The two-year course of late-life depression; results from the Netherlands study of depression in older persons
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BACKGROUND: We aimed to examine the course of depression during 2-year follow-up in a group clinically depressed older persons. Subsequently, we studied which socio-demographic and clinical characteristics predict a depression diagnoses at 2-year follow-up. METHODS: Data were used from the Netherlands Study of Depression in Older persons (NESDO; N = 510). Diagnoses of depression DSM-IV-TR criteria were available from 285 patients at baseline and at 2-year follow-up. Severity of the depressive symptoms, as assessed with the Inventory of Depressive Symptoms (IDS), was obtained from 6-monthly postal questionnaires. Information about socio-demographic and clinical variables was obtained from the baseline measurement. RESULT: From the 285 older persons who were clinically depressed at baseline almost half (48.4%) also suffered from a depressive disorder two years later. Patients with more severe depressive symptoms, comorbid dysthymia, younger age of onset and more chronic diseases were more likely to be depressed at 2-year follow-up. 61% of the persons that were depressed at baseline had a chronic course of depressive symptoms during these two years. CONCLUSIONS: Late-life depression often has a chronic course, even when treated conform current guidelines for older persons. Our results suggest that physical comorbidity may be candidate for adjusted and intensified treatment strategies of older depressed patients with chronic and complex pathology.
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The idiom 'thinking too much' denotes a broader mental health syndrome, with manifestations such as sadness, lack of motivation, poor concentration, sleep difficulties and irritability, perhaps similar to the construct of 'common mental disorders'.
“The idiom 'thinking too much' denotes a broader mental health syndrome, with manifestations such as sadness, lack of motivation, poor concentration, sleep difficulties and irritability, perhaps similar to the construct of 'common mental disorders'. 112-117”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [115]
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Self-citation
- Authors
- Comijs, H. C., Nieuwesteeg, J., Kok, R., van Marwijk, H. W., van der Mast, R. C., Naarding, P., Voshaar, R. C. O., Verhaak, P., de Waal, M. W., & Stek, M. L.
- Affiliations
- Amsterdam Public Health (NL)
- GGZ inGeest (NL)
- Parnassia Groep (NL)
- GGNet (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Comijs, Hannie C
- Venue
- BMC Psychiatry
- Published
- 2015-02-12
- Volume
- 15
- Issue
- 1
- Pages
- 20-20
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC4329675
- OpenAlex
- W2059949121
- Cited by
- 136
- References
- 47
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 15 · 2021: 19 · 2020: 9 · 2019: 16 · 2018: 19 · 2017: 14 · 2016: 14 · 2015: 3
- FWCI
- 17.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Leiden Repository (Leiden University) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Research Explorer (The University of Manchester) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Funders
- Vrije Universiteit Amsterdam
- Fonds NutsOhra (0701-065, project 0701‐065)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- geriatric depression, course of depression, older adults, chronic depression, depression severity, dysthymia, age of onset, comorbidities, chronic physical illness, predictors of recurrence
- MeSH terms
- Aged, Aged, 80 and over, Chronic Disease, Depression, Depressive Disorder, Female, Humans, Male, Middle Aged, Netherlands, Personality Inventory, Surveys and Questionnaires, Recurrence, Comorbidity, Treatment Outcome, Dysthymic Disorder
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