Standardising outcomes for clinical trials and systematic reviews
Open accessAbstract
Fifteen years ago, what was to become OMERACT met for the first time in The Netherlands to discuss ways in which the multitude of outcomes in assessments of the effects of treatments for rheumatoid arthritis might be standardised. In Trials , Tugwell et al have described the need for, and success of, this initiative [ 1 ] and Cooney and colleagues have set out their plans for a corresponding initiative for ulcerative colitis [ 2 ]. Why do we need such initiatives? What's the problem? And are these and other initiatives the solution?
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Application of COSs in routine care supports generation of evidence from observational studies and clinical registries.
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“the key outcomes that should be reported in all clinical trials, thereby ensuring consistency in outcome reporting.(306,307) COSCA identified three outcomes: survival at discharge/30-days; modified Rankin score at discharge/30-days; and health-related quality of life at 180-days/1year.”
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- Authors
- Clarke, M.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- Clarke, Mike
- ORCID
- Clarke, Mike
- Venue
- Trials
- Published
- 2007-11-26
- Volume
- 8
- Issue
- 1
- Pages
- 39-39
- ISSN
- 1745-6215 (ISSN-L)
- PMC
- PMC2169261
- OpenAlex
- W2015610252
- Cited by
- 483
- References
- 18
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 28 · 2023: 23 · 2022: 48 · 2021: 48 · 2020: 49 · 2019: 28 · 2018: 29 · 2017: 47 · 2016: 31 · 2015: 35 · 2014: 25 · 2013: 17 · 2012: 14
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Trials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Keywords
- outcome standardization, OMERACT, rheumatoid arthritis, clinical trial results, systematic reviews, outcome measures, ulcerative colitis
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