Cited by 132Reproductive Biology and FertilityAdvanced Proteomics Techniques and ApplicationsReproductive biology and impacts on aquatic species

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Proteomic analysis of human follicular fluid from fertile women

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Zamah, Alberuni M, Hassis, Maria E, Albertolle, Matthew E, Williams, Katherine E·2015·Clinical Proteomics

DOI 10.1186/s12014-015-9077-6PMC PMC4357057

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Abstract

BACKGROUND: Follicular fluid is a unique biological fluid in which the critical events of oocyte and follicular maturation and somatic cell-germ cell communication occur. Because of the intimate proximity of follicular fluid to the maturing oocyte, this fluid provides a unique window into the processes occurring during follicular maturation. A thorough identification of the specific components within follicular fluid may provide a better understanding of intrafollicular signaling, as well as reveal potential biomarkers of oocyte health for women undergoing assisted reproductive treatment. In this study, we used high and low pH HPLC peptide separations followed by mass spectrometry to perform a comprehensive proteomic analysis of human follicular fluid from healthy ovum donors. Next, using samples from a second set of patients, an isobaric mass tagging strategy for quantitative analysis was used to identify proteins with altered abundances after hCG treatment. RESULTS: A total of 742 follicular fluid proteins were identified in healthy ovum donors, including 413 that have not been previously reported. The proteins belong to diverse functional groups including insulin growth factor and insulin growth factor binding protein families, growth factor and related proteins, receptor signaling, defense/immunity, anti-apoptotic proteins, matrix metalloprotease related proteins, and complement activity. In a quantitative analysis, follicular fluid samples from age-matched women undergoing in vitro fertilization oocyte retrieval were compared and 17 follicular fluid proteins were found at significantly altered levels (p < 0.05) between pre-hCG and post-hCG samples. These proteins belong to a variety of functional processes, including protease inhibition, inflammation, and cell adhesion. CONCLUSIONS: This database of FF proteins significantly extends the known protein components present during the peri-ovulatory period and provides a useful basis for future studies comparing follicular fluid proteomes in various fertility, disease, and environmental exposure conditions. We identified 17 differentially expressed proteins after hCG treatment and together these data showed the feasibility for defining biomarkers that illuminate how the ovarian follicle microenvironment is altered in various infertility-related conditions.

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Figure 1 Overlap of proteins identified at 5% false discovery rate in three follicular fluid samples from ovum donors undergoing ovarian stimulation for assisted reproductive technology. A total of 742 proteins were identified, of which 305 were found in all three samples. Source accessions for the identified proteins are listed in Additional file 1: Table S1.CC BY · PubMed Central

Figure 2 Gene ontology analysis of the proteins identified in human follicular fluid. Proteins were classified according to A) biological processes, B) molecular function, and C) cellular compartment. Results are displayed as percent of genes classified to a category over the total number of class hits.CC BY · PubMed Central

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See all 132

Authors: Zamah, A. M., Hassis, M. E., Albertolle, M. E., & Williams, K. E.
Affiliations: University of Illinois Chicago (US)
University of California, San Francisco (US)
Corresponding author: Zamah, Alberuni M
ORCID: Albertolle, Matthew E
Venue: Clinical Proteomics
Publisher: Springer Science and Business Media LLC
Published: 2015-03-03
Volume: 12
Issue: 1
Pages: 5-5
ISSN: 1542-6416 (ISSN-L)
1559-0275
DOI: 10.1186/s12014-015-9077-6
PMC: PMC4357057
OpenAlex: W2146697938
Cited by: 132
References: 105
Citations by year: 2026: 8 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 26 · 2021: 6 · 2020: 16 · 2019: 9 · 2018: 16 · 2017: 17 · 2016: 6 · 2015: 2
FWCI: 14.66
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: Clinical Proteomics (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Cancer Institute (P30CA082103)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD001262)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Keywords: follicular fluid, oocyte maturation, follicle maturation, human chorionic gonadotropin, hCG treatment, differentially expressed proteins, insulin-like growth factor, protease inhibition, inflammation, cell adhesion, infertility

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Proteomic analysis of human follicular fluid from fertile women

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