Biron, K. E., Dickstein, D. L., Gopaul, R., & Jefferies, W. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023789 · Cited by 300

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 299

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

Harry, G. J., & Kraft, A. D. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.10.1265 · Cited by 304

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

Qin, L., & Crews, F. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-5 · Cited by 290

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

Werry, E. L., Bright, F., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kril, J. J., & Kassiou, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133161 · Cited by 298

Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes

Holder, M. K., & Blaustein, J. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.004 · Cited by 279

Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve

Hu, P., Bembrick, A. L., Keay, K. A., & McLachlan, E. M. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.013 · Cited by 279

The neuropathology, pathophysiology and genetics of multiple system atrophy

Ahmed, Z., Asi, Y. T., Sailer, A., Lees, A. J., Houlden, H., Révész, T., & Holton, J. L. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01234.x · Cited by 275

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258

The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease

Corrêa, S. A. L., & Eales, K. L. (2012) · Journal of Signal Transduction · doi:10.1155/2012/649079 · Cited by 258

Neuronal and microglial mechanisms of neuropathic pain

Zhuo, M., Wu, G., & Wu, L. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-31 · Cited by 256

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Sobue, A., Komine, O., Hara, Y., Endo, F., Mizoguchi, H., Watanabe, S., Murayama, S., Saito, T., Saido, T. C., Sahara, N., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01099-x · Cited by 253

Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition

Bilbo, S. D., Biedenkapp, J. C., Der-Avakian, A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1748-05.2005 · Cited by 251

Cutting Edge: TLR2-Mediated Proinflammatory Cytokine and Chemokine Production by Microglial Cells in Response to Herpes Simplex Virus

Aravalli, R. N., Hu, S., Rowen, T. N., Palmquist, J. M., & Lokensgard, J. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4189 · Cited by 251

Neuroinflammation in animal models of traumatic brain injury

Chiu, C., Liao, Y.-E., Yang, L.-Y., Wang, J.-Y., Tweedie, D., Karnati, H. K., Greig, N. H., & Wang, J. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.06.018 · Cited by 261

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

Frank, S., Burbach, G. J., Bonin, M., Walter, M., Streit, W., Bechmann, I., & Deller, T. (2008) · Glia · doi:10.1002/glia.20710 · Cited by 247

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

Marrone, M. C., Morabito, A., Giustizieri, M., Chiurchiù, V., Leuti, A., Mattioli, M., Marinelli, S., Riganti, L., Lombardi, M., Murana, E., et al. (2017) · Nature Communications · doi:10.1038/ncomms15292 · Cited by 250

Sex differences in pain

Mapplebeck, J. C. S., Beggs, S., & Salter, M. W. (2015) · Pain · doi:10.1097/j.pain.0000000000000389 · Cited by 243

Microglial Dynamics During Human Brain Development

Menassa, D. A., & Gómez‐Nicola, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01014 · Cited by 259

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

Nichol, K. E., Poon, W. W., Parachikova, A. I., Cribbs, D. H., Glabe, C. G., & Cotman, C. W. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-13 · Cited by 250

Lactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond

Mason, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00043 · Cited by 240

Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Wu, Z., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A. W., Ibbett, P., & Nakanishi, H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.002 · Cited by 246

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236

TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity

Brás, J. P., Bravo, J., Freitas, J., Barbosa, M. A., Santos, S. G., Summavielle, T., & Almeida, M. I. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2626-6 · Cited by 236

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer’s Disease

Shal, B., Ding, W., Ali, H., Kim, Y. S., & Khan, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00548 · Cited by 234

Neuroprotective Natural Products for Alzheimer’s Disease

Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236

Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin

Fiala, M., Liu, P. T., Monteros, A. E. D. L., Rosenthal, M. J., Bernard, G. W., Ringman, J. M., Sayre, J. W., Zhang, L., Zaghi, J., Dejbakhsh, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701267104 · Cited by 236

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

George, S., Rey, N. L., Tyson, T., Esquibel, C., Meyerdirk, L., Schulz, E., Pierce, S., Burmeister, A. R., Madaj, Z., Steiner, J. A., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0335-3 · Cited by 229

Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials

Mandler, M., Valera, E., Rockenstein, E. M., Weninger, H., Patrick, C., Adame, A., Santic, R., Meindl, S., Vigl, B., Smrzka, O. W., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1256-4 · Cited by 239

Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

Lee, C., Hsu, L., Wu, I.-L., Wang, Y., Chen, W.-C., Liu, Y., Yang, L.-T., Tan, C.-L., Luo, Y.-H., Wang, C.-C., et al. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128431 · Cited by 237

Automated Morphological Analysis of Microglia After Stroke

Heindl, S., Gesierich, B. G., Benakis, C., Llovera, G., Duering, M., & Liesz, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00106 · Cited by 237

Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia

Candelario-Jalil, E., de Oliveira, A. C. P., Gräf, S., Bhatia, H. S., Hüll, M., Muñoz, E., & Fiebich, B. L. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-25 · Cited by 223

Progranulin in frontotemporal lobar degeneration and neuroinflammation

Ahmed, Z., Mackenzie, I. R., Hutton, M. L., & Dickson, D. W. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-7 · Cited by 222

Melatonin in Alzheimer’s Disease

Li, L., Qiong-xia, H., Yang, S.-S., Chu, J., Wang, J., & Tian, Q. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140714575 · Cited by 229

P2X ion channel receptors and inflammation

Burnstock, G. (2016) · Purinergic Signalling · doi:10.1007/s11302-015-9493-0 · Cited by 215

Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia

Fan, Z., Aman, Y., Ahmed, I., Chetelat, G., Landeau, B., Ray Chaudhuri, K., Brooks, D. J., & Edison, P. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.016 · Cited by 212

The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats

Pearson-Leary, J., Zhao, C., Bittinger, K., Eacret, D., Luz, S., Vigderman, A. S., Dayanim, G., & Bhatnagar, S. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0380-x · Cited by 206

Evidence of microglial activation in autism and its possible role in brain underconnectivity

Rodriguez, J. I., & Kern, J. K. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000142 · Cited by 214

Inflammation context in Alzheimer’s disease, a relationship intricate to define

Novoa, C., Salazar, P., Cisternas, P., Gherardelli, C., Vera-Salazar, R., Zolezzi, J. M., & Inestrosa, N. C. (2022) · Biological Research · doi:10.1186/s40659-022-00404-3 · Cited by 206

Regulation of Dynamic Behavior of Retinal Microglia by CX3CR1 Signaling

Liang, K. J., Lee, J. E., Wang, Y. D., Ma, W., Fontainhas, A. M., Fariss, R. N., & Wong, W. T. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-3357 · Cited by 220

PET Imaging of Inflammation Biomarkers

Wu, C., Li, F., Niu, G., & Chen, X. S. (2013) · Theranostics · doi:10.7150/thno.6592 · Cited by 204

Microglia: Multitasking Specialists of the Brain

Casano, A. M., & Peri, F. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.018 · Cited by 209

Neuroimmune Function and the Consequences of Alcohol Exposure

Crews, F. T. (2015) · Alcohol research · doi:10.35946/arcr.v37.2.15 · Cited by 203

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

Rezai-Zadeh, K. P., Gate, D., & Town, T. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9166-2 · Cited by 202

Circulating monocytes engraft in the brain, differentiate into microglia and contribute to the pathology following meningitis in mice

Djukic, M. (2006) · Brain · doi:10.1093/brain/awl206 · Cited by 195

Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke

Wang, A., Tian, Y., Zhang, W., Tian, T., Gong, S.-X., Huang, W., & Zhou, Q. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286954 · Cited by 187

The Glutathione System in Parkinson’s Disease and Its Progression

Bjørklund, G., Peana, M., Maes, M., Dadar, M., & Severin, B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.004 · Cited by 186

Toll-Like Receptor 2 Signaling in Response to Brain Injury: An Innate Bridge to Neuroinflammation

Babcock, A. A., Wirenfeldt, M., Holm, T. H., Nielsen, H. H., Dissing‐Olesen, L., Toft‐Hansen, H., Millward, J. M., Landmann, R. M., Rivest, S., Finsen, B. R., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4937-05.2006 · Cited by 188

P2 receptors and neuronal injury

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