DRD2 and PPP1R1B (DARPP-32) polymorphisms independently confer increased risk for autism spectrum disorders and additively predict affected status in male-only affected sib-pair families

Haploview: analysis and visualization of LD and haplotype maps

Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works

The control of the false discovery rate in multiple testing under dependency

Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490 · see citing works

Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders

Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065 · see citing works

Controlling the false discovery rate in behavior genetics research

Benjamini, Y., Drai, D., Elmer, G., Kafkafi, N., & Golani, I. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00297-2 · Cited by 4,146 · see citing works

Executive dysfunction in autism☆

Hill, E. L. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2003.11.003 · Cited by 1,468 · see citing works

The genetics of autism

Muhle, R., Trentacoste, S. V., & Rapin, I. (2004) · Pediatrics · doi:10.1542/peds.113.5.e472 · Cited by 1,207 · see citing works

Implementing a unified approach to family-based tests of association

Laird, N. M., Horvath, S., & Xu, X. P. (2000) · Genetic Epidemiology · doi:10.1002/1098-2272(2000)19:1+ · Cited by 854 · see citing works

Prevalence of Autism Spectrum Disorders --- Autism and Developmental Disabilities Monitoring Network, United States, 2006

Rice, C. E. (2009) · PsycEXTRA Dataset · doi:10.1037/e562722010-001 · Cited by 760 · see citing works

DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization

Ouimet, C. C., Miller, P. E., Hemmings, H. C., Walaas, S. I., & Greengard, P. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-01-00111.1984 · Cited by 655 · see citing works

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651 · see citing works

The Dopamine D2 Receptor Locus as a Modifying Gene in Neuropsychiatric Disorders

Comings, D. E. (1991) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1991.03470130073032 · Cited by 587 · see citing works

Searching for ways out of the autism maze: genetic, epigenetic and environmental clues

Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works

Mesolimbic dopaminergic pathways in fear conditioning

Pezze, M. A., & Feldon, J. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.004 · Cited by 510 · see citing works

FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization

Yuan, H., Chiou, J.-J., Tseng, W.-H., Liu, C.-H., Liu, C.-K., Lin, Y.-J., Wang, H.-H., Yao, A., Chen, Y., & Hsu, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl236 · Cited by 510 · see citing works

D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes

Noble, E. P. (2003) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.10005 · Cited by 501 · see citing works

DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Chéramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) · Science · doi:10.1126/science.281.5378.838 · Cited by 491 · see citing works

A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia

Arinami, T. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.4.577 · Cited by 455 · see citing works

Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory

Zhang, Y., Bertolino, A., Fazio, L., Blasi, G., Rampino, A., Romano, R., Lee, M. T., Xiao, T., Papp, A. C., Wang, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707106104 · Cited by 427 · see citing works

A Double-blind, Placebo-Controlled Study of Risperidone in Adults With Autistic Disorder and Other Pervasive Developmental Disorders

McDougle, C. J., Holmes, J. P., Carlson, D. C., Pelton, G. H., Cohen, D. J., & Price, L. H. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.633 · Cited by 425 · see citing works

A measure of striatal function predicts motor stereotypy

Canales, J. J., & Graybiel, A. M. (2000) · Nature Neuroscience · doi:10.1038/73949 · Cited by 423 · see citing works

The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP.

Grandy, D. K., Litt, M. J., Allen, L., Bunzow, J. R., Marchionni, M. A., Makam, H., Reed, L., Magenis, R. E., & Civelli, O. (1989) · PubMed · Cited by 421 · see citing works

Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition

Bissière, S., Humeau, Y., & Lüthi, A. (2003) · Nature Neuroscience · doi:10.1038/nn1058 · Cited by 415 · see citing works

Prevalence of autism spectrum disorders - Autism and Developmental Disabilities Monitoring Network, United States, 2006.

(2009) · PubMed · Cited by 409 · see citing works

Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting

Floresco, S. B., Magyar, O., Ghods-Sharifi, S., Vexelman, C., & Tse, M. T. L. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300825 · Cited by 395 · see citing works

Dopamine and cAMP-Regulated Phosphoprotein 32 kDa Controls Both Striatal Long-Term Depression and Long-Term Potentiation, Opposing Forms of Synaptic Plasticity

Calabresi, P., Gubellini, P., Centonze, D., Picconi, B., Bernardi, G., Chergui, K., Svenningsson, P., Fienberg, A. A., & Greengard, P. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08443.2000 · Cited by 379 · see citing works

Autism and maternally derived aberrations of chromosome 15q

Schroer, R. J., Phelan, M. C., Michaelis, R. C., Crawford, E. C., Skinner, S. A., Cuccaro, M. L., Simensen, R. J., Bishop, J., Skinner, C. D., Fender, D., et al. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980401)76:4 · Cited by 375 · see citing works

EPIGENETICS AND HUMAN DISEASE

Jiang, Y.-H., Bressler, J., & Beaudet, A. L. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.180014 · Cited by 365 · see citing works

Dopaminergic control of synaptic plasticity in the dorsal striatum

Centonze, D., Picconi, B., Gubellini, P., Bernardi, G., & Calabresi, P. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01485.x · Cited by 361 · see citing works

Contributions of amygdala and striatal activity in emotion regulation.

Hare, T. A., Tottenham, N., Davidson, M. C., Glover, G. H., & Casey, B. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.038 · Cited by 351 · see citing works

Medial temporal lobe structures and autism: A review of clinical and experimental findings

Bachevalier, J. (1994) · Neuropsychologia · doi:10.1016/0028-3932(94)90025-6 · Cited by 322 · see citing works

A unified genetic theory for sporadic and inherited autism

Zhao, X., Leotta, A., Kustanovich, V., Lajonchere, C., Geschwind, D. H., Law, K., Law, P., Qiu, S., Lord, C., Sebat, J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705803104 · Cited by 319 · see citing works

The Autism Genetic Resource Exchange: A Resource for the Study of Autism and Related Neuropsychiatric Conditions

Geschwind, D. H., Sowinski, J., Lord, C., Iversen, P., Shestack, J., Jones, P., Ducat, L., & Spence, S. J. (2001) · The American Journal of Human Genetics · doi:10.1086/321292 · Cited by 302 · see citing works

Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set

Crofts, H. S. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.11.1015 · Cited by 284 · see citing works

Bipolar disorder, schizophrenia and other psychotic disorders in adults with childhood onset AD/HD and/or autism spectrum disorders

Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0115-1 · Cited by 273 · see citing works

Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a

Yamasaki, K. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg106 · Cited by 273 · see citing works

Gait Disturbances in Patients With Autistic Behavior

Vilensky, J. A. (1981) · Archives of Neurology · doi:10.1001/archneur.1981.00510100074013 · Cited by 268 · see citing works

Low medial prefrontal dopaminergic activity in autistic children

Ernst, M., Zametkin, A., Matochik, J., Pascualvaca, D., & Cohen, R. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63326-0 · Cited by 246 · see citing works

Spatial Working Memory Deficits in Autism

Steele, S. D., Minshew, N. J., Luna, B., & Sweeney, J. A. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0202-2 · Cited by 235 · see citing works

Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition

Meyer‐Lindenberg, A., Straub, R. E., Lipska, B. K., Verchinski, B. A., Goldberg, T. E., Callicott, J. H., Egan, M. F., Huffaker, S., Mattay, V. S., Kolachana, B. S., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30413 · Cited by 226 · see citing works

A Paradigm Shift in Brain Research

Carlsson, A. (2001) · Science · doi:10.1126/science.1066969 · Cited by 224 · see citing works

Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease

Mehta, M. A., Sahakian, B. J., McKenna, P. J., & Robbins, T. W. (1999) · Psychopharmacology · doi:10.1007/s002130051102 · Cited by 223 · see citing works

Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach

Ogden, C. A., Rich, M. E., Schork, N. J., Paulus, M. P., Geyer, M. A., Lohr, J. B., Kuczenski, R., & Niculescu, A. B. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001547 · Cited by 221 · see citing works

Long-Term Effects of Risperidone in Children With Autism Spectrum Disorders: A Placebo Discontinuation Study

Troost, P. W., Lahuis, B., Steenhuis, M., Ketelaars, C. E. J., Buitelaar, J. K., van Engeland, H., Scahill, L. D., Minderaa, R. B., & Hoekstra, P. J. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000177055.11229.76 · Cited by 206 · see citing works

Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): A mechanism for pair bonding?

Wang, Z., Yu, G., Cascio, C., Liu, Y., Gingrich, B., & Insel, T. R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.3.602 · Cited by 205 · see citing works

Correspondence

Mercuri, N. B., Saiardi, A., Bonci, A., Picetti, R., Calabresi, P., Bernardi, G., & Borrelli, E. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00135-8 · Cited by 198 · see citing works

PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes

Conde, L., Vaquerizas, J. M., Dopazo, H., Arbiza, L., Reumers, J., Rousseau, F., Schymkowitz, J. W. H., & Dopazo, J. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl071 · Cited by 198 · see citing works

Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations.

Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.5.891 · Cited by 194 · see citing works

Inhibition of the mesoamygdala dopaminergic pathway impairs the retrieval of conditioned fear associations.

Nader, K., & LeDoux, J. E. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.891 · Cited by 174 · see citing works

Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle

Greba, Q., Gifkins, A., & Kokkinidis, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02243-0 · Cited by 160 · see citing works

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia

Bertolino, A., Fazio, L., Caforio, G., Blasi, G., Rampino, A., Romano, R., Giorgio, A. D., Taurisano, P., Papp, A. C., Pinsonneault, J. K., et al. (2008) · Brain · doi:10.1093/brain/awn248 · Cited by 142 · see citing works

The 3′ region of the DRD2 gene is involved in genetic susceptibility to schizophrenia

Dubertret, C. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00220-2 · Cited by 129 · see citing works

CSF Monoamines in Autistic Syndromes and Other Pervasive Developmental Disorders of Early Childhood

Gillberg, C., & Svennerholm, L. (1987) · The British Journal of Psychiatry · doi:10.1192/bjp.151.1.89 · Cited by 128 · see citing works

Regional and ultrastructural distribution of the ?8 integrin subunit in developing and adult rat brain suggests a role in synaptic function

Einheber, S., Schnapp, L. M., Salzer, J. L., Cappiello, Z. B., & Milner, T. A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960617)370:1 · Cited by 126 · see citing works

Modification of practice-dependent plasticity in human motor cortex by neuromodulators.

Meintzschel, F., & Ziemann, U. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj052 · Cited by 119 · see citing works

Activation of dopaminergic D1 receptors promotes morphogenesis of developing striatal neurons

Schmidt, U. G., Beyer, C., Oestreicher, A. B., Reisert, I., Schilling, K., & Pilgrim, C. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00201-1 · Cited by 98 · see citing works

Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance

Bertolino, A., Taurisano, P., Pisciotta, N. M., Blasi, G., Fazio, L., Romano, R., Gelao, B., Bianco, L. L., Lozupone, M., Giorgio, A. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009348 · Cited by 97 · see citing works

Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936

Houlihan, L. M., Harris, S. E., Michelle Luciano, A., Gow, A. J., Starr, J. M., Visscher, P. M., & Deary, I. J. (2008) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2008.00470.x · Cited by 89 · see citing works

Genetically determined low maternal serum dopamine ?-hydroxylase levels and the etiology of autism spectrum disorders

Robinson, P. D., Schutz, C. K., Macciardi, F. M., White, B. N., & Holden, J. J. A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1187 · Cited by 88 · see citing works

A dopaminergic-glutamatergic basis for the action of amphetamine and cocaine

Karler, R., Calder, L. D., Thai, L. H., & Bedingfield, J. B. (1994) · Brain Research · doi:10.1016/s0006-8993(09)90003-8 · Cited by 86 · see citing works

A DRD1 haplotype is associated with risk for autism spectrum disorders in male‐only affected sib‐pair families

Hettinger, J. A., Liu, X., Schwartz, C. E., Michaelis, R. C., & Holden, J. J. A. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30655 · Cited by 86 · see citing works

Differential fear conditioning in Asperger's syndrome: Implications for an amygdala theory of autism

Gaigg, S., & Bowler, D. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.01.012 · Cited by 82 · see citing works

The DARPP-32 knockout mouse

Fienberg, A. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00047-8 · Cited by 77 · see citing works

D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex

Hotte, M., Thuault, S., Lachaise, F., Dineley, K. T., Hemmings, H. C., Nairn, A. C., & Jay, T. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.026 · Cited by 76 · see citing works

Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23

Eubanks, J. H., Djabali, M., Selleri, L., et al. (1992) · Genomics · doi:10.1016/s0888-7543(05)80124-7 · Cited by 73 · see citing works

D1 and D2 Receptor Antagonist Injections in the Prefrontal Cortex Selectively Impair Spatial Learning in Mice

Rinaldi, A., Mandillo, S., Oliverio, A., & Mele, A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301176 · Cited by 71 · see citing works

DARPP-32 knockout mice exhibit impaired reversal learning in a discriminated operant task

Heyser, C. J., Fienberg, A. A., Greengard, P., & Gold, L. H. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02272-1 · Cited by 69 · see citing works

Autism spectrum disorders: Molecular genetic advances

Bacchelli, E., & Maestrini, E. (2006) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30078 · Cited by 67 · see citing works

The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations

Glaser, R. L. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj101 · Cited by 66 · see citing works

Immunohistochemical and immunoblot analysis of Dopamine and cyclic AMP-regulated phosphoprotein, relative molecular mass 32,000 (DARPP-32) in the prefrontal cortex of subjects with schizophrenia and bipolar disorder

Ishikawa, M., Mizukami, K., Iwakiri, M., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.04.013 · Cited by 58 · see citing works

Different mechanisms of glutamate-induced neuronal death between dopaminergic and non-dopaminergic neurons in rat mesencephalic culture

Sawada, H., Kawamura, T., Shimohama, S., AKAIKE, A., & Kimura, J. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960215)43:4 · Cited by 52 · see citing works

Spatial Reversal as a Measure of Executive Functioning in Children With Autism

Coldren, J. T., & Halloran, C. (2003) · The Journal of Genetic Psychology · doi:10.1080/00221320309597501 · Cited by 48 · see citing works

Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice

Kruzich, P. J., Mitchell, S. H., YOUNKIN, A., & Grandy, D. K. (2006) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.6.1.86 · Cited by 37 · see citing works

Paternal Imprinting of Mouse Serotonin Receptor 2A GeneHtr2in Embryonic Eye: A Conserved Imprinting Regulation on theRB/RbLocus

Kato, M. V., Ikawa, Y., Hayashizaki, Y., & Shibata, H. (1998) · Genomics · doi:10.1006/geno.1997.5089 · Cited by 36 · see citing works

Involvement of adenylate cyclase inhibition in dopamine autoreceptor regulation of tyrosine hydroxylase in rat nucleus accumbens

Onali, P., & Olianas, M. C. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90313-3 · Cited by 31 · see citing works

A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells

Petit, A., Gallo‐Payet, N., Vaillancourt, C., et al. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.3.7690361 · Cited by 30 · see citing works

Ontogeny of the striatal neurons expressing the D2 dopamine receptor in humans: an in situ hybridization and receptor-binding study

Brana, C., Aubert, I., Charron, G., Pellevoisin, C., & Bloch, B. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00114-9 · Cited by 26 · see citing works

Analysis of ten candidate genes in autism by association and linkage

Philippe, A., GUILLOUD-BATAILLE, M., Martinez, M. M., Gillberg, C., Råstam, M., Sponheim, E., Coleman, M., Zappella, M., Aschauer, H. N., Penet, C., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10041 · Cited by 23 · see citing works

Tissue specificity of methylation and expression of human genes coding for neuropeptides and their receptors, and of a human endogenous retrovirus K family

Shen, H., Nakamura, A. M., Sugimoto, J., Sakumoto, N., Oda, T., Jinno, Y., & Okazaki, Y. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0382-9 · Cited by 15 · see citing works

Expression of human placental D2-dopamine receptor during normal and abnormal pregnancies

Vaillancourt, C., Petit, A., & Bélisle, S. (1998) · Placenta · doi:10.1016/s0143-4004(98)90101-1 · Cited by 15 · see citing works

Presence of dopamine DA-1 receptors in human decidua

Yanagawa, T., Kishimoto, Y., Tada, K., et al. (1997) · Placenta · doi:10.1016/s0143-4004(97)90089-8 · Cited by 11 · see citing works

Dopamine effects the in vitro basal secretion of rat placenta opioids in an opioid and dopamine receptor type-specific manner

Stratakis, C. A., Mitsiades, N., Chrousos, G. P., et al. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00577-8 · Cited by 6 · see citing works

Oxytocin pathway gene networks in the human brain

Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works

Dopamine and glucose, obesity, and reward deficiency syndrome

Blum, K., Thanos, P. K., & Gold, M. S. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00919 · Cited by 230 · see citing works

Developmental origins of brain disorders: roles for dopamine

Money, K. M., & Stanwood, G. D. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00260 · Cited by 221 · see citing works

Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric

Blum, K., Febo, M., McLaughlin, T., Cronje, F. J., Han, D. C., & Gold, M. S. (2014) · Journal of Behavioral Addictions · doi:10.1556/jba.3.2014.019 · Cited by 121 · see citing works

Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models

Kosillo, P., & Bateup, H. S. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.700968 · Cited by 110 · see citing works

Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD)

Nguyen, M., Roth, A., Kyzar, E. J., Poudel, M. K., Wong, K., Stewart, A., & Kalueff, A. V. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.01.002 · Cited by 95 · see citing works

Excessive D1 Dopamine Receptor Activation in the Dorsal Striatum Promotes Autistic-Like Behaviors

Lee, Y., Kim, H., Kim, J., Park, J. Y., Choi, J., Lee, J. E., Lee, E. H., & Han, P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0770-5 · Cited by 89 · see citing works

Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders

Cabana‐Domínguez, J., Torrico, B., Reif, A., Noèlia Fernàndez-castillo, A., & Cormand, B. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01771-3 · Cited by 83 · see citing works

Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (HDAT R51W) in dopamine neurotransmission and behaviors

Cartier, E., Hamilton, P. J., Belovich, A. N., Shekar, A., Campbell, N. G., Saunders, C., Andreassen, T. F., Gether, U., Veenstra-Vanderweele, J., Sutcliffe, J. S., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.01.007 · Cited by 74 · see citing works

Dysfunctional dopaminergic neurotransmission in asocial BTBR mice

Squillace, M., Dodero, L., Federici, M., Migliarini, S., Errico, F., Napolitano, F., Krashia, P., Maio, A. D., Galbusera, A., Bifone, A., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.69 · Cited by 73 · see citing works

16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Sundberg, M., Pinson, H., Smith, R. S., Winden, K. D., Venugopal, P., Tai, D. J. C., Gusella, J. F., Talkowski, M. E., Walsh, C. A., Tegmark, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23113-z · Cited by 55 · see citing works

Neuroimaging genetics approaches to identify new biomarkers for the early diagnosis of autism spectrum disorder

Nisar, S., & Haris, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02060-9 · Cited by 64 · see citing works

T‐Brain‐1 – A Potential Master Regulator in Autism Spectrum Disorders

Chuang, H., Huang, T., & Hsueh, Y. (2015) · Autism Research · doi:10.1002/aur.1456 · Cited by 52 · see citing works

Molecular Pathology and Pharmacological Treatment of Autism Spectrum Disorder-Like Phenotypes Using Rodent Models

Kuo, H., & Liu, F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00422 · Cited by 46 · see citing works

Pathophysiological Studies of Monoaminergic Neurotransmission Systems in Valproic Acid-Induced Model of Autism Spectrum Disorder

Kuo, H., & Liu, F. (2022) · Biomedicines · doi:10.3390/biomedicines10030560 · Cited by 45 · see citing works

A review of gene–environment correlations and their implications for autism: A conceptual model.

Meek, S. E., Lemery‐Chalfant, K., Jahromi, L. B., & Valiente, C. (2013) · Psychological Review · doi:10.1037/a0033139 · Cited by 41 · see citing works

Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?

Rothwell, P. E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00020 · Cited by 37 · see citing works

Gut-Amygdala Interactions in Autism Spectrum Disorders: Developmental Roles via regulating Mitochondria, Exosomes, Immunity and microRNAs

Seo, M., & Anderson, G. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191105102545 · Cited by 38 · see citing works

DRD1 and DRD2 Receptor Polymorphisms: Genetic Neuromodulation of the Dopaminergic System as a Risk Factor for ASD, ADHD and ASD/ADHD Overlap

Mariggiò, M. A., Palumbi, R., Vinella, A., Laterza, R., Petruzzelli, M. G., Peschechera, A., Gabellone, A., Gentile, O., Vincenti, A., & Margari, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.705890 · Cited by 38 · see citing works

Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits

He, X., Thacker, S., Romigh, T., Yu, Q., Frazier, T. W., & Eng, C. (2015) · Molecular Autism · doi:10.1186/s13229-015-0056-6 · Cited by 32 · see citing works

Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study

Murayama, C., Iwabuchi, T., Kato, Y., Yokokura, M., Harada, T., Goto, T., Tamayama, T., Kameno, Y., Wakuda, T., Kuwabara, H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01464-3 · Cited by 32 · see citing works

Updated Findings of the Association and Functional Studies of DRD2/ANKK1 Variants with Addictions

Ma, Y., Yuan, W., Jiang, X., Cui, W.-Y., & Li, M. D. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8826-2 · Cited by 30 · see citing works

Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee, Y., & Han, P. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.3.337 · Cited by 30 · see citing works

Brain-Derived Neurotrophic Factor (BDNF) in Mechanisms of Autistic-like Behavior in BTBR Mice: Crosstalk with the Dopaminergic Brain System

Ilchibaeva, T. V., Tsybko, A. S., Lipnitskaya, M., Eremin, D. V., Milutinovich, K. S., Naumenko, V. S., & Popova, N. K. (2023) · Biomedicines · doi:10.3390/biomedicines11051482 · Cited by 29 · see citing works

Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala

Anderson, G., & Maes, M. H. J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223757 · Cited by 30 · see citing works

Early-Life Adversity Induces Epigenetically Regulated Changes in Hippocampal Dopaminergic Molecular Pathways

Köhler, J. C., Gröger, N., Lesse, A., Guara Ciurana, S., Rether, K., Fegert, J., Bock, J., & Braun, K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1199-1 · Cited by 28 · see citing works

Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language

Eicher, J. D., Powers, N. R., Cho, K., Miller, L. L., Mueller, K. L., Ring, S. M., Tomblin, J. B., & Gruen, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063762 · Cited by 26 · see citing works

MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat

Lin, T.-C., Lo, Y., Lin, H., Li, S., Lin, S.-H., Wu, H.-F., Chu, M.-C., Lee, C. J., Lin, I., Chang, C.-W., et al. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.07.004 · Cited by 25 · see citing works

The dopamine hypothesis of autism spectrum disorder: A comprehensive analysis of the evidence

Pavăl, D. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.08.009 · Cited by 25 · see citing works

Novel Interactive Partners of Neuroligin 3: New Aspects for Pathogenesis of Autism

Shen, C., Huo, L.-R., Zhao, X., Wang, P., & Zhong, N. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0470-9 · Cited by 23 · see citing works

Dopaminergic variants in siblings at high risk for autism: Associations with initiating joint attention

Gangi, D. N., Messinger, D. S., Martin, E. R., & Cuccaro, M. L. (2016) · Autism Research · doi:10.1002/aur.1623 · Cited by 23 · see citing works

Sex‐specific association of a common variant of the XG gene with autism spectrum disorders

Chang, S., Pauls, D. L., Lange, C., Sasanfar, R., & Santangelo, S. L. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32165 · Cited by 19 · see citing works

Genetic Variants of Neurotransmitter‐Related Genes and miRNAs in Egyptian Autistic Patients

Salem, A. M. H., Ismail, S. I., Zarouk, W. A., et al. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/670621 · Cited by 19 · see citing works

Decoding the genetic landscape of autism: A comprehensive review

Al‐Beltagi, M., Saeed, N. K., Bediwy, A. S., Bediwy, E. A., & Elbeltagi, R. M. (2024) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v13.i3.98468 · Cited by 18 · see citing works

Emotions in action: The relationship between motor function and social cognition across multiple clinical populations

Eddy, C. M., & Cook, J. L. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.021 · Cited by 16 · see citing works

DRD3 Ser9Gly Polymorphism and Its Influence on Risperidone Response in Autistic Children

Firouzabadi, N., Nazariat, A., & Zomorrodian, K. (2017) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3h63t · Cited by 14 · see citing works

From molecules to behavior: An integrative theory of autism spectrum disorder

Niculae, A.-Ş., & Pavăl, D. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.10.016 · Cited by 12 · see citing works

A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population

Zhang, L., Qin, Y., Gong, X., Peng, R., Cai, C., Zheng, Y., Du, Y., & Wang, H. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0369-x · Cited by 12 · see citing works

Genetic biomarkers predict susceptibility to autism spectrum disorder through interactive models of inheritance in a Saudi community

Elhawary, N. A., Tayeb, M. T., Sindi, I. A., Qutub, N. A., Rashad, M. M., Mufti, A. H., Arab, A. H., Khogeer, A., Elhawary, E. N., Dannoun, A. I., et al. (2019) · Cogent Biology · doi:10.1080/23312025.2019.1606555 · Cited by 12 · see citing works

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis studyPreprint

Quintana, D. S. (2018) · OSF Preprints (OSF Preprints) · Cited by 12 · see citing works

Cariprazine in Pediatric Patients with Autism Spectrum Disorder: Results of a Pharmacokinetic, Safety and Tolerability Study

Yeung, P. P., Johnson, K. A., Riesenberg, R. A., Orejudos, A. C., Riccobene, T. A., Kalluri, H. V., Malik, P. R. V., Varughese, S., & Findling, R. L. (2023) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2022.0097 · Cited by 11 · see citing works

Oxytocin gene networks in the human brain: A gene expression and large-scale fMRI meta-analysis studyPreprint

Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/149526 · Cited by 12 · see citing works

Sex-biased single-cell genetic landscape in mice with autism spectrum disorder

Zhang, Q., Wang, Y., Tao, J., Xia, R., Zhang, Y., Liu, Z., & Cheng, J. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.08.012 · Cited by 11 · see citing works

Pharmaceuticals and Stem Cells in Autism Spectrum Disorders: Wishful Thinking?

Sivanesan, S., Tan, A., Jeyaraj, R., Lam, J. M., Gole, M., Hardan, A. Y., Ashkan, K., & Rajadas, J. (2016) · World Neurosurgery · doi:10.1016/j.wneu.2016.09.100 · Cited by 8 · see citing works

Gene–environment interactions in human health: case studies and strategies for developing new paradigms and research methodologies

Jackson, F. L. C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00271 · Cited by 6 · see citing works

Darpp-32 is regulated by dopamine and is required for the formation of GABAergic neurons in the developing telencephalon

Souza, B. R., Codo, B. C., Romano‐Silva, M. A., & Tropepe, V. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111060 · Cited by 5 · see citing works

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylasesPreprint

Diaz, L., Kong, A. X., Zhang, P., Chi, J., Pham, K. T., Johnson, M., Eno, A. F., Douglas, I., Mao, Y., MacDonald, J. W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.19.683261 · Cited by 5 · see citing works

Perinatal hyperandrogenization and immune activation in rodents model subtypes of autism

Burke, F. F., Randell, A. M., Sparkes, K. M., Salia, S., Hinks, M., Martin, Y. H., Porter, Z. R., Hynes, C., Maekawa, A. S., Sled, J. G., et al. (2026) · Translational Psychiatry · doi:10.1038/s41398-026-03821-0 · Cited by 2 · see citing works

Identification of primary copy number variations reveal enrichment of Calcium, and MAPK pathways sensitizing secondary sites for autism

Agarwala, S., Veerappa, A. M., & Ramachandra, N. B. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00091-3 · Cited by 2 · see citing works

Modulating autism spectrum disorder pathophysiology using a trace amine-focused approach: targeting the gut

Pretorius, L., Coetzee, J. A., dos Santos, A. P., & Smith, C. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01232-3 · Cited by 2 · see citing works

An exploration of common dopaminergic variants and behavior problems in siblings at high risk for autism spectrum disorder

Gangi, D. N., Usher, L. V., & Messinger, D. S. (2017) · Infant Behavior and Development · doi:10.1016/j.infbeh.2017.10.002 · Cited by 2 · see citing works

Dysregulation of G protein subunits in autism: decreased GNAO1 and elevated GNAI1 levels in ASD

Topal, H., Şahın, N., Özdemir, Ç., Yazici, Ö. N., Başkaya, G. D., Topal, Y., & Edgünlü, T. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1587727 · Cited by 1 · see citing works

Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking andOther Addictions

Li, M. D. (2018) · Springer eBooks · doi:10.1007/978-981-10-7530-8_8 · Cited by 1 · see citing works

L1-79 and the Role of Catecholamines in Autism

Rothman, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95052 · Cited by 1 · see citing works

Aggressive Prolactin-Secreting Pituitary Adenomas and Carcinomas

Zhang, D., & Heaney, A. P. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-11836-5_13

The reversal of dopamine transporter function is governed by plasma membrane interactions and disrupted by genetic variations

Hamilton, P. J. (2014)

DARPP-32 (Ppp1r1b)

Rosa, D. V., Magno, L. A. V., Souza, B. R., & Romano‐Silva, M. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_557

DARPP-32 (Ppp1r1b)

Rosa, D. V., Magno, L. A. V., Souza, B. R., & Romano‐Silva, M. A. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_557-1

Lack of the glycine receptor alpha 2 increases striatal activity and motivated behaviorPreprint

Devoght, J., Comhair, J., Morelli, G., Rigo, J., D’Hooge, R., Touma, C., Palme, R., Dewachter, I., vandeVen, M., Harvey, R. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.31.506020

Performance Analysis of Transfer Learning Models for Detecting Autism Spectrum Disorder Using Facial Images

Sharma, H., & Sharma, O. (2023) · International Conference on Intelligent Systems and Embedded Design (ISED) · doi:10.1109/ised59382.2023.10444603

Lcn2 deficiency leads to social impairments independent of maternal immune activationPreprint

Pękała, M., Zawiślak, S., Romanis, S., Nader, K., Cabaj, A., Madecka, A., Puścian, A., Knapska, E., Pawlak, R., Kaczmarek, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.27.661499

Lcn2 deficiency leads to long-lasting social impairments independent of maternal immune activation

Pekala, M., Zawiślak, S., Romanis, S., Nader, K., Dzwonek, J., Cabaj, A., Madecka, A., Puścian, A., Knapska, E., Pawlak, R., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03742-1

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylasesPreprint

Diaz, L., Kong, A. X., Zhang, P., Jinhua, C. H. I., Pham, K. T., Johnson, M., Eno, A. F., Douglas, I., Mao, Y., MacDonald, J. K., et al. (2026) · eLife · doi:10.7554/elife.110280.1

Butyrate rescues chlorpyrifos-induced social deficits through inhibition of class I histone deacetylasesPreprint

Diaz, L., Kong, A. X., Zhang, P., Jinhua, C. H. I., Pham, K. T., Johnson, M., Eno, A. F., Douglas, I., Mao, Y., MacDonald, J. K., et al. (2026) · eLife · doi:10.7554/elife.110280

Polymorphisms in GPCR genes: Their role in schizophrenia, autism diseases and response to antipsychotic treatment — A systematic review

DelaCuesta-Barrutia, J., Peñagarikano, O., Ramos-Miguel, A., & Erdozain, A. M. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111669

Inference of Autism Risk Genes Through Comparative Sociogenomics and Molecular Network Analysis

Chiodi, A., Mosca, E., Cupaioli, F. A., & Mezzelani, A. (2026) · Genes · doi:10.3390/genes17040368

Term or preterm cesarean section delivery does not lead to long-term detrimental consequences in mice

Chiesa, M. (2018) · theses.fr (ABES) · doi:10.70675/6ef32b4fzb74az4b06zb8edz92268c28d542

Do Autism-Specific and General Developmental Screens Have Complementary Clinical Value?

STURNER, R. A., Bergmann, P. E., Howard, B. J., Bet, K., Stewart, L., & Attar, S. M. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05541-y · Cited by 6 · see citing works

Brief Report: Learning About Autism: Is the Source of Autism Knowledge Associated with Differences in Autism Knowledge, Autism Identity, and Experiences of Stigma

Bury, S., Haschek, A., Wenzel, M., Spoor, J., & Hedley, D. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-022-05823-5 · Cited by 22 · see citing works

Which terms should be used to describe autism? Perspectives from the UK autism community

Kenny, L., Hattersley, C., Molins, B., Buckley, C., Povey, C., & Pellicano, E. (2016) · Autism · doi:10.1177/1362361315588200 · Cited by 1,941 · see citing works

Autism and the School Nurse

Cade, M., & Tidwell, S. (2001) · Journal of School Health · doi:10.1111/j.1746-1561.2001.tb07300.x · Cited by 13 · see citing works

One autism story, two autism theories, many autism gifts

Lawson, R. (2023) · Theology in Scotland · doi:10.15664/tis.v30i1.2575 · Cited by 5 · see citing works