The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice
Open accessAbstract
BACKGROUND: Abnormal accumulation of amyloid β-protein (Aβ) in the brain plays an important role in the pathogenesis \of Alzheimer's disease (AD). Aβ monomers assemble into oligomers and fibrils that promote neuronal dysfunction. This assembly pathway is influenced by naturally occurring brain molecules, the Aβ chaperone proteins, which bind to Aβ and modulate its aggregation. Myelin basic protein (MBP) was previously identified as a novel Aβ chaperone protein and a potent inhibitor for Aβ fibril assembly in vitro. METHODS: In this study, we determined whether the absence of MBP would influence Aβ pathology in vivo by breeding MBP knockout mice (MBP-/-) with Tg-5xFAD mice, a model of AD-like parenchymal Aβ pathology. RESULTS: Through biochemical and immunohistochemical experiments, we found that bigenic Tg-5xFAD/MBP-/- mice had a significant decrease of insoluble Aβ and parenchymal plaque deposition at an early age. The expression of transgene encoded human AβPP, the levels of C-terminal fragments generated during Aβ production and the intracellular Aβ were unaffected in the absence of MBP. Likewise, we did not find a significant difference in plasma Aβ or cerebrospinal fluid Aβ, suggesting these clearance routes were unaltered in bigenic Tg-5xFAD/MBP-/- mice. However, MBP-/- mice and bigenic Tg-5xFAD/MBP-/- mice exhibited elevated reactive astrocytes and activated microglia compared with Tg-5xFAD mice. The Aβ degrading enzyme matrix metalloproteinase 9 (MMP-9), which is expressed by activated glial cells, was significantly increased in the Tg-5xFAD/MBP-/- mice. CONCLUSIONS: These findings indicate that the absence of MBP decreases Aβ deposition in transgenic mice and that this consequence may result from increased glial activation and expression of MMP-9, an Aβ degrading enzyme.
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Mbp maintained myelination and prevented further neuroinflammation.
“Long term infection also induced Mbp gene, which maintained myelination and prevented further neuroinflammation94.”
From Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk (2022) · cites this paper as [94]
The Background identifies MBP as a major structural protein of the myelin sheath, and the Discussion links MBP loss and abnormal myelination to increased neuroinflammatory cells. The paper studies MBP-deficient mice; it does not show that infection-induced Mbp maintained myelination or prevented further inflammation during infection. (LLM, conf=0.84)
Experimental — accuracy not yet measuredMyelin basic protein (MBP) can influence β-amyloid accumulation in the brain.
“Myelin basic protein, MBP, can influence β-amyloid accumulation in the brain.”
From Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age (2019) · cites this paper as [49]
Deletion of MBP gene led to a significant reduction in cerebral β-amyloid levels in Tg-3xFAD mice.
“Indeed, deletion of MBP gene led to a significant reduction in cerebral β-amyloid levels in Tg-3xFAD mice49”
From Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age (2019) · cites this paper as [49]
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- Authors
- Ou-Yang, M.-H., & Van Nostrand, W. E.
- Affiliations
- Stony Brook University (US)
- Venue
- Journal of Neuroinflammation
- Published
- 2013-11-05
- Volume
- 10
- Issue
- 1
- Pages
- 134-134
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC4228351
- OpenAlex
- W2137664031
- Cited by
- 30
- References
- 81
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 6 · 2014: 2
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- National Institutes of Health
- National Institute on Aging (R21AG039215)
- National Institute of Neurological Disorders and Stroke (R21NS079951)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- myelin basic protein, amyloid-beta, Alzheimer's disease, neuroinflammation, reactive astrocytes, microglial activation, MMP-9, amyloid beta degradation
- MeSH terms
- Alzheimer Disease, Animals, Brain, Disease Models, Animal, Myelin Basic Protein, Enzyme-Linked Immunosorbent Assay, Humans, Immunohistochemistry, Inflammation, Mice, Transgenic, Immunoblotting, Amyloid beta-Peptides, Mice, Knockout, Mice
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