The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The leading causes of death after burn injury in a single pediatric burn center
Open accessAbstract
Introduction: Severe thermal injury is characterized by profound morbidity and mortality. Advances in burn and critical care, including early excision and grafting, aggressive resuscitation and advances in antimicrobial therapy have made substantial contributions to decrease morbidity and mortality. Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival. Methods: Primary causes of death were reviewed from 144 pediatric autopsy reports. Percentages of patients that died from anoxic brain injuries, sepsis, or multi-organ failure were calculated by comparing to the total number of deaths. Data was stratified by time (from 1989 to 1999, and 1999 to 2009), and gender. Statistical analysis was done by chi-squared, Student's t-test and Kaplan-Meier for survival where applicable. Significance was accepted as P < 0.05. Results: Five-thousand two-hundred-sixty patients were admitted after burn injury from July 1989 to June 2009, and of those, 145 patients died after burn injury. Of these patients, 144 patients had an autopsy. The leading causes of death over 20 years were sepsis (47%), respiratory failure (29%), anoxic brain injury (16%), and shock (8%). From 1989 to 1999, sepsis accounted for 35% of deaths but increased to 54% from 1999 to 2009, with a significant increase in the proportion due to antibiotic resistant organisms (P < 0.05). Conclusions: Sepsis is the leading cause of death after burn injury. Multiple antibiotic resistant bacteria now account for the bulk of deaths due to sepsis. Further improvement in survival may require improved strategies to deal with this problem.
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(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746
The Value of the Autopsy in Three Medical Eras
Goldman, L., Sayson, R., Robbins, S., Cohn, L. H., Bettmann, M., & Weisberg, M. (1983) · New England Journal of Medicine · doi:10.1056/nejm198304283081704 · Cited by 809
Pathophysiologic Response to Severe Burn Injury
Jeschke, M. G., Chinkes, D. L., Finnerty, C. C., Kulp, G., Suman, O. E., Norbury, W. B., Branski, L. K., Gauglitz, G. G., Mlcak, R. P., & Herndon, D. N. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e3181856241 · Cited by 695
Self-citationAmerican Burn Association Consensus Conference to Define Sepsis and Infection in Burns
Greenhalgh, D. G., Saffle, J. R., Holmes, J. H., Gamelli, R. L., Palmieri, T. L., Horton, J. W., Tompkins, R. G., Traber, D. L., Mozingo, D. W., Deitch, E. A., et al. (2007) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181599bc9 · Cited by 695
Self-citationReversal of Catabolism by Beta-Blockade after Severe Burns
Herndon, D. N., Hart, D. W., Wolf, S. E., Chinkes, D. L., & Wolfe, R. R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010342 · Cited by 639
Self-citationPersistence of muscle catabolism after severe burn
Hart, D. W., Wolf, S. E., Mlcak, R., Chinkes, D. L., Ramzy, P. I., Obeng, M. K., Ferrando, A. A., Wolfe, R. R., & Herndon, D. N. (2000) · Surgery · doi:10.1067/msy.2000.108059 · Cited by 543
Self-citationSupport of the metabolic response to burn injury
Herndon, D. N., & Tompkins, R. G. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16360-5 · Cited by 532
Self-citationDeterminants of Skeletal Muscle Catabolism After Severe Burn
Hart, D. W., Wolf, S. E., Chinkes, D. L., Gore, D. C., Mlcak, R. P., Beauford, R. B., Obeng, M. K., Lal, S., Gold, W. F., Wolfe, R. R., et al. (2000) · Annals of Surgery · doi:10.1097/00000658-200010000-00001 · Cited by 339
Self-citationAntibiotic resistance—What’s dosing got to do with it?
Roberts, J. A., Kruger, P., Paterson, D. L., & Lipman, J. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e318180fe62 · Cited by 339
Cited by
Burn wound healing and treatment: review and advancements
Rowan, M. P., Cancio, L. C., Elster, E. A., Burmeister, D. M., Rose, L. F., Natesan, S., Chan, R. K., Christy, R. J., & Chung, K. K. (2015) · Critical Care · doi:10.1186/s13054-015-0961-2 · Cited by 1,015
How to manage Pseudomonas aeruginosa infections
Bassetti, M., Vena, A., Croxatto, A., Righi, E., & Guery, B. (2018) · Drugs in Context · doi:10.7573/dic.212527 · Cited by 746
The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update
Reynolds, D., & Kollef, M. (2021) · Drugs · doi:10.1007/s40265-021-01635-6 · Cited by 721
Metadata
- Authors
- Williams, F. N., Herndon, D. N., Hawkins, H. K., Lee, J. O., Cox, R. A., Kulp, G. A., Finnerty, C. C., Chinkes, D. L., & Jeschke, M. G.
- Venue
- Critical Care
- Published
- 2009-11-17
- Volume
- 13
- Issue
- 6
- Pages
- R183-R183
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2132481695
- Cited by
- 375
- References
- 22
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- gold
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