The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Sex differences in primary hypertension
Open accessAbstract
Men have higher blood pressure than women through much of life regardless of race and ethnicity. This is a robust and highly conserved sex difference that it is also observed across species including dogs, rats, mice and chickens and it is found in induced, genetic and transgenic animal models of hypertension. Not only do the differences between the ovarian and testicular hormonal milieu contribute to this sexual dimorphism in blood pressure, the sex chromosomes also play a role in and of themselves. This review primarily focuses on epidemiological studies of blood pressure in men and women and experimental models of hypertension in both sexes. Gaps in current knowledge regarding what underlie male-female differences in blood pressure control are discussed. Elucidating the mechanisms underlying sex differences in hypertension may lead to the development of anti-hypertensives tailored to one's sex and ultimately to improved therapeutic strategies for treating this disease and preventing its devastating consequences.
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Cites
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Cited by
Sex and gender differences in myocarditis and dilated cardiomyopathy: An update
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The Renin-Angiotensin-Aldosterone System in Postmenopausal Women: The Promise of Hormone Therapy
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Self-citationEffect of menopausal hormone therapy on components of the metabolic syndrome
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Metadata
- Authors
- Sandberg, K., & Ji, H.
- Venue
- Biology of Sex Differences
- Published
- 2012
- Volume
- 3
- Issue
- 1
- Pages
- 7
- ISSN
- 2042-6410 (ISSN-L)
- OpenAlex
- W2124882888
- Cited by
- 442
- References
- 10
- FWCI
- 12.85
- Type
- journal article
- Language
- en
- Open access
- gold
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