The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome
Open accessAbstract
Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Research shows that patients with CFS and other so-called functional somatic disorders have alterations in the intestinal microbial flora. Emerging studies have suggested that pathogenic and non-pathogenic gut bacteria might influence mood-related symptoms and even behavior in animals and humans. In this pilot study, 39 CFS patients were randomized to receive either 24 billion colony forming units of Lactobacillus casei strain Shirota (LcS) or a placebo daily for two months. Patients provided stool samples and completed the Beck Depression and Beck Anxiety Inventories before and after the intervention. We found a significant rise in both Lactobacillus and Bifidobacteria in those taking the LcS, and there was also a significant decrease in anxiety symptoms among those taking the probiotic vs controls (p = 0.01). These results lend further support to the presence of a gut-brain interface, one that may be mediated by microbes that reside or pass through the intestinal tract.
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In the citing paper
“Furthermore, L. casei strain significantly reduced anxiety symptoms in patients with chronic fatigue syndrome (Rao et al. 2009)”
From Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer’s disease and Parkinson’s disease (2020) · cites this paper as Rao et al. 2009
In the citing paper
“Additionally, there is now preliminary evidence for reduced subjective feelings of anxiety and improved aspects of well-being after probiotic intake (Rao et al. 2009; Messaoudi et al. 2011).”
From Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers (2015) · cites this paper as Rao et al. 2009
In the citing paper
“The current results also differ from previous findings that indicate subjective anxiolytic effects of probiotics (Rao et al. 2009; Messaoudi et al. 2011) as we found no effects of prebiotics on subjective measures of subclinical anxiety or perceived stress.”
From Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers (2015) · cites this paper as Rao et al. 2009
In the citing paper
“A study by Rao et al. [277], reported that 8 weeks of 8 × 107 CFU of L. casei given to individuals with chronic fatigue syndrome reduced anxiety symptoms.”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [277]
In the citing paper
“There was no effect on depression, but those receiving the probiotic demonstrated significant improvement on the Beck Anxiety Inventory compared with the placebo group.131”
From The Gut Microbiome and the Brain (2014) · cites this paper as [131]
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Cites
Carruthers, B. M., Jain, A. K., De Meirleir, K. L., Peterson, D. L., Klimas, N. G., Lerner, A. M., Bested, A. C., Flor-Henry, P., Joshi, P., Powles, A. C. P., et al. (2003) · Journal of Chronic Fatigue Syndrome · doi:10.1300/j092v11n01_02 · Cited by 1,180
Self-citationWhitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · cited 5×
“It is also true that LcS has been shown to reduce small intestinal bacterial overgrowth and the subjective reporting of the passage of gas in patients with IBS [29].”
BackgroundInfluentialDesbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952
Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784
Aaron, L. A., Burke, M. M., & Buchwald, D. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.2.221 · Cited by 607
Impact of consuming a milk drink containing a probiotic on mood and cognition
Benton, D., Williams, C., & Brown, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602546 · Cited by 554
Gut microflora as a target for energy and metabolic homeostasis
Cani, P. D., & Delzenne, N. M. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282efdebb · Cited by 332
MITSUOKA, T. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1992.tb02499.x · Cited by 296
Koebnick, C., Wagner, I., Leitzmann, P., Stern, U., & Zunft, H. F. (2003) · Canadian Journal of Gastroenterology · doi:10.1155/2003/654907 · Cited by 288 · cited 1×
“Indeed LcS has been shown to regulate bowel function and decrease constipation in a controlled trial [28].”
BackgroundMajor depressive disorder: probiotics may be an adjuvant therapy.
Logan, A., & Katzman, M. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2004.08.019 · Cited by 277
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Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324
Metadata
- Authors
- Rao, A. V., Bested, A. C., Beaulne, T. M., Katzman, M. A., Iorio, C., Berardi, J. M., & Logan, A. C.
- Affiliations
- University of Toronto (CA)
- Women's College Hospital (CA)
- START Clinic (CA)
- Corresponding author
- Logan, Alan C
- Venue
- Gut Pathogens
- Published
- 2009-03-19
- Volume
- 1
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1757-4749 (ISSN-L)
- PMC
- PMC2664325
- OpenAlex
- W2024392981
- Cited by
- 577
- References
- 31
- Citations by year
- 2026: 12 · 2025: 43 · 2024: 23 · 2023: 38 · 2022: 46 · 2021: 42 · 2020: 53 · 2019: 48 · 2018: 48 · 2017: 48 · 2016: 50 · 2015: 46 · 2014: 31 · 2013: 21 · 2012: 9
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Gut Pathogens (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- chronic fatigue syndrome, probiotics, Lactobacillus casei Shirota, anxiety, depression, gut microbiota, gut-brain axis, Bifidobacterium, functional somatic syndromes, mood symptoms
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