Cited by 1,748Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerMultiple Sclerosis Research Studies

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Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

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Cherry, Jonathan D, Olschowka, John A, O’Banion, M Kerry·2014·Journal of Neuroinflammation

DOI 10.1186/1742-2094-11-98PMC PMC4060849

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Abstract

The concept of multiple macrophage activation states is not new. However, extending this idea to resident tissue macrophages, like microglia, has gained increased interest in recent years. Unfortunately, the research on peripheral macrophage polarization does not necessarily translate accurately to their central nervous system (CNS) counterparts. Even though pro- and anti-inflammatory cytokines can polarize microglia to distinct activation states, the specific functions of these states is still an area of intense debate. This review examines the multiple possible activation states microglia can be polarized to. This is followed by a detailed description of microglial polarization and the functional relevance of this process in both acute and chronic CNS disease models described in the literature. Particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.

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Figure 1 Working model of microglial polarization. (A) A variety of cytokines are able to polarize microglia to unique phenotypes. These phenotypes constitute a spectrum as opposed to two binary states. Depending on the stimulus, microglia can be polarized towards one end of the spectrum and be more M1- or M2-like. (B) Upon prolonged or chronic inflammation, an overabundance of inflammatory cytokines skews microglial polarization towards the M1 phenotype. M1 microglia, in turn, produce additional inflammatory cytokines, generating a cycle that further induces inflammation and maintains the M1 state. This skewed population of M1 microglia exhibits impaired phagocytosis and is cytotoxic in, for example, Alzheimer’s disease and multiple sclerosis. (C) To treat neuroinflammatory diseases, certain therapeutic agents, such as glatiramer acetate, bexarotene, and PPARγ agonists, have been used. These treatments have been shown to inhibit inflammation as well as induce M2 activation, resulting in reduced disease severity. A more complete list of such therapeutic agents can be found in Table 2. AD, Alzheimer’s disease, EAE, experimental autoimmune encephalomyelitis; GA, glatiramer acetate; MS, multiple sclerosis.CC BY · PubMed Central

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2 retracted

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis
Yang, J., Jiang, Z., Fitzgerald, D. C., Ma, C., Yu, S., Li, H., Zhao, Z., Li, Y., Ćirić, B., Curtis, M. T., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37914 · Cited by 194
Retracted
RETRACTED: CD163 and its expanding functional repertoire
Akila, P., Prashant, A., Suma, M., Prashant, S., & Chaitra, T. R. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2012.01.028 · Cited by 50
Retracted
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · cited 1×
“One additional type of M2 activated cell, the so-called tumor-associated macrophage, has recently been recognized [52].”
Background
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · cited 2×
“These observations have led to the inflammatory cascade hypothesis of Alzheimer’s disease, which states that Aβ deposition induces neuroinflammation, which in turn generates more Aβ, resulting in a vicious cycle [120].”
Background
Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord
Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130
Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.
Nathan, C. F., Murray, H. W., Wiebe, M. E., & Rubin, B. Y. (1983) · The Journal of experimental medicine · doi:10.1084/jem.158.3.670 · Cited by 1,962
Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
The Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930
Microglial physiology: unique stimuli, specialized responses
Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858
Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
Hu, X., Li, P., Guo, Y., Wang, H., Leak, R. K., Chen, S., Gao, Y., & Chen, J. (2012) · Stroke · doi:10.1161/strokeaha.112.659656 · Cited by 1,573
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Stewart, C. R., Stuart, L. M., Wilkinson, K., van Gils, J. M., Deng, J., Halle, A., Rayner, K. J., Boyer, L., Zhong, R., Frazier, W. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1836 · Cited by 1,513
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Kierdorf, K., Erny, D., Goldmann, T., Sander, V., Schulz, C., Perdiguero, E. G., Wieghofer, P., Heinrich, A., Riemke, P., Hölscher, C., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3318 · Cited by 1,457
MACROPHAGE RECEPTORS AND IMMUNE RECOGNITION
Taylor, P. R., Martínez‐Pomares, L., Stacey, M. A., Lin, H.-H., Brown, G. D., & Gordon, S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115816 · Cited by 1,366
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 1×
“Correspondingly, in older, non-diseased mice there is downregulation of receptors associated with Aβ engulfment, such as scavenger receptor A and the Aβ degradation enzymes Nep, IDE, and MMP-9 [134].”
Background
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1×
“In fact, it is a necessary step in wound repair [61].”
Background
Phagocyte partnership during the onset and resolution of inflammation
Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050
Innate immunity in the central nervous system
Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034
Review: Activation patterns of microglia and their identification in the human brain
Boche, D., Perry, V. H., & Nicoll, J. A. R. (2012) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12011 · Cited by 955
Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain
Colton, C. A. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9164-4 · Cited by 916
Biochemical and functional characterization of three activated macrophage populations
Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406249 · Cited by 863
The cellular inflammatory response in human spinal cords after injury
Fleming, J. C., Norenberg, M. D., Ramsay, D. A., Dekaban, G. A., Marcillo, A. E., Saenz, A. D., Pasquale-Styles, M., Dietrich, W. D., & Weaver, L. C. (2006) · Brain · doi:10.1093/brain/awl296 · Cited by 847
Does neuroinflammation fan the flame in neurodegenerative diseases?
Frank-Cannon, T. C., Alto, L. T., McAlpine, F. E., & Tansey, M. G. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-47 · Cited by 751
Arginase: an emerging key player in the mammalian immune system
Munder, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00291.x · Cited by 725
The role of microglia in amyloid clearance from the AD brain
Lee, C. Y. D., & Landreth, G. E. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0433-4 · Cited by 701
An overview of APP processing enzymes and products.
Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8104-z · Cited by 684
Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus
Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683
FIZZ1, a novel cysteine‐rich secreted protein associated with pulmonary inflammation, defines a new gene family
Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A. L., Henzel, W. J., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 662
Arginine Metabolism: Boundaries of Our Knowledge
Morris, S. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.6.1602s · Cited by 649
Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
Perry, V. H., & Teeling, J. L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0382-8 · Cited by 638
The mannose receptor is a pattern recognition receptor involved in host defense
Stahl, P. D., & Ezekowitz, R. A. B. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80031-9 · Cited by 630
Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells.
Munder, M., Eichmann, K., Morán, J., Centeno, F., Soler, G., & Modolell, M. (1999) · Journal of Immunology · doi:10.4049/jimmunol.163.7.3771 · Cited by 619
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587
IL-4 in the brain: a cytokine to remember
Gadani, S. P., Cronk, J. C., Norris, G. T., & Kipnis, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202246 · Cited by 549
Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease
Griffin, W. S. T., Sheng, J. G., Roberts, G. W., & Mrak, R. E. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00014 · Cited by 546
Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Vogel, D. Y., Vereyken, E. J., Glim, J. E., Heijnen, P. D., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J., & Dijkstra, C. D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-35 · Cited by 479
Microglial Phagocytosis Induced by Fibrillar β-Amyloid and IgGs Are Differentially Regulated by Proinflammatory Cytokines
Koenigsknecht-Talboo, J., & Landreth, G. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1808-05.2005 · Cited by 477
Comparison of polarization properties of human adult microglia and blood‐derived macrophages
Durafourt, B. A., Moore, C. S., Zammit, D., Johnson, T., Zaguia, F., Guiot, M., Bar‐Or, A., & Antel, J. P. (2012) · Glia · doi:10.1002/glia.22298 · Cited by 470
Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection
Davis, M. J., Tsang, T. M., Qiu, Y., Dayrit, J. K., Freij, J. B., Huffnagle, G. B., & Olszewski, M. A. (2013) · mBio · doi:10.1128/mbio.00264-13 · Cited by 462
Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis.
Bagasra, O., Michaels, F. H., Zheng, Y., Bobroski, L. E., Spitsin, S. V., Fu, Z., Tawadros, R., & Koprowski, H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12041 · Cited by 456
TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation
Liu, S., Liu, Y., Hao, W., Wolf, L., Kiliaan, A. J., Penke, B., Rübe, C. E., Walter, J., Heneka, M. T., Hartmann, T., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101121 · Cited by 439
Transplantation of Mesenchymal Stem Cells Promotes an Alternative Pathway of Macrophage Activation and Functional Recovery after Spinal Cord Injury
Nakajima, H., Uchida, K., Guerrero, A. R., Watanabe, S., Sugita, D., Takeura, N., Yoshida, A., Long, G., Wright, K. T., Johnson, W. E. B., et al. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.2109 · Cited by 434
Histology and Histopathology of the Nervous System
Moossy, J. J. (1982) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198209000-00010 · Cited by 426
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.003 · Cited by 411
Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis
Jadidi‐Niaragh, F., & Mirshafiey, A. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02536.x · Cited by 397
CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells
Ponomarev, E. D., Maresz, K., Tan, Y., & Dittel, B. N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1922-07.2007 · Cited by 396
Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388
Inflammatory Response in the Hippocampus of PS1M146L/APP751SLMouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic
Jimenez, S., Baglietto-Vargas, D., Caballero, C., Moreno-Gonzalez, I., Torres, M., Sanchez-Varo, R., Ruano, D., Vizuete, M., Gutierrez, A., & Vitorica, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3024-08.2008 · Cited by 383 · cited 1×
“[132] observed at 6 months, when Aβ begins to accumulate in the APP/ PS1 Alzheimer’s disease mouse model, that there were YM1 cells present in the CNS; however, by 18 months YM1 mRNA levels decreased and there was a massive upregulation in inflammatory factors, suggesting a switch from M2 to M1 as pathology worsened […”
Background
Neurogenesis, inflammation and behavior
Kohman, R. A., & Rhodes, J. S. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.003 · Cited by 380
Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived Macrophages
Corraliza, I., Soler, G., Eichmann, K., & Modolell, M. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1094 · Cited by 364
Alternative activation of macrophages: immune function and cellular biology
Varin, A., & Gordon, S. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.009 · Cited by 361
Identification of a microglia phenotype supportive of remyelination
Olah, M., Amor, S., Brouwer, N., Vinet, J., Eggen, B., Biber, K., & Boddeke, H. W. G. M. (2012) · Glia · doi:10.1002/glia.21266 · Cited by 358
Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease
Mandrekar-Colucci, S., Karlo, J. C., & Landreth, G. E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5268-11.2012 · Cited by 355 · cited 8×
“Several groups have observed that prolonged treatment with PPARγ agonists can reduce Alzheimer’s disease pathology, demonstrating its potential therapeutic efficacy [102,136,137].”
BackgroundInfluential
Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology
Tesseur, I., Zou, K., Esposito, L., Bard, F., Berber, E., Can, J. V., Lin, A. H., Crews, L., Tremblay, P., Mathews, P., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27341 · Cited by 355
Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo
Weldon, D. T., Rogers, S. D., Ghilardi, J. R., Finke, M. P., Cleary, J. P., O’Hare, E., Esler, W. P., Maggio, J. E., & Mantyh, P. W. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02161.1998 · Cited by 348
Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions
Horn, K. P., Busch, S. A., Hawthorne, A. L., van Rooijen, N., & Silver, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-08.2008 · Cited by 332
Massive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
Chakrabarty, P., Jansen‐West, K., Beccard, A., Ceballos‐Diaz, C., Levites, Y., Verbeeck, C., Zubair, A. C., Dickson, D., Golde, T. E., & Das, P. (2010) · The FASEB Journal · doi:10.1096/fj.09-141754 · Cited by 328
PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice
Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326 · cited 4×
“In addition to reducing plaques, the PPARγ agonist pioglitazone increased mRNA levels of the M2 marker YM1 [137] as well as the scavenger receptor CD36 [102].”
BackgroundInfluential
Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer’s disease
Reiserer, R. S., Harrison, F. E., Syverud, D. C., & McDonald, M. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00221.x · Cited by 324
IL ‐33 attenuates EAE by suppressing IL ‐17 and IFN ‐γ production and inducing alternatively activated macrophages
Jiang, H., Milovanović, M., Allan, D., Niedbała, W., Besnard, A., Fukada, S. Y., Alves-Filho, J. C., Togbe, D., Goodyear, C. S., Linington, C., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201141947 · Cited by 319
Arginase I and Polyamines Act Downstream from Cyclic AMP in Overcoming Inhibition of Axonal Growth MAG and Myelin In Vitro
Cai, D., Deng, K., Mellado, W., Lee, J.-H., Ratan, R. R., & Filbin, M. T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00826-7 · Cited by 313
Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells
Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6561 · Cited by 302
Resolution of inflammation is altered in Alzheimer's disease
Wang, X., Zhu, M., Hjorth, E., Cortés‐Toro, V., Eyjolfsdottir, H., Graff, C., Nennesmo, I., Palmblad, J., Eriksdotter, M., Sambamurti, K., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.024 · Cited by 301
Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice
Schilling, M., Besselmann, M., Müller, M., Strecker, J. K., Ringelstein, E. B., & Kiefer, R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.004 · Cited by 288
Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Kanekiyo, T., Cirrito, J. R., Liu, C.-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., & Bu, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-13.2013 · Cited by 280
In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury
Frugier, T., Morganti-Kossmann, M. C., O'Reilly, D., & McLean, C. A. (2010) · Journal of Neurotrauma · doi:10.1089/neu.2009.1120 · Cited by 278 · cited 1×
“weeks to months after traumatic brain injury [74-76].”
Background
Neuroinflammation and Synaptic Loss
Rao, J. S., Kellom, M., Kim, H., Rapoport, S. I., & Reese, E. A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0708-2 · Cited by 271
Activation of Microglia Acidifies Lysosomes and Leads to Degradation of Alzheimer Amyloid Fibrils
Majumdar, A., Cruz, D., Asamoah, N., Buxbaum, A., Sohar, I., Lobel, P., & Maxfield, F. R. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0975 · Cited by 271
Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07002.x · Cited by 261
Local Delivery of Interleukin 4 by Retrovirus-Transduced T Lymphocytes Ameliorates Experimental Autoimmune Encephalomyelitis
Shaw, M. K., Lorens, J. B., Dhawan, A., DalCanto, R., Tse, H. Y., Tran, A. B., Bonpane, C. M., Eswaran, S. L., Brocke, S., Sarvetnick, N., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.9.1711 · Cited by 259
Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury
Lalancette-Hébert, M., Swarup, V., Beaulieu, J. M., Bohacek, I., Abdelhamid, E., Weng, Y. C., Sato, S., & Kriz, J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1498-12.2012 · Cited by 251
Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis
Neumann, H., & Takahashi, K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.032 · Cited by 249
A Macrophage Protein, Ym1, Transiently Expressed during Inflammation Is a Novel Mammalian Lectin
Chang, N.-C. A., Chung, W., Hwa, K., Kato, I., Chen, J.-E., Liu, C.-H., & Chang, A. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010417200 · Cited by 245
Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244
Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide
Willment, J. A., Lin, H.-H., Reid, D. M., Taylor, P. R., Williams, D. L., Wong, S. Y. C., Gordon, S., & Brown, G. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4569 · Cited by 238
Proinflammatory Clearance of Apoptotic Neutrophils Induces an IL-12lowIL-10high Regulatory Phenotype in Macrophages
Filardy, A. A., Pires, D. R., Nunes, M. P., Takiya, C. M., Freire-de-Lima, C. G., Ribeiro-Gomes, F. L., & DosReis, G. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000017 · Cited by 237
Rosiglitazone rescues memory impairment in Alzheimer’s transgenic mice: Mechanisms involving a reduced amyloid and tau pathology
Escribano, L., Simón, A.-M., Gimeno, E., Cuadrado-Tejedor, M., López de Maturana, R., García-Osta, A., Ricobaraza, A., Pérez-Mediavilla, A., Del Río, J., & Frechilla, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.32 · Cited by 235
Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
Skeen, M. J., Miller, M. A., Shinnick, T. M., & Ziegler, H. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.3.1196 · Cited by 231
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
Kiyota, T., Dixie, K. L. I., Swan, R. J., Jacobsen, M. T., Andrews, S. J., & Ikezu, T. (2011) · Gene Therapy · doi:10.1038/gt.2011.126 · Cited by 230
Intrahippocampal LPS injections reduce AÎ² load in APP+PS1 transgenic mice
DiCarlo, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00292-5 · Cited by 223
Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity?
Antel, J. P., Antel, S. B., Caramanos, Z., Arnold, D. L., & Kuhlmann, T. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0953-0 · Cited by 219
The immunology of neurodegeneration
Czirr, E., & Wyss‐Coray, T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58656 · Cited by 218
CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice
Kiyota, T., Okuyama, S., Swan, R. J., Jacobsen, M. T., Gendelman, H. E., & Ikezu, T. (2010) · The FASEB Journal · doi:10.1096/fj.10-155317 · Cited by 212
A Novel Anti-Inflammatory and Pro-Resolving Role for Resolvin D1 in Acute Cigarette Smoke-Induced Lung Inflammation
Hsiao, H.-M., Sapinoro, R., Thatcher, T. H., Croasdell, A., Levy, E. P., Fulton, R. A., Olsen, K. C., Pollock, S. J., Serhan, C. N., Phipps, R. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058258 · Cited by 212
PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms
Yi, J., Park, S. W., Brooks, N. P., Lang, B. T., & Vemuganti, R. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.074 · Cited by 207
IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice
Chakrabarty, P., Ceballos-Diaz, C., Beccard, A., Janus, C., Dickson, D., Golde, T. E., & Das, P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903382 · Cited by 206
Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
Guerrero, A. R., Uchida, K., Nakajima, H., Watanabe, S., Nakamura, M., Johnson, W. E., & Baba, H. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-40 · Cited by 201
Neuroinflammatory phenotype in early Alzheimer's disease
Sudduth, T. L., Schmitt, F. A., Nelson, P. T., & Wilcock, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.012 · Cited by 201
CNS-specific T cells shape brain function via the choroid plexus
Baruch, K., & Schwartz, M. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.04.002 · Cited by 200
Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia
Xiong, X., Barreto, G. E., Xu, L., Ouyang, Y., Xie, X., & Giffard, R. G. (2011) · Stroke · doi:10.1161/strokeaha.110.593772 · Cited by 199
Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198
Histology and histopathology of the nervous system
Haymaker, W., & Adams, R. D. (1982) · Thomas eBooks · Cited by 195
Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage
Lindsberg, P. J., Strbian, D., & Karjalainen‐Lindsberg, M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.282 · Cited by 190
Traumatic brain injury induces macrophage subsets in the brain
Hsieh, C. L., Kim, C. C., Ryba, B. E., Niemi, E. C., Bando, J. K., Locksley, R. M., Liu, J., Nakamura, M. C., & Seaman, W. E. (2013) · European Journal of Immunology · doi:10.1002/eji.201243084 · Cited by 185
Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
Galea, I., Palin, K., Newman, T. A., van Rooijen, N., Perry, V. H., & Boche, D. (2004) · Glia · doi:10.1002/glia.20124 · Cited by 183
Toll-Like Receptors in Alzheimer's Disease
Landreth, G. E., & Reed-Geaghan, E. G. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00549-7_8 · Cited by 180
Variant TREM2 as Risk Factor for Alzheimer's Disease
Neumann, H., & Daly, M. J. (2013) · New England Journal of Medicine · doi:10.1056/nejme1213157 · Cited by 177
Neuroinflammation and Memory: The Role of Prostaglandins
Hein, A. M., & O’Banion, M. K. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8066-z · Cited by 176
Self-citation
Glatiramer acetate: Mechanisms of action in multiple sclerosis
Schrempf, W., & Ziemssen, T. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.02.003 · Cited by 168
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia
Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P., & Meldolesi, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03729.x · Cited by 165
CD163 and its role in inflammation
Kowal, K., Silver, R., Sławińska, E., Bielecki, M., Chyczewski, L., & Kowal‐Bielecka, O. (2011) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2011.0052 · Cited by 165
Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke
Denker, S. P., Ji, S., Dingman, A., Lee, S., Derugin, N., Wendland, M. F., & Vexler, Z. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04162.x · Cited by 163
FIZZ1 and Ym as Tools to Discriminate between Differentially Activated Macrophages
Raes, G., Noël, W., Beschin, A., Brys, L., BAETSELIER, P. D., & Hassanzadeh, G. G. (2002) · Journal of Immunology Research · doi:10.1080/1044667031000137629 · Cited by 147
Butovsky, O. et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl Acad. Sci. USA 103, 11784-11789
Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144
Cellular localization and expression patterns of interleukin‐10, interleukin‐4, and their receptors in multiple sclerosis lesions
Hulshof, S. C. J., Montagne, L., Groot, C. J. A. D., & van der Valk, P. (2002) · Glia · doi:10.1002/glia.10050 · Cited by 140
Alternative activation of macrophages by IL-4 enhances the proteolytic capacity of their phagosomes through synergistic mechanisms
Balce, D. R., Li, B., Allan, E. R. O., Rybicka, J. M., Krohn, R. M., & Yates, R. M. (2011) · Blood · doi:10.1182/blood-2011-01-328906 · Cited by 134
Production of interferon-γ by microglia
Kawanokuchi, J., Mizuno, T., Takeuchi, H., Kato, H., Wang, J.-J., Mitsuma, N., & Suzumura, A. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070763 · Cited by 133
Substance P induces M2-type macrophages after spinal cord injury
Jiang, M., Chung, E., Chi, G. F., Ahn, W., Lim, J. E., Hong, H. S., Kim, D., Choi, H., Kim, J., & Son, Y. (2012) · Neuroreport · doi:10.1097/wnr.0b013e3283572206 · Cited by 122
Microglia and macrophages as innate producers of interferon-gamma in the brain following infection with Toxoplasma gondii
Suzuki, Y., Claflin, J., Wang, X., Lengi, A. J., & Kikuchi, T. (2004) · International Journal for Parasitology · doi:10.1016/j.ijpara.2004.10.020 · Cited by 122
Aging enhances classical activation but mitigates alternative activation in the central nervous system
Lee, D. C., Ruiz, C. R., Lebson, L. A., Selenica, M. B., Rizer, J., Hunt, J. B., Rojiani, R., Reid, P., Kammath, S., Nash, K. R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.014 · Cited by 122
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
Chakrabarty, P., Herring, A., Ceballos-Diaz, C., Das, P., & Golde, T. E. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-16 · Cited by 117
Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
Satō, A., Ohtaki, H., Tsumuraya, T., Song, D., Ohara, K., Asano, M., Iwakura, Y., Atsumi, T., & Shioda, S. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-65 · Cited by 116
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Chakrabarty, P., Tianbai, L., Herring, A., Ceballos-Diaz, C., Das, P., & Golde, T. E. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-36 · Cited by 116
Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice
Kawahara, K., Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., & Nakayama, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.049 · Cited by 113
Brain injury, neuroinflammation and Alzheimer's disease
Breunig, J. J., Guillot‐Sestier, M., & Town, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00026 · Cited by 106
β-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner
Shah, V. B., Huang, Y., Keshwara, R., Ozment-Skelton, T. R., Williams, D. L., & Keshvara, L. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2777 · Cited by 104
IL-10 Deficiency Exacerbates the Brain Inflammatory Response to Permanent Ischemia without Preventing Resolution of the Lesion
Puig, I. P.-D., Miró‐Mur, F., Salas-Perdomo, A., Bonfill‐Teixidor, E., Ferrer-Ferrer, M., Márquez‐Kisinousky, L., & Planas, A. M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.155 · Cited by 104
CD163 Identifies a Unique Population of Ramified Microglia in HIV Encephalitis (HIVE)
Roberts, E. S., Masliah, E., & Fox, H. S. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.12.1255 · Cited by 100
Cytokine-Mediated Inhibition of Fibrillar Amyloid-β Peptide Degradation by Human Mononuclear Phagocytes
Yamamoto, M., Kiyota, T., Walsh, S. M., Liu, J., Kipnis, J., & Ikezu, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3877 · Cited by 100
IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis
Butti, E., Bergami, A., Recchia, A., Brambilla, E., Carro, U. D., Amadio, S., Cattalini, A., Esposito, M., Stornaiuolo, A., Comı, G., et al. (2008) · Gene Therapy · doi:10.1038/gt.2008.10 · Cited by 97
Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury
Haber, M., Abdel Baki, S. G., Grin'kina, N. M., Irizarry, R., Ershova, A., Orsi, S., Grill, R. J., Dash, P., & Bergold, P. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.002 · Cited by 95
Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system
Soulet, D., & Rivest, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200301097 · Cited by 93
The role of mast cells in neuroinflammation
Nelissen, S., Lemmens, E., Geurts, N., Kramer, P. P. G., Maurer, M., Hendriks, J. J. A., & Hendrix, S. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1092-y · Cited by 91
Transforming growth factor‐β stimulates β amyloid uptake by microglia through Smad3‐dependent mechanisms
Tichauer, J. E., & Rommy von Bernhardi, M. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23082 · Cited by 91
Transient expression of Ym1, a heparin-binding lectin, during developmental hematopoiesis and inflammation
Chung, W., Chang, A. C., Kato, I., & Chang, N.-C. A. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.1.72 · Cited by 88
Activation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome
Denney, L., Kok, W. L., Cole, S., Sanderson, S., McMichael, A. J., & Ho, L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103608 · Cited by 87
Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injury
Bao, F., Bailey, C. S., Gurr, K. R., Bailey, S. I., Rosas-Arellano, M. P., Dekaban, G. A., & Weaver, L. C. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.10.022 · Cited by 86
Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration
Matousek, S. B., Ghosh, S., Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., & O’Banion, M. K. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9331-2 · Cited by 86
Self-citation
Central Nervous System Delivery of Interleukin 4 by a Nonreplicative Herpes Simplex Type 1 Viral Vector Ameliorates Autoimmune Demyelination
Furlan, R., Poliani, P. L., Galbiati, F., Bergami, A., Grimaldi, L. M. E., Comı, G., Adorini, L., & Martino, G. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.17-2605 · Cited by 85
Aquaporin-4 mediates astrocyte response to β-amyloid
Yang, W., Wu, Q., Chan, Y., Gao, J., Xiao, M., Gu, M., Ding, J., & Hu, G. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.02.002 · Cited by 84
Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury
Zhang, Z., Zhang, Z.-Y., Wu, Y., & Schluesener, H. J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.04.038 · Cited by 83
Microglia can be induced by IFN-γ or IL-4 to express neural or dendritic-like markers
Butovsky, O., Bukshpan, S., Kunis, G., Jung, S., & Schwartz, M. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.04.009 · Cited by 77
Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model
Wirz, K. T. S., Bossers, K., Stargardt, A., Kamphuis, W., Swaab, D. F., Hol, E. M., & Verhaagen, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.008 · Cited by 65
Temporal changes in monocyte and macrophage subsets and microglial macrophages following spinal cord injury in the lys-egfp-ki mouse model
Thawer, S. G., Mawhinney, L., Chadwick, K., de Chickera, S. N., Weaver, L. C., Brown, A. M., & Dekaban, G. A. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.04.008 · Cited by 62
A C-Type Lectin MGL1/CD301a Plays an Anti-Inflammatory Role in Murine Experimental Colitis
Saba, K., Denda‐Nagai, K., & Irimura, T. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080235 · Cited by 61
Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury.
Guo, Y., Zhang, H., Yang, J., Liu, S.-M., Bing, L.-J., Gao, J., & Hao, A.-J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.047 · Cited by 59
Regional and cellular expression of the mannose receptor in the post-natal developing mouse brain
Burudi, E. M. E., & Régnier‐Vigouroux, A. (2001) · Cell and Tissue Research · doi:10.1007/s004410000311 · Cited by 52
Oligodendrocyte Progenitors Reversibly Exit the Cell Cycle and Give Rise to Astrocytes in Response to Interferon-γ
Tanner, D. C., Cherry, J. D., & Mayer‐Pröschel, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5905-10.2011 · Cited by 52
Self-citation
History of Innate Immunity in Neurodegenerative Disorders
McGeer, P. L., & McGeer, E. G. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00077 · Cited by 52
Toll-Like Receptors in Spinal Cord Injury
Kigerl, K. A., & Popovich, P. G. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00549-7_7 · Cited by 50
Endogenous expression of interleukin‐4 regulates macrophage activation and confines cavity formation after traumatic spinal cord injury
Lee, S. I., Jeong, S. R., Kang, Y. M., Han, D. H., Jin, B. K., Namgung, U., & Kim, B. G. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22411 · Cited by 50
Pillars Article: M-1/M-2 Macrophages and the Th1/Th2 Paradigm. J. Immunol. 2000. 164: 6166–6173
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701141 · Cited by 48
PPARγagonist rosiglitazone is neuroprotective after traumatic spinal cord injury via anti-inflammatory in adult rats
Zhang, Q., Hu, W., Meng, B., & Tang, T. (2010) · Neurological Research · doi:10.1179/016164110x12556180206112 · Cited by 43
Neuroinflammatory Phenotypes and Their Roles in Alzheimer's Disease
Wilcock, D. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354228 · Cited by 41
LPS-induced CCL2 expression and macrophage influx into the murine central nervous system is polyamine-dependent
Puntambekar, S. S., Davis, D. S., Hawel, L., Crane, J., Byus, C. V., & Carson, M. J. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.016 · Cited by 40
The role of peroxisome proliferator-activated receptor γ, and effects of its agonist, rosiglitazone, on transient cerebral ischemic damage
Lee, C. H., Park, O. K., Yoo, K., Byun, K., Lee, B., Choi, J. H., Hwang, I. K., Kim, Y., & Won, M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.09.005 · Cited by 27
Peroxisome proliferator activated receptor-γ and traumatic brain injury.
Qi, L., Jacob, A., Wang, P., & Wu, R. (2010) · PubMed Central · Cited by 25
Lo que debe entenderse por «tercer elemento» de los centros nerviosos (Boletín de la Sociedad española de Biología. Vol. XI, fasc. 1, 1919)
del Río-Hortega, P. (2005) · Arbor · doi:10.3989/arbor.2005.i714.433 · Cited by 6

Research works printed but not linked: 1

Del Rio-Hortega P: El tercer elemento de los centros nerviosos. Bio Soc Esp Biol. 1919, 9: 69-129.

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Authors: Cherry, J. D., Olschowka, J. A., & O’Banion, M. K.
Affiliations: University of Rochester Medicine (US)
Corresponding author: O’Banion, M Kerry
ORCID: Cherry, Jonathan D
Olschowka, John A
O’Banion, M Kerry
Venue: Journal of Neuroinflammation
Publisher: Springer Science and Business Media LLC
Published: 2014-06-03
Volume: 11
Issue: 1
Pages: 98-98
ISSN: 1742-2094 (ISSN-L)
DOI: 10.1186/1742-2094-11-98
PMC: PMC4060849
OpenAlex: W2147180300
Cited by: 1,748
References: 167
Citations by year: 2026: 127 · 2025: 129 · 2024: 170 · 2023: 157 · 2022: 205 · 2021: 185 · 2020: 173 · 2019: 138 · 2018: 129 · 2017: 128 · 2016: 115 · 2015: 75 · 2014: 14
FWCI: 8.81
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Journal of Neuroinflammation (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Aeronautics and Space Administration (NNX13AC33G)
National Institutes of Health
National Institute on Aging (R01AG030149)
National Institute of Allergy and Infectious Diseases (U19AI091036)
National Institute of Environmental Health Sciences (R01 ES020322)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: microglia, M2 microglia, microglial polarization, neuroinflammation, central nervous system disorders, pro- and anti-inflammatory cytokines
MeSH terms: Animals, Central Nervous System, Encephalitis, Humans, Macrophage Activation, Microglia

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Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

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