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Cited by 320

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Clinical review: Critical illness polyneuropathy and myopathy

Open access
Hermans, Greet, De Jonghe, Bernard, Bruyninckx, Frans, Berghe, Greet·2008·Critical Care
DOI 10.1186/cc7100
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Abstract

Critical illness polyneuropathy (CIP) and myopathy (CIM) are major complications of severe critical illness and its management. CIP/CIM prolongs weaning from mechanical ventilation and physical rehabilitation since both limb and respiratory muscles can be affected. Among many risk factors implicated, sepsis, systemic inflammatory response syndrome, and multiple organ failure appear to play a crucial role in CIP/CIM. This review focuses on epidemiology, diagnostic challenges, the current understanding of pathophysiology, risk factors, important clinical consequences, and potential interventions to reduce the incidence of CIP/CIM. CIP/CIM is associated with increased hospital and intensive care unit (ICU) stays and increased mortality rates. Recently, it was shown in a single centre that intensive insulin therapy significantly reduced the electrophysiological incidence of CIP/CIM and the need for prolonged mechanical ventilation in patients in a medical or surgical ICU for at least 1 week. The electrophysiological diagnosis was limited by the fact that muscle membrane inexcitability was not detected. These results have yet to be confirmed in a larger patient population. One of the main risks of this therapy is hypoglycemia. Also, conflicting evidence concerning the neuromuscular effects of corticosteroids exists. A systematic review of the available literature on the optimal approach for preventing CIP/CIM seems warranted.

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Metadata

Authors
Hermans, G., De Jonghe, B., Bruyninckx, F., & Berghe, G.
Venue
Critical Care
Publisher
Springer Science and Business Media LLC
Published
2008
Volume
12
Issue
6
Pages
238
ISSN
1364-8535 (ISSN-L)
DOI
10.1186/cc7100
OpenAlex
W2078620010
Cited by
320
References
88
FWCI
8.37
Type
journal article
Language
en
Open access
gold

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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