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Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader–Willi syndrome: a randomised placebo-controlled trial in 24 patients
Open accessAbstract
BACKGROUND: Prader-Willi syndrome (PWS) is a complex neurodevelopmental genetic disorder with hypothalamic dysfunction, early morbid obesity with hyperphagia, and specific psychiatric phenotypes including cognitive and behavioural problems, particularly disruptive behaviours and frequent temper outbursts that preclude socialization. A deficit in oxytocin (OT)-producing neurons of the hypothalamic paraventricular nucleus has been reported in these patients. METHODS: In a double-blind, randomised, placebo-controlled study, 24 adult patients with PWS received a single intranasal administration of 24 IU of OT or placebo and were tested 45 min later on social skills. Behaviours were carefully monitored and scored using an in-house grid as follows: over the two days before drug administration, on the half-day following administration, and over the subsequent two days. All patients were in a dedicated PWS centre with more than ten years of experience. Patients are regularly admitted to this controlled environment. RESULTS: Patients with PWS who received a single intranasal administration of OT displayed significantly increased trust in others (P = 0.02) and decreased sadness tendencies (P = 0.02) with less disruptive behaviour (P = 0.03) in the two days following administration than did patients who received placebo. In the half-day following administration, we observed a trend towards less conflict with others (p = 0.07) in the OT group compared with the placebo group. Scores in tests assessing social skills were not significantly different between the two groups. CONCLUSIONS: This study needs to be reproduced and adapted. It nevertheless opens new perspectives for patients with PWS and perhaps other syndromes with behavioural disturbances and obesity. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov: NCT01038570.
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“IN-OT administration increases trust in others and decreases disruptive behavior in individuals with PWS (Tauber et al., 2011).”
From Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders (2014) · cites this paper as Tauber et al., 2011
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Cites
Does the autistic child have a “theory of mind” ?
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“The Sally and Ann test assesses one’s ability to understand simple situations by story-telling and pictures [19].”
BackgroundBaron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555 · cited 1×
“A shortened test with 19 images from the 36-item revised version [20] was chosen by the team psychologist.”
MethodBaron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313
Frith, C., & Frith, U. (2005) · Current Biology · doi:10.1016/j.cub.2005.08.041 · Cited by 3,561
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · cited 1×
“OT was identified as a key neuropeptide involved in social interactions by enhancing peer recognition and bonding behaviour in numerous species [7].”
BackgroundOxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · cited 3×
“OT appears to be the main neurohormone to explain empathy and theory of mind (TOM) [8-14].”
BackgroundDitzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.011 · Cited by 805 · cited 3×
“OT appears to be the main neurohormone to explain empathy and theory of mind (TOM) [8-14].”
BackgroundOxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · cited 3×
“OT appears to be the main neurohormone to explain empathy and theory of mind (TOM) [8-14].”
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Research works printed but not linked: 1
- 10.1210/jc.80.2.573 · DOI
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Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.34 · Cited by 383
“Twenty-four Prader–Willi syndrome patients (8 males) were tested with a single dose of 24 IU OT (n1⁄4 12) or placebo (n1⁄4 12).(99) Patients were observed in their daily routines and scored by trained staff on behavioral scales before and immediately after treatment and during two days following treatment.”
BackgroundMethodMicrobial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068596 · Cited by 164
“Oxytocin, a neuropeptide hormone associated with reproduction and social bonding, has also been linked with dietary satiety [53–54].”
BackgroundIntranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis
Keech, B., Crowe, S., & Hocking, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.022 · Cited by 145
Miller, J. L., Tamura, R., Butler, M. G., Kimonis, V. E., Sulsona, C. R., Gold, J., & Driscoll, D. J. (2017) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.38160 · Cited by 149
“In a double blind placebo study of adults with PWS, a single dose of IN-OT significantly decreased depressive mood tendencies and tantrums while increasing trust in others, with supportive data to decrease appetite with higher satiety (Tauber et al., 2011).”
BackgroundResultInfluentialMüller, H. L., Tauber, M., Lawson, E. A., Özyurt, J., Bison, B., Martinez-Barbera, J.-P., Puget, S., Merchant, T. E., & van Santen, H. M. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00351-z · Cited by 144
Self-citation
Metadata
- Authors
- Tauber, M., Mantoulan, C., Copet, P., Jauregui, J., Demeer, G., Diene, G., Rogé, B., Laurier, V., Ehlinger, V., Arnaud, C., Molinas, C., & Thuilleaux, D.
- Affiliations
- Hôpital des Enfants (FR)
- Hôpital Marin de Hendaye (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Corresponding author
- Tauber, Maïthe
- Venue
- Orphanet Journal of Rare Diseases
- Published
- 2011
- Volume
- 6
- Issue
- 1
- Pages
- 47
- ISSN
- 1750-1172 (ISSN-L)
- PMC
- PMC3141367
- OpenAlex
- W2169805657
- Cited by
- 117
- References
- 22
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 11 · 2014: 9 · 2013: 3 · 2012: 3
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Orphanet Journal of Rare Diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Prader-Willi syndrome, oxytocin, intranasal administration, interpersonal trust, disruptive behavior, temper outbursts, social skills, hypothalamic dysfunction, paraventricular nucleus, obesity, hyperphagia
- MeSH terms
- Adolescent, Adult, Double-Blind Method, Female, Humans, Male, Oxytocin, Placebos, Prader-Willi Syndrome, Young Adult
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