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The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention
Open accessAbstract
A global health problem, traumatic brain injury (TBI) is especially prevalent in the current era of ongoing world military conflicts. Its pathological hallmark is one or more primary injury foci, followed by a spread to initially normal brain areas via cascades of inflammatory cytokines and chemokines resulting in an amplification of the original tissue injury by microglia and other central nervous system immune cells. In some cases this may predispose individuals to later development of Alzheimer's disease (AD). The inflammatory-based progression of TBI has been shown to be active in humans for up to 17 years post TBI. Unfortunately, all neuroprotective drug trials have failed, and specific treatments remain less than efficacious. These poor results might be explained by too much of a scientific focus on neurons without addressing the functions of microglia in the brain, which are at the center of proinflammatory cytokine generation. To address this issue, we provide a survey of the TBI-related brain immunological mechanisms that may promote progression to AD. We discuss these immune and microglia-based inflammatory mechanisms involved in the progression of post-trauma brain damage to AD. Flavonoid-based strategies to oppose the antigen-presenting cell-like inflammatory phenotype of microglia will also be reviewed. The goal is to provide a rationale for investigations of inflammatory response following TBI which may represent a pathological link to AD. In the end, a better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI to later AD.
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“Neuroinflammation may be a significant contributor to secondary cell death immediately following moderate to severe TBI and inflammatory effects have been shown to persist up to 17 years post-injury [97, 98].”
From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [97]
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Cites
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956
Forecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370
Guskiewicz, K. M., Marshall, S. W., Bailes, J. E., McCrea, M., Cantu, R. C., RANDOLPH, C. C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1093/neurosurgery/57.4.719 · Cited by 1,226
Guskiewicz, K. M., Marshall, S. W., Bailes, J., McCrea, M., Cantu, R. C., Randolph, C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1227/01.neu.0000175725.75780.dd · Cited by 1,197
Microglia: Intrinsic immuneffector cell of the brain
Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111
Inflammation after trauma: Microglial activation and traumatic brain injury
Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999
A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia
Le Bars, P. L. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550160047037 · Cited by 966
Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases
Adams, J. H., Graham, D. I., Murray, L. S., & Scott, G. (1982) · Annals of Neurology · doi:10.1002/ana.410120610 · Cited by 950
Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias
Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896
Guidelines for the Management of Severe Head Injury
Chesnut, R. M. (1997) · doi:10.1097/00005373-199705001-00004 · Cited by 801
Research works printed but not linked: 3
- Halama P: Ginkgo biloba: effectiveness of a special extract in patients with cerebral insufficiency. Munch Med Wochenschr 1991, 133:190–194.
- Arrigo CS, Weitbrecht WV: Clinical and Psychometric Evaluation of Ginkgo Biloba Extract in Chronic Cerebrovascular Diseases. John Libbey & Company, London; 1985.
- Lovell MK FM: Neuropsychiatry of Traumatic Brain Injury. Neuropsychological assessment. American Psychiatric Press, Washington, DC; 1994:152–153.
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Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799
Microglial Activation in Traumatic Brain Injury
Donat, C. K., Scott, G., Gentleman, S., & Sastre, M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00208 · Cited by 512
NADPH oxidase in brain injury and neurodegenerative disorders
Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432
Borlongan, C. V., Acosta, S., de la Peña, I., Tajiri, N., Kaneko, Y., Lozano, D., & Gonzales-Portillo, G. S. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65815 · Cited by 433
Self-citationGlial contributions to neurodegeneration in tauopathies
Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409
Gyoneva, S., & Ransohoff, R. M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.003 · Cited by 351
Microglia Activation as a Biomarker for Traumatic Brain Injury
Hernandez‐Ontiveros, D. G., Tajiri, N., Acosta, S., Giunta, B. N., Tan, J., & Borlongan, C. V. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00030 · Cited by 292
Self-citationEmerging Roles for the Immune System in Traumatic Brain Injury
McKee, C. A., & Lukens, J. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00556 · Cited by 277
Morganti, J. M., Jopson, T. D., Liu, S., Riparip, L.-K., Guandique, C. K., Gupta, N., Ferguson, A. R., & Rosi, S. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2405-14.2015 · Cited by 253
Role of Interleukin-10 in Acute Brain Injuries
Garcia, J. M., Stillings, S. A., Leclerc, J. L., Phillips, H., Edwards, N. J., Robicsek, S. A., Hoh, B. L., Blackburn, S., & Doré, S. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00244 · Cited by 247
Call off the dog(ma): M1/M2 polarization is concurrent following traumatic brain injury
Morganti, J. M., Riparip, L.-K., & Rosi, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148001 · Cited by 229
Review article What causes alzheimer’s disease?
Armstrong, R. A. (2013) · Folia Neuropathologica · doi:10.5114/fn.2013.37702 · Cited by 237
Amanollahi, M., Jameie, M., Heidari, A., & Rezaei, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03102-z · Cited by 207
Neuroinflammation in traumatic brain injury: A chronic response to an acute injury
Lozano, D., Schimmel, S. J., & Acosta, S. (2017) · Brain Circulation · doi:10.4103/bc.bc_18_17 · Cited by 183
Chronic neurodegenerative consequences of traumatic brain injury
Chauhan, N. B. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-130354 · Cited by 133
The p38α MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury
Bachstetter, A. D., Rowe, R. K., Kaneko, M., Goulding, D. S., Lifshitz, J., & Eldik, L. J. V. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5399-12.2013 · Cited by 131
Reintegration Challenges in U.S. Service Members and Veterans Following Combat Deployment
Sayer, N. A., Carlson, K. F., & Frazier, P. A. (2014) · Social Issues and Policy Review · doi:10.1111/sipr.12001 · Cited by 138
Role of Wnt Signaling in Central Nervous System Injury
Lambert, C., Cisternas, P., & Inestrosa, N. C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9138-x · Cited by 121
NADPH oxidases in traumatic brain injury – Promising therapeutic targets?
Ma, M. W., Wang, J., Dhandapani, K. M., Wang, R., & Brann, D. W. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.005 · Cited by 116
Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury
Febinger, H. Y., Thomasy, H. E., Pavlova, M. N., Ringgold, K. M., Barf, P. R., George, A. M., Grillo, J. N., Bachstetter, A. D., Garcia, J. A., Cardona, A. E., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0386-5 · Cited by 110
“A consensus based on recent evidence considers neuroinflammation as an important secondary mechanism that plays a role in delaying injury after TBI [1–3].”
Plants-derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms
Elufioye, T. O., Berida, T. I., & Habtemariam, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3574012 · Cited by 107
Dams-O’Connor, K., Guetta, G., Hahn-Ketter, A. E., & Fedor, A. F. (2016) · Neurodegenerative Disease Management · doi:10.2217/nmt-2016-0017 · Cited by 106
White matter damage after traumatic brain injury: A role for damage associated molecular patterns
Braun, M., Vaibhav, K., Saad, N., Fatima, S., Vender, J. R., Baban, B., Hoda, M. N., & Dhandapani, K. M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.05.020 · Cited by 108
Lin, C., Chao, H., Li, Z., Xu, X., Liu, Y., Bao, Z., Hou, L., Liu, Y., Wang, X., You, Y., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.01.005 · Cited by 103
Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury
Gyoneva, S., Kim, D., Katsumoto, A., Kokiko-Cochran, O. N., Lamb, B. T., & Ransohoff, R. M. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0443-0 · Cited by 95
The impact of alcohol on Alzheimer's disease: A systematic review
Piazza-Gardner, A. K., Gaffud, T. J. B., & Barry, A. E. (2013) · Aging & Mental Health · doi:10.1080/13607863.2012.742488 · Cited by 94
Brezova, V., Moen, K. G., Skandsen, T., Vik, A., Brewer, J. B., Salvesen, Ø. O., & Haberg, A. K. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.03.012 · Cited by 88
Immunological regulation of neurogenic niches in the adult brain
González-Pérez, Ó., Gutierrez-Fernandez, F., Lopez-Virgen, V., Collas-Aguilar, J., Quinones-Hinojosa, A., & García‐Verdugo, J. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.053 · Cited by 90
Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury
Morganti, J. M., Riparip, L., Chou, A., Liu, S., Gupta, N. M., & Rosi, S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0547-1 · Cited by 86
Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury
Bonsack, B., Corey, S., Shear, A., Heyck, M., Cozene, B., Sadanandan, N., Zhang, H., Gonzales‐Portillo, B., Sheyner, M., & Borlongan, C. V. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13378 · Cited by 82
Self-citationKohno, H., Maeda, T., Perusek, L., Pearlman, E. M., & Maeda, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301738 · Cited by 82
Lippert, T., & Borlongan, C. V. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13124 · Cited by 76
Self-citationPast, Present, and Future of Traumatic Brain Injury Research
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Koul, B., Farooq, U., Yadav, D., & Song, M. (2023) · Life · doi:10.3390/life13040999 · Cited by 60
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Morganti, J. M., Goulding, D. S., & Eldik, L. J. V. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1493-5 · Cited by 59
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Mele, C., Pingue, V., Caputo, M., Zavattaro, M., Pagano, L., Prodam, F., Nardone, A., Aimaretti, G., & Marzullo, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052686 · Cited by 60
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Lok, J. M., Wang, X.-S., Xing, C., Maki, T., Wu, L., Guo, S., Noviski, N., Arai, K., Whalen, M. J., Lo, E. H., et al. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12359 · Cited by 50
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Borlongan, C., Gonzales‐Portillo, B., Lippert, T., Nguyen, H., & Lee, J.-Y. (2019) · Brain Circulation · doi:10.4103/bc.bc_31_19 · Cited by 50
Self-citationSajja, V. S. S. S., Hubbard, W. B., & VandeVord, P. J. (2015) · Shock · doi:10.1097/shk.0000000000000311 · Cited by 50
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Marcet, P. A., Santos, N., & Borlongan, C. V. (2017) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2017.07 · Cited by 50
Self-citationMatrone, C., Djelloul, M., Taglialatela, G., & Perrone, L. (2015) · PubMed · doi:10.14670/hh-30.125 · Cited by 46
Yang, N. R., Song, J., Yoon, K.-W., & Seo, E. K. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.10.117 · Cited by 46
Karelina, K., Nicholson, S., & Weil, Z. M. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.012 · Cited by 44
Tsai, Y.-R., Chang, C.-F., Lai, J.-H., Wu, J. C.-C., Chen, Y., Kang, S.-J., Hoffer, B. J., Tweedie, D., Luo, W., Greig, N. H., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103252 · Cited by 42
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Jansson, D., Scotter, E. L., Rustenhoven, J., Coppieters, N., Smyth, L. C. D., Oldfield, R. L., Bergin, P., Mee, E. W., Graham, E. S., Faull, R. L. M., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0722-4 · Cited by 43
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Cozene, B., Sadanandan, N., Farooq, J., Kingsbury, C., Park, Y. J., Wang, Z.-J., Moscatello, A., Saft, M., Cho, J., Gonzales‐Portillo, B., et al. (2021) · Cell Transplantation · doi:10.1177/09636897211035715 · Cited by 41
Self-citationChronic Effects of Mild Neurotrauma: Putting the Cart Before the Horse?
Castellani, R. J., Perry, G., & Iverson, G. L. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000193 · Cited by 40
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Garg, C., Seo, J. H., Ramachandran, J., Loh, J. M., Calderón, F. H., & Contreras, J. E. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1069-9 · Cited by 42
Zhang, K., Jiang, Y., Wang, B., Li, T., Shang, D., & Zhang, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4645021 · Cited by 36
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Rosi, S. (2016) · Brain Circulation · doi:10.4103/2394-8108.192517 · Cited by 35
Ciaramella, A., Vedova, C. D., Salani, F., Viganotti, M., D’Ippolito, M., Caltagirone, C., Formisano, R., Sabatini, U., & Bossù, P. (2013) · NeuroImmunoModulation · doi:10.1159/000354764 · Cited by 35
Schwarzmaier, S. M., & Plesnila, N. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00358 · Cited by 37
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Ghadery, C., Best, L. A., Pavese, N., Tai, Y., & Strafella, A. P. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0951-x · Cited by 34
Godinho, D. B., Fiorin, F. D. S., Oliveira, M. S., Furian, A. F., Fighera, M. R., & Royes, L. F. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.006 · Cited by 29
Prabhakara, K. S., Kota, D. J., Jones, G. H., Srivastava, A. K., Cox, C. S., & Olson, S. D. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.022 · Cited by 28
Neuroinflammation and neurodegeneration following traumatic brain injuries
Boulton, M., & Al-Rubaie, A. (2024) · Anatomical Science International · doi:10.1007/s12565-024-00778-2 · Cited by 26
Lee, J.-Y., Tuazon, J. P., Ehrhart, J. C., Sanberg, P. R., & Borlongan, C. V. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14429 · Cited by 27
Self-citationParham, C. L., Auckland, L. D., Rachwal, J., Clarke, D. N., & Bix, G. J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130683 · Cited by 25
Tajiri, N., Hernandez, D., Acosta, S., Shinozuka, K., Ishikawa, H., Ehrhart, J. C., Diamandis, T., Gonzales-Portillo, C., Borlongan, M. C., Tan, J., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.041 · Cited by 22
Self-citationBaby, N., Li, Y., Ling, E., Lu, J., & Dheen, S. T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089326 · Cited by 21
Ravi, S., Criado‐Marrero, M., Barroso, D., Braga, I., Bolen, M. L., Rubinovich, U., Hery, G. P., Grudny, M. M., Koren, J., Prokop, S., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0464 · Cited by 23
Pabon, M. M., Acosta, S., Guedes, V. A., Tajiri, N., Kaneko, Y., & Borlongan, C. V. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12485 · Cited by 20
Self-citationSoluble complement complex C5b-9 promotes microglia activation
Yang, C., Yang, L., & Liu, Y. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.11.007 · Cited by 19
McCunn, P., Xu, X., Moszczynski, A. J., Li, A., Brown, A. M., & Bartha, R. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12917 · Cited by 18
Kahriman, A., Bouley, J., Bosco, D. A., Shazeeb, M. S., & Henninger, N. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136430 · Cited by 18
Lee, J.-Y., Tuazon, J. P., Corey, S., Bonsack, B., Acosta, S., Ehrhart, J. C., Sanberg, P. R., & Borlongan, C. V. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09906-2 · Cited by 17
Self-citationTau overexpression exacerbates neuropathology after repeated mild head impacts in male mice
Cheng, H., Deaton, L. M., Qiu, M., Ha, S., Pacoma, R., Lao, J., Tolley, V., Moran, R., Keeton, A., Lamb, J. R., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104683 · Cited by 16
Quarta, A., Berneman, Z. N., & Ponsaerts, P. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru0820-536r · Cited by 17
Izzy, S., Brown-Whalen, A., Yahya, T., Sarro-Schwartz, A., Jin, G., Chung, J. Y., Lüle, S., Morsett, L. M., Alquraini, A., Wu, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020907 · Cited by 16
Jorge, R. E. (2015) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63521-1.00038-8 · Cited by 19
Traumatic Brain Injury and Immunological Outcomes: the double-edged Killer
Datta, S., Lin, F., Jones, L., Pingle, S. C., Kesari, S., & Ashili, S. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0037 · Cited by 15
The role of IL-6 in TBI and PTSD, a potential therapeutic target?
Monsour, M., Croci, D. M., & Agazzi, S. (2022) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2022.107280 · Cited by 18
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Naseer, S., Abelleira, L. E., Savani, D., de Burgh, R., Aleksynas, R., Donat, C. K., Syed, N., & Sastre, M. (2022) · Biomolecules · doi:10.3390/biom12101457 · Cited by 15
Tyagi, M., Naik, U. P., Tyagi, K., Sharma, M., Kaushal, G., Bhushan, A., Bukrinsky, M., & Tyagi, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052192 · Cited by 15
Neumann, K. D., Seshadri, V., Thompson, X. D., Broshek, D. K., Druzgal, T. J., Massey, J. C., Newman, B. T., Reyes, J. M. S., Simpson, S. R., McCauley, K. S., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1127708 · Cited by 14
Concussion: Beyond the Cascade
Neumann, K. D., Broshek, D. K., Newman, B. T., Druzgal, T. J., Kundu, B. K., & Resch, J. E. (2023) · Cells · doi:10.3390/cells12172128 · Cited by 17
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Dewan, S., Schimmel, S. J., & Borlongan, C. V. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2018.1439473 · Cited by 14
Self-citationOriginal article Electrospun nanofiber mat as a protector against the consequences of brain injury
Sulejczak, D., Andrychowski, J., Kowalczyk, T., Nakielski, P., Frontczak‐Baniewicz, M., & Kowalewski, T. A. (2014) · Folia Neuropathologica · doi:10.5114/fn.2014.41744 · Cited by 15
Almeida-Suhett, C. P., Namboodiri, A. M. A., Clarke, K., & Deuster, P. A. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1853414 · Cited by 13
Chronic traumatic encephalopathy: A paradigm in search of evidence?
Castellani, R. J. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.54 · Cited by 13
Chronic Traumatic Encephalopathy as the Course of Alzheimer’s Disease
Pszczołowska, M., Walczak, K., Miśków, W., Antosz, K., Batko, J., Kurpas, D., & Leszek, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094639 · Cited by 13
Schneider, L. E., Reichert, E. C., Faulkner, J., Reichert, B., Sonnen, J. A., & Hawryluk, G. W. J. (2019) · Journal of neurosurgery · doi:10.3171/2018.10.jns181517 · Cited by 10
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Metadata
- Authors
- Giunta, B., Obregon, D., Velisetty, R., Sanberg, P. R., Borlongan, C. V., & Tan, J.
- Affiliations
- James A. Haley Veterans' Hospital (US)
- University of South Florida (US)
- Corresponding author
- Giunta, Brian
- Venue
- Journal of Neuroinflammation
- Published
- 2012-08-01
- Volume
- 9
- Issue
- 1
- Pages
- 185-185
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3458981
- OpenAlex
- W2097143517
- Cited by
- 112
- References
- 98
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 7 · 2019: 11 · 2018: 7 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 10 · 2013: 7 · 2012: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH098737)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- traumatic brain injury, Alzheimer's disease, neuroinflammation, microglia, inflammatory cytokines, chemokines, secondary injury, flavonoids, neuroprotection, armed conflict
- MeSH terms
- Alzheimer Disease, Animals, Brain, Brain Injuries, Humans, Disease Progression, Inflammation Mediators
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