CoChat
Sign Up
Cited by 132Air Quality and Health ImpactsToxic Organic Pollutants ImpactCarcinogens and Genotoxicity Assessment

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice

Open access
Hougaard, Karin S, Jensen, Keld A, Nordly, Pernille, Taxvig, Camilla, Vogel, Ulla, Saber, Anne T, Wallin, Håkan·2008·Particle and Fibre Toxicology
DOI 10.1186/1743-8977-5-3PMC PMC2323399
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Results from epidemiological studies indicate that particulate air pollution constitutes a hazard for human health. Recent studies suggest that diesel exhaust possesses endocrine activity and therefore may affect reproductive outcome. This study in mice aimed to investigate whether exposure to diesel exhaust particles (DEP; NIST 2975) would affect gestation, postnatal development, activity, learning and memory, and biomarkers of transplacental toxicity. Pregnant mice (C57BL/6; BomTac) were exposed to 19 mg/m3 DEP (~1.106 particles/cm3; mass median diameter congruent with 240 nm) on gestational days 9-19, for 1 h/day. RESULTS: Gestational parameters were similar in control and diesel groups. Shortly after birth, body weights of DEP offspring were slightly lower than in controls. This difference increased during lactation, so by weaning the DEP exposed offspring weighed significantly less than the control progeny. Only slight effects of exposure were observed on cognitive function in female DEP offspring and on biomarkers of exposure to particles or genotoxic substances. CONCLUSION: In utero exposure to DEP decreased weight gain during lactation. Cognitive function and levels of biomarkers of exposure to particles or to genotoxic substances were generally similar in exposed and control offspring. The particle size and chemical composition of the DEP and differences in exposure methods (fresh, whole exhaust versus aged, resuspended DEP) may play a significant role on the biological effects observed in this compared to other studies.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/1743-8977-5-3

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Average particle number distribution during DEP-exposure compared to the average particle size distribution in exposure to controls.n = 26. Error bars denote the SD of the average concentrations calculated based on the average for each N exposure.
Figure 1 Average particle number distribution during DEP-exposure compared to the average particle size distribution in exposure to controls.n = 26. Error bars denote the SD of the average concentrations calculated based on the average for each N exposure.CC BY · PubMed Central
Figure 2 Average mass number distribution during DEP-exposure compared to the average mass distribution in exposure to controls.n = 26. Error bars denote the SD of the average concentrations calculated based on the average for each N exposure.
Figure 2 Average mass number distribution during DEP-exposure compared to the average mass distribution in exposure to controls.n = 26. Error bars denote the SD of the average concentrations calculated based on the average for each N exposure.CC BY · PubMed Central
Figure 3 Average litter weight during lactation. Litters were either controls or exposed to DEP during gestation. Data represent mean+SEM. Mean Offspring exposed to DEP during fetal life gained statistically significantly less weight during the latter half of lactation compared to control offspring. n = 12. *p < 0.05.
Figure 3 Average litter weight during lactation. Litters were either controls or exposed to DEP during gestation. Data represent mean+SEM. Mean Offspring exposed to DEP during fetal life gained statistically significantly less weight during the latter half of lactation compared to control offspring. n = 12. *p < 0.05.CC BY · PubMed Central
Figure 4 mRNA expression of inflammatory cytokines in liver from pups at PND 2. Expression of mRNA is normalized to 18S rRNA. Empty squares: Controls; filled squares: DEP. Horisontal line: mean value. Levels of mRNA of IL-6, MCP-1, and MIP-2 were normalized to the 18S levels. n = 6–7.
Figure 4 mRNA expression of inflammatory cytokines in liver from pups at PND 2. Expression of mRNA is normalized to 18S rRNA. Empty squares: Controls; filled squares: DEP. Horisontal line: mean value. Levels of mRNA of IL-6, MCP-1, and MIP-2 were normalized to the 18S levels. n = 6–7.CC BY · PubMed Central
Figure 5 T4 plasma hormone levels in mothers and offspring. Blood for T4 plasma hormone levels were collected at the time of weaning and measured by immunoassay. Data represent mean+SEM, n = 11–12 for the dams. Data for male and female pups were similar and were therefore collapsed within each prenatal exposure group, n = 9.
Figure 5 T4 plasma hormone levels in mothers and offspring. Blood for T4 plasma hormone levels were collected at the time of weaning and measured by immunoassay. Data represent mean+SEM, n = 11–12 for the dams. Data for male and female pups were similar and were therefore collapsed within each prenatal exposure group, n = 9.CC BY · PubMed Central
Figure 6 Memory in the Morris water maze for female offspring. Data represent mean+SEM. Latency to locate the hidden platform is presented for memory (three days, i.e. trial 1–12; reversal, trial 13–16, and new, trial 17–20). DEP exposed offspring located the platform faster than controls on the first trial of reversal learning. n = 10. *p < 0.05.
Figure 6 Memory in the Morris water maze for female offspring. Data represent mean+SEM. Latency to locate the hidden platform is presented for memory (three days, i.e. trial 1–12; reversal, trial 13–16, and new, trial 17–20). DEP exposed offspring located the platform faster than controls on the first trial of reversal learning. n = 10. *p < 0.05.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Cited by

Sorted by citations

See all 132

Related

See all

Metadata

Authors
Hougaard, K. S., Jensen, K. A., Nordly, P., Taxvig, C., Vogel, U., Saber, A. T., & Wallin, H.
Affiliations
  • National Research Centre for the Working Environment (DK)
  • University of Copenhagen (DK)
  • Technical University of Denmark (DK)
ORCID
Venue
Particle and Fibre Toxicology
Publisher
Springer Science and Business Media LLC
Published
2008
Volume
5
Issue
1
Pages
3
ISSN
1743-8977 (ISSN-L)
DOI
10.1186/1743-8977-5-3
PMC
PMC2323399
OpenAlex
W2102523805
Cited by
132
References
54
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 11 · 2014: 6 · 2013: 10 · 2012: 7
FWCI
5.76
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Particle and Fibre Toxicology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Keywords
diesel exhaust particles, prenatal exposure, postnatal development, weight gain, lactation, cognitive function, learning and memory, genotoxicity, inflammation, particulate matter pollution, endocrine activity, gestation, mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review