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Cited by 213Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Meta-analyses on prevalence of selected Parkinson's nonmotor symptoms before and after diagnosis

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Chen, Honglei, Zhao, Edward J, Zhang, Wen, Lu, Yi, Liu, Rui, Huang, Xuemei, Ciesielski-Jones, Anna J, Justice, Michele A, Cousins, Deborah S, Peddada, Shyamal·2015·Translational Neurodegeneration
DOI 10.1186/2047-9158-4-1PMC PMC4322463
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Abstract

BACKGROUND: Nonmotor symptoms are common among patients with Parkinson's disease (PD) and some may precede disease diagnosis. METHODS: We conducted a meta-analysis on the prevalence of selected nonmotor symptoms before and after PD diagnosis, using random-effect models. We searched PubMed (1965 through October/November 2012) for the following symptoms: hyposmia, constipation, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, depression, and anxiety. Eligible studies were publications in English with original data on one or more of these symptoms. RESULTS: The search generated 2,373 non-duplicated publications and 332 met the inclusion criteria, mostly (n = 320) on symptoms after PD diagnosis. For all symptoms, the prevalence was substantially higher in PD cases than in controls, each affecting over a third of the patients. Hyposmia was the most prevalent (75.5% in cases vs. 19.1% in controls), followed by constipation (50% vs. 17.7%), anxiety (39.9% vs. 19.1%), rapid eye movement sleep behavior disorder (37.0% vs. 7.0%), depression (36.6% vs. 14.9%), and excessive daytime sleepiness (33.9% vs. 10.5%). We observed substantial heterogeneities across studies and meta-regression analyses suggested that several factors might have contributed to this. However, the prevalence estimates were fairly robust in several sensitivity analyses. Only 20 studies had data on any symptoms prior to PD diagnosis, but still the analyses revealed higher prevalence in future PD cases than in controls. CONCLUSION: These symptoms are common among PD patients both before and after diagnosis. Further studies are needed to understand the natural history of nonmotor symptoms in PD and their etiological and clinical implications.

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Figure 1 Flow chart of literature review and data abstraction.
Figure 1 Flow chart of literature review and data abstraction.CC BY · PubMed Central
Figure 2 Meta-analysis of the prevalence of selected non-motor symptoms after PD diagnosis.
Figure 2 Meta-analysis of the prevalence of selected non-motor symptoms after PD diagnosis.CC BY · PubMed Central
Figure 3 Meta-analysis of the prevalence of selected non-motor symptoms prior to PD diagnosis.
Figure 3 Meta-analysis of the prevalence of selected non-motor symptoms prior to PD diagnosis.CC BY · PubMed Central

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Authors
Chen, H., Zhao, E. J., Zhang, W., Lu, Y., Liu, R., Huang, X., Ciesielski-Jones, A. J., Justice, M. A., Cousins, D. S., & Peddada, S.
Affiliations
  • National Institutes of Health (US)
  • Social and Scientific Systems (United States) (US)
  • Pennsylvania State University (US)
  • National Institute of Environmental Health Sciences (US)
Corresponding author
Chen, Honglei
ORCID
Venue
Translational Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2015-01-08
Volume
4
Issue
1
Pages
1-1
ISSN
2047-9158 (ISSN-L)
DOI
10.1186/2047-9158-4-1
PMC
PMC4322463
OpenAlex
W2126909058
Cited by
212
References
40
Citations by year
2026: 11 · 2025: 22 · 2024: 16 · 2023: 21 · 2022: 20 · 2021: 26 · 2020: 20 · 2019: 16 · 2018: 21 · 2017: 28 · 2016: 7 · 2015: 4
FWCI
14.10
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Translational Neurodegeneration (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1z01es101986-03, Z01-ES101986)
  • National Institute of Neurological Disorders and Stroke (U01NS082151)
  • National Institute of Environmental Health Sciences
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, non-motor symptoms, hyposmia, constipation, REM sleep behavior disorder, excessive daytime sleepiness, depression, anxiety, symptom prevalence, preclinical Parkinson's disease

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