Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice
Open accessAbstract
Background: The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors. Methods: C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine. Results: Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice. Conclusions: Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indicating that separate mechanisms underlie the psychomotor and rewarding effects of cocaine.
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The genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization.
“There is also evidence suggesting that the genetic variation in acute responsiveness to drugs is different to that responsible for differences in sensitization (Eisener-Dorman, Grabowski-Boase, & Tarantino, 2011; Phillips, Huson, & McKinnon, 1998; Phillips, Huson, Gwiazdon, Kasch, & Shen, 1995).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Eisener-Dorman, Grabowski-Boase, & Tarantino, 2011
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Manipulating a “Cocaine Engram” in Mice
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- Authors
- Eisener-Dorman, A. F., Grabowski-Boase, L., & Tarantino, L. M.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Genomics Institute of the Novartis Research Foundation (US)
- Corresponding author
- Tarantino, Lisa M
- ORCID
- Tarantino, Lisa M
- Venue
- Behavioral and Brain Functions
- Published
- 2011-08-01
- Volume
- 7
- Issue
- 1
- Pages
- 29-29
- ISSN
- 1744-9081 (ISSN-L)
- PMC
- PMC3160884
- OpenAlex
- W2126513479
- Cited by
- 62
- References
- 53
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 3 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 4 · 2012: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Behavioral and Brain Functions (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (SFP-1406)
- National Institute on Drug Abuse (DA 022392, R01DA022392, R01DA023690, DA023690)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- cocaine, locomotor sensitization, conditioned place preference, locomotor activation, inbred mouse strains, genetic variation in drug response, psychomotor effects, rewarding effects, C57BL/6J mice, BALB/cJ, C3H/HeJ, DBA/2J, strain differences
- MeSH terms
- Animals, Cocaine, Conditioning, Psychological, Male, Mice, Inbred BALB C, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Motor Activity, Psychomotor Performance, Species Specificity, Mice, Mice, 129 Strain
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