Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader–Willi syndrome: a randomised placebo-controlled trial in 24 patients
Open accessAbstract
BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and specific psychiatric phenotypes including cognitive and behavioural problems, particularly disruptive behaviours and frequent temper outbursts that preclude socialization. A deficit in oxytocin (OT)-producing neurons of the hypothalamic paraventricular nucleus has been reported in these patients. METHODS: In a double-blind, randomised, placebo-controlled study, 24 adult patients with PWS received a single intranasal administration of 24 IU of OT or placebo and were tested 45 min later on social skills. Behaviours were carefully monitored and scored using an in-house grid as follows: over the two days before drug administration, on the half-day following administration, and over the subsequent two days. All patients were in a dedicated PWS centre with more than ten years of experience. Patients are regularly admitted to this controlled environment. RESULTS: Patients with PWS who received a single intranasal administration of OT displayed significantly increased trust in others (P = 0.02) and decreased sadness tendencies (P = 0.02) with less disruptive behaviour (P = 0.03) in the two days following administration than did patients who received placebo. In the half-day following administration, we observed a trend towards less conflict with others (p = 0.07) in the OT group compared with the placebo group. Scores in tests assessing social skills were not significantly different between the two groups. CONCLUSIONS: This study needs to be reproduced and adapted. It nevertheless opens new perspectives for patients with PWS and perhaps other syndromes with behavioural disturbances and obesity. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT01038570.
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IN-OT administration increases trust in others and decreases disruptive behavior in individuals with PWS.
“IN-OT administration increases trust in others and decreases disruptive behavior in individuals with PWS (Tauber et al., 2011).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Tauber et al., 2011
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Self-citationThe neurobiology of the Prader-Willi phenotype of fragile X syndrome
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Alteraciones psicopatológicas en el síndrome de Prader-Willi
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The sociability spectrum: evidence from reciprocal genetic copy number variations
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“The usefulness of intra-nasal oxytocin in PWS remains uncertain as findings from initial clinical trials exploring the use of oxytocin in PWS are mixed [44], found positive effects of intra-nasal oxytocin on social functioning and behavior in PWS.”
BackgroundSingh, D., Wakimoto, Y., Filangieri, C. M., Pinkhasov, A., & Angulo, M. (2019) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2018.0102 · Cited by 20 · see citing works
“…some medications such as N-acetylcysteine and oxytocin have been suggested for management of skin-picking behaviors, safe and effective modalities remainsparse for themanagement of behavioral symptoms in PWS (Tauber et al. 2011; Miller and Angulo, 2014; Kuppens et al. 2016; Miller et al. 2017).”
Psychopathological disorders in Prader–Willi syndrome
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Prader–Willi syndrome: Hormone therapies
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“A question of utmost importance arises from these results concerning whether it would be possible to modify the methylation status caused by a lack of expression of SNORD116, MAGEL2 and perhaps other genes in the PWS region [50] with, for example, oxytocin treatment [33] or other drugs and/or social disability rehabil…”
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Self-citationCircadian Rhythms in Socializing Propensity
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“First, research has shown that the release of hormones such as oxytocin may promote a higher trust in others that may in turn improve socialization [24], and that their release demonstrates circadian rhythms [25].”
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“Our team especially demonstrated that intranasal OXT treatment administered to infants provided a positive effect on feeding and social skills, and administration to adults resulted in increased trust in others, decreased sadness tendencies and less disruptive behaviors [27, 28].”
Self-citationIs Oxytocin a Contributor to Behavioral and Metabolic Features in Prader–Willi Syndrome?
Petersson, M., & Höybye, C. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080518 · Cited by 9 · see citing works
“No statistical difference was observed in the eating behavior scores between the groups, but there was improvement in social skills in the oxytocin-treated group [85].”
BackgroundOxytocin’s Regulation of Thermogenesis May Be the Link to Prader–Willi Syndrome
Camerino, C. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45060313 · Cited by 9 · see citing works
“In conclusion, the best results with IN-Oxt are obtained in infants, toddler and sometimes in adolescents [37–39], albeit some positive effects were also reported in adults with PWS [40].”
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Microbial Reprogramming Inhibits Western Diet-Associated Obesity
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Obesity, Overweight, and Pituitary Stalk Interruption Syndrome in Children and Young Adults
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“[65–72] Diazoxide choline-controlled release (DCCR) DCCR, a benzothiadiazine, is used to treat hyperinsulinemia-related hypoglycemia in newborns, children, and adults by increasing ion flow through ATP-sensitive K + channels.”
BackgroundSíndrome de Prader-Willi: relato de caso
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Oxytocin Treatment May Improve Infant Feeding and Social Skills in Prader-Willi Syndrome
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Imprinting disorders as a window to understand pediatric feeding disorders
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“Our team especially demonstrated that intranasal OXT treat-ment administered to infants provided a positive effect on feeding and social skills, and administration to adults resulted in increased trust in others, decreased sadness tendencies and less disruptive behaviors [16, 17].”
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“Carbetocin, an oxytocin analogue, has undergone multiple clinical trials from infants to adults with PWS, but with equivocal outcomes as related to hyperphagia, food intake, and behavior [42–48].”
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Genetics, Metabolomics, Hormonal Function, and New Approaches to Therapy
Irizarry, K. A., Miller, M. D., Freemark, M., & Haqq, A. M. (2016)
- Authors
- Tauber, M., Mantoulan, C., Copet, P., Jauregui, J., Demeer, G., Diene, G., Rogé, B., Laurier, V., Ehlinger, V., Arnaud, C., Molinas, C., & Thuilleaux, D.
- Affiliations
- Hôpital des Enfants (FR)
- Hôpital Marin de Hendaye (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Corresponding author
- Tauber, Maïthe
- Venue
- Orphanet Journal of Rare Diseases
- Published
- 2011
- Volume
- 6
- Issue
- 1
- Pages
- 47
- ISSN
- 1750-1172 (ISSN-L)
- PMC
- PMC3141367
- OpenAlex
- W2169805657
- Cited by
- 117
- References
- 22
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 9 · 2013: 3 · 2012: 3
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Orphanet Journal of Rare Diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Prader-Willi syndrome, oxytocin, intranasal administration, interpersonal trust, disruptive behavior, temper outbursts, social skills, hypothalamic dysfunction, paraventricular nucleus, obesity, hyperphagia
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Female, Humans, Male, Oxytocin, Placebos, Prader-Willi Syndrome, Young Adult
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