Neuronal position in the developing brain is regulated by mouse disabled-1
Abstract
During mammalian brain development, immature neurons migrate radially from the neuroectoderm to defined locations, giving rise to characteristic cell layers. Here we show that targeted disruption of the mouse disabled1 (mdab1) gene disturbs neuronal layering in the cerebral cortex, hippocampus and cerebellum. The gene encodes a cytoplasmic protein, mDab1 p80, which is expressed and tyrosine-phosphorylated in the developing nervous system. It is likely to be an adaptor protein, docking to others through its phosphotyrosine residues and protein-interacting domain. The mdab1 mutant phenotype is very similar to that of the reeler mouse. The product of the reeler gene, Reelin, is a secreted protein that has been proposed to act as an extracellular signpost for migrating neurons. Because mDab1 is expressed in wild-type cortical neurons, and Reelin expression is normal in mdab1 mutants, mDab1 may be part of a Reelin-regulated or parallel pathway that controls the final positioning of neurons.
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VLDLR and ApoER2 have a critical role in the neuronal Reelin pathway essential for proper neuronal positioning and brain development.
“studies in recent years have established a critical role for VLDLR and ApoER2 in the neuronal Reelin pathway that is essential for proper neuronal positioning and brain development (16–19).”
From The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2 (2010) · cites this paper as [18]
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“The product of the reeler gene, Reelin, is a secreted protein that has been proposed to act as an extracellular signpost for migrating neuron”
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- Authors
- Howell, B. W., Hawkes, R., Soriano, P., & Cooper, J. A.
- Affiliations
- Fred Hutch Cancer Center (US)
- University of Calgary (CA)
- Venue
- Nature
- Published
- 1997-10
- Volume
- 389
- Issue
- 6652
- Pages
- 733-737
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1667992367
- Cited by
- 692
- References
- 2
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 12 · 2021: 16 · 2020: 14 · 2019: 9 · 2018: 11 · 2017: 21 · 2016: 16 · 2015: 14 · 2014: 15 · 2013: 28 · 2012: 24
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Disabled-1, neuronal migration, cerebral cortex, hippocampus, cerebellum, reelin, reeler mice, tyrosine phosphorylation, adaptor proteins, gene targeting, brain development
- MeSH terms
- Reelin Protein, Animals, Brain, Cell Line, Cell Movement, Cerebellum, Mice, Neurologic Mutants, Nerve Tissue Proteins, Neurons, Serine Endopeptidases, Signal Transduction, Cell Adhesion Molecules, Neuronal, Mutagenesis, Extracellular Matrix Proteins, Gene Targeting, Neocortex, Mice
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