Behavioral signatures related to genetic disorders in autism
Open accessAbstract
BACKGROUND: Autism spectrum disorder (ASD) is well recognized to be genetically heterogeneous. It is assumed that the genetic risk factors give rise to a broad spectrum of indistinguishable behavioral presentations. METHODS: We tested this assumption by analyzing the Autism Diagnostic Interview-Revised (ADI-R) symptom profiles in samples comprising six genetic disorders that carry an increased risk for ASD (22q11.2 deletion, Down's syndrome, Prader-Willi, supernumerary marker chromosome 15, tuberous sclerosis complex and Klinefelter syndrome; total n = 322 cases, groups ranging in sample sizes from 21 to 90 cases). We mined the data to test the existence and specificity of ADI-R profiles using a multiclass extension of support vector machine (SVM) learning. We subsequently applied the SVM genetic disorder algorithm on idiopathic ASD profiles from the Autism Genetics Resource Exchange (AGRE). RESULTS: Genetic disorders were associated with behavioral specificity, indicated by the accuracy and certainty of SVM predictions; one-by-one genetic disorder stratifications were highly accurate leading to 63% accuracy of correct genotype prediction when all six genetic disorder groups were analyzed simultaneously. Application of the SVM algorithm to AGRE cases indicated that the algorithm could detect similarity of genetic behavioral signatures in idiopathic ASD subjects. Also, affected sib pairs in the AGRE were behaviorally more similar when they had been allocated to the same genetic disorder group. CONCLUSIONS: Our findings provide evidence for genotype-phenotype correlations in relation to autistic symptomatology. SVM algorithms may be used to stratify idiopathic cases of ASD according to behavioral signature patterns associated with genetic disorders. Together, the results suggest a new approach for disentangling the heterogeneity of ASD.
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Efforts have been made to look at genotype-phenotype relations in ASD.
“efforts have been made to look at genotype-phenotype relations in ASD (Bruining et al., 2014; Chang et al., 2015; Schauder et al., 2015b; Veatch et al., 2014)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Bruining et al., 2014
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- Authors
- Bruining, H., Eijkemans, M. J., Kas, M. J., Curran, S. R., Vorstman, J. A., & Bolton, P. F.
- Affiliations
- University Medical Center Utrecht (NL)
- King's College London (GB)
- Corresponding author
- Bruining, Hilgo
- ORCID
- Venue
- Molecular Autism
- Published
- 2014
- Volume
- 5
- Issue
- 1
- Pages
- 11
- ISSN
- 2040-2392 (ISSN-L)
- PMC
- PMC3936826
- OpenAlex
- W2123735083
- Cited by
- 77
- References
- 47
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 4
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Autism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- Funders
- Autism Speaks
- National Institute for Health and Care Research (NF-SI-0510-10268)
- Tuberous Sclerosis Association
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, genetic disorders, behavioral signatures, genotype-phenotype correlation, 22q11.2 deletion syndrome, Down syndrome, Prader-Willi syndrome, tuberous sclerosis complex, Klinefelter syndrome, idiopathic autism, ASD heterogeneity, affected sib pairs, support vector machine classification
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