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Cited by 131Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionHealth Education and Validation

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

The validity and reliability of the PHQ-9 on screening of depression in neurology: a cross sectional study

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Sun, Yajing, Kong, Zhifei, Song, Yuqing, Liu, Jing, Wang, Xilin·2022·BMC Psychiatry
DOI 10.1186/s12888-021-03661-wPMC PMC8827244
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Abstract

BACKGROUND: This study aimed to explore the validity and reliability of the Patient Health Questionnaire-9 (PHQ-9) on screening of depression among patients with neurological disorders, and to explore factors influencing such patients. METHODS: In this study, 277 subjects who were admitted to the department of neurology of our hospital due to different neurological disorders completed the PHQ-9 questionnaire. The Mini-International Neuropsychiatric Interview (MINI) and Hamilton Rating Scale for Depression (HAMD) were employed to evaluate the depressive symptoms of patients who completed the PHQ-9 questionnaire. The internal consistency, criterion validity, structural validity, and optimal cut-off values of PHQ-9 were evaluated, and the consistency assessment was conducted between the depression severity as assessed by PHQ-9, HAMD and MINI. Logistic regression analysis was used to calculate the risk factors of depression. RESULTS: The Cronbach's α coefficient of the PHQ-9 was 0.839. The Pearson's correlation coefficient among the 9 items of the PHQ-9 scale was 0.160 ~ 0.578 (P < 0.01), and the Pearson's correlation coefficient between each item and the total score was at the range of 0.608 ~ 0.773. Taking the results of MINI as the gold standard, the area under the receiver operating characteristic (ROC) curve of the PHQ-9 results for all the subjects (n = 277) was 0.898 (95% confidence interval (CI): 0.859 ~ 0.937, P < 0.01). When the cut-off score was equal to 5, the values of sensitivity, specificity, and the Youden's index were 91.2, 76.6%, and 0.678, respectively. Multivariate logistic regression analysis showed that the influence of unemployment on the occurrence of depression was statistically significant (P = 0.027, OR = 3.080, 95%CI: 1.133 ~ 8.374). CONCLUSIONS: The application of PHQ-9 for screening of depression among Chinese patients with neurological disorders showed a good reliability and validity.

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Crossref · 10.1186/s12888-021-03661-w

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Fig. 1 Flow chart
Fig. 1 Flow chartCC BY · PubMed Central
Fig. 2 ROC Curve
Fig. 2 ROC CurveCC BY · PubMed Central
Fig. 3 Consistency analysis between PHQ-9 and HAMD
Fig. 3 Consistency analysis between PHQ-9 and HAMDCC BY · PubMed Central

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Cites

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Research works printed but not linked: 7

  1. WHO. The global burden of disease: 2004 update. Geneva: World Health Organization; 2008.
  2. Zhang J, Wei J, Shi LL, et al. Zhonghua Yi Xue Za Zhi. 2007;87:889–93.
  3. First MB, Spitzer RL, Gibbon M, Williams J. Structured clinical interview for DSM-V-TR Axis I disorders-non-patient ed. (SCII/ NP-2/2001 Revision). New York: Biometrics Research Department; 2001.
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  5. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1976;6:278–96. · DOI
  6. Haihong Y. Value of 9 items patients' health questionnaire depression scale in screening of post-stroke depression. J Clin Med Pract. 2016;8:28–30.
  7. Cleary P, Guy W. Factor analysis of the Hamilton depression scale. Drugs Exp Clin Res. 1977;1:115–20.

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Metadata

Authors
Sun, Y., Kong, Z., Song, Y., Liu, J., & Wang, X.
Affiliations
Peking University (CN)
Corresponding author
  • Song, Yuqing
  • Liu, Jing
  • Wang, Xilin
ORCID
Venue
BMC Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2022-02-09
Volume
22
Issue
1
Pages
98-98
ISSN
1471-244X (ISSN-L)
DOI
10.1186/s12888-021-03661-w
PMC
PMC8827244
OpenAlex
W4210925784
Cited by
131
References
46
Citations by year
2026: 32 · 2025: 51 · 2024: 26 · 2023: 19 · 2022: 3
FWCI
22.76
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Nursing › Research and Theory › Health Education and Validation
Keywords
PHQ-9, depression screening, neurological disorders, psychometric validation, internal consistency, cut-off values, unemployment, risk factors for depression, Chinese patients
MeSH terms
Patient Health Questionnaire, Cross-Sectional Studies, Depression, Humans, Nervous System Diseases, Neurology, Surveys and Questionnaires, Reproducibility of Results

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