The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Clinical review: Critical illness polyneuropathy and myopathy
Open accessAbstract
Critical illness polyneuropathy (CIP) and myopathy (CIM) are major complications of severe critical illness and its management. CIP/CIM prolongs weaning from mechanical ventilation and physical rehabilitation since both limb and respiratory muscles can be affected. Among many risk factors implicated, sepsis, systemic inflammatory response syndrome, and multiple organ failure appear to play a crucial role in CIP/CIM. This review focuses on epidemiology, diagnostic challenges, the current understanding of pathophysiology, risk factors, important clinical consequences, and potential interventions to reduce the incidence of CIP/CIM. CIP/CIM is associated with increased hospital and intensive care unit (ICU) stays and increased mortality rates. Recently, it was shown in a single centre that intensive insulin therapy significantly reduced the electrophysiological incidence of CIP/CIM and the need for prolonged mechanical ventilation in patients in a medical or surgical ICU for at least 1 week. The electrophysiological diagnosis was limited by the fact that muscle membrane inexcitability was not detected. These results have yet to be confirmed in a larger patient population. One of the main risks of this therapy is hypoglycemia. Also, conflicting evidence concerning the neuromuscular effects of corticosteroids exists. A systematic review of the available literature on the optimal approach for preventing CIP/CIM seems warranted.
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Cites
Intensive insulin therapy in critically ill patients.
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Self-citationIntensive insulin therapy in the medical ICU
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Insulin therapy protects the central and peripheral nervous system of intensive care patients
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Self-citationNeuromuscular dysfunction acquired in critical illness: a systematic review
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Cited by
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Self-citationICU-Acquired Swallowing Disorders
Macht, M., Wimbish, T., Bodine, C., & Moss, M. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31829caf33 · Cited by 261
Endocrine Responses to Critical Illness: Novel Insights and Therapeutic Implications
Boonen, E., & Van den Berghe, G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4115 · Cited by 105
Vargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51
Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis
Mizokami, T., Fukui, T., Imoto, H., Fujii, H., Sato, Y., Nunoi, K., & Okamura, K. (2015) · Internal Medicine · doi:10.2169/internalmedicine.54.2954 · Cited by 4
Metadata
- Authors
- Hermans, G., De Jonghe, B., Bruyninckx, F., & Berghe, G.
- Venue
- Critical Care
- Published
- 2008
- Volume
- 12
- Issue
- 6
- Pages
- 238
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2078620010
- Cited by
- 320
- References
- 88
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- gold
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