Reactive oxygen species, aging and antioxidative nutraceuticals

Lee, J.; Koo, N.; Min, D. B.

doi:10.1111/j.1541-4337.2004.tb00058.x

Cited by 864Antioxidant Activity and Oxidative StressPhytochemicals and Antioxidant ActivitiesExercise and Physiological Responses

Reactive oxygen species, aging and antioxidative nutraceuticals

Lee, J., Koo, N., Min, D. B.·2004·Comprehensive Reviews in Food Science and Food Safety

DOI 10.1111/j.1541-4337.2004.tb00058.x

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Abstract

The important roles of reactive oxygen species in diseases related to aging and the necessity and benefits of antioxidative nutraceuticals in the prevention of diseases and promotion of healthy aging have been extensively reported in recent years. Oxygen is an essential component of living organisms. The generation of reactive oxygen species such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and singlet oxygen is inevitable in aerobic metabolism of the body. Reactive oxygen species cause lipid oxidation, protein oxidation, DNA strand break and base modification, and modulation of gene expression. In the past several years, unprecedented progress has been made in the recognition and understanding of roles of reactive oxygen species in many diseases. These include atherosclerosis, vasospasms, cancers, trauma, stroke, asthma, hyperoxia, arthritis, heart attack, age pigments, dermatitis, cataractogenesis, retinal damage, hepatitis, liver injury, and periodontis, which are age-related. The body protects itself from the potential damages of reactive oxygen species. Its first line of defense is superoxide dismutases, glutathione peroxidases, and catalase. Scientists have indicated that antioxidant nutraceuticals supplied from daily diets quench the reactive oxygen species or are required as cofactors for antioxidant enzymes. Nutraceuticals play significant roles in the prevention of a number of age-related diseases and are essential for healthy aging. Epidemiological studies also reported the relevance of antioxidative nutraceuticals to health issues and the prevention of age-related diseases. Health-conscious consumers have made antioxidative nutraceuticals the leading trend in the food industry worldwide in recent years.

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Dietary sources commonly known for antioxidant properties include vitamin A, C, and E along with carotenoids, lipoic acid, and phenolic compounds found in plant products like fruits and vegetables.
“Dietary sources that are commonly known for their antioxidant properties include vitamin A, C, and E along with other antioxidants in carotenoids, lipoic acid, and phenolic compounds found in abundance in many plant products like fruits and vegetables [2,17,66].”
From Equol’s Anti-Aging Effects Protect against Environmental Assaults by Increasing Skin Antioxidant Defense and ECM Proteins While Decreasing Oxidative Stress and Inflammation (2018) · cites this paper as [66]
Carotenoid substances and vitamins A, C and E are said to be the most protective and correlate negatively with levels of oxidative stress.
“Carotenoid substances, found in fruit and vegetables, as well as vitamins A, C and E, are said to be the most protective and correlate negatively with levels of oxidative stress [45].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [45]

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Watkins, T. R., Bierenbaum, M. L., & Giampaolo, A. (2019) · CRC Press eBooks · doi:10.1201/9780367811099-22 · Cited by 7 · see citing works

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Role of oxidative stress in Alzheimer’s disease
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Review of methods to determine antioxidant capacities
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Authors: Lee, J., Koo, N., & Min, D. B.
Affiliations: Daejeon University (KR)
The Ohio State University (US)
ORCID: Lee, J.
Venue: Comprehensive Reviews in Food Science and Food Safety
Publisher: Wiley
Published: 2004-01
Volume: 3
Issue: 1
Pages: 21-33
ISSN: 1541-4337 (ISSN-L)
DOI: 10.1111/j.1541-4337.2004.tb00058.x
OpenAlex: W2054276115
Cited by: 864
References: 100
Citations by year: 2026: 14 · 2025: 28 · 2024: 37 · 2023: 43 · 2022: 60 · 2021: 60 · 2020: 50 · 2019: 52 · 2018: 55 · 2017: 43 · 2016: 46 · 2015: 63 · 2014: 50 · 2013: 54 · 2012: 51
FWCI: 8.79
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1054 d)
Locations: Comprehensive Reviews in Food Science and Food Safety (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: reactive oxygen species, aging, oxidative stress, age-related diseases, healthy aging, superoxide dismutase, glutathione peroxidase, catalase, lipid peroxidation, DNA damage, atherosclerosis, cancer prevention, cataract formation, antioxidant enzymes, dietary antioxidants

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Reactive oxygen species, aging and antioxidative nutraceuticals

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