National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence
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The mechanisms of salt sensitivity of blood pressure are complex and likely involve responses beyond excess volume retention, including vascular dysfunction, arterial stiffness, sympathetic activation, impaired renin-angiotensin axis suppression, mineralocorticoid receptor activation, and immune cell modulation.
“The mechanisms are complex and likely involve a host of responses beyond excess volume retention, including vascular dysfunction, arterial stiffness, sympathetic activation, impaired renin-angiotensin axis suppression, mineralocorticoid receptor activation, and immune cell modulation.156,157”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [157]
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- Authors
- Oh, Y. S., Appel, L. J., Galis, Z. S., Hafler, D. A., He, J., Hernandez, A. L., Joe, B., Karumanchi, S. A., Maric-Bilkan, C., Mattson, D., Mehta, N. N., Randolph, G., Ryan, M., Sandberg, K., Titze, J., Tolunay, E., Toney, G. M., & Harrison, D. G.
- Affiliations
- Tulane University (US)
- From the Division of Cardiovascular Sciences (Y.S.O, Z.S.G., C.M.-B., E.T.) and Division of Intramural Research (N.N.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Johns Hopkins University, Baltimore, MD (L.J.A.); Department of Neurology and Department of Immunobiology, Yale University School of Medicine, New Haven, CT (A.L.H., D.A.H.); Department of Epidemiology, Tulane University, New Orleans, LA (J.H.); Department of Physiology...
- Corresponding author
- Oh, Young S.
- ORCID
- Venue
- Hypertension
- Published
- 2016-08
- Volume
- 68
- Issue
- 2
- Pages
- 281-288
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4945367
- OpenAlex
- W2466915263
- Cited by
- 52
- References
- 69
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2021: 4 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 12 · 2016: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01hl119380-04, Z99 HL999999, UL1TR001863)
- National Heart, Lung, and Blood Institute (R01HL020176, R01 HL-119380)
- National Institute of General Medical Sciences (T32GM007205)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072488)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- dietary salt, sodium intake, cardiovascular disease, salt reduction, human health, disease risk
- MeSH terms
- Humans, United States, Sodium Chloride, Dietary, National Heart, Lung, and Blood Institute (U.S.)
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