Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): A mechanism for pair bonding?
Abstract
This study examined the role of dopamine (DA) in partner preference (PP) formation in female prairie voles (Microtus ochrogaster). The nonspecific DA antagonist haloperidol blocked mating-induced PP, whereas the nonspecific DA agonist apomorphine induced PP without mating. The D2 antagonist eticlopride, but not the D1 antagonist SCH23390, blocked PP, whereas the D2 agonist quinpirole, but not the D1 agonist SKF38393, induced PP without mating. Injections of eticlopride before or immediately after mating, but not 24 hr after mating, impaired PP, indicating that DA's effects were not due to an interference with mating or sensory recognition. Finally, intracerebroventricular injections of eticlopride diminished PP. Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior.
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In prairie voles, pair bonding between mating partners is prevented if dopamine receptors in the nucleus accumbens shell are non-specifically blocked.
“In prairie voles, pair bonding between mating partners is prevented if DA receptors in the NAC shell are non-specifically blocked (Wang et al 1999; Aragona et al 2003).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Wang et al 1999
Prairie voles reliably form a pair bond after 24 hours of mating, but not after 6 hours of cohabitation where mating is prevented.
“Although mating is not required for pair bonding, prairie voles will reliably form a pair bond with a partner after 24 hours of mating, but not after 6 hours of cohabitation where mating is prevented (Wang et al 1999).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Wang et al 1999
Mating-induced pair bonding is prevented by selective blockade of D2R in the nucleus accumbens shell, while activation of these receptors induces bonding in the absence of mating.
“Mating-induced pair bonding is prevented by selective blockade of D2R in the NAC shell, while activation of these receptors induces bonding in the absence of mating (Wang et al 1999; Gingrich et al 2000; Aragona et al 2006).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Wang et al 1999
Blockade of D1R neither enhances nor prevents pair bonding.
“Blockade of D1R neither enhances nor prevents pair bonding (Wang et al 1999; Aragona et al 2006; Curtis et al 2006).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Wang et al 1999
Dopamine is released in the NAcc during mating.
“Dopamine is released in the NAcc during mating and an intra-NAcc shell injection of dopamine 2 receptor antagonist inhibit mating-induced partner preference or partner preference induced by OT treatment (Aragona et al. 2003; Liu and Wang 2003; Wang et al. 1999).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Wang et al. 1999
Intra-NAcc shell injection of dopamine 2 receptor antagonist inhibits mating-induced partner preference or partner preference induced by OT treatment.
“Dopamine is released in the NAcc during mating and an intra-NAcc shell injection of dopamine 2 receptor antagonist inhibit mating-induced partner preference or partner preference induced by OT treatment (Aragona et al. 2003; Liu and Wang 2003; Wang et al. 1999).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Wang et al. 1999
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- Authors
- Wang, Z., Yu, G., Cascio, C., Liu, Y., Gingrich, B., & Insel, T. R.
- Affiliations
- Emory University (US)
- Venue
- Behavioral Neuroscience
- Published
- 1999
- Volume
- 113
- Issue
- 3
- Pages
- 602-611
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W4233382152
- Cited by
- 205
- References
- 36
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 14 · 2016: 7 · 2015: 15 · 2014: 7 · 2013: 9 · 2012: 10
- FWCI
- 9.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (54554, 56539)
- National Institute of Mental Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- dopamine D2 receptor, mate preferences, pair bonding, Microtus ochrogaster, female behavior, social bonding
- MeSH terms
- Animals, Apomorphine, Benzazepines, Arvicolinae, Female, Male, Memory, Pair Bond, Receptors, Dopamine, Reward, Salicylamides, Sexual Behavior, Animal, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, Dopamine D2, Dopamine Agonists, Dopamine Antagonists, Quinpirole
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