Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411

Siglecs as modulators of macrophage phenotype and function

Kukan, E. N., Fabiano, G. L., & Cobb, B. A. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101887 · Cited by 24

The Role of Hypothalamic Microglia in the Onset of Insulin Resistance and Type 2 Diabetes: A Neuro-Immune Perspective

Darwish, R., Alcibahy, Y., Bucheeri, S., Albishtawi, A., Tama, M., Shetty, J. K., & Butler, A. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313169 · Cited by 25

Neuroinflammation, Blood–Brain Barrier, and HIV Reservoirs in the CNS: An In-Depth Exploration of Latency Mechanisms and Emerging Therapeutic Strategies

Said, N., & Venketaraman, V. (2025) · Viruses · doi:10.3390/v17040572 · Cited by 26

Targeting Senescence, Oxidative Stress, and Inflammation: Quercetin-Based Strategies for Ocular Diseases in Older Adults

Medoro, A., Davinelli, S., Scuderi, L., Scuderi, G., Scapagnini, G., & Fragiotta, S. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s516946 · Cited by 25

Polyphenols in the Central Nervous System: Cellular Effects and Liposomal Delivery Approaches

Kaluza, M., Ksiazek-Winiarek, D. J., Szpakowski, P., Czpakowska, J., Fijalkowska, J., & Glabinski, A. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136477 · Cited by 28

Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes

Lee, E.-J., Choi, M. J., Lee, G., Gaire, B. P., Choi, J. W., & Kim, H.-S. (2017) · Oncotarget · doi:10.18632/oncotarget.20207 · Cited by 25

Progressive long‐term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities

Honig, M. G., Dorian, C. C., Worthen, J. D., Micetich, A. C., Mulder, I. A., Sanchez, K. B., Pierce, W. F., Mar, N. A. D., & Reiner, A. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14711 · Cited by 26

Modeling Microglia Activation and Inflammation-Based Neuroprotectant Strategies During Ischemic Stroke

Amato, S., & Arnold, A. (2021) · Bulletin of Mathematical Biology · doi:10.1007/s11538-021-00905-4 · Cited by 24

Neuroimmune reactivity marker expression in rodent models of chemotherapy-induced cognitive impairment: A systematic scoping review

George, R. P., Semendric, I., Hutchinson, M. R., & Whittaker, A. L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.021 · Cited by 24

Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 28

A high fat, sugar, and salt Western diet induces motor‐muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin

Hong, S., Nagayach, A., Lü, Y., Peng, H., Duong, Q.-V., Pham, N. B., Vuong, C. A., & Bazan, N. G. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13726 · Cited by 24

The role of microglia in prion diseases and possible therapeutic targets: a literature review

de Melo, A. S. L. F., Lima, J. L. D., Malta, M. C., Marroquim, N. F., Moreira, Á. R., Ladeia, I. D. A., Cardoso, F. D. S., Gonçalves, D. B., Dutra, B. G., & dos Santos, J. C. C. (2021) · Prion · doi:10.1080/19336896.2021.1991771 · Cited by 27

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus

Jhan, M.-K., Chen, C., Shen, T., Tseng, P., Wang, Y.-T., Satria, R. D., Yu, C.-Y., & Lin, C. (2021) · Cells · doi:10.3390/cells10113181 · Cited by 25

(−)-Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling

Chen, G., Cheng, K., Niu, Y., Zhu, L., & Wang, X. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109393 · Cited by 25

The Protective Role of Microglial PPARα in Diabetic Retinal Neurodegeneration and Neurovascular Dysfunction

Yuan, T., Dong, L., Pearsall, E., Zhou, K., Cheng, R., & Ma, J. (2022) · Cells · doi:10.3390/cells11233869 · Cited by 25

IGF2 inhibits hippocampal over-activated microglia and alleviates depression-like behavior in LPS- treated male mice

Guo, D., Xu, Y., Liu, Z., Wang, Y., Xu, X., Li, C., Li, S., Zhang, J., Xiong, T., Cao, W., et al. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.01.001 · Cited by 25

Neuroprotective effects of the salidroside derivative SHPL-49 via the BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia

You, S., Ma, Z., Zhang, P., Xu, W., Zhan, C., Sang, N., Xu, J., Wang, F., & Zhang, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116460 · Cited by 27

How dependent is synaptic plasticity on microglial phenotype?

Jones, R. S., & Lynch, M. A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.08.012 · Cited by 25

Differential response to intrahippocampal interleukin-4/interleukin-13 in aged and exercise mice

Littlefield, A. M., & Kohman, R. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.027 · Cited by 24

Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells

Choi, M. J., Park, J., Park, J.-E., Kim, H. S., & Kim, H.-S. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.173 · Cited by 24

Role of microglia M1/M2 polarisation in the paraventricular nucleus: New insight into the development of stress-induced hypertension in rats

Mi, Y., Wu, Q. J., Yuan, W., Chen, F., & Du, D. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.06.003 · Cited by 25

Suppressing the Na+/H+ exchanger 1: a new sight to treat depression

Deng, X., Ji, Z., Xu, B., Guo, L., Xu, L., Qin, T., Feng, L., Ma, Z., Fu, Q., Qu, R., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1602-5 · Cited by 24

Dimethyl Fumarate Reduces Microglia Functional Response to Tissue Damage and Favors Brain Iron Homeostasis

Pagani, F., Testi, C., Grimaldi, A., Corsi, G., Cortese, B., Basilico, B., Baiocco, P., Panfilis, S. D., Ragozzino, D., & Angelantonio, S. D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.041 · Cited by 25

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Yang, C., Hou, X., Feng, Q., Li, Y., Wang, X., Qin, L., & Yang, P. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02175-0 · Cited by 24

When glia meet induced pluripotent stem cells (iPSCs)

Li, L., & Shi, Y. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103565 · Cited by 24

Lack of functional P2X7 receptor aggravates brain edema development after middle cerebral artery occlusion

Kaiser, M., Penk, A., Franke, H., Krügel, U., Nörenberg, W., Huster, D., & Schaefer, M. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9511-x · Cited by 24

Chronic fatigue syndrome and fibromyalgia-like symptoms are an integral component of the phenome of schizophrenia: neuro-immune and opioid system correlates

Mousa, R. F., Al‐Hakeim, H. K., Alhaideri, A. F., & Maes, M. H. J. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00619-x · Cited by 23

Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain

Clark, P. A., Sriramaneni, R. N., Bates, A. M., Jin, W. J., Jagodinsky, J. C., Hernandez, R. T., Le, T. Q. H., Jeffery, J. J., Marsh, I. R., Grudzinski, J. J., et al. (2021) · Radiation Research · doi:10.1667/rade-20-00237.1 · Cited by 23

TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy

Bertoglio, D., Amhaoul, H., Goossens, J., Ali, I. Y., Jonckers, E., Bijnens, T., Siano, M., Wyffels, L., Verhaeghe, J. A. J., der Linden, A. V., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102701 · Cited by 24

Impact of the apelin/APJ axis in the pathogenesis of Parkinson’s disease with therapeutic potential

Angelopoulou, E., Paudel, Y. N., Bougea, A. M., & Piperi, C. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24895 · Cited by 24

Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-Inflammatory Cytokines

Ahuja, S., & Lazar, I. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.646043 · Cited by 24

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells

Broome, S. T., Musumeci, G., & Castorina, A. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-01968-1 · Cited by 23

Mitochondrial-targeting antioxidant MitoQ modulates angiogenesis and promotes functional recovery after spinal cord injury

Huang, T., Shen, J., Bao, B., Hu, W., Sun, Y. X., Zhu, T., Lin, J., Gao, T., Li, X., & Zheng, X. (2022) · Brain Research · doi:10.1016/j.brainres.2022.147902 · Cited by 23

Trehalose Treatment in Zebrafish Model of Lafora Disease

Vecchia, S. D., Ogi, A., Licitra, R., Abramo, F., Nardi, G., Mero, S., Landi, S., Battini, R., Sicca, F., Ratto, G. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126874 · Cited by 23

Synergistic photobiomodulation with 808-nm and 1064-nm lasers to reduce the β-amyloid neurotoxicity in the in vitro Alzheimer's disease models

Zhang, R., Zhou, T., Samanta, S., Luo, Z., Li, S., Xu, H., & Qu, J. (2022) · Frontiers in Neuroimaging · doi:10.3389/fnimg.2022.903531 · Cited by 24

NOX2 inhibition enables retention of the circadian clock in BV2 microglia and primary macrophages

Muthukumarasamy, I., Buel, S. M., Hurley, J., & Dordick, J. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1106515 · Cited by 23

The Yin and Yang Effect of the Apelinergic System in Oxidative Stress

Fibbi, B., Marroncini, G., Naldi, L., & Peri, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054745 · Cited by 23

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

Rao, M., Huang, Y., Liu, C.-C., Meadows, C., Cheng, H.-C., Zhou, M., Chen, Y., Xia, X., Goldberg, J. L., Williams, A. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32702-5 · Cited by 23

The Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy

Fowler, M., Theunissen, F., Carr, J. M., & Rogers, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03472-y · Cited by 23

CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis

Zaccai, S., Nemirovsky, A., Lerner, L., Alfahel, L., Eremenko, E., Israelson, A., & Monsonego, A. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-03007-1 · Cited by 23

The Interplay between Glioblastoma Cells and Tumor Microenvironment: New Perspectives for Early Diagnosis and Targeted Cancer Therapy

Virtuoso, A., D’Amico, G., Scalia, F., Luca, C. D., Papa, M., Maugeri, G., D’Agata, V., Bavisotto, C. C., & D’Amico, A. G. (2024) · Brain Sciences · doi:10.3390/brainsci14040331 · Cited by 25

Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats

Liaudanskaya, V., Jgamadze, D., Berk, A. N., Bischoff, D. J., Gu, B. J., Hawks-Mayer, H., Whalen, M. J., Chen, H. I., & Kaplan, D. L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.11.031 · Cited by 23

Inverse Relationship Between Alzheimer’s Disease and Cancer: How Immune Checkpoints Might Explain the Mechanisms Underlying Age-Related Diseases

Rogers, N. K., Romero, C., SanMartín, C. D., Ponce, D. P., Salech, F., López, M. N., Gleisner, M. A., Tempio, F., & Behrens, M. I. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190839 · Cited by 23

Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms

Cherry, J. D., Babcock, K. J., & Goldstein, L. E. (2020) · Seminars in Neurology · doi:10.1055/s-0040-1713620 · Cited by 24

Pharmacological Activation of RXR-α Promotes Hematoma Absorption via a PPAR-γ-dependent Pathway After Intracerebral Hemorrhage

Xu, C., Chen, H., Zhou, S., Sun, C., Xia, X., Peng, Y., Zhuang, J., Fu, X., Zeng, H., Zhou, H., et al. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00735-3 · Cited by 24

HIV Neuroinflammation: The Role of Exosomes in Cell Signaling, Prognostic and Diagnostic Biomarkers and Drug Delivery

Mahajan, S. D., Ordain, N. S., Kutscher, H. L., Karki, S., & Reynolds, J. L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637192 · Cited by 23

Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy

Mahmoudi, N. E., Rastoldo, G., Marouane, E., Péricat, D., Watabe, I., Tonetto, A., Hautefort, C., Chabbert, C., Sargolini, F., & Tighilet, B. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02222-y · Cited by 24

Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model

Kim, N., Yoo, H., Ju, Y., Oh, M. S., Lee, K., Inn, K., Kim, N., & Lee, J. K. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.008 · Cited by 23

Metabolic partitioning in the brain and its hijacking by glioblastomaPreprint

Swain, J. D. R., Michalopoulou, E., Noch, E., Lukey, M. J., & Aelst, L. V. (2023) · Genes & Development · doi:10.1101/gad.350693.123 · Cited by 24

Simultaneous Pericytes and M2 Microglia Transplantation Improve Cognitive Function in Mice Model of mPFC Ischemia

Geranmayeh, M. H., Farokhi-Sisakht, F., Sadigh‐Eteghad, S., Rahbarghazi‬, R., Mahmoudi, J., & Farhoudi, M. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.08.010 · Cited by 22

Immune Modulation in Alzheimer’s Disease: From Pathogenesis to Immunotherapy

Balkhi, S., Spirito, A. D., Poggi, A. D., & Mortara, L. (2025) · Cells · doi:10.3390/cells14040264 · Cited by 21

Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia

Klettner, A., Harms, A., Waetzig, V., Tode, J., Purtskhvanidze, K., & Roider, J. B. (2020) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-020-04763-z · Cited by 22

Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation

Wang, H., Xiong, W., Hang, S., Wang, Y., Zhang, S., & Liu, S. (2021) · Aging · doi:10.18632/aging.203084 · Cited by 22

Morphologic Analysis of M2 Macrophage in Glioblastoma: Involvement of Macrophage Extracellular Traps (METs)

Michiba, A., Shiogama, K., Tsukamoto, T., Hirayama, M., Yamada, S., & Abe, M. (2022) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.22-00018 · Cited by 22

Advancement of epigenetics in stroke

Peng, J., Dipritu, G., Zhang, F., Yang, L., Wu, J., Pang, J., Zhang, L., Yin, S., & Jiang, Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.981726 · Cited by 22

Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders

Asveda, T., Talwar, P., & Ravanan, P. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121920 · Cited by 23

Phloretin alleviates sleep deprivation-induced cognitive impairment by reducing inflammation through PPARγ/NF-κB signaling pathway

Chen, W., Liu, M., Li, Z., Luo, Z.-C., & Wu, J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114949 · Cited by 23

Absence of the neurogenesis-dependent nuclear receptor TLX induces inflammation in the hippocampus

Kozareva, D. A., Hueston, C. M., Ó’Léime, C. S., Crotty, S., Dockery, P., Cryan, J. F., & Nolan, Y. M. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.08.008 · Cited by 22

Gene expression profiles of M1 and M2 microglia characterized by comparative analysis of public datasets

Satoh, J. (2017) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12426 · Cited by 22

Ibuprofen prevents progression of ataxia telangiectasia symptoms in ATM-deficient mice

Hui, C. W., Song, X., Ma, F., Shen, X., & Herrup, K. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1338-7 · Cited by 22

Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Zheng, Z., Wu, Y.-Q., Li, Z., Ye, L.-X., Lu, Q., Zhou, Y., Yuan, Y., Jiang, T., Xie, L., Liu, Y.-L., et al. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14892 · Cited by 21

Increased Behavioral Deficits and Inflammation in a Mouse Model of Co-Morbid Traumatic Brain Injury and Post-Traumatic Stress Disorder

Fesharaki‐Zadeh, A., Miyauchi, J. T., Laurent-Ariot, K. S., Tsirka, S. E., & Bergold, P. J. (2020) · ASN NEURO · doi:10.1177/1759091420979567 · Cited by 23

ALZT-OP1: an experimental combination regimen for the treatment of Alzheimer’s disease

Lozupone, M., Berardino, G., Mollica, A., Sardone, R., Dibello, V., Zupo, R., Lampignano, L., Castellana, F., Bortone, I., Stallone, R., et al. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2095261 · Cited by 22

Long non‐coding RNA uc.80‐ overexpression promotes M2 polarization of microglias to ameliorate depression in rats

Gu, X., Xu, L., Zheng, L., Yang, Y., Tang, Z., Wu, H., Chen, Z., & Wang, W. (2020) · IUBMB Life · doi:10.1002/iub.2353 · Cited by 21

Sleep deprivation-induced shifts in gut microbiota: Implications for neurological disorders

Wankhede, N. L., Kale, M. B., Kyada, A., Rekha, M. M., Chaudhary, K., Naidu, K. S., Rahangdale, S. R., Shende, P. V., Taksande, B. G., Khalid, M., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.070 · Cited by 21

Intracerebral transplantation of HLA‐homozygous human iPSC‐derived neural precursors ameliorates the behavioural and pathological deficits in a rodent model of ischaemic stroke

Noh, J., Oh, S., Lee, S., Lee, S., Kim, Y. H., Park, H.-J., Ju, J. H., Kim, H. S., Huh, J. Y., & Song, J. (2020) · Cell Proliferation · doi:10.1111/cpr.12884 · Cited by 21

Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice

Zhou, L., Tao, X., Pang, G., Mu, M., Sun, Q., Liu, F., Hu, Y., Tao, H., Li, B., & Xu, K. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.661304 · Cited by 22

Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis

Jansen, M. I., Broome, S. T., & Castorina, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094788 · Cited by 21

Effects of neuronal cell adhesion molecule L1 and nanoparticle surface modification on microglia

Kushwah, N. S., Woeppel, K. M., Dhawan, V., Shi, D., & Cui, X. T. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.038 · Cited by 22

Restoration of spinal cord injury: From endogenous repairing process to cellular therapy

Wu, Y., Tang, Z., Zhang, J., Wang, Y., & Liu, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1077441 · Cited by 21

TGF-β Activated Kinase 1 (TAK1) Is Activated in Microglia After Experimental Epilepsy and Contributes to Epileptogenesis

Khan, D., Bedner, P., Müller, J., Luelsberg, F., Henning, L., Prinz, M., Steinhäuser, C., & Muhammad, S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03290-2 · Cited by 21

Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells

Lee, J. H., Lee, B. H., Jeong, S., Joh, C. S.-Y., Nam, H. J., Choi, H. S., Sserwadda, H., Oh, J. W., Park, C., Jin, S., et al. (2023) · Genomics & Informatics · doi:10.5808/gi.23009 · Cited by 23

Differential transcriptional response profiles in human myeloid cell populations

Healy, L. M., Perron, G., Won, S., Rao, V. T. S., Guiot, M., Moore, C. S., Bar‐Or, A., & Antel, J. P. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.04.006 · Cited by 22

Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA

Ruiz-Roso, M. B., Olivares-Álvaro, E., Quintela, J. C., Ballesteros, S., Espinosa‐Parrilla, J. F., Ruiz‐Roso, B., Lahera, V., Heras, N. D. L., & Martín‐Fernández, B. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8496-8 · Cited by 21

Molecular Imaging of Neuroinflammation in Idiopathic Parkinson's Disease

Roussakis, A., & Piccini, P. P. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.08.009 · Cited by 23

Stem cells from the dental apical papilla in extracellular matrix hydrogels mitigate inflammation of microglial cells

Tatic, N., Rose, F. R. A. J., Rieux, A. D., & White, L. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-50367-x · Cited by 21

Soluble epoxide hydrolase inhibition enhances anti-inflammatory and antioxidative processes, modulates microglia polarization, and promotes recovery after ischemic stroke

Yeh, C., Chuang, T., Hung, Y., Lan, M., Tsai, C.-H., Huang, H.-X., & Lin, Y.-Y. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s210403 · Cited by 21

Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3

Li, C., Fan, C., Zhao, J., Di, M., Sui, C., Han, L., & Hu, L. (2020) · Inflammation · doi:10.1007/s10753-020-01278-x · Cited by 21

Abnormal brain structure and behavior in MyD88-deficient mice

Schroeder, P., Rivalan, M., Zaqout, S., Krüger, C., Schüler, J., Long, M., Meisel, A., Winter, Y., Kaindl, A. M., & Lehnardt, S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.024 · Cited by 24

Post-stroke Delivery of Valproic Acid Promotes Functional Recovery and Differentially Modifies Responses of Peri-Infarct Microglia

Kuo, T., Chen, Y.-H., Wang, V., Wu, J., & Tseng, K.-Y. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.639145 · Cited by 21

Association of Genetic Polymorphisms in Oxidative Stress and Inflammation Pathways with Glaucoma Risk and Phenotype

Velkovska, M. A., Goričar, K., Blagus, T., Dolžan, V., & Cvenkel, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051148 · Cited by 21

Immunosuppression and Neuroinflammation in Stroke Pathobiology

Jiang, Q., Stone, C. R., Elkin, K. B., Geng, X., & Ding, Y. (2021) · Experimental Neurobiology · doi:10.5607/en20033 · Cited by 21

Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases

Sánchez-Castillo, A. I., Sepúlveda, M. R., Marín‐Teva, J. L., Cuadros, M. Á., Martín‐Oliva, D., González‐Rey, E., Delgado, M., & Neubrand, V. E. (2022) · Biomolecules · doi:10.3390/biom12020219 · Cited by 22

Tanshinone IIA decreases the levels of inflammation induced by Aβ1–42 in brain tissues of Alzheimer’s disease model rats

Lu, B.-L., Li, J., Zhou, J., Li, W., & Wu, H.-F. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000618 · Cited by 21

Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients

van Rees, G. F., Lago, S. G., Cox, D., Tomasik, J., Rustogi, N., Weigelt, K., Özcan, S., Cooper, J. D., Drexhage, H. A., Leweke, F. M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.003 · Cited by 22

N-acetylcysteine protects against cuprizone-induced demyelination: histological and immunohistochemical study

Sharouny, S. H. E., Shaaban, M. H., Elsayed, R. M., Tahef, A. W., & ElWahed, M. K. A. (2021) · Folia Morphologica · doi:10.5603/fm.a2021.0044 · Cited by 21

Microglia subtypes show substrate- and time-dependent phagocytosis preferences and phenotype plasticity

Li, S., Wernersbach, I., Harms, G. S., & Schäfer, M. K. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.945485 · Cited by 22

Daphne genkwa flower extract promotes the neuroprotective effects of microglia

Gupta, D. P., Park, S. H., Lee, Y., Lee, S., Lim, S.-J., Byun, J., Cho, I., & Song, G. J. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154486 · Cited by 20

Schisandra chinensis Lignans Exert Antidepressant Effects by Promoting BV2 Microglia Polarization toward the M2 Phenotype through the Activation of the Cannabinoid Receptor Type-2–Signal Transducer and Activator of Transcription 6 Pathway

Wang, J., Zhang, G., Yang, Y., Zhang, X., Shi, K., Zhang, X., Yan, T., & Jia, Y. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c04565 · Cited by 20

Total saponins of panax ginseng via the CX3CL1 / CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild stress in rats

Qin, M., Chen, C., Wang, N., Yu, D., Yu, S., Wang, X., Liu, T., Lv, L., & Guan, Q. (2022) · Phytotherapy Research · doi:10.1002/ptr.7696 · Cited by 20

Neuronal and Glial Communication via Non-Coding RNAs: Messages in Extracellular Vesicles

Marangon, D., Silva, J. H. C. E., & Lecca, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010470 · Cited by 21

HIF ‐1α promotes astrocytic production of macrophage migration inhibitory factor following spinal cord injury

Hao, H., Hou, Y., Li, A., Niu, L., Li, S., He, B., Zhang, X., Song, H., Cai, R., Zhou, Y., et al. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14300 · Cited by 20

Targeting the AKT‐P53 / CREB pathway with epicatechin for improved prognosis of traumatic brain injury

Wang, Z., Lu, Z., Chen, Y., Wang, C., Gong, P., Jiang, R., & Liu, Q. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14364 · Cited by 22

Low-dose ionizing radiation promotes motor recovery and brain rewiring by resolving inflammatory response after brain injury and stroke

Au, N. P. B., Wu, T., Kumar, G., Jin, Y., Li, Y. Y. T., Chan, S. L., Lai, J. H. C., Chan, K. W. Y., Yu, K. N., Wang, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.015 · Cited by 21

The interplay between neuroinflammatory pathways and Parkinson's disease

Ocak, P. E., Kocabıçak, E., Bekâr, A., & Temel, Y. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114644 · Cited by 20

Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections.

Zegenhagen, L., Kurhade, C., Koniszewski, N., Överby, A. K., & Kröger, A. (2016) · Cytokine & growth factor reviews · doi:10.1016/j.cytogfr.2016.03.006 · Cited by 20

OMIP‐041: Optimized multicolor immunofluorescence panel rat microglial staining protocol

Furman, N. E. T., Prabhakara, K. S., Bedi, S. S., Cox, C. S., & Olson, S. D. (2017) · Cytometry Part A · doi:10.1002/cyto.a.23267 · Cited by 20

Neuronal EphA4 Regulates OGD/R-Induced Apoptosis by Promoting Alternative Activation of Microglia

Wei, H., Yao, P., Chen, P., Guan, J., Zhuang, J.-H., Zhu, J., Wu, G., & Yang, J. (2018) · Inflammation · doi:10.1007/s10753-018-0914-4 · Cited by 20

Aβ stimulates microglial activation through antizyme‐dependent downregulation of ornithine decarboxylase

Cheng, Y., Chang, C., Chang, T., Li, H., Hung, H., Liu, G., & Lin, C. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27659 · Cited by 20

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280

Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders

Jha, M. K., Lee, W., & Suk, K. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.003 · Cited by 267

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208

A Richer and More Diverse Future for Microglia Phenotype

Wang, J., He, W., & Zhang, J. (2022) · Heliyon · doi:10.1016/j.heliyon.2023.e14713 · Cited by 113

[MicroRNAs in microglia polarization and CNS diseases: mechanism and functions].

Xue, F., Tan, W., He, C., & Cao, L. (2015) · PubMed