IL-23 and TGF-β1 levels as potential predictive biomarkers in treatment of bipolar I disorder with acute manic episode
Abstract
Background Growing evidence suggests that immune dysfunction may be involved in the physiopathology of bipolar disorders, with typical first-line treatment using lithium and quetiapine serving to restore pro-inflammation status. This study aimed to explore the relationship between inflammatory cytokines-especially regulatory factors and the effect of combination treatment-with quetiapine and lithium in manic patients. Methods 41 patients of bipolar I disorder with manic episode were enrolled and received combination treatment with quetiapine and lithium. Blood sampling and assessments were performed at baseline and after 8-week treatment. YMRS was used to evaluate the severity of manic symptoms at the same time of detecting plasma levels. A control group comprised of 36 age and gender matched healthy volunteers were enrolled, and their blood samples were assessed at the time of enrollment. Results TGF-β1 and IL-23 plasma levels in patients were significantly higher than healthy controls at baseline (P Limitations The relatively small sample size in patients and control groups should be considered as a limitation of the study. Conclusions The high initial plasma level of TGF-β1 and low initial plasma level of IL-23 indicated better prognosis during combination treatment with quetiapine and lithium in manic patients. The trend of decreasing plasma levels of TNF-α, TGF-β1, IL-23 and IL-17 indicated therapeutic effect.
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During acute manic episodes, high baseline levels of transforming growth factor beta 1 predicted a better response to quetiapine and lithium combination therapy.
“During acute manic episodes, for example, high baseline levels of transforming growth factor beta 1 predicted a better response to quetiapine and lithium combination therapy.10”
From Association Between Mood Disorder Severity, Treatment Response and Systemic Inflammatory Markers: Exploring the Role of NLR, PLR, MLR, and SII (2024) · cites this paper as [10]
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- Authors
- Li, H., Hong, W., Zhang, C., Wu, Z., Wang, Z., Yuan, C., Li, Z., Huang, J., Lin, Z., & Fang, Y.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Second Military Medical University (CN)
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 174
- Pages
- 361-366
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2016121778
- Cited by
- 63
- References
- 8
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 5
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- bipolar I disorder, manic episodes, IL-23, TGF-β1, inflammatory cytokines, predictive biomarkers, quetiapine, lithium, TNF-α, IL-17, treatment response, immune dysfunction
- MeSH terms
- Quetiapine Fumarate, Adult, Bipolar Disorder, Dibenzothiazepines, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Severity of Illness Index, Antipsychotic Agents, Tumor Necrosis Factor-alpha, Biomarkers, Case-Control Studies, Lithium Compounds, Interleukin-17, Interleukin-23, Transforming Growth Factor beta1
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