The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
Open accessAbstract
Background: Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors. Results: Unsupervised hierarchical clustering analysis showed that six models (TgWAP-Myc, TgMMTV-Neu, TgMMTV-PyMT, TgWAP-Int3, TgWAP-Tag, and TgC3(1)-Tag) yielded tumors with distinctive and homogeneous expression patterns within each strain. However, in each of four other models (TgWAP-T 121 , TgMMTV-Wnt1, Brca1 Co/Co ;TgMMTV-Cre;p53+/- and DMBA-induced), tumors with a variety of histologies and expression profiles developed. In many models, similarities to human breast tumors were recognized, including proliferation and human breast tumor subtype signatures. Significantly, tumors of several models displayed characteristics of human basal-like breast tumors, including two models with induced Brca1 deficiencies. Tumors of other murine models shared features and trended towards significance of gene enrichment with human luminal tumors; however, these murine tumors lacked expression of estrogen receptor (ER) and ER-regulated genes. TgMMTV-Neu tumors did not have a significant gene overlap with the human HER2+/ER- subtype and were more similar to human luminal tumors. Conclusion: Many of the defining characteristics of human subtypes were conserved among the mouse models. Although no single mouse model recapitulated all the expression features of a given human subtype, these shared expression features provide a common framework for an improved integration of murine mammary tumor models with human breast tumors.
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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
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Self-citationAn oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.
Sweet-Cordero, A., Mukherjee, S., Subramanian, A., You, H., Roix, J. J., Ladd-Acosta, C., Mesirov, J., Golub, T. R., & Jacks, T. (2005) · Nature Genetics · doi:10.1038/ng1490 · Cited by 414
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Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2344 · Cited by 1,967
Choosing the right cell line for breast cancer research
Holliday, D. L., & Speirs, V. (2011) · Breast Cancer Research · doi:10.1186/bcr2889 · Cited by 1,541
kConFab, Lim, E., Vaillant, F., Wu, D., Forrest, N. C., Pal, B., Hart, A. H., Asselin-Labat, M.-L., Gyorki, D. E., Ward, T., et al. (2009) · Nature Medicine · doi:10.1038/nm.2000 · Cited by 1,492
Metadata
- Authors
- Herschkowitz, J. I., Simin, K., Weigman, V. J., Mikaelian, I., Usary, J., Hu, Z., Rasmussen, K. E., Jones, L. P., Assefnia, S., Chandrasekharan, S., Backlund, M. G., Yin, Y., Khramtsov, A. I., Bastein, R., Quackenbush, J., Glazer, R. I., Brown, P. H., Green, J. E., Kopelovich, L., Furth, P. A., Palazzo, J. P., Olopade, O. I., Bernard, P. S., Churchill, G. A., Van Dyke, T., & Perou, C. M.
- Venue
- Genome Biology
- Published
- 2007-05-10
- Volume
- 8
- Issue
- 5
- Pages
- R76-R76
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- OpenAlex
- W2135548733
- Cited by
- 1,285
- References
- 7
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- gold
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- Herschkowitz, J. I., Simin, K., Weigman, V. J., Mikaelian, I., Usary, J., Hu, Z., Rasmussen, K. E., Jones, L. P., Assefnia, S., Chandrasekharan, S., Backlund, M. G., Yin, Y., Khramtsov, A. I., Bastein, R., Quackenbush, J., Glazer, R. I., Brown, P. H., Green, J. E., Kopelovich, L., . . . Perou, C. M. (2007). Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biology. https://doi.org/10.1186/gb-2007-8-5-r76
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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