Focal demyelination in Alzheimer’s disease and transgenic mouse models
Open accessAbstract
We have investigated alterations in myelin associated with Abeta plaques, a major pathological hallmark of Alzheimer's disease (AD), in human tissue and relevant transgenic mice models. Using quantitative morphological techniques, we determined that fibrillar Abeta pathology in the grey matter of the neocortex was associated with focal demyelination in human presenilin-1 familial, sporadic and preclinical AD cases, as well as in two mouse transgenic models of AD, compared with age-matched control tissue. This demyelination was most pronounced at the core of Abeta plaques. Furthermore, we found a focal loss of oligodendrocytes in sporadic and preclinical AD cases associated with Abeta plaque cores. In human and transgenic mice alike, plaque-free neocortical regions showed no significant demyelination or oligodendrocyte loss compared with controls. Dystrophic neurites associated with the plaques were also demyelinated. We suggest that such plaque-associated focal demyelination of the cortical grey matter might impair cortical processing, and may also be associated with aberrant axonal sprouting that underlies dystrophic neurite formation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nearly all studies of oligodendrocytes and myelin in amyloid mouse models of AD have focused on the effect of amyloid plaques and Aβ on oligodendrocytes and myelin, partially describing secondary demyelination or hypomyelination.
“Nearly all have focused on the effect of amyloid plaques and Aβ on oligodendrocytes and myelin, partially describing secondary demyelination or hypomyelination.”
From Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease (2023) · cites this paper as [42]
Only a few studies have experimentally investigated oligodendrocytes and myelin in amyloid mouse models of AD.
“Only a few studies have experimentally investigated oligodendrocytes and myelin in amyloid mouse models of AD20,21,41–43.”
From Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease (2023) · cites this paper as [42]
AD pathology in the white matter includes loss of myelin and a decrease in oligodendrocyte proteins.
“AD pathology in the white matter includes the loss of myelin and a decrease in oligodendrocyte proteins [62–68].”
From Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts (2016) · cites this paper as [67]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
Cortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836 · see citing works
Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125 · see citing works
Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K., Gonzales, V., Jenkins, N. A., Copeland, N. G., Price, D. L., & Sisodia, S. S. (1997) · Neuron · doi:10.1016/s0896-6273(00)80974-5 · Cited by 1,023 · see citing works
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014 · see citing works
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Koffie, R. M., Meyer-Luehmann, M., Hashimoto, T., Adams, K. W., Mielke, M. L., Garcia-Alloza, M., Micheva, K. D., Smith, S. J., Kim, M. L., Lee, V. M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811698106 · Cited by 850 · see citing works
The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal
Hardy, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06181.x · Cited by 814 · see citing works
Molecular pathways to neurodegeneration
Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740 · see citing works
Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614 · see citing works
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561 · see citing works
Spires, T. L., Meyer-Luehmann, M., Stern, E. A., McLean, P. J., Skoch, J., Nguyen, P. T., Bacskai, B. J., & Hyman, B. T. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1879-05.2005 · Cited by 550 · cited 2× · see citing works
“It has been proposed that the accumulation of abnormal Ab into plaques causes a cascade of aberrant cytoskeletal changes leading to the loss of dendritic spines, the formation of dystrophic axons and, ultimately, neuronal degeneration [51, 58].”
BackgroundShen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works
Two Types of Sporadic Cerebral Amyloid Angiopathy
Thal, D. R., Ghebremedhin, E., Rüb, U., Yamaguchi, H., Del Tredici, K., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.3.282 · Cited by 446 · see citing works
Remyelination protects axons from demyelination-associated axon degeneration
Irvine, K. A., & Blakemore, W. F. (2008) · Brain · doi:10.1093/brain/awn080 · Cited by 420 · see citing works
White Matter Structural Integrity in Healthy Aging Adults and Patients With Alzheimer Disease
Bartzokis, G., Cummings, J. L., Sultzer, D. L., Henderson, V. W., Nuechterlein, K. H., & Mintz, J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.393 · Cited by 415 · see citing works
Myelinated nerve fibres in the CNS
Hildebrand, C., Remahl, S., Persson, H., & Bjartmar, C. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90015-k · Cited by 376 · see citing works
Age-induced white matter changes in the human brain: a stereological investigation.
Tang, Y., Nyengaard, J., Pakkenberg, B., & Gundersen, H. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00155-3 · Cited by 345 · see citing works
Svennerholm, L. T., & Gottfries, C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62031039.x · Cited by 327 · see citing works
Extensive cortical remyelination in patients with chronic multiple sclerosis
Albert, M., Antel, J., Brück, W., & Stadelmann, C. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00043.x · Cited by 314 · see citing works
Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 308 · see citing works
Li, S., Liu, B. P., Budel, S., Li, M., Ji, B., Walus, L. R., Li, W., Jirik, A., Rabacchi, S. A., Choi, E., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2828-04.2004 · Cited by 306 · see citing works
Dickson, T. C., & Vickers, J. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00169-5 · Cited by 294 · see citing works
Self-citationRingman, J. M., O'Neill, J., Geschwind, D., Medina, L., Apostolova, L. G., Rodriguez, Y., Schaffer, B., Varpetian, A., Tseng, B., Ortiz, F., et al. (2007) · Brain · doi:10.1093/brain/awm102 · Cited by 290 · see citing works
Roher, A. E., Weiss, N., Kokjohn, T. A., Kuo, Y.-M., Kalback, W., Anthony, J., Watson, D., Luehrs, D. C., Sue, L., Walker, D., et al. (2002) · Biochemistry · doi:10.1021/bi026173d · Cited by 279 · see citing works
Desai, M. K., Sudol, K. L., Janelsins, M. C., Mastrangelo, M. A., Frazer, M. E., & Bowers, W. J. (2009) · Glia · doi:10.1002/glia.20734 · Cited by 266 · see citing works
Age‐Related White Matter Atrophy in the Human Brain
Meier-Ruge, W., Ulrich, J., Brühlmann, M., & Meier, E. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27462.x · Cited by 252 · see citing works
Ihara, M., Polvikoski, T. M., Hall, R., Slade, J. Y., Perry, R. H., Oakley, A. E., Englund, E. M., O'Brien, J. T., Ince, P. G., & Kalaria, R. N. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0635-8 · Cited by 242 · see citing works
Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes
Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230 · see citing works
Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease
de la Monte, S. M. (1989) · Annals of Neurology · doi:10.1002/ana.410250506 · Cited by 229 · see citing works
Merkler, D. (2006) · Brain · doi:10.1093/brain/awl135 · Cited by 222 · see citing works
Overcoming remyelination failure in multiple sclerosis and other myelin disorders.
Fancy, S., Kotter, M., Harrington, E. P., Huang, J. K., Zhao, C., Rowitch, D., & Franklin, R. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.020 · Cited by 201 · see citing works
p25α Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy
Song, Y. J. C., Lundvig, D. M. S., Huang, Y. M., Gai, W., Blumbergs, P. C., Højrup, P., Otzen, D. E., Halliday, G. M., & Jensen, P. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070201 · Cited by 201 · see citing works
Self-citationFormation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton
Brady, S. T., Witt, A. S., Kirkpatrick, L., de Waegh, S. M., Readhead, C. W., Tu, P., & Lee, V. M. ‐. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07278.1999 · Cited by 197 · see citing works
Reisberg, ., Franssen, E., Hasan, S. M., Monteiro, I., Boksay, I., Souren, L. E. M., Kenowsky, S., Auer, S., Elahi, S., & Kluger, A. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014170 · Cited by 195 · see citing works
Phinney, A. L., Deller, T., Stalder, M., Calhoun, M. E., Frotscher, M., Sommer, B., Staufenbiel, M., & Jucker, M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08552.1999 · Cited by 187 · see citing works
Burns, J. M., Church, J. A., Johnson, D. K., Xiong, C., Marcus, D., Fotenos, A. F., Snyder, A. Z., Morris, J. C., & Buckner, R. L. (2005) · Archives of Neurology · doi:10.1001/archneur.62.12.1870 · Cited by 155 · see citing works
Vulnerability of Select Neuronal Types to Alzheimer's Disease
BRAAK, H., DEL TREDICI, K., SCHULTZ, C., & BRAAK, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05560.x · Cited by 150 · see citing works
Neurochemical Diversity of Dystrophic Neurites in the Early and Late Stages of Alzheimer's Disease
Dickson, T. C., King, C., McCormack, G. H., & Vickers, J. C. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.7010 · Cited by 144 · see citing works
Self-citationLindner, M., Fokuhl, J., Linsmeier, F., Trebst, C., & Stangel, M. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.02.004 · Cited by 136 · see citing works
Multiple sclerosis and Alzheimer's disease
Dal Bianco, A., Bradl, M., Frischer, J., Kutzelnigg, A., Jellinger, K., & Lassmann, H. (2008) · Annals of Neurology · doi:10.1002/ana.21240 · Cited by 123 · see citing works
Cerebrovascular Pathology in Alzheimer's Disease and Leukoaraiosis
Brown, W. R., Moody, D. M., Thore, C. R., & Challa, V. R. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06348.x · Cited by 102 · see citing works
Le, R., Cruz, L., Urbanc, B., Knowles, R. B., Ashe, K. H., Duff, K., Irizarry, M. C., Stanley, E., & Hyman, B. T. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.753 · Cited by 90 · see citing works
Tian, J., Shi, J., Bailey, K. L., & Mann, D. M. A. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00510.x · Cited by 88 · see citing works
Power, J., Mayer-Pröschel, M., Smith, J., & Noble, M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0610 · Cited by 88 · see citing works
Haglund, M., & Englund, E. M. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000063606 · Cited by 87 · see citing works
Vickers, J. C., Chin, D., Edwards, A.-M., Sampson, V., Harper, C. G., & Morrison, J. H. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0133 · Cited by 86 · see citing works
Self-citationA modified technique for high-resolution staining of myelin
Pistorio, A. L., Hendry, S. H., & Wang, X. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.10.014 · Cited by 83 · see citing works
The neuroglial population in the primary visual cortex of the aging rhesus monkey
Peters, A., Verderosa, A., & Sethares, C. (2008) · Glia · doi:10.1002/glia.20686 · Cited by 82 · see citing works
Bauer, J., Bradl, M., Klein, M., Leisser, M., Deckwerth, T. L., Wekerle, H., & Lassmann, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.1.12 · Cited by 71 · see citing works
Matsuo, A., Lee, G. C., Terai, K., Takami, K., Hickey, W. F., McGeer, E. G., & McGeer, P. L. (1997) · Europe PMC (PubMed Central) · Cited by 71 · see citing works
Degradation of Amyloid β Protein by Purified Myelin Basic Protein*
Liao, M.-C., Ahmed, M., Smith, S. O., & Nostrand, W. V. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050856 · Cited by 54 · see citing works
Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau
Tomidokoro, Y., Harigaya, Y., Matsubara, E., Ikeda, M., Kawarabayashi, T., Shirao, T., Ishiguro, K., Okamoto, K., Younkin, S. G., & Shoji, M. (2001) · The Journal of Pathology · doi:10.1002/path.897 · Cited by 53 · see citing works
White matter mapping in Alzheimer's disease: A neuropathological study.
Sjöbeck, M., Haglund, M., & Englund, E. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.007 · Cited by 50 · see citing works
Oligodendrocytes are a Novel Source of Amyloid Peptide Generation
Skaper, S. D., Evans, N. A., Soden, P. E., Rosin, C., Facci, L., & Richardson, J. C. (2009) · Neurochemical Research · doi:10.1007/s11064-009-0022-9 · Cited by 43 · see citing works
Regenerative Failure: A Potential Mechanism for Neuritic Dystrophy in Alzheimer's Disease
DeWitt, D. A., & Silver, J. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0182 · Cited by 42 · see citing works
Myelin Basic Protein Binds to and Inhibits the Fibrillar Assembly of Aβ42 in Vitro
Hoos, M. D., Ahmed, M., Smith, S. O., & Nostrand, W. E. V. (2009) · Biochemistry · doi:10.1021/bi900037s · Cited by 35 · see citing works
Woodhouse, A., Dickson, T., West, A., Mclean, C., & Vickers, J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.010 · Cited by 34 · see citing works
Self-citationCytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer’s disease
Woodhouse, A., Shepherd, C. E., Sokolova, A., Carroll, V. L., King, A. E., Halliday, G. M., Dickson, T. C., & Vickers, J. C. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0458-z · Cited by 29 · see citing works
Self-citationPrice (1999) · doi:10.1002/1531-8249(199903)45:3
Flagged first, then by citations
Cited by
Sorted by citations
Immune attack: the role of inflammation in Alzheimer disease
Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · see citing works
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature · doi:10.1038/s41586-023-06120-6 · Cited by 476 · see citing works
Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease
Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346 · see citing works
Disease-specific molecular events in cortical multiple sclerosis lesions
Fischer, M. T., Wimmer, I., Höftberger, R., Gerlach, S., Haider, L., Zrzavy, T., Hametner, S., Mahad, D., Binder, C. J., Krumbholz, M., et al. (2013) · Brain · doi:10.1093/brain/awt110 · Cited by 311 · see citing works
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
Tollervey, J. R., Wang, Z., Hortobágyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., et al. (2011) · Genome Research · doi:10.1101/gr.122226.111 · Cited by 252 · see citing works
Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219 · see citing works
Zhang, X., Wang, R., Hu, D., Sun, X., Fujioka, H., Lundberg, K., Chan, E. R., Wang, Q., Xu, R., Flanagan, M. E., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb8680 · Cited by 200 · see citing works
TREM2 dependent and independent functions of microglia in Alzheimer’s disease
Hou, J., Chen, Y., Grajales-Reyes, G., & Colonna, M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00588-y · Cited by 191 · see citing works
The role of myelin damage in Alzheimer’s disease pathology
Papuć, E., & Rejdak, K. (2020) · Archives of Medical Science · doi:10.5114/aoms.2018.76863 · Cited by 188 · see citing works
Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?
Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160 · see citing works
De Rossi, P., Buggia-Prévot, V., Clayton, B. L. L., Vasquez, J. B., van Sanford, C., Andrew, R. J., Lesnick, R., Botté, A., Deyts, C., Salem, S., et al. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0124-1 · Cited by 151 · see citing works
Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments
Bartzokis, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.015 · Cited by 142 · see citing works
Conserved brain myelination networks are altered in Alzheimer’s and other neurodegenerative diseases
Allen, M., Wang, X., Burgess, J. D., Watzlawik, J., Serie, D. J., Younkin, C. S., Nguyen, T., Malphrus, K. G., Lincoln, S., Carrasquillo, M. M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.09.012 · Cited by 143 · see citing works
Altered synapses and gliotransmission in Alzheimer's disease and AD model mice
Mitew, S., Kirkcaldie, M. T. K., Dickson, T. C., & Vickers, J. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.010 · Cited by 138 · see citing works
Self-citationIs Alzheimer’s a disease of the white matter?
Sachdev, P. S., Zhuang, L., Braidy, N., & Wen, W. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835ed6e8 · Cited by 137 · see citing works
Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to pathology
Zou, P., Wu, C., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00385-7 · Cited by 97 · see citing works
Microglia promote remyelination independent of their role in clearing myelin debris
Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73 · see citing works
Wu, D., Tang, X., Gu, L., Li, X., Qi, X., Bai, F., Chen, X., Wang, J., Ren, Q., & Zhang, Z. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12809 · Cited by 64 · see citing works
Ou-Yang, M.-H., & Van Nostrand, W. E. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-134 · Cited by 30 · see citing works
Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model
Nishioka, C., Liang, H.-F., Barsamian, B., & Sun, S.-W. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.007 · Cited by 30 · see citing works
Gong, Z., Laporte, J. P., Guo, A. Y., Bilgel, M., Bae, J., Fox, N. Y., de Rouen, A., Zhang, N., Taranath, A., de Cabo, R., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci196638 · Cited by 7 · see citing works
“Reduced WM integrity was observed in a transgenic mouse model of amyloidosis (20), and experimentally induced myelin damage caused accelerated parenchymal amyloidosis, suggesting a role of WM damage in the development of A β .”
- Authors
- Mitew, S., Kirkcaldie, M. T. K., Halliday, G. M., Shepherd, C. E., Vickers, J. C., & Dickson, T. C.
- Affiliations
- University of Tasmania (AU)
- UNSW Sydney (AU)
- Corresponding author
- Dickson, Tracey C.
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2010-03-03
- Volume
- 119
- Issue
- 5
- Pages
- 567-577
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2011554023
- Cited by
- 186
- References
- 62
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 13 · 2023: 23 · 2022: 19 · 2021: 19 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 13 · 2012: 6
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, focal demyelination, amyloid plaques, oligodendrocyte loss, neocortex, transgenic mouse model, presenilin 1, dystrophic neurites, axonal sprouting, gray matter pathology
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Analysis of Variance, Animals, Demyelinating Diseases, Disease Models, Animal, Female, Humans, Immunohistochemistry, Male, Mice, Transgenic, Middle Aged, Myelin Sheath, Nerve Degeneration, Nerve Fibers, Myelinated, Neurons, Oligodendroglia, Amyloid beta-Peptides, Neocortex, Mice, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
