The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention

Advances in flavonoid research since 1992

Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956

Forecasting the global burden of Alzheimer's disease

Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370

Association between Recurrent Concussion and Late-Life Cognitive Impairment in Retired Professional Football Players

Guskiewicz, K. M., Marshall, S. W., Bailes, J. E., McCrea, M., Cantu, R. C., RANDOLPH, C. C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1093/neurosurgery/57.4.719 · Cited by 1,226

Association between recurrent concussion and late-life cognitive impairment in retired professional football players

Guskiewicz, K. M., Marshall, S. W., Bailes, J., McCrea, M., Cantu, R. C., Randolph, C., & Jordan, B. D. (2005) · Neurosurgery · doi:10.1227/01.neu.0000175725.75780.dd · Cited by 1,197

Microglia: Intrinsic immuneffector cell of the brain

Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111

Inflammation after trauma: Microglial activation and traumatic brain injury

Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999

A Placebo-Controlled, Double-blind, Randomized Trial of an Extract of Ginkgo Biloba for Dementia

Le Bars, P. L. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550160047037 · Cited by 966

Diffuse axonal injury due to nonmissile head injury in humans: An analysis of 45 cases

Adams, J. H., Graham, D. I., Murray, L. S., & Scott, G. (1982) · Annals of Neurology · doi:10.1002/ana.410120610 · Cited by 950

Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias

Plassman, B. L., Havlik, R. J., Steffens, D. C., Helms, M. J., Newman, T. N., Drosdick, D., Phillips, C., Gau, B. A., Welsh–Bohmer, K. A., Burke, J. R., et al. (2000) · Neurology · doi:10.1212/wnl.55.8.1158 · Cited by 896

Guidelines for the Management of Severe Head Injury

Chesnut, R. M. (1997) · doi:10.1097/00005373-199705001-00004 · Cited by 801

Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication

Fleminger, S. (2003) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.857 · Cited by 719

Flavonoid Antioxidants

Rice-Evans, C. A. (2001) · Current Medicinal Chemistry · doi:10.2174/0929867013373011 · Cited by 719

Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-05.2005 · Cited by 713

Absorption, metabolism and health effects of dietary flavonoids in man

Hollman, P., & Katan, M. (1997) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(97)88045-6 · Cited by 609 · cited 1×

Flavonoid permeability across an in situ model of the blood–brain barrier

Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.023 · Cited by 605

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

Roberts, G. W., Gentleman, S. M., Lynch, A., Murray, L., Landon, M., & Graham, D. I. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.419 · Cited by 569

Head injury and the risk of AD in the MIRAGE study

Guo, Z., Cupples, L. A., Kurz, A., Auerbach, S. H., Volicer, L., Chui, H., Green, R. C., Sadovnick, A. D., Duara, R., DeCarli, C., et al. (2000) · Neurology · doi:10.1212/wnl.54.6.1316 · Cited by 506

Measuring the Burden of Secondary Insults in Head-Injured Patients During Intensive Care

Jones, P. A., Andrews, P., Midgley, S., Anderson, S. I., Piper, I., Tocher, J. L., Housley, A. M., Corrie, J., Slattery, J. M. A., Dearden, M. N., et al. (1994) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199401000-00001 · Cited by 490

Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin

Day, A. J., Mellon, F. A., Barron, D., Sarrazin, G., Morgan, M. R. A., & Williamson, G. (2001) · Free Radical Research · doi:10.1080/10715760100301441 · Cited by 472

The microglial "activation" continuum: from innate to adaptive responses

Town, T., Nikolic, V., & Tan, J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-24 · Cited by 467

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

Rezai-Zadeh, K., Arendash, G. W., Hou, H., Fernandez, F., Jensen, M., Runfeldt, M., Shytle, R. D., & Tan, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.107 · Cited by 459

Development of dementing illnesses in an 80‐year‐old volunteer cohort

Katzman, R., Aronson, M., Fuld, P. A., Kawas, C. H., Brown, T., Morgenstern, H., Frishman, W. H., Gidez, L. I., Eder, H., & Ooi, W. L. (1989) · Annals of Neurology · doi:10.1002/ana.410250402 · Cited by 453

A case‐control study of Alzheimer's disease in Australia

Broe, G. A., Henderson, A. S., Creasey, H. M., McCusker, E. A., Korten, A. E., Jorm, A. F., Longley, W. A., & Anthony, J. C. (1990) · Neurology · doi:10.1212/wnl.40.11.1698 · Cited by 446

Progressive atrophy and neuron death for one year following brain trauma in the rat

Smith, D. H., Chen, X.-H., Pierce, J. E. S., Wolf, J. A., Trojanowski, J. Q., Graham, D. I., & McIntosh, T. K. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.715 · Cited by 440

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

Town, T., Laouar, Y., Pittenger, C., Mori, T., Szekely, C. A., Tan, J., Duman, R. S., & Flavell, R. A. (2008) · Nature Medicine · doi:10.1038/nm1781 · Cited by 422

Prognostic Value of Secondary Insults in Traumatic Brain Injury: Results from The IMPACT Study

McHugh, G. S., Engel, D. C., Butcher, I., Steyerberg, E. W., Lü, J., Mushkudiani, N. A., Hernández, A. V., Marmarou, A., Maas, A. I. R., & Murray, G. D. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0031 · Cited by 414

Modulation of immune response by head injury

Morganti-Kossmann, M. C., Satgunaseelan, L., Bye, N., & Kossmann, T. (2007) · Injury · doi:10.1016/j.injury.2007.10.005 · Cited by 412

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

Ikonomovic, M. D., Uryu, K., Abrahamson, E. E., Ciallella, J. R., Trojanowski, J. Q., Lee, V. M.-Y., Clark, R. S., Marion, D. W., Wisniewski, S. R., & DeKosky, S. T. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.011 · Cited by 399

Ginkgo biloba extract: Mechanisms and clinical indications

Diamond, B. J., Shiflett, S. C., Feiwel, N., Matheis, R. J., Noskin, O., Richards, J. A., & Schoenberger, N. E. (2000) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(00)90052-2 · Cited by 389

Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

Giovanni, S. D., Movsesyan, V. A., Ahmed, F. A. K. M., Černak, I., Schinelli, S., Stoica, B. A., & Faden, A. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500989102 · Cited by 380

How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

Blasko, I., Stampfer‐Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P., & Grubeck‐Loebenstein, B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00101.x · Cited by 374

Risk factors for clinically diagnosed Alzheimer's disease

Amaducci, L. A., Fratiglioni, L., Rocca, W. A., Fieschi, C., Livrea, P., Pedone, D., Bracco, L., Lippi, A., Gandolfo, C., Bino, G., et al. (1986) · Neurology · doi:10.1212/wnl.36.7.922 · Cited by 365

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Bureau, G., Longpré, F., & Martinoli, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21503 · Cited by 344

Ineffective phagocytosis of amyloid-β by macrophages of Alzheimer's disease patients

Fiala, M., Lin, J., Ringman, J. M., Kermani-Arab, V., Tsao, G., Patel, A. J., Lossinsky, A. S., Graves, M. C., Gustavson, A. R., Sayre, J. W., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7304 · Cited by 331

ROLE OF CEREBRAL INFLAMMATION AFTER TRAUMATIC BRAIN INJURY: A REVISITED CONCEPT

Morganti-Kossmann, M. C., Rancan, M., Otto, V. I., Stahel, P. F., & Kossmann, T. (2001) · Shock · doi:10.1097/00024382-200116030-00001 · Cited by 330

Inflammaging as a prodrome to Alzheimer's disease

Giunta, B., Fernandez, F., Nikolic, W. V., Obregon, D., Rrapo, E., Town, T., & Tan, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-51 · Cited by 327

Neuronal cytoskeletal changes are an early consequence of repetitive head injury

Geddes, J. F., Vowles, G. H., Nicoll, J. A. R., & Révész, T. (1999) · Acta Neuropathologica · doi:10.1007/s004010051066 · Cited by 323

Harbingers of Poor Outcome the Day after Severe Brain Injury: Hypothermia, Hypoxia, and Hypoperfusion

Jeremitsky, É., Omert, L., Dunham, C. M., Protetch, J., & Rodríguez, A. (2003) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000037876.37236.d6 · Cited by 310

Prognostic Value of Demographic Characteristics in Traumatic Brain Injury: Results from The IMPACT Study

Mushkudiani, N. A., Engel, D. C., Steyerberg, E. W., Butcher, I., Lü, J., Marmarou, A., Slieker, F. J. A., McHugh, G. S., Murray, G. D., & Maas, A. I. R. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0028 · Cited by 304

Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study

Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., & Kurland, L. T. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009724 · Cited by 295

Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study

Gerhard, A., Schwarz, J., Myers, R., Wise, R. J. S., & Banati, R. B. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.034 · Cited by 286

Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia

Lee, H., Kim, Y. O., Kim, H., Kim, S. Y., Noh, H. S., Kang, S. S., Cho, G. J., Choi, W. S., & Suk, K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0057fje · Cited by 280

Long-term intracerebral inflammatory response after traumatic brain injury

Gentleman, S. M., Leclercq, P. D., Moyes, L., Graham, D. I., Smith, C., Griffin, W. S. T., & Nicoll, J. A. R. (2004) · Forensic Science International · doi:10.1016/j.forsciint.2004.06.027 · Cited by 272

A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long‐Term Survivors of Traumatic Brain Injury

Chen, X., Johnson, V. E., Uryu, K., Trojanowski, J. Q., & Smith, D. H. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00176.x · Cited by 267

Chronic traumatic brain injury associated with boxing

Jordan, B. D. (2000) · Seminars in Neurology · doi:10.1055/s-2000-9826 · Cited by 262

Accumulation of Amyloid β and Tau and the Formation of Neurofilament Inclusions Following Diffuse Brain Injury in the Pig

Smith, D. H., Chen, X.-H., Nonaka, M., Trojanowski, J. Q., Lee, V.-Y., Saatman, K. E., Leoni, M. J., Xu, B.-N., Wolf, J. A., & Meaney, D. F. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199909000-00008 · Cited by 260

Alzheimer’s disease after remote head injury: an incidence study

Schofield, P. W., Tang, M., Marder, K., Bell, K., Dooneief, G., Chun, M., Sano, M., Stern, Y., & Mayeux, R. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.2.119 · Cited by 260

Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease: A Review

Lye, T. C., & Shores, E. A. (2000) · Neuropsychology Review · doi:10.1023/a:1009068804787 · Cited by 259

Pharmacokinetics and Modeling of Quercetin and Metabolites

Chen, X., Yin, O. Q. P., Zuo, Z., & Chow, M. S. S. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-4584-1 · Cited by 233

Flavonoids and isoflavones: absorption, metabolism, and bioactivity

Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.12.012 · Cited by 231

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression

Rezai-Zadeh, K. P., Ehrhart, J. C., Bai, Y., Sanberg, P. R., Bickford, P. C., Tan, J. R., & Shytle, R. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-41 · Cited by 217

ADAM10 Activation Is Required for Green Tea (–)-Epigallocatechin-3-gallate-induced α-Secretase Cleavage of Amyloid Precursor Protein

Obregon, D. F., Rezai-Zadeh, K. P., Bai, Y., Sun, N., Hou, H., Ehrhart, J. C., Zeng, J., Mori, T., Arendash, G. W., Shytle, D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600617200 · Cited by 210

Structures of (−)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (−)-epicatechin: differences between human and rat

Natsume, M., Osakabe, N., Makoto, O., Sasaki, M., Baba, S., Nakamura, Y., Osawa, T., & Terao, J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01434-x · Cited by 209

Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?

Gehrmann, J., Banati, R. B., Wiessnert, C., Hossmann, K. ‐., & Kreutzberg, G. W. (1995) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1995.tb01062.x · Cited by 206

Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype

Dirscherl, K., Karlstetter, M., Ebert, S., Kraus, D., Hlawatsch, J., Walczak, Y., Moehle, C., Fuchshofer, R., & Langmann, T. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-3 · Cited by 175

Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats

Thornton, E., Vink, R., Blumbergs, P. C., & van den Heuvel, C. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.107 · Cited by 172

Post‐injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury

Chen, S. H., Hsu, C.-W., Huang, W., & Wang, J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.345 · Cited by 170

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity

Zheng, L. T., Ock, J., Kwon, B., & Suk, K. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2007.12.012 · Cited by 168

The Temporal Dynamics of Poststroke Neuroinflammation: A Longitudinal Diffusion Tensor Imaging–Guided PET Study with 11C-PK11195 in Acute Subcortical Stroke

Thiel, A., Radlinska, B. A., Paquette, C., Sidel, M., Soucy, J., Schirrmacher, R., & Minuk, J. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.076612 · Cited by 167

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 157

Prolonged Microgliosis in the Rhesus Monkey Central Nervous System after Traumatic Brain Injury

Nagamoto-Combs, K., McNeal, D. W., Morecraft, R. J., & Combs, C. K. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2007.0377 · Cited by 156

Association of increased cortical soluble Aβ42 levels with diffuse plaques after severe brain injury in humans

DeKosky, S. T., Abrahamson, E. E., Ciallella, J. R., Paljug, W. R., Wisniewski, S. R., Clark, R. S. B., & Ikonomovic, M. D. (2007) · Archives of Neurology · doi:10.1001/archneur.64.4.541 · Cited by 152

Brain injury and neurologic sequelae: A cohort study of dementia, parkinsonism, and amyotrophic lateral sclerosis

Williams, D. B., Annegers, J. F., Kokmen, E., O'Brien, P. C., & Kurland, L. T. (1991) · Neurology · doi:10.1212/wnl.41.10.1554 · Cited by 149

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats.

Zhang, B., West, E., Van, K. C., Gurkoff, G. G., Zhou, J., Zhang, X.-M., Kozikowski, A., & Lyeth, B. G. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.085 · Cited by 138

Case‐control study of late onset “probable Alzheimer's disease”

Chandra, V., Philipose, V., BELL, P. A., Lazaroff, A. E., & Schoenberg, B. S. (1987) · Neurology · doi:10.1212/wnl.37.8.1295 · Cited by 131

Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications

Newcombe, V. F. J., Williams, G. B., Scoffings, D., Cross, J., Carpenter, T. A., Pickard, J. D., & Menon, D. K. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.196246 · Cited by 122

Craniocerebral Trauma: Protection and Retrieval of the Neuronal Population after Injury

Teasdale, G. M., & Graham, D. I. (1998) · Neurosurgery · doi:10.1097/00006123-199810000-00001 · Cited by 122

Corrigendum to Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic. Biol. Med. 36: 592–604; 2004.

Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.003 · Cited by 118

Widespread cellular proliferation and focal neurogenesis after traumatic brain injury in the rat

Urrea, C., Castellanos, D. A., Sagen, J., Tsoulfas, P., Bramlett, H. M., & Dietrich, W. D. (2007) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2007-00369 · Cited by 117

Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography

Peng, H., Cheng, F. C., Huang, Y., Chen, C. F., & Tsai, T. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00204-7 · Cited by 112

Hippocampal pathology in fatal non-missile human head injury

Kotapka, M. J., Graham, D. I., Adams, J. H., & Gennarelli, T. A. (1992) · Acta Neuropathologica · doi:10.1007/bf00310031 · Cited by 111

Regional and temporal characterization of neuronal, glial, and axonal response after traumatic brain injury in the mouse

Carbonell, W. S., & Grady, M. S. (1999) · Acta Neuropathologica · doi:10.1007/s004010051100 · Cited by 110 · cited 1×

Microglial Phenotype Is Regulated by Activity of the Transcription Factor, NFAT (Nuclear Factor of Activated T Cells)

Nagamoto‐Combs, K., & Combs, C. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0828-10.2010 · Cited by 104

Genistein protects dopaminergic neurons by inhibiting microglial activation

Wang, X., Chen, S., Ma, G., Ye, M., & Lü, G. (2005) · Neuroreport · doi:10.1097/00001756-200502280-00013 · Cited by 99

The role of inflammatory processes in the pathophysiology and treatment of brain and spinal cord trauma

Dietrich, W. D., Chatzipanteli, K., Vitarbo, E. A., Wada, K., & Kinoshita, K. (2004) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-0603-7_9 · Cited by 94

Stereology of cerebral cortex after traumatic brain injury matched to the Glasgow Outcome Score

Maxwell, W., MacKinnon, M.-A., Stewart, J. E., & Graham, D. I. (2009) · Brain · doi:10.1093/brain/awp264 · Cited by 94

Severe Head Injury Hastens Age of Onset of Alzheimer's Disease

Gedye, A., Beattie, B. L., Tuokko, H. A., Horton, A., & Korsarek, E. (1989) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1989.tb07283.x · Cited by 90

Rapid and Widespread Microglial Activation Induced by Traumatic Brain Injury in Rat Brain Slices

Koshinaga, M., Katayama, Y., Fukushima, M., Oshima, H., Suma, T., & Takahata, T. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.185 · Cited by 89

Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice

Giunta, B. N., Hou, H., Zhu, Y., Salemi, J., Ruscin, A., Shytle, R. D., & Tan, J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.026 · Cited by 88

EGCG functions through estrogen receptor‐mediated activation of ADAM10 in the promotion of non‐amyloidogenic processing of APP

Fernandez, J. W., Rezai-Zadeh, K. P., Obregon, D. F., & Tan, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.022 · Cited by 86

Natural substances in psychiatry (Ginkgo biloba in dementia).

Itil, T. M., & Martorano, D. (1995) · PubMed · Cited by 83

EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-γ: Role of JAK/STAT1 signaling and implications for HIV-associated dementia

Giunta, B. N., Obregon, D. F., Hou, H., Zeng, J., Sun, N., Nikolic, V., Ehrhart, J. C., Shytle, R. D., Fernandez, F., & Tan, J. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.057 · Cited by 75

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

Corrigan, F., Pham, C. L. L., Vink, R., Blumbergs, P. C., Masters, C. L., van den Heuvel, C., & Cappai, R. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.077 · Cited by 75

Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study

Ferini‐Strambi, L., Smirne, S., Garancini, P., Pinto, P., & Franceschi, M. (1990) · Neuroepidemiology · doi:10.1159/000110750 · Cited by 71

Pulse oximetry at the roadside: a study of pulse oximetry in immediate care.

Silverston, P. P. (1989) · BMJ · doi:10.1136/bmj.298.6675.711 · Cited by 68

Effects of Ginkgo biloba extract on cell proliferation and cytotoxicity in human hepatocellular carcinoma cells

Chao, J. C., & Chu, C.-C. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i1.37 · Cited by 66

IL6 deficiency affects function after traumatic brain injury.

Ley, E. J., Clond, M. A., Singer, M., Shouhed, D., & Salim, A. (2011) · Journal of Surgical Research · doi:10.1016/j.jss.2011.03.006 · Cited by 57

(−)-Epigallocatechin-3-gallate Protects Against Neuronal Cell Death and Improves Cerebral Function After Traumatic Brain Injury in Rats

Itoh, T., Imano, M., Nishida, S., Tsubaki, M., Hashimoto, S., Ito, A., & Satou, T. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8162-x · Cited by 45

HIV-1 TAT inhibits microglial phagocytosis of Abeta peptide.

(2008) · PubMed Central · Cited by 37

Can consuming flavonoids restore old microglia to their youthful state?

Jang, S., & Johnson, R. W. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00336.x · Cited by 34

[Absorption, distribution and elimination of a labelled extract of Ginkgo biloba leaves in the rat].

Moreau, J. P., Eck, C. R., McCabe, J. G., & Skinner, S. (1986) · PubMed · Cited by 32

Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.

Rrapo, E., Zhu, Y., Tian, J., Hou, H., Smith, A., Fernandez, F., Tan, J., & Giunta, B. N. (2009) · PubMed Central · Cited by 27

Gastroretentive drug delivery system of DA-6034, a new flavonoid derivative, for the treatment of gastritis

Jang, S. W., Lee, J. W., Park, S. H., Kim, J. H., Yoo, M., Na, D. H., & Lee, K. C. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.12.042 · Cited by 25

[Disorders of brain performance of vascular origin. Randomized double-blind study of the effectiveness of Gingko biloba extract].

Halama, P., Bartsch, G., & Meng, G. (1988) · PubMed · Cited by 21

Mechanisms of immune regulation in Alzheimer's disease: a viewpoint.

Marx, F., Blasko, I., & Grubeck‐Loebenstein, B. (1999) · PubMed · Cited by 17

[Controlled double-blind study for the determination of the effect of Tebonin forte in patients with cerebrovascular insufficiency].

Eckmann, F., & Schlag, H. (1982) · PubMed · Cited by 14

Glucuronidation of Naringenin in Rats

Peng, H.-W., Huang, Y., Chen, C.-F., & Tsai, T. (1998) · Planta Medica · doi:10.1055/s-2006-957587 · Cited by 2

Untitled work

Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799

Microglial Activation in Traumatic Brain Injury

Donat, C. K., Scott, G., Gentleman, S., & Sastre, M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00208 · Cited by 512

NADPH oxidase in brain injury and neurodegenerative disorders

Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432

Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

Borlongan, C. V., Acosta, S., de la Peña, I., Tajiri, N., Kaneko, Y., Lozano, D., & Gonzales-Portillo, G. S. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s65815 · Cited by 433

Glial contributions to neurodegeneration in tauopathies

Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409

REVIEW Open Access The immunology of traumatic brain injury: a prime target for Alzheimer’s disease prevention

Giunta, B. N., Obregon, D. F., Velisetty, R., Sanberg, P. R., Borlongan, C. V., & Tan, J. (2013)

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128

Inflammasome activation in traumatic brain injury and Alzheimer's disease

Johnson, N. H., Vaccari, J. P. D. R., Bramlett, H. M., Keane, R. W., & Dietrich, W. D. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.014 · Cited by 74

Brain injury, neuroinflammation and Alzheimer's disease

Breunig, J. J., Guillot‐Sestier, M., & Town, T. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00026 · Cited by 106

Traumatic Brain Injury and the Road to Alzheimer’s Disease

Kaveh, R., Kamari, F., Høilund‐Carlsen, P. F., Blaabjerg, M., Christensen, A. A., Poulsen, F. R., Ghaedi, S., Alavi, A. A., & Andalib, S. (2026) · Biomedicines · doi:10.3390/biomedicines14092056