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Cited by 94Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesRedox biology and oxidative stress

Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study

Open access
Mao, Chen, Yuan, Jin-Qiu, Lv, Yue-Bin, Gao, Xiang, Yin, Zhao-Xue, Kraus, Virginia Byers, Luo, Jie-Si, Chei, Choy-Lye +3 more·2019·BMC Geriatrics
DOI 10.1186/s12877-019-1109-zPMC PMC6466801
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Abstract

BACKGROUND: Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA), with all-cause mortality in older adults. METHODS: This is a community-based cohort study of 2224 participants (women:1227, median age: 86 years). We included individuals aged 65 or above and with plasma SOD activity and/or MDA tests at baseline. We evaluated the hazard ratios (HRs) and 95% confidence intervals (CIs) by multivariable Cox models. RESULTS: We documented 858 deaths during six years of follow-up. There was a significant interaction effect of sex with the association between SOD activity and mortality (P < 0.001). Compared with the lowest quintile, the risk of all-cause mortality was inversely associated with increasing quintiles of plasma SOD activity in women(P-trend< 0.001), with adjusted HRs for the second through fifth quintiles of 0.73 (95% CI 0.53-1.02), 0.52(95% CI 0.38-0.72), 0.53(95% CI 0.39-0.73), and 0.48(95% CI 0.35-0.66). There were no significant associations between SOD activity and mortality in men (P-trend = 0.64), and between MDA and mortality in all participants (P-trend = 0.79). CONCLUSIONS: Increased activity of SOD was independently associated with lower all-cause mortality in older women but not in men. This epidemiological study lent support for the free radical/oxidative stress theory of aging.

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  • Upregulation of SODs might mirror an impaired regulation of the cell survival machinery, to the point of even increasing mortality in elderly patients.

    “Upregulation of SODs might, therefore, mirror an impaired regulation of the cell survival machinery, to the point of even increase mortality in elderly patients [41].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [41]

  • In 858 deaths investigated over 6 years, a strong effect of sex (female) in the association between SOD activity and mortality was observed.

    “The recent contribution by Mao et al. reported that, in 858 deaths investigated throughout a period of 6 years, a strong effect of sex (female) in the association between SOD activity and mortality was observed [41].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [41]

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  1. [15]Pham TM Fujino Y Nakachi K Suzuki K Ito Y Watanabe Y Inaba Y Tajima K Tamakoshi A Yoshimura T Relationship between serum levels of superoxide dismutase activity and subsequent risk of Cancer mortality: findings from a nested case-control study within the Japan collaborative cohort study Asian Pac J Cancer Prev 2009 10 69 73 20553085
  2. [25]Joint Committee for Developing Chinese guidelines on Prevention and Treatment of Dyslipidemia in Adults. Chinese guidelines on prevention and treatment of dyslipidemia in adults (2016). Chinese Circulation Journal. 2016;31:937–53.
  3. [38]Kautzky WA Sex and gender differences in endocrinology. In sex and gender aspects in clinical medicine (eds Oertelt-Prigione S, Regitz-Zagrosek V), pp 125–149 2012 London, UK Springer

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Authors
Mao, C., Yuan, J.-Q., Lv, Y.-B., Gao, X., Yin, Z.-X., Kraus, V. B., Luo, J.-S., Chei, C.-L., Matchar, D. B., Zeng, Y., & Shi, X.-M.
Affiliations
  • Southern Medical University (CN)
  • Sun Yat-sen University (CN)
  • Pennsylvania State University (US)
  • Duke University (US)
  • Chinese Center For Disease Control and Prevention (CN)
  • Duke-NUS Medical School (SG)
  • Peking University (CN)
Corresponding author
Shi, Xiao-Ming
ORCID
Venue
BMC Geriatrics
Publisher
Springer Science and Business Media LLC
Published
2019-04-15
Volume
19
Issue
1
Pages
104-104
ISSN
1471-2318 (ISSN-L)
DOI
10.1186/s12877-019-1109-z
PMC
PMC6466801
OpenAlex
W2945055189
Cited by
94
References
41
Citations by year
2026: 8 · 2025: 11 · 2024: 19 · 2023: 12 · 2022: 22 · 2021: 14 · 2020: 7 · 2019: 1
FWCI
6.61
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Geriatrics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Sciences Foundation of China (71233001, 71490732 and 81573247)
  • United Nations Fund for Population Activities (2P01AG031719)
  • Claude D. Pepper Older Americans Independence Centers grant (5P30 AG028716)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
superoxide dismutase, malondialdehyde, oxidative stress, all-cause mortality, older adults, sex differences, free radical theory of aging, aging biomarkers, plasma biomarkers
MeSH terms
Age Factors, Aged, Aged, 80 and over, Female, Follow-Up Studies, Humans, Male, Malondialdehyde, Mortality, Prospective Studies, Sex Factors, Superoxide Dismutase, Cohort Studies, Biomarkers, Oxidative Stress, Independent Living

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