Serum folate levels in bipolar disorder: a systematic review and meta-analysis
Open accessAbstract
Background: Bipolar disorder (BD) is a major psychiatric illness, however its physiopathology is unclear. The role of folate in the physiopathology of BD is controversial. We conducted this systematic review and meta-analysis to investigate the effect of folate in BD patients. Methods: We performed a thorough literature study of the PubMed, Embase, ScienceDirect, ClinicalKey, Cochrane Library, ProQuest, Web of Science, and ClinicalTrials.gov databases until December 21st, 2018. Random effects meta-analysis was conducted. Results: Six articles involving 481 patients with BD and 760 controls were included. The meta-analysis results suggested that serum folate levels in the patients with BD were significantly lower than those in the controls (Hedges’ g = − 0.211, 95% confidence interval = − 0.391 to − 0.031, p = 0.021). Conclusion: The current meta-analysis show it might be association between lower serum folate levels and patient with BD. However, we could not distinguish the potentially confounding effects of mood states on the folate levels. Further prospective studies including subjects with different mood states and possible physiopathology are warranted to investigate the association between folate deficiency and the etiology of BD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with bipolar disorder have low levels of vitamin B9 (folate).
“In a recent study, it has been reported that patients with bipolar disorder have low levels of vitamin B9 (folate) (Hsieh et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Hsieh et al. 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722 · see citing works
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,769 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, 5th ed.
Carter, M. J. (2014) · Therapeutic Recreation Journal · Cited by 15,154 · see citing works
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099 · see citing works
(1996) · Cited by 6,884 · see citing works
Using Effect Size—or Why the P Value Is Not Enough
Sullivan, G. M., & Feinn, R. (2012) · Journal of Graduate Medical Education · doi:10.4300/jgme-d-12-00156.1 · Cited by 5,553 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · see citing works
Judd, L. L., Akiskal, H. S., Schettler, P. J., Coryell, W., Endicott, J., Maser, J. D., Solomon, D. A., Leon, A. C., & Keller, M. B. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.3.261 · Cited by 1,243 · see citing works
5, 10-Methylenetetrahydrofolate Reductase Gene Variants and Congenital Anomalies: A HuGE Review
Botto, L. D., & Yang, Q. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010290 · Cited by 1,045 · see citing works
Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role
Crider, K. S., Yang, T. P., Berry, R. J., & Bailey, L. B. (2012) · Advances in Nutrition · doi:10.3945/an.111.000992 · Cited by 1,022 · see citing works
Vitamin D deficiency and depression in adults: systematic review and meta-analysis
Anglin, R. E. S., Samaan, Z., Walter, S. D., & McDonald, S. D. (2013) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.106666 · Cited by 820 · see citing works
Molendijk, M. L., Spinhoven, P., Polak, M., Bus, B. A. A., Penninx, B. W. J. H., & Elzinga, B. M. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.105 · Cited by 702 · see citing works
The enduring psychosocial consequences of mania and depression
Coryell, W. H., Scheftner, W. A., Keller, M. B., Endicott, J., Maser, J. D., & Klerman, G. L. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.5.720 · Cited by 658 · see citing works
Cantoni, G. L. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66148-4 · Cited by 576 · see citing works
Assessing the influence of a single study in the meta-anyalysis estimate
Tobı́as, A. (1999) · Stata technical bulletin · Cited by 504 · see citing works
Nutritional psychiatry: The present state of the evidence
Marx, W., Moseley, G., Berk, M., & Jacka, F. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002026 · Cited by 469 · see citing works
Fernandes, B. S., Gama, C. S., Maria Ceresér, K., Yatham, L. N., Fries, G. R., Colpo, G., de Lucena, D., Kunz, M., Gomes, F. A., & Kapczinski, F. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.002 · Cited by 389 · see citing works
Domenici, E., Willé, D. R., Tozzi, F., Prokopenko, I., Miller, S. L., McKeown, A., Brittain, C. F., Rujescu, D., Giegling, I., Turck, C. W., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009166 · Cited by 347 · see citing works
Nutritional therapies for mental disorders
Lakhan, S. E., & Vieira, K. F. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-2 · Cited by 279 · see citing works
Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity
Gilbody, S. M., Lightfoot, T., & Sheldon, T. (2007) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.050385 · Cited by 251 · see citing works
L-Methylfolate: A Vitamin for Your Monoamines
Stahl, S. M. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0901 · Cited by 238 · see citing works
Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234 · see citing works
Determinants of Overweight and Obesity in Patients With Bipolar Disorder
Elmslie, J. L., Mann, J. I., Silverstone, J. T., Williams, S. M., & Romans, S. E. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0614 · Cited by 203 · see citing works
Nutrition and exercise behavior among patients with bipolar disorder1
Kilbourne, A. M., Rofey, D. L., McCarthy, J. F., Post, E. P., Welsh, D. E., & Blow, F. C. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00386.x · Cited by 193 · see citing works
The Psychopathology and Treatment of Bipolar Disorder
Miklowitz, D. J., & Johnson, S. L. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095332 · Cited by 183 · see citing works
Peerbooms, O., van Os, J., Drukker, M., Kenis, G., Hoogveld, L., Binder, M. D., Delespaul, P., van Winkel, R., & Rutten, B. P. F. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.006 · Cited by 162 · see citing works
Belbasis, L., Köhler, C. A., Stefanis, N. C., Stubbs, B., van Os, J., Vieta, E., Seeman, M. V., Arango, C., Carvalho, A. F., & Εvangelou, Ε. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12847 · Cited by 148 · see citing works
Morgan, V. A., Mitchell, P. B., & Jablensky, A. V. (2005) · Bipolar Disorders · doi:10.1111/j.1399-5618.2005.00229.x · Cited by 129 · see citing works
Challenges in the management of bipolar depression.
Suppes, T. M., Kelly, D. I., & Perla, J. M. (2005) · PubMed · Cited by 128 · see citing works
Prodromal and residual symptoms in bipolar I disorder
Keitner, G. I., Solomon, D. A., Ryan, C. E., Miller, I. W., Mallinger, A. G., Kupfer, D. J., & Frank, E. (1996) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(96)90018-8 · Cited by 124 · see citing works
Post, R. M., Altshuler, L. L., Frye, M. A., Suppes, T. M., Keck, P. E., McElroy, S. L., Leverich, G. S., Luckenbaugh, D. A., Rowe, M., Pizzarello, S., et al. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04811yel · Cited by 113 · see citing works
The functional impact of subsyndromal depressive symptoms in bipolar disorder: Data from STEP-BD
Marangell, L. B., Dennehy, E. B., Miyahara, S., Wisniewski, S. R., Bauer, M. S., Rapaport, M. H., & Allen, M. H. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.07.006 · Cited by 111 · see citing works
Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis
Bartoli, F., Crocamo, C., Mazza, M. G., Clerici, M., & Carrà, G. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.007 · Cited by 88 · see citing works
Stahl, S. M. (2007) · CNS Spectrums · doi:10.1017/s1092852900015418 · Cited by 71 · see citing works
Vitamin B12 and folate serum levels in newly admitted psychiatric patients
Lerner, V., Kanevsky, M., Dwolatzky, T., Rouach, T., Kamin, R., & Miodownik, C. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.08.014 · Cited by 71 · see citing works
Lazarou, C., & Kapsou, M. (2010) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2010.01.003 · Cited by 64 · see citing works
Li, H., Hong, W., Zhang, C., Wu, Z., Wang, Z., Yuan, C., Li, Z., Huang, J., Lin, Z., & Fang, Y. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.033 · Cited by 63 · see citing works
Kempisty, B., Mostowska, A., Górska, I., Łuczak, M., Czerski, P. M., Szczepankiewicz, A., Hauser, J., & Jagodziński, P. P. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.055 · Cited by 57 · see citing works
Adjunct Treatments for Schizophrenia and Bipolar Disorder: What to Try When You Are Out of Ideas
Torrey, E. F., & Davis, J. M. (2011) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.5.4.5 · Cited by 56 · see citing works
Nutrient-Based Therapies for Bipolar Disorder: A Systematic Review
Sylvia, L., Peters, A., Deckersbach, T., & Nierenberg, A. (2012) · Psychotherapy and Psychosomatics · doi:10.1159/000341309 · Cited by 51 · see citing works
The Role of L-Methylfolate in Depressive Disorders
Farah, A. (2009) · CNS Spectrums · doi:10.1017/s1092852900003473 · Cited by 50 · see citing works
Systems Biology, Bioinformatics, and Biomarkers in Neuropsychiatry
Alawieh, A. M., Zaraket, F. A., Li, J., Mondello, S., Nokkari, A., Razafsha, M., Fadlallah, B. H., Boustany, R., & Kobeissy, F. H. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00187 · Cited by 49 · see citing works
Bartoli, F., Crocamo, C., Dakanalis, A., Brosio, E., Miotto, A., Capuzzi, E., Clerici, M., & Carrà, G. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.09.011 · Cited by 48 · see citing works
Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis
Salagre, E., Vizuete, A. F. K., Leite, M. C., Brownstein, D. J., McGuinness, A. J., Jacka, F. N., Dodd, S., Stubbs, B., Köhler, C. A., Vieta, E., et al. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2017.02.482 · Cited by 46 · see citing works
Ozbek, Z., Küçükali, C. İ., Özkök, E., Orhan, N., Aydın, M., Kılıç, G., Sazcı, A., & Kara, İ. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.016 · Cited by 40 · see citing works
Misiak, B., Frydecka, D., Łaczmański, Ł., Ślężak, R., & Kiejna, A. (2014) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-014-1762-2 · Cited by 34 · see citing works
Davison, K., & Kaplan, B. J. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10720001 · Cited by 33 · see citing works
Hyperhomocysteinemia in Tunisian bipolar I patients
Ezzaher, A., Mouhamed, D. H., Mechri, A., Omezzine, A., Neffati, F., Douki, W., Bouslama, A., Gaha, L., & Najjar, M. F. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2011.02284.x · Cited by 32 · see citing works
Serum homocysteine levels and cognitive functioning in euthymic bipolar patients
Dias, V. V., Brissos, S., Cardoso, C., Andreazza, A. C., & Kapczinski, F. P. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.05.011 · Cited by 31 · see citing works
Reduced red-cell folate in mania
Hasanah, C. I., Khan, U., Musalmah, M., & Salleh, M. R. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00096-7 · Cited by 29 · see citing works
James, S. J., Miller, B., Cross, D. R., McGarrity, L. J., & Morris, S. M. (1993) · Environmental Health Perspectives · doi:10.1289/ehp.93101s5173 · Cited by 29 · see citing works
Bipolar disorder: Improving diagnosis and optimizing integrated care
Culver, J. L., Arnow, B. A., & Ketter, T. A. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20333 · Cited by 29 · see citing works
REVIEW OF NUTRITIONAL SUPPLEMENTS FOR THE TREATMENT OF BIPOLAR DEPRESSION
Rakofsky, J. J., & Dunlop, B. W. (2013) · Depression and Anxiety · doi:10.1002/da.22220 · Cited by 24 · see citing works
Fusar‐Poli, L., Surace, T., Vanella, A., Meo, V., Patania, F., Furnari, R., Signorelli, M. S., & Aguglia, E. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.039 · Cited by 24 · see citing works
Association between homocysteine and endothelial dysfunction markers in stroke disease
Abdulle, A. M., Yasin, J., Moussa, N. A., & Gariballa, S. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460763562 · Cited by 22 · see citing works
Chiarani, F., Tramontina, J., Ceresér, K. M. M., Kunz, M., Paim, L. L., Vargas, C. R., Sitta, Â., Machado, S. P., Wyse, Â. T. D. S., & Kapczinski, F. P. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2012-0797 · Cited by 18 · see citing works
Baysal, G. Ö. D., Gökmen, Z., Akbas, H. S., Ci̇nemre, B., Metin, Ö., & Karaman, T. (2012) · Turkish Journal of Psychiatry · doi:10.5080/u6881 · Cited by 12 · see citing works
Tunbridge, E. M., Attenburrow, M.-J., Gardiner, A., Rendell, J., Hinds, C., Goodwin, G., Harrison, P. J., & Geddes, J. R. (2017) · Bipolar Disorders · doi:10.1111/bdi.12531 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 63 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Robinson, N., & Bergen, S. E. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.686666 · Cited by 189 · see citing works
Weissella: An Emerging Bacterium with Promising Health Benefits
Teixeira, C. G., Fusieger, A., Milião, G. L., Martins, E., Drider, D., Nero, L. A., & de Carvalho, A. F. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09751-1 · Cited by 164 · see citing works
Nutrition-based interventions for mood disorders
Martins, L. B., Tibães, J. R. B., Sanches, M., Jacka, F. N., Berk, M., & Teixeira, A. L. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1881482 · Cited by 77 · see citing works
Sobral, A. F., Cunha, A., Silva, V., Gil-Martins, E., Silva, R., & Barbosa, D. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179339 · Cited by 67 · see citing works
Nutrition and bipolar disorder: a systematic review
Gabriel, F. C., Oliveira, M., Martella, B. D. M., Berk, M., Brietzke, E., Jacka, F. N., & Lafer, B. (2023) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2077031 · Cited by 59 · see citing works
Altaf, R., Gonzalez, I., Rubino, K., & Nemec, E. C. (2021) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2021.102770 · Cited by 36 · see citing works
Calcaterra, V., Rossi, V., Magenes, V. C., Baldassarre, P., Grazi, R., Loiodice, M., Fabiano, V., & Zuccotti, G. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2024.1368283 · Cited by 40 · see citing works
The Way to a Human’s Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder
Aly, J. S., & Engmann, O. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.582853 · Cited by 32 · see citing works
Gao, S., Khalid, A., Amini‐Salehi, E., Radkhah, N., Jamilian, P., Badpeyma, M., & Zarezadeh, M. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4073 · Cited by 20 · see citing works
Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers
Fuentes‐Claramonte, P., Estradé, A., Solanes, A., Ramella‐Cravaro, V., García‐León, M. Á., de Diego-Adeliño, J., Molins, C., Fung, E., Valentí, M., Anmella, G., et al. (2024) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgae018 · Cited by 17 · see citing works
Association between serum folate levels and schizophrenia based on sex
Tomioka, Y., Kinoshita, M., Umehara, H., Nakayama, T., Watanabe, S., Nakataki, M., Numata, S., & Ohmori, T. (2020) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13074 · Cited by 14 · see citing works
Aguiar‐Geraldo, J. M., Della, T. P., Menegas, S., Peper‐Nascimento, J., Quevedo, J., & Valvassori, S. S. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.04.137 · Cited by 8 · see citing works
Mangiapane, P., Carbone, M. G., Arone, A., Massa, L., Palermo, S., Flamini, W., Parra, E., Morana, B., Morana, F., Bertini, G., et al. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2134589 · Cited by 9 · see citing works
From Food to Mood: Psychological and Psychiatric Impact of Diet in Bipolar Disorder
Marano, G., Boggio, G., Abate, F., Caroppo, E., Traversi, G., Mazza, O., Capristo, E., Gaetani, E., & Mazza, M. (2025) · Nutrients · doi:10.3390/nu17233728 · Cited by 8 · see citing works
Hu, Y., Yu, M., Wang, Y., Wu, H., Yang, X., Chen, X., & Wu, J. (2024) · Nutrients · doi:10.3390/nu16131986 · Cited by 6 · see citing works
Self-citationAkbarzadeh, F., Talaei, A., Nematy, M., Ganji, D., Ebrahimi, A., & Talaeı, A. (2025) · Brain and Behavior · doi:10.1002/brb3.70432 · Cited by 3 · see citing works
The role of environmental factors in the etiology of schizophrenia
Brzuszkiewicz, K., Rudziński, G., Łozowski, B., Raczkiewicz, P., Kusak, N., & Soroka, E. (2023) · Journal of Education Health and Sport · doi:10.12775/jehs.2023.23.01.006 · Cited by 3 · see citing works
Mania secondary to cotrimoxazole antibiotherapy: a case report and review of literature
Jouart, M., Ramaholimihaso, T., Hadjoudj, J., Bermejo, M., & Kaladjian, A. (2025) · Journal of Medical Case Reports · doi:10.1186/s13256-024-05004-1 · Cited by 2 · see citing works
Wei, H., Jin, Z., Zhou, L., Tang, G., Chai, S., Che, X., Tan, Y., & Zeng, W. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1559043 · Cited by 2 · see citing works
Relevancia del metabolismo del folato en el contexto de enfermedades neurodegenerativas
Saínz, Y. J., Almarales, D. A. C., & Mederos, L. E. A. (2021) · Revista Habanera de Ciencias Médicas · Cited by 1 · see citing works
Cuthrell, K. M. (2022) · International Neuropsychiatric Disease Journal · doi:10.9734/indj/2022/v18i3354 · Cited by 1 · see citing works
Folate Deficiency: Is it Related to the Development of Depression
Bajwa, A. A., Ali, S., Khan, S. A., Raza, H., Hussain, F., & Nazir, T. B. (2023) · Pakistan Armed Forces Medical Journal · doi:10.51253/pafmj.v73i4.9187
The use of supplements in the treatment of patients with bipolar disorders
Jeremić, N., Gostiljac, M., Stojanović, D., Nešić, M., Dodić, S., Erić, E., Dunjić-Kostić, B., Puric, M., & Pantović-Stefanović, M. (2022) · Engrami · doi:10.5937/engrami44-42748
Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study
Wang, Y., Huang, C.-C., Yeh, T., Chen, W., Chang, W., Singh, A., Yeh, C., Hung, Y., Hung, K., & Chang, H. (2025) · Medicina · doi:10.3390/medicina61030486
Bipolar Disorder, Diet, and Nutrition
Kartal, M. E., & Dağ, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_169-1
Scoping Review: Environmental Factors Influencing Food Intake in Mental Health Inpatient Settings
Marino, L. V., Meyer, R. W., Veale, S., & Brown, J. V. E. (2025) · Dietetics · doi:10.3390/dietetics4020018 · Cited by 1 · see citing works
Fries, G. R., Mirza, S. A., Wang, J., Lima, C. N. D. C., Zhang, W., Tamez, M. C. C., Scaini, G., Soares, J. C., & Quevedo, J. (2025) · medRxiv · doi:10.1101/2025.06.06.25329080
Pharmacoepigenetics of mood disorders
Bellia, F., Ballerini, P., & D’Addario, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00019-0
Bipolar Disorder, Diet, and Nutrition
Kartal, M. E., & Dağ, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_169
Folate and global health: part 5. syntheses on neuropsychiatric disorders
Yoo, S., Montazeri, A., Bennett, D., Bo, Y., Chen, P., Duthie, S., Jensen, N., Kaminga, A., Lai, J.-S., Li, X. Q., et al. (2026) · Journal of Global Health · doi:10.7189/jogh.16.04286
Pisanu, C., Nishioka, M., Manchia, M., Squassina, A., & Kato, T. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03946-0
- Authors
- Hsieh, Y.-C., Chou, L.-S., Lin, C.-H., Wu, H.-C., Li, D.-J., & Tseng, P.-T.
- Affiliations
- Kaohsiung Municipal Kai-Syuan Psychiatric Hospital (TW)
- Corresponding author
- Li, Dian-Jeng
- Tseng, Ping-Tao
- Venue
- BMC Psychiatry
- Published
- 2019-10-22
- Volume
- 19
- Issue
- 1
- Pages
- 305-305
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC6805488
- OpenAlex
- W2982072312
- Cited by
- 33
- References
- 63
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, serum folate, folate deficiency, folate metabolism, pathophysiology, mood states, folic acid
- MeSH terms
- Bipolar Disorder, Female, Folic Acid, Humans, Male, Nutritional Status
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
