Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
Open accessAbstract
Breast cancer progression is associated with and dependent upon robust neovascularization. It is becoming clear that tumour-associated 'normal' cells, such as immune/inflammatory cells, endothelial cells and stromal cells, conspire with cancer cells in promoting this process. In particular, infiltrating immune/inflammatory cells secrete a diverse repertoire of growth factors and proteases that enable them to enhance tumour growth by stimulating angiogenesis and, as we suggest here, by promoting 'tumour arteriogenesis' - enlargement of feeding vessels supplying the expanding tumour capillary bed. Macrophages and their chemoattractants (e.g. macrophage chemoattractant protein-1) are critical for the arteriogenic process in ischaemia, and probably also in breast neoplasia. A better understanding of these various cellular and molecular constituents of breast cancer neovascularization may be useful in designing more effective therapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis.
“Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [57]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Biology of Vascular Endothelial Growth Factor
Ferrara, N., & Davis-Smyth, T. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0287 · Cited by 4,540 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135 · see citing works
Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022 · cited 1× · see citing works
“contribute to tumour progression in large part by stimulating tumour neovascularization [10,11].”
BackgroundMetcalfe, D. D., Baram, D., & Mekori, Y. A. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1033 · Cited by 1,723 · see citing works
Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy
Lin, E. Y., Nguyen, A. V., Russell, R. G., & Pollard, J. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.6.727 · Cited by 1,594 · cited 1× · see citing works
“The critical importance of CSF-1 production, not only for macrophage recruitment but also for tumour vascularization and progression, has also been demonstrated in transgenic mouse models of breast cancer [45,46].”
BackgroundGranules of the Human Neutrophilic Polymorphonuclear Leukocyte
Borregaard, N., & Cowland, J. B. (1997) · Blood · doi:10.1182/blood.v89.10.3503 · Cited by 1,514 · see citing works
Barleon, B., Sozzani, S., Zhou, D., Weich, H., Mantovani, A., & Marmé, D. (1996) · Blood · doi:10.1182/blood.v87.8.3336.bloodjournal8783336 · Cited by 1,350 · cited 1× · see citing works
“macrophages, as well as on endothelial cells [33,34].”
BackgroundProgress in human tumour immunology and immunotherapy
Rosenberg, S. A. (2001) · Nature · doi:10.1038/35077246 · Cited by 1,317 · cited 1× · see citing works
“tors of antitumour immunity and may oppose tumour expansion [3].”
BackgroundMMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
Coussens, L. M., Tinkle, C. L., Hanahan, D., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00139-2 · Cited by 1,306 · see citing works
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
Leek, R., Lewis, C. E., Whitehouse, R. M., Greenall, M. J., Clarke, J., & Harris, A. L. (1996) · PubMed · Cited by 1,187 · see citing works
Sunderkötter, C. H., Steinbrink, K., Goebeler, M., Bhardwaj, R. S., & Sorg, C. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.3.410 · Cited by 1,113 · cited 3× · see citing works
“transforming growth factor-β, IL-1β, IL-6, tumour necrosis factor-α) are known to have pleiotropic effects, stimulating angiogenesis under certain conditions and inhibiting it under others [47].”
BackgroundInfluentialWound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping
Rappolee, D. A., Mark, D., Banda, M. J., & Werb, Z. (1988) · Science · doi:10.1126/science.3041594 · Cited by 1,101 · see citing works
Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics
Padera, T. P., Kadambi, A., di Tomaso, E., Carreira, C. M., Brown, E. B., Boucher, Y., Choi, N. C., Mathisen, D. J., Wain, J. R., Mark, E. J., et al. (2002) · Science · doi:10.1126/science.1071420 · Cited by 964 · cited 1× · see citing works
“The formation of peritumoural lymphatic vessels, which in one study correlated with the extent of TAM recruitment, represents an important conduit for the metastasis of tumours to regional lymph nodes, with major implications for patient prognosis [54,55].”
BackgroundInflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
Coussens, L. M., Raymond, W. W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G. H., & Hanahan, D. (1999) · Genes & Development · doi:10.1101/gad.13.11.1382 · Cited by 946 · cited 1× · see citing works
“moting angiogenesis during the earliest stages of neoplastic progression [9,12,13].”
BackgroundClauss, M. A., Gerlach, M. L., Gerlach, H., Brett, J., Wang, F., Familletti, P. C., Pan, Y.-C. E., Olander, J. V., Connolly, D. T., & Stern, D. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1535 · Cited by 831 · cited 2× · see citing works
“However, in addition to these direct effects on endothelial cells, VEGF also stimulates monocyte migration through VEGFR-1 [32], which is expressed on monocytes and”
BackgroundThe Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities
Clauss, M. A., Weich, H. A., Breier, G., Knies, U. E., Röckl, W., Waltenberger, J. L., & Risau, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17629 · Cited by 828 · cited 1× · see citing works
“tumour-derived growth factors – can also stimulate monocyte chemotaxis [38,39].”
BackgroundActivated macrophages induce vascular proliferation
Polverini, P. J., Cotran, R. S., Gimbrone, M. A., & Unanue, E. R. (1977) · Nature · doi:10.1038/269804a0 · Cited by 805 · cited 1× · see citing works
“in 1976 [58], shortly before their role in angiogenesis in 1977 [7].”
BackgroundSchoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64255-1 · Cited by 794 · cited 2× · see citing works
“Finally, immune/inflammatory cells may also promote tumour lymphangiogenesis by secreting the lymphangiogenic growth factors VEGF-C and VEGF-D [53,54].”
BackgroundRole of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis
Pepper, M. S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.093685 · Cited by 774 · cited 1× · see citing works
“angiogenesis and tumour development [49].”
Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb.
Arras, M., Ito, W., Scholz, D., Winkler, B. E., Schaper, J., & Schaper, W. K. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119877 · Cited by 733 · cited 1× · see citing works
“Monocytes that adhere and then invade the arteriolar wall subsequently promote collateral artery growth by producing cytokines such as tumour necrosis factor-α and basic fibroblast growth factor [60].”
Background(2000) · PubMed · Cited by 706 · see citing works
Macrophages synthesise and release prostaglandins in response to inflammatory stimuli
Humes, J. L., Bonney, R. J., Pelus, L. M., Dahlgren, M. E., Sadowski, S. J., Kuehl, F. A., & DAVIES, P. (1977) · Nature · doi:10.1038/269149a0 · Cited by 566 · see citing works
Neutrophil-Derived Proteins: Selling Cytokines by the Pound
Cassatella, M. A. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60791-9 · Cited by 558 · see citing works
Dong, Z., Kumar, R., Yang, X., & Fidler, I. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81926-1 · Cited by 525 · cited 1× · see citing works
“85 MMP-12 (metalloelastase), has been shown to generate angiostatin, an endogenous angiogenesis inhibitor, from its precursor – plasminogen [51].”
BackgroundCSF‐1—A mononuclear phagocyte lineage‐specific hemopoietic growth factor
Stanley, E. R., Guilbert, L. J., Tushinski, R. J., & Bartelmez, S. H. (1983) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240210206 · Cited by 516 · see citing works
Sakaue-Sawano, A., Iwai, S., Sakurai, Y., Ito, M., Shitara, K., Nakahata, T., & Shibuya, M. (2001) · Blood · doi:10.1182/blood.v97.3.785 · Cited by 498 · see citing works
Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants.
Yoshimura, T., Robinson, E. A., Tanaka, S., Appella, E., Kuratsu, J. I., & Leonard, E. J. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.4.1449 · Cited by 484 · cited 1× · see citing works
“MCP-1, a member of the C–C chemokine family, is involved in monocyte and T-lymphocyte migration, and is secreted by many human and murine tumour cells in addition to activated stromal cells [24,25].”
BackgroundRobinson, B. W. S., McLemore, T. L., & Crystal, R. G. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111852 · Cited by 454 · see citing works
Leek, R., Landers, R. J., Harris, A. L., & Lewis, C. E. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690158 · Cited by 450 · see citing works
Vascular Growth Factors and Lymphangiogenesis
Jussila, L., & Alitalo, K. K. (2002) · Physiological Reviews · doi:10.1152/physrev.00005.2002 · Cited by 439 · cited 1× · see citing works
“Finally, immune/inflammatory cells may also promote tumour lymphangiogenesis by secreting the lymphangiogenic growth factors VEGF-C and VEGF-D [53,54].”
BackgroundTumstatin, an Endothelial Cell-Specific Inhibitor of Protein Synthesis
Maeshima, Y., Sudhakar, A., Lively, J. C., Ueki, K., Kharbanda, S. M., Kahn, C. R., Sonenberg, N., Hynes, R. O., & Kalluri, R. (2002) · Science · doi:10.1126/science.1065298 · Cited by 434 · cited 1× · see citing works
“lagen to the angiogenesis inhibitor tumstatin [50].”
Patterson, B. C., & Sang, Q. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.46.28823 · Cited by 431 · see citing works
Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors
Crowther, M., Brown, N. J., Bishop, E., & Lewis, C. E. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.4.478 · Cited by 414 · cited 1× · see citing works
“contribute to tumour progression in large part by stimulating tumour neovascularization [10,11].”
BackgroundSkobe, M., Hamberg, L. M., Hawighorst, T., Schirner, M., Wolf, G. L., Alitalo, K. K., & Detmar, M. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61765-8 · Cited by 388 · cited 1× · see citing works
“tumour-derived growth factors – can also stimulate monocyte chemotaxis [38,39].”
BackgroundNorrby, K. (2002) · Apmis · doi:10.1034/j.1600-0463.2002.100501.x · Cited by 378 · see citing works
Martinet, Y., Bitterman, P. B., Mornex, J., Grotendorst, G. R., Martin, G. R., & Crystal, R. G. (1986) · Nature · doi:10.1038/319158a0 · Cited by 370 · see citing works
Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.
Urban, J. L., Shepard, H. M., Rothstein, J. L., Sugarman, B. J., & Schreiber, H. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.14.5233 · Cited by 356 · cited 1× · see citing works
“possess both direct and indirect tumouricidal activity [5,6].”
BackgroundInduction of transforming growth factor-α in activated human alveolar macrophages
Madtes, D. K., Raines, E. W., Sakaríassen, K. S., Assoian, R. K., Sporn, M. B., Bell, G. I., & Ross, R. (1988) · Cell · doi:10.1016/0092-8674(88)90390-x · Cited by 345 · see citing works
Huang, S. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.15.1134 · Cited by 345 · cited 1× · see citing works
“moting angiogenesis during the earliest stages of neoplastic progression [9,12,13].”
BackgroundBoesiger, J., Tsai, M. M., Maurer, M., Yamaguchi, M., Brown, L. F., Claffey, K. P., Dvorak, H. F., & Galli, S. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.6.1135 · Cited by 336 · see citing works
Grützkau, A., Krüger‐Krasagakes, S., Baumeister, H., Schwarz, C., Koegel, H., Welker, P., Lippert, U., Henz, B. M., & Möller, A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.4.875 · Cited by 336 · see citing works
Negus, R. P., Stamp, G. W., Relf, M. G., Burke, F., Malik, S. T., Bernasconi, S., Allavena, P., Sozzani, S., Mantovani, A., & Balkwill, F. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117933 · Cited by 315 · cited 1× · see citing works
“MCP-1 expression in tumour cells is significantly correlated with the extent of TAM infiltration [26,27], and in particular both MCP-1 and VEGF expression have been positively correlated with TAM infiltration,”
BackgroundGasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L. M., Olsen, H. S., Murphy, M., Liao, F., Farber, J. M., & Cassatella, M. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4928 · Cited by 314 · see citing works
Production of Vascular Endothelial Growth Factor by Murine Macrophages
Xiong, M., Elson, G., Legarda, D., & Leibovich, S. J. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65601-5 · Cited by 306 · see citing works
Ultrastructure and molecular histology of rabbit hind-limb collateral artery growth (arteriogenesis)
Scholz, D., Ito, W., Fleming, I., Deindl, E., Sauer, A., Wiesnet, M., Busse, R., Schaper, J., & Schaper, W. K. A. (2000) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050039 · Cited by 306 · cited 1× · see citing works
“86 them to upregulate Mac-1, the receptor for intercellular adhesion molecule-1 (ICAM-1) that is expressed in activated endothelium [59].”
BackgroundGasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L. M., Olsen, H., Murphy, M., Liao, F., Farber, J. M., & Cassatella, M. A. (1999) · PubMed · Cited by 304 · see citing works
Saji, H., Koike, M., Yamori, T., Saji, S., Seiki, M., Matsushima, K., & Toi, M. (2001) · Cancer · doi:10.1002/1097-0142(20010901)92:5 · Cited by 283 · see citing works
Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.
Sidky, Y. A., & Auerbach, R. (1975) · The Journal of Experimental Medicine · doi:10.1084/jem.141.5.1084 · Cited by 280 · see citing works
Monocytes and macrophages synthesize and secrete thrombospondin
Jaffe, E., Ruggiero, J. T., & Falcone, D. (1985) · Blood · doi:10.1182/blood.v65.1.79.79 · Cited by 214 · see citing works
Placental growth factor is a survival factor for tumor endothelial cells and macrophages.
Adini, A., Kornaga, T., Firoozbakht, F., & Benjamin, L. E. (2002) · PubMed · Cited by 212 · see citing works
Cytokine networks in solid human tumors: regulation of angiogenesis
Leek, R., Harris, A. L., & Lewis, C. E. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.4.423 · Cited by 206 · see citing works
Identification of Monocyte Chemotactic Activity Produced by Malignant Cells
Graves, D. T., Jiang, Y., Williamson, M. J., & Valente, A. J. (1989) · Science · doi:10.1126/science.2781291 · Cited by 204 · cited 1× · see citing works
“MCP-1, a member of the C–C chemokine family, is involved in monocyte and T-lymphocyte migration, and is secreted by many human and murine tumour cells in addition to activated stromal cells [24,25].”
BackgroundClaasen, H. H. V. R., Kluin, P. M., & Fleuren, G. J. (1992) · PubMed · Cited by 201 · see citing works
Yeo, K. T., Wang, H. H., Nagy, J. A., Sioussat, T. M., Ledbetter, S. R., Hoogewerf, A. J., Zhou, Y., Masse, E., Senger, D. R., & Dvorak, H. F. (1993) · PubMed · Cited by 194 · see citing works
Arteriogenesis, a new concept of vascular adaptation in occlusive disease
Scholz, D., Cai, W., & Schaper, W. K. A. (2001) · Angiogenesis · doi:10.1023/a:1016094004084 · Cited by 180 · cited 2× · see citing works
“sure differences between perfused areas [57].”
Schaper, J., K�nig, R., Franz, D., & Schaper, W. K. A. (1976) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00427580 · Cited by 162 · cited 1× · see citing works
“in 1976 [58], shortly before their role in angiogenesis in 1977 [7].”
BackgroundCSF-1 and Its Receptor in Ovarian, Endometrial and Breast Cancer
Kacinski, B. M. (1995) · Annals of Medicine · doi:10.3109/07853899509031941 · Cited by 161 · see citing works
Valković, T., Dobrila, F., Melato, M., Sasso, F., Rizzardi, C., & Jonjić, N. (2001) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280100458 · Cited by 152 · cited 1× · see citing works
“positive correlation between VEGF expression and degree of macrophage infiltration has been observed in invasive breast carcinoma [28,35] and other malignancies [36,37].”
BackgroundRhoC GTPase Overexpression Modulates Induction of Angiogenic Factors in Breast Cells
van Golen, K. L., Wu, Z.-F., Qiao, X. T., Bao, L., & Merajver, S. D. (2000) · Neoplasia · doi:10.1038/sj.neo.7900115 · Cited by 150 · cited 1× · see citing works
“In inflammatory breast cancer, expression of constitutively activated RhoC oncoprotein is associated with concomitant upregulation of both angiogenic (vascular endothelial growth factor [VEGF]) and inflammatory (IL-6) cytokines, leading to the formation of a specific type of inflammatory/angiogenic stroma in this part…”
BackgroundGeneration of Biologically Active Angiostatin Kringle 1–3 by Activated Human Neutrophils
Scapini, P., Nesi, L., Morini, M., Tanghetti, E., Belleri, M., Noonan, D. M., Presta, M., Albini, A., & Cassatella, M. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5798 · Cited by 139 · see citing works
Mast-cell histamine is angiogenic through receptors for histamine1 and histamine2.
Sörbo, J., Jakobsson, A., & Norrby, K. (1994) · Europe PMC (PubMed Central) · Cited by 135 · see citing works
Wright, K., Wilson, P. J., Morland, S. J., Campbell, I., Walsh, M. D., Hurst, T., Ward, B. G., Cummings, M. C., & Chenevix‐Trench, G. (1999) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19990827)82:5 · Cited by 133 · see citing works
Ramakrishnan, S., Xu, F., Brandt, S. J., Niedel, J. E., Bast, R. C., & Brown, E. L. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113977 · Cited by 130 · see citing works
Nowicki, A., Szenajch, J., Ostrowska, G., Wójtowicz, A., Wójtowicz, K., Kruszewski, A. A., Maruszyński, M., Aukerman, S. L., & Wiktor-Jędrzejczak, W. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960103)65:1 · Cited by 122 · see citing works
Heil, M., Clauss, M. A., Suzuki, K., Buschmann, I. R., Willuweit, A., Fischer, S., & Schaper, W. K. A. (2000) · European Journal of Cell Biology · doi:10.1078/0171-9335-00113 · Cited by 122 · cited 1× · see citing works
“to the endothelium and their transmigration through it [61].”
BackgroundHuman cutaneous mast cells express basic fibroblast growth factor.
Reed, J. A., Albino, A. P., & McNutt, N. S. (1995) · PubMed · Cited by 119 · see citing works
Hypoxia inhibits macrophage migration
Turner, L., Scotton, C. J., Negus, R. P. M., & Balkwill, F. R. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199907)29:07 · Cited by 117 · see citing works
Urokinase and macrophages in tumour angiogenesis
Hildenbrand, R., Dilger, I., Hörlin, A., & Stutte, H. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.419 · Cited by 116 · see citing works
Tang, R., Ojeda‐Uribe, M., Pouillart, P., Scholl, S., Beuvon, F., & Mosseri, V. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240500403 · Cited by 98 · see citing works
Angiogenesis and inflammation in invasive carcinoma of the breast.
Lee, A. H., Happerfield, L. C., Bobrow, L. G., & Millis, R. R. (1997) · Journal of Clinical Pathology · doi:10.1136/jcp.50.8.669 · Cited by 95 · see citing works
Dog mastocytoma cells produce transforming growth factor beta 1.
Pennington, D. W., Lopez, A. R., Thomas, P. S., Peck, C., & Gold, W. M. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115853 · Cited by 82 · see citing works
Duyndam, M. C. A., Hilhorst, M. C. G. W., Schlüper, H. M. M., Verheul, H. M. W., van Diest, P. J., Kraal, G., Pinedo, H. M., & Boven, E. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64873-0 · Cited by 81 · cited 1× · see citing works
“positive correlation between VEGF expression and degree of macrophage infiltration has been observed in invasive breast carcinoma [28,35] and other malignancies [36,37].”
BackgroundLymphokine‐induced secretion of plasminogen activator by murine macrophages
Klimetzek, V., & Sorg, C. (1977) · European Journal of Immunology · doi:10.1002/eji.1830070314 · Cited by 73 · see citing works
Tang, R., Kacinski, B. M., Validire, P., Beuvon, F., Sastre‐Garau, X., Benoit, P., de la Rochefordière, A., Mosseri, V., Pouillart, P., & Scholl, S. (1990) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240440307 · Cited by 73 · cited 1× · see citing works
“amplification in breast tumour samples and the density of lymphocyte infiltration of the tumour [22].”
BackgroundBashkin, P., Razin, E., Eldor, A., & Vlodavsky, I. (1990) · Blood · doi:10.1182/blood.v75.11.2204.2204 · Cited by 68 · see citing works
Bv, S. (1976) · PubMed · Cited by 66 · see citing works
Production of interferon by in vitro derived bone marrow macrophages
Fleit, H. B., & Rabinovitch, M. (1981) · Cellular Immunology · doi:10.1016/0008-8749(81)90107-6 · Cited by 58 · see citing works
Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes
Kalra, V. K., Shen, Y. M., Sultana, C., & Rattan, V. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.5.h2025 · Cited by 58 · cited 1× · see citing works
“Tumour hypoxia is an important stimulus for extravasation of monocytes [14], which migrate into the tumour tissue along gradients of chemoattractants, and these TAMs become immobilized in ischaemic, necrotic areas of tumours, where they can remain for an extended time [15–18].”
BackgroundZiche, M., Morbidelli, L., Geppetti, P., Maggi, C. A., & Dolara, P. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90417-a · Cited by 54 · see citing works
Tumour-associated macrophages in breast cancer and their prognostic correlations
Volodko, N., Reiner, A., Rudas, M., & Jakesz, R. (1998) · The Breast · doi:10.1016/s0960-9776(98)90065-0 · Cited by 53 · see citing works
Nagaoka, H., Iino, Y., Takei, H., & Morishita, Y. (1998) · International Journal of Oncology · doi:10.3892/ijo.13.3.449 · Cited by 50 · see citing works
Expression of monocyte chemoattractant protein-1 in meningioma
Sato, K., Kuratsu, J., Takeshima, H., Yoshimura, T., & Ushio, Y. (1995) · Journal of neurosurgery · doi:10.3171/jns.1995.82.5.0874 · Cited by 47 · cited 1× · see citing works
“MCP-1 expression in tumour cells is significantly correlated with the extent of TAM infiltration [26,27], and in particular both MCP-1 and VEGF expression have been positively correlated with TAM infiltration,”
BackgroundHuman recombinant migration inhibitory factor activates human macrophages to kill tumor cells
Pozzi, L.-A. M., & Weiser, W. Y. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90339-q · Cited by 36 · cited 1× · see citing works
“possess both direct and indirect tumouricidal activity [5,6].”
BackgroundXu, Y., Hagège, J., Doublet, J.-D., Callard, P., Sraer, J., Rønne, E., & Rondeau, É. (1997) · Human Pathology · doi:10.1016/s0046-8177(97)90108-8 · Cited by 26 · see citing works
Valković, T., Dobrila, F., Melato, M., Sasso, F., Rizzardi, C., & Jonjić, N. (2002) · Cited by 24 · see citing works
Low, E. O. W., Jones, A. M., Gibbins, J. R., & Walker, D. M. (2000) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(200003)190:4 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., Wu, L., Sloan, A. E., McLendon, R. E., Li, X., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3090 · Cited by 940 · see citing works
Inflammation: Gearing the journey to cancer
Kundu, J. K., & Surh, Y. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.03.002 · Cited by 804 · see citing works
“factors that increase vascular permeability [209–211].”
Inflammation and necrosis promote tumour growth
Vakkila, J., & Lotze, M. T. (2004) · Nature reviews. Immunology · doi:10.1038/nri1415 · Cited by 692 · see citing works
Chemical Biology of the Sugar Code
Gabius, H., Siebert, H., André, S., Jiménez‐Barbero, J., & Rüdiger, H. E. F. (2004) · ChemBioChem · doi:10.1002/cbic.200300753 · Cited by 523 · see citing works
Ryder, M., Ghossein, R. A., Ricarte‐Filho, J. C., Knauf, J. A., & Fagin, J. A. (2008) · Endocrine Related Cancer · doi:10.1677/erc-08-0036 · Cited by 447 · see citing works
“1996, Yu 2003, Tsutsui et al .”
Mast cells: the JEKYLL and HYDE of tumor growth
Theoharides, T. C., & Conti, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.02.013 · Cited by 352 · see citing works
Ben‐Baruch, A. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.07.006 · Cited by 336 · see citing works
Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
Taurin, S., Nehoff, H. L., & Greish, K. F. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.07.013 · Cited by 309 · see citing works
27-Hydroxycholesterol Is an Endogenous Selective Estrogen Receptor Modulator
DuSell, C. D., Umetani, M., Shaul, P. W., Mangelsdorf, D. J., & McDonnell, D. P. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0383 · Cited by 298 · see citing works
LaMontagne, K. R., Littlewood-Evans, A. J., Schnell, C., O’Reilly, T., Wyder, L., Sánchez, T., Probst, B., Butler, J., Wood, A. W., Liau, G., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2001 · Cited by 295 · see citing works
“matory cells can also promote angiogenesis and tumor growth (32),”
Iron as a central player and promising target in cancer progression
Jung, M., Mertens, C., Tomat, E., & Brüne, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020273 · Cited by 268 · see citing works
“Of note, the appearance of tumor-supporting, iron-donating immune cells, in particular macrophages, is associated with tumor size and aggressiveness as well as poor patient prognosis [56,57].”
BackgroundThe multifaceted roles of chemokines in malignancy
Ben‐Baruch, A. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9003-5 · Cited by 258 · see citing works
“In breast carcinoma, high counts of TAM in the tumors are significantly correlated with clinical aggressiveness, high tumor grade and poor prognosis [28, 34–38].”
BackgroundLymphangiogenesis and lymphatic metastasis in breast cancer
Ran, S., Volk, L. D., Hall, K. L., & Flister, M. J. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.11.003 · Cited by 250 · see citing works
“[188] J.”
Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy
Yang, S., & Gao, H. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.05.004 · Cited by 256 · see citing works
The immune system and inflammation in breast cancer
Jiang, X., & Shapiro, D. J. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.06.003 · Cited by 243 · see citing works
“Other cells, such as bone marrow-derived Tie2 expressing monocytes (TEMs), tumor associated neutrophils (TANs), immature dendritic cells (DCs) and mast cells all plays roles in breast cancer angiogenesis (Yu and Rak, 2003; De Palma et al., 2005; Fainaru et al., 2010; Gregory and Houghton, 2011).”
BackgroundAngiogenesis in prostate cancer: onset, progression and imaging
Russo, G., Mischi, M., Scheepens, W. A., de la Rosette, J. J. M. C. H., & Wijkstra, H. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11444.x · Cited by 196 · see citing works
Farnsworth, R. H., Lackmann, M., Achen, M. G., & Stacker, S. A. (2013) · Oncogene · doi:10.1038/onc.2013.304 · Cited by 192 · see citing works
Veinotte, C. J., Dellaire, G., & Berman, J. N. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.015784 · Cited by 168 · see citing works
“A number of studies have highlighted the impact of the tumor microenvironment on the proliferation and migration of a variety of human cancers (Gupta and Massagué, 2006; Hanahan et al., 2000; Yu and Rak, 2003).”
BackgroundEterno, V., Zambelli, A., Pavesi, L., Villani, L., Zanini, V., Petrolo, G., Manera, S., Tuscano, A., & Amato, A. M. (2013) · Oncotarget · doi:10.18632/oncotarget.1359 · Cited by 160 · see citing works
“However, it was found that a well orchestrated inflammatory response supports tumorigenesis, creating an optimal microenvironment where cancer cells are continuously stimulated to proliferate, also by recruitment of several cell types able to promote tumor neoangiogenesis [4, 5].”
BackgroundNitric oxide, apoptosis and macrophage polarization during tumor progression
Weigert, A., & Brüne, B. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.04.021 · Cited by 148 · see citing works
Ran, S., & Montgomery, K. E. (2012) · Cancers · doi:10.3390/cancers4030618 · Cited by 131 · see citing works
“Chronic inflammation is a hallmark of breast cancer [187,188] and has been repeatedly linked to increased tumorigenesis [189,190], angiogenesis [191,192], lymphangiogenesis [65,193] and metastatic progression [194–196].”
BackgroundChemokine Networks and Breast Cancer Metastasis
Karnoub, A. E., & Weinberg, R. A. (2007) · Breast Disease · doi:10.3233/bd-2007-26107 · Cited by 130 · see citing works
“Enhanced leukocyte and stromal infiltrates within tumors almost always signify enhanced tumor vascularity [96].”
Pistelli, M., Lisa, M. D., Ballatore, Z., Caramanti, M., Pagliacci, A., Battelli, N., Ridolfi, F., Santoni, M., Maccaroni, E., Bracci, R., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1204-2 · Cited by 119 · see citing works
Taroni, P., Torricelli, A. M., Spinelli, L., Pifferi, A., Arpaia, F., Danesini, G. M., & Cubeddu, R. (2005) · Physics in Medicine and Biology · doi:10.1088/0031-9155/50/11/003 · Cited by 116 · see citing works
Du, Y.-E., Tu, G., Yang, G., Li, G., Yang, D., Lang, L., Xi, L., Sun, K., Chen, Y., Shu, K., et al. (2017) · Theranostics · doi:10.7150/thno.18990 · Cited by 108 · see citing works
Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer
Lanigan, F. T., O’Connor, D. P., Martin, F., & Gallagher, W. M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7386-2 · Cited by 105 · see citing works
Macrophage iron homeostasis and polarization in the context of cancer
Jung, M., Mertens, C., & Brüne, B. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.011 · Cited by 103 · see citing works
“Precisely, TAM reflect a panel of different subpopulations of the oversimplified binary M1/M2 scenario and share features of both types with a greater overall similarity to macrophages involved in developmental processes (Ojalvo et al. 2010).”
BackgroundInfluentialExtratumoral Macrophages Promote Tumor and Vascular Growth in an Orthotopic Rat Prostate Tumor Model
Bergström, S. H., Rudolfsson, S. H., van Rooijen, N., & Bergh, A. R. J. (2009) · Neoplasia · doi:10.1593/neo.81338 · Cited by 100 · see citing works
“Several of these factors have been shown to be produced by macrophages (for reviews, see [5,17]), and staining of MMP-9 and IL-1β in the tumors showed that both these proteins were located in macrophage-like cells, particularly at the invasive border.”
BackgroundThe relationship between hypoxia and angiogenesis
Moeller, B. J., Cao, Y., Vujašković, Ž., Li, C. Y., Haroon, Z. A., & Dewhirst, M. W. (2004) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2004.04.005 · Cited by 97 · see citing works
Perspectives for Clinical Translation of Adipose Stromal/Stem Cells
Patrikoski, M., Mannerström, B., & Miettinen, S. (2019) · Stem Cells International · doi:10.1155/2019/5858247 · Cited by 93 · see citing works
Murri, A. M. A., Hilmy, M., Bell, J., Wilson, C., McNicol, A. M., Lannigan, A., Doughty, J., & McMillan, D. C. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604667 · Cited by 81 · see citing works
“However, this immune response, in particular the local environment of cytokines, proteases, angiogenic/growth factors and the resulting systemic inflammatory response, may, in turn, stimulate tumour growth and metastasis (O’Sullivan and Lewis, 1994; Leek et al, 1996; Yu and Rak, 2003; Lin and Pollard, 2007).”
BackgroundChandrashekar, N., Asokkumar, S., Subramanian, R., Anandakumar, P., & Devaki, T. (2012) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2012.02.004 · Cited by 79 · see citing works
Minimal Contribution of Marrow-Derived Endothelial Precursors to Tumor Vasculature
Larrivée, B., Niessen, K. S., Pollet, I. L., Corbel, S. Y., Long, M., Rossi, F. M. V., Olive, P. L., & Karsan, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.2890 · Cited by 77 · see citing works
“It is also possible that VEGF-induced activation of VEGFR-2, even though it does not induce mobilization of endothelial progenitors per se, can promote the expansion and mobilization of myeloid cells such as macrophages, which in turn can actively promote tumor growth through their close interaction with tumor endothe…”
BackgroundZijlmans, H. J. M. A. A., Fleuren, G. J., Baelde, H. J., Eilers, P. H. C., Kenter, G. G., & Gorter, A. (2006) · The Journal of Pathology · doi:10.1002/path.1918 · Cited by 76 · see citing works
Transactivation of MCP‐1/CCL2 by β‐catenin/TCF‐4 in human breast cancer cells
Mestdagt, M., Polette, M., Butticè, G., Noël, A., Ueda, A., Foidart, J., & Gilles, C. (2005) · International Journal of Cancer · doi:10.1002/ijc.21291 · Cited by 76 · see citing works
“It has been particularly implicated in processes characterized by mononuclear cell infiltration including breast cancer.(4,5) In some models, MCP-1 has been shown to display an antitumoral effect.”
BackgroundSystematic review: The oncological safety of adipose fat transfer after breast cancer surgery
Waked, K., Colle, J., Doornaert, M. A. J., Cocquyt, V., & Blondeel, P. N. (2016) · The Breast · doi:10.1016/j.breast.2016.11.001 · Cited by 74 · see citing works
“Experimental studies have pointed out that they can promote tumour growth through several pathways such as enhancing the proliferation and survival of cancer cells, supporting the tumour vasculature, and sustaining a chronic inflammatory state in which tissue regeneration is stimulated [15,25,34,45,64].”
BackgroundThe Tumor Microenvironment: Key to Early Detection
Ariztia, E. V., Lee, C. J., Gogoi, R. P., & Fishman, D. A. (2006) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360600778836 · Cited by 71 · see citing works
Jung, M., Weigert, A., Tausendschön, M., Mora, J., Ören, B., Solà, A., Hotter, G., Muta, T., & Brüne, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00413-12 · Cited by 71 · see citing works
“The functional TAM phenotype is at least in part a response to tumor-released components, such as interleukin 10 (IL-10), transforming growth factor (TGF- ), prostanglandin E2 (PGE2), other chemokines, and tumor hypoxia (19).”
BackgroundVascular Growth in Health and Disease
Persson, A. B., & Buschmann, I. R. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00014 · Cited by 69 · see citing works
Interleukin-6 Increases Expression and Secretion of Cathepsin B by Breast Tumor-Associated Monocytes
Mohamed, M. M., Cavallo‐Medved, D., Rudy, D., Anbalagan, A., Moin, K., & Sloane, B. F. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000276564 · Cited by 66 · see citing works
Peng, S. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i41.6521 · Cited by 66 · see citing works
“. Tumor infi ltrating infl ammatory cells in the microenvironment plays very important functions in tumor angiogenesis [ 6-8 ]”
BackgroundA Critical Role for the Inflammatory Response in a Mouse Model of Preneoplastic Progression
Schwertfeger, K. L., Xian, W., Kaplan, A. M., Burnett, S. H., Cohen, D. A., & Rosen, J. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3781 · Cited by 66 · see citing works
“Studies of human breast cancer have shown that increased TAM density predicts poor prognosis and is associated with increased VEGF expression and microvessel density (36, 37), suggesting that macrophages may be involved in tumor angiogenesis.”
BackgroundBarrera, I., & Spiegel, D. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2013.864259 · Cited by 75 · see citing works
“Immune and tumour cell secretion of cytokines (i.e. IL-8) and angiogenic factors (i.e. VEGF) have been associated with increased metastasis (Yu & Rak, 2003).”
BackgroundMammary Gland Macrophages: Pleiotropic Functions in Mammary Development
Schwertfeger, K. L., Rosen, J. M., & Cohen, D. A. (2006) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-006-9028-y · Cited by 61 · see citing works
Annexin 1: Differential expression in tumor and mast cells in human larynx cancer
Silistino‐Souza, R., Rodrigues‐Lisoni, F. C., Cury, P. M., Maniglia, J. V., Raposo, L. S., Tajara, E. H., Christian, H., & Oliani, S. M. (2007) · International Journal of Cancer · doi:10.1002/ijc.22639 · Cited by 59 · see citing works
A Comparative Approach of Tumor-Associated Inflammation in Mammary Cancer between Humans and Dogs
Carvalho, M. I., Silva-Carvalho, R., Pires, I. C. R., Prada, J., Bianchini, R., Jensen‐Jarolim, E., & QUEIROGA, F. L. (2016) · BioMed Research International · doi:10.1155/2016/4917387 · Cited by 57 · see citing works
“Furthermore, some of these proinflammatory mediators directly stimulate the migration and proliferation of endothelial cells, thus promoting angiogenesis and consequently tumor growth [10, 38].”
Psychoneurological symptom cluster in breast cancer: the role of inflammation and diet
George, M. A., Lustberg, M. B., & Orchard, T. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05808-x · Cited by 56 · see citing works
Patel, S. K., Zhang, Y., Pollock, J. A., & Janjic, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055802 · Cited by 55 · see citing works
“The tumor environment contains a wide variety of inflammatory cells such as mast cells, dendritic cells, natural killer cells and macrophages [2].”
BackgroundTumor microenvironment and breast cancer progression
Artacho-Cordón, A., Artacho‐Cordón, F., Ríos‐Arrabal, S., Calvente, I., & Núñez, M. I. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.13.1.18869 · Cited by 50 · see citing works
“Tumor-associated macrophages (TAMs) are a major component of the leukocyte infiltrate, and activated macrophages have been shown to exert both direct and indirect tumoricidal action.(88) Studies on their function using different mouse models of breast cancer revealed that macrophages are required to regulate both the…”
BackgroundImaging and quantifying the dynamics of tumor-associated proteolysis
Sameni, M., Cavallo‐Medved, D., Dosescu, J., Jedeszko, C., Moin, K., Mullins, S., Olive, M. B., Rudy, D., & Sloane, B. F. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9218-7 · Cited by 50 · see citing works
Carvalho, M. I., Pires, I. C. R., Prada, J., Gregório, H., Lobo, L., & QUEIROGA, F. L. (2016) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2016.06.006 · Cited by 49 · see citing works
Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins
Nasser, M. W., Elbaz, M., Ahirwar, D. K., & Ganju, R. K. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.05.002 · Cited by 48 · see citing works
“ing breast cancer [142,143].”
Endothelins in breast tumour cell invasion
Grimshaw, M. J. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.08.029 · Cited by 48 · see citing works
Microenvironmental influences on mutagenesis in mammary epithelial cells
Papp-Szabó, E., Josephy, P. D., & Coomber, B. L. (2005) · International Journal of Cancer · doi:10.1002/ijc.21088 · Cited by 47 · see citing works
Pattern response of dendritic cells in the tumor microenvironment and breast cancer
da Cunha, A. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.495 · Cited by 45 · see citing works
Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don
Dai, Z.-J., Lu, W.-F., Gao, J., Kang, H., Ma, Y., Zhang, S.-Q., Diao, Y., Lin, S., Wang, X.-J., & Wu, W. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-150 · Cited by 45 · see citing works
“Previous studies have suggested that these inflammatory cells promote the neoplastic progression by stimulating tumor revascularization and other processes related to tumor angiogenesis [31].”
BackgroundYang, M. G., Meng, J., Cheng, X., Lei, J., Guo, H., Zhang, W., Kong, H., & Xu, H. (2012) · Theranostics · doi:10.7150/thno.3629 · Cited by 45 · see citing works
“Extensive research has demonstrated that macrophages in the tumor microenvironment are closely associated with the development and progression of a variety of tumors, such as breast cancer [4-5], prostate [6], glioma [7], lymphoma [8], bladder [9], lung [10], cervical [11] and melanoma [12].”
BackgroundShishido‐Hara, Y., Kurata, A., Fujiwara, M., Itoh, H., Imoto, S., & Kamma, H. (2010) · Diagnostic Pathology · doi:10.1186/1746-1596-5-55 · Cited by 44 · see citing works
“Microenvironments, with secretion of cytokines, seem to affect progression of breast cancer [9,10], and may also determine whether OGCs are formed.”
BackgroundRole of Prolactin and Vasoinhibins in the Regulation of Vascular Function in Mammary Gland
Clapp, C., Thébault, S. C., & de la Escalera, G. M. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9067-7 · Cited by 43 · see citing works
“Because immune cells contribute to mammary gland involution after lactation [3] and are critical for breast cancer progression [90], the stimulation by PRL to release proangiogenic factors probably influences the way these cells regulate the normal and malignant mammary gland.”
BackgroundBergström, S. H., Hammarsten, P., Adamo, H. H., Wikström, P., & Bergh, A. R. J. (2010) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2011.540009 · Cited by 42 · see citing works
Kim, J. H., Hur, J. H., Lee, S. M., Im, K.-S., Kim, N., & Sur, J. (2011) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.10.022 · Cited by 42 · see citing works
Klement, H., Croix, B. S., Milsom, C., May, L. L., Guo, Q., Yu, J., Klement, P., & Rak, J. W. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070298 · Cited by 41 · see citing works
“It is thought provoking that many cellular components of the angiogenic circuitry in cancer (eg, endothelial or inflammatory cells) are also profoundly affected by the atherosclerotic process and other aspects of vascular aging.(13) This could be of considerable significance for the efficacy of anticancer therapies in…”
Tumor-Associated Macrophages as Targets for Tumor Immunotherapy
Weigert, A., Sekar, D., & Brüne, B. (2008) · Immunotherapy · doi:10.2217/1750743x.1.1.83 · Cited by 40 · see citing works
Kim, J. H., Yu, C.-H., Yhee, J. Y., Im, K.-S., & Sur, J. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.10.023 · Cited by 38 · see citing works
Dong, L., Yuan, Y., Opansky, C., Chen, Y., Aguilera‐Barrantes, I., Wu, S., Yuan, R., Cao, Q., Cheng, Y. C., Sahoo, D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15123 · Cited by 38 · see citing works
“Stimulating microvascular remodeling that may lead to de novo tumor arteriogenesis rather than increasing microvascular density [15, 35, 36] could play a key role in the malignant progression of BCs.”
BackgroundResultInfluentialMartı́nez-Poveda, B., Garcia‐Vilas, J. A., Cárdenas, C., Melgarejo, E., Quesada, A. R., & Medina, M. Á. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055203 · Cited by 38 · see citing works
d’Onofrio, A., Gandolfi, A., & Rocca, A. (2009) · Cell Proliferation · doi:10.1111/j.1365-2184.2009.00595.x · Cited by 38 · see citing works
Continuous Delivery of IFN-β Promotes Sustained Maturation of Intratumoral Vasculature
Dickson, P. V., Hamner, J. B., Streck, C. J., Ng, C. Y., McCarville, M. B., Calabrese, C. R., Gilbertson, R. J., Stewart, C. F., Wilson, C., Gaber, M. W., et al. (2007) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0259 · Cited by 37 · see citing works
“Using this approach, we have identified an additional activity not previously ascribed to IFN-h, that being arterialization of the intratumoral vessels, a process characterized by remodeling and maturation of the vasculature of established tumors (13).”
MethodAngiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases
Kobayashi, H. (2005) · Frontiers in bioscience · doi:10.2741/1561 · Cited by 35 · see citing works
“The infiltrated inflammatory cells promote the formation and enlargement of peritumoral lymphatic vessels, and contribute to tumor to metastasize to distant organs (100).”
BackgroundLiu, J., Wang, P., Zhang, P., Zhang, X., Du, H., Liu, Q., Huang, B., Qian, C., Zhang, S., Zhu, W., et al. (2019) · Journal of Applied Genetics · doi:10.1007/s13353-019-00507-w · Cited by 33 · see citing works
Ren, B., Rose, J. B., Liu, Y., Jaskula‐Sztul, R., Contreras, C. M., Beck, A. W., & Chen, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111980 · Cited by 32 · see citing works
“The significant increase in intratumoral capillaries during tumor progression [89,90] reasonably requires the concurrent expansion of upstream arterioles [20,55,89,91].”
BackgroundTyrosine kinase inhibitors of VEGF receptors: clinical issues and remaining questions
van Cruijsen, H. (2009) · Frontiers in bioscience · doi:10.2741/3377 · Cited by 31 · see citing works
Vicioso, L., Gonzalez, F. J., Alvarez, M., Ribelles, N., Molina, M., Márquez, A., Pérez, L. M. G., Matilla, A., & Alba, E. (2005) · American Journal of Clinical Pathology · doi:10.1309/0864af2u3lgpcf3j · Cited by 31 · see citing works
Diodovich, C., Bianchi, M. G., Bowe, G., Acquati, F., Taramelli, R., Parent‐Massin, D., & Gribaldo, L. (2004) · Toxicology · doi:10.1016/j.tox.2004.03.021 · Cited by 31 · see citing works
Live-cell imaging of tumor proteolysis: Impact of cellular and non-cellular microenvironment
Rothberg, J. M., Sameni, M., Moin, K., & Sloane, B. F. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.07.025 · Cited by 29 · see citing works
“There is an extensive literature [155–168] on the role of the tumor microenvironment in promoting breast tumor progression.”
BackgroundRole of monocyte‐lineage cells in prostate cancer cell invasion and tissue factor expression
Lindholm, P. F., Lü, Y., Adley, B. P., Vladislav, I. T., Jovanovic, B. D., Sivapurapu, N., Yang, X. J., & Kajdacsy‐Balla, A. (2010) · The Prostate · doi:10.1002/pros.21202 · Cited by 28 · see citing works
Owen, J. L., Criscitiello, M. F., Libreros, S., Garcia‐Areas, R., Guthrie, K. M., Torroella‐Kouri, M., & Iragavarapu‐Charyulu, V. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.05.004 · Cited by 28 · see citing works
“Enhanced leukocyte infiltration of tumors has been associated with increased tumor vascularity [64].”
BackgroundAronica, S. M., Raiber, L., Hanzly, M. I., & Kisela, C. (2008) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0034 · Cited by 27 · see citing works
“Several studies have shown that cancerous tumors can produce increased amounts of VEGF, which, in turn stimulate the proliferation and migration of endothelial cells (Bachelder and others 2002; Yu and Rak 2003).”
A Basis for Distinguishing Cultured Dendritic Cells and Macrophages in Cytospins and Fixed Sections
Vakkila, J., Lotze, M. T., Riga, C., & Jaffe, R. (2005) · Pediatric and Developmental Pathology · doi:10.1007/s10024-004-5045-2 · Cited by 27 · see citing works
“complex, and substantial evidence supports the notion that they actually promote tumour growth [24,30].”
BackgroundTumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer
Yoshida, S., Kawai, H., Eguchi, T., Sukegawa, S., Oo, M. W., Chang, A., Takabatake, K., Nakano, K., Okamoto, K., & Nagatsuka, H. (2019) · Cells · doi:10.3390/cells8070761 · Cited by 26 · see citing works
“Blood vessels generally supply oxygen and nutrients crucial for tumor growth [28,29].”
BackgroundAge‐related properties of the tumour vasculature in renal cell carcinoma
Meehan, B., Appu, S., Croix, B. S., Rak‐Poznanska, K., Klotz, L., & Rak, J. W. (2010) · British Journal of Urology · doi:10.1111/j.1464-410x.2010.09569.x · Cited by 26 · see citing works
Clinical relevance of circulating midkine in ulcerative colitis
Krzystek‐Korpacka, M., Neubauer, K., & Matusiewicz, M. (2009) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2009.248 · Cited by 26 · see citing works
“Also, the recruitment of inflammatory cells secreting angiogenic factors indirectly supports angiogenesis (37).”
BackgroundRego, S. L., Helms, R. S., & Dréau, D. (2013) · Immunologic Research · doi:10.1007/s12026-013-8434-7 · Cited by 26 · see citing works
Goodale, D. B., Phay, C., Brown, W., Gray‐Statchuk, L., Furlong, P., Lock, M. I., Chin-Yee, I. H., Keeney, M., & Allan, A. L. (2008) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20449 · Cited by 25 · see citing works
Collateral Growth in the Peripheral Circulation: A Review
Unthank, J. L., Sheridan, K. M., & Dalsing, M. C. (2004) · Vascular and Endovascular Surgery · doi:10.1177/153857440403800401 · Cited by 25 · see citing works
Ilyas, A., Asghar, W., Ahmed, S., Lotan, Y., Hsieh, J., Kim, Y. T., & Iqbal, S. M. (2014) · Analytical Methods · doi:10.1039/c4ay00781f · Cited by 24 · see citing works
Duggan, C. R., Tapsoba, J. D. D., Shivappa, N., Harris, H. R., Hébert, J. R., Wang, C., & McTiernan, A. (2020) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-20-0181 · Cited by 24 · see citing works
“In addition, consumption of energy-dense foods contributes to the likelihood of increased adiposity which, in turn, is linked to chronic inflammation and increased risk of cancer (5, 28, 29).”
BackgroundSerum levels of angiogenic cytokines decrease after radiotherapy in non-Hodgkin lymphomas
Ria, R., Cirulli, T., Giannini, T., Bambace, S., Serio, G., Portaluri, M. G. A., Ribatti, D., Vacca, A., & Dammacco, F. (2008) · Clinical and Experimental Medicine · doi:10.1007/s10238-008-0170-2 · Cited by 24 · see citing works
“mast cells [4] and macrophages [5], and stimulate resting endothelial cells by means of cognate-specific tyrosinekinase receptors [2].”
BackgroundAronica, S. M., Fanti, P., Kaminskaya, K., Gibbs, K., Raiber, L., Nazareth, M. R., Bucelli, R. C., Mineo, M., Grzybek, K., Kumin, M., et al. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000019961.59306.f6 · Cited by 23 · see citing works
“Chemokines displaying a conserved ELR (glutamine–leucine–arginine) motif have been shown to promote the growth of some cancer cells, potentially through the stimulation of angiogenesis [12, 26, 27].”
BackgroundTamma, R., Limongelli, L., Maiorano, E., Pastore, D., Cascardi, E., Tempesta, A., Carluccio, P., Mastropasqua, M. G., Capodiferro, S., Covelli, C., et al. (2018) · Annals of Hematology · doi:10.1007/s00277-018-3575-3 · Cited by 20 · see citing works
Adamo, H. H., Strömvall, K., Nilsson, M., Bergström, S. H., & Bergh, A. R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141601 · Cited by 20 · see citing works
Serum levels of angiogenic cytokines decrease after antineoplastic radiotherapy
Ria, R., Portaluri, M. G. A., Russo, F., Cirulli, T., Pietro, G. D., Bambace, S., Cucci, F., Romano, T., Vacca, A., & Dammacco, F. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.05.022 · Cited by 20 · see citing works
Correlation of vascularization and inflammation with severity of oral leukoplakia
Abbas, F. M., & Fayazi-Boroujeni, M. (2017) · Iranian journal of pathology · doi:10.30699/ijp.2017.25044 · Cited by 18 · see citing works
The Angiogenic Switch in Tumorigenesis
WICKI, A. N., & Christofori, G. (2007) · Springer eBooks · doi:10.1007/978-3-540-33177-3_4 · Cited by 17 · see citing works
Interleukin13 haplotypes and susceptibility of Iranian women to breast cancer
Faghih, Z., Erfani, N., Razmkhah, M., Sameni, S., Talei, A., & Ghaderi, A. A. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9400-7 · Cited by 16 · see citing works
Carvalho, M. I., Pires, I. C. R., Dias, M., Prada, J., Gregório, H., Lobo, L., & QUEIROGA, F. L. (2015) · Analytical Cellular Pathology · doi:10.1155/2015/920409 · Cited by 13 · see citing works
“Angiogenesis is crucial in the growth and spread of malignant mammary tumors [38, 39].”
BackgroundResultInhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy
de Keijzer, M. J., de Klerk, D. J., de Haan, L. R., van Kooten, R. T., Franchi, L. P., Dias, L. M., Kleijn, T. G., van Doorn, D. J., Heger, M., & on behalf of the Photodynamic Therapy Study Group (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2099-1_19 · Cited by 12 · see citing works
Spontaneous regression of pancreatic cancer
Cann, S. A. H., Gunn, H., van Netten, J. P., & van Netten, C. (2004) · Cited by 12 · see citing works
Time‐lapse microscopy of macrophages during embryonic vascular development
Al‐Roubaie, S., Hughes, J. H., Filla, M. B., Lansford, R. D., Lehoux, S., & Jones, E. A. V. (2012) · Developmental Dynamics · doi:10.1002/dvdy.23835 · Cited by 11 · see citing works
Tumor Development Under Combination Treatments with Anti-angiogenic Therapies
Ledzewicz, U., d’Onofrio, A., & Schättler, H. (2012) · Lecture notes on mathematical modelling in the life sciences · doi:10.1007/978-1-4614-4178-6_11 · Cited by 10 · see citing works
“complex process driven by pro-angiogenic factors that are being released as the tumor cells lack a full level of nutrients [66].”
Background
- Authors
- Yu, J. L., & Rak, J. W.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Rak, Janusz W
- Venue
- Breast Cancer Research
- Published
- 2003-04
- Volume
- 5
- Issue
- 2
- Pages
- 83-8
- ISSN
- 1465-5411 (ISSN-L)
- 1465-542X
- PMC
- PMC154151
- OpenAlex
- W1860557886
- Cited by
- 146
- References
- 88
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 1 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 13
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Breast Cancer Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- breast cancer, tumor microenvironment, tumor angiogenesis, arteriogenesis, inflammatory cells, immune cells, macrophages, MCP-1, endothelial cells, stromal cells, growth factors, proteolytic enzymes
- MeSH terms
- Animals, Blood Vessels, Breast Neoplasms, Humans, Lymphokines, Macrophages, Monocytes, Neovascularization, Pathologic, Macrophage Colony-Stimulating Factor, Endothelial Growth Factors, Chemokine CCL2, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
