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Cited by 215Blood Pressure and Hypertension StudiesDiabetes, Cardiovascular Risks, and LipoproteinsSodium Intake and Health

The influence of family history of Hypertension on disease prevalence and associated metabolic risk factors among Sri Lankan adults

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Ranasinghe, Priyanga, Cooray, Dilini N., Jayawardena, Ranil, Katulanda, Prasad·2015·BMC Public Health
DOI 10.1186/s12889-015-1927-7PMC PMC4475303
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Abstract

BACKGROUND: Hypertension is a major contributor to the global non-communicable disease burden. Family history is an important non-modifiable risk factor for hypertension. The present study aims to describe the influence of family history (FH) on hypertension prevalence and associated metabolic risk factors in a large cohort of South Asian adults, from a nationally representative sample from Sri Lanka. METHODS: A cross-sectional survey among 5,000 Sri Lankan adults, evaluating FH at the levels of parents, grandparents, siblings and children. A binary logistic regression analysis was performed in all patients with 'presence of hypertension' as dichotomous dependent variable and using family history in parents, grandparents, siblings and children as binary independent variables. The adjusted odds ratio controlling for confounders (age, gender, body mass index, diabetes, hyperlipidemia and physical activity) are presented below. RESULTS: In all adults the prevalence of hypertension was significantly higher in patients with a FH (29.3%, n = 572/1951) than those without (24.4%, n = 616/2530) (p < 0.001). Presence of a FH significantly increased the risk of hypertension (OR:1.29; 95% CI:1.13-1.47), obesity (OR:1.36; 95% CI: 1.27-1.45), central obesity (OR:1.30; 95% CI 1.22-1.40) and metabolic syndrome (OR:1.19; 95% CI: 1.08-1.30). In all adults presence of family history in parents (OR:1.28; 95% CI: 1.12-1.48), grandparents (OR:1.34; 95% CI: 1.20-1.50) and siblings (OR:1.27; 95% CI: 1.21-1.33) all were associated with significantly increased risk of developing hypertension. CONCLUSIONS: Our results show that the prevalence of hypertension was significantly higher in those with a FH of hypertension. FH of hypertension was also associated with the prevalence of obesity, central obesity and metabolic syndrome. Individuals with a FH of hypertension form an easily identifiable group who may benefit from targeted interventions.

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Cited by

Sorted by citations

Authors
Ranasinghe, P., Cooray, D. N., Jayawardena, R., & Katulanda, P.
Affiliations
  • University of Colombo (LK)
  • Queensland University of Technology (AU)
Corresponding author
Katulanda, Prasad
ORCID
Venue
BMC Public Health
Publisher
Springer Science and Business Media LLC
Published
2015-06-20
Volume
15
Issue
1
Pages
576-576
ISSN
1471-2458 (ISSN-L)
DOI
10.1186/s12889-015-1927-7
PMC
PMC4475303
OpenAlex
W1497026041
Cited by
215
References
2
Citations by year
2026: 8 · 2025: 22 · 2024: 27 · 2023: 37 · 2022: 19 · 2021: 21 · 2020: 21 · 2019: 15 · 2018: 21 · 2017: 11 · 2016: 9 · 2015: 4
FWCI
10.92
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Public Health (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by)
  • Faculty of Health; Institute of Health and Biomedical Innovation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
Keywords
hypertension, family history (medicine), hypertension prevalence, metabolic risk factors, obesity, abdominal obesity, metabolic syndrome, Sri Lankan adults, South Asian populations, genetic risk
MeSH terms
Adult, Cross-Sectional Studies, Diabetes Mellitus, Family Health, Female, Humans, Hypertension, Male, Middle Aged, Obesity, Risk Factors, Socioeconomic Factors, Sri Lanka, Comorbidity, Body Mass Index, Prevalence, Odds Ratio, Metabolic Syndrome, Young Adult, Obesity, Abdominal

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