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Cited by 308Chronic Kidney Disease and DiabetesMuscle metabolism and nutritionDiet and metabolism studies

Dietary protein intake and renal function

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Martin, William F, Armstrong, Lawrence E, Rodriguez, Nancy R·2005·Nutrition & Metabolism
DOI 10.1186/1743-7075-2-25PMC PMC1262767
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Abstract

Recent trends in weight loss diets have led to a substantial increase in protein intake by individuals. As a result, the safety of habitually consuming dietary protein in excess of recommended intakes has been questioned. In particular, there is concern that high protein intake may promote renal damage by chronically increasing glomerular pressure and hyperfiltration. There is, however, a serious question as to whether there is significant evidence to support this relationship in healthy individuals. In fact, some studies suggest that hyperfiltration, the purported mechanism for renal damage, is a normal adaptative mechanism that occurs in response to several physiological conditions. This paper reviews the available evidence that increased dietary protein intake is a health concern in terms of the potential to initiate or promote renal disease. While protein restriction may be appropriate for treatment of existing kidney disease, we find no significant evidence for a detrimental effect of high protein intakes on kidney function in healthy persons after centuries of a high protein Western diet.

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  • Reviews of research studies reveal little or no evidence that high-protein diets cause kidney damage in healthy individuals, including older persons.

    “However, reviews of research studies reveal little or no evidence that high-protein diets cause kidney damage in healthy individuals, including those who are older.6,54,55”

    From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [55]

    The Conclusion (page not provided) says the literature lacks significant evidence linking high protein intake to renal disease in healthy individuals, and the Evidence in healthy individuals section describes studies finding no detrimental renal effects. The paper does not specifically establish this conclusion for older healthy people; searches for older and elderly found no age-specific evidence supporting that part of the claim. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Published reviews consistently report that an increased intake of protein by competitive athletes and active individuals provides no indication of hepato-renal harm or damage.

    “Published reviews on this topic consistently report that an increased intake of protein by competitive athletes and active individuals provides no indication of hepato-renal harm or damage [216, 217].”

    From International Society of Sports Nutrition Position Stand: protein and exercise (2017) · cites this paper as [216]

    In “Evidence in healthy individuals” (page not provided), the review says it found no data linking high protein intake to impaired kidney function in healthy, physically active people, including athletes. It addresses renal harm, but does not establish the claim about liver harm or that published reviews consistently reach that broader conclusion. (LLM, conf=0.88)

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Cited by

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Authors
Martin, W. F., Armstrong, L. E., & Rodriguez, N. R.
Affiliations
University of Connecticut (US)
Corresponding author
Rodriguez, Nancy R
ORCID
Venue
Nutrition & Metabolism
Publisher
Springer Science and Business Media LLC
Published
2005-09-20
Volume
2
Issue
1
Pages
25-25
ISSN
1743-7075 (ISSN-L)
DOI
10.1186/1743-7075-2-25
PMC
PMC1262767
OpenAlex
W1823884849
Cited by
308
References
6
Citations by year
2026: 13 · 2025: 17 · 2024: 19 · 2023: 12 · 2022: 16 · 2021: 18 · 2020: 16 · 2019: 19 · 2018: 26 · 2017: 18 · 2016: 21 · 2015: 20 · 2014: 17 · 2013: 15 · 2012: 11
FWCI
4.31
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nutrition & Metabolism (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
Keywords
protein intake, renal function, high-protein diet, weight loss diet, glomerular hyperfiltration, glomerular pressure, kidney injury, kidney disease, protein restriction, Western diet, healthy individuals

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