Non‐surgical periodontal treatment reduces cardiovascular risk in refractory hypertensive patients: a pilot study
Abstract
AIM: To evaluate the effects of non-surgical periodontal treatment on left ventricular mass (LVM), arterial stiffness, systolic and diastolic blood pressure and plasma levels of inflammatory markers (C-reactive protein (CRP), fibrinogen and interleukin-6) in refractory hypertension patients. MATERIAL AND METHODS: This interventional prospective cohort pilot study included 26 patients (53.6 ± 8.0 years old) diagnosed with refractory hypertension and generalized chronic periodontitis. Subjects received non-surgical periodontal treatment according to their needs. Plasma levels of systemic inflammation (CRP; fibrinogen and interleukin-6) and established cardiovascular risk factors [systolic and diastolic blood pressure (SBP and DBP), left ventricular mass (LVM) and arterial stiffness] were assessed at three time points (baseline, 3 months after baseline and 6 months after periodontal therapy). RESULTS: Periodontal therapy significantly reduced all cardiovascular risk markers evaluated. Median values of SBP and DBP were reduced by 12.5 mmHg and 10.0 mmHg, respectively, whereas left ventricular mass (LVM) reduced by 12.9 g and pulse wave velocity reduced by 0.9 m/s (p < 0.01). Levels of CRP, IL-6 and fibrinogen lowered by 0.5 mg/dl, 1.4 pg/dl and 37.5 mg/dl (p < 0.01), respectively, 6 months after periodontal therapy. CONCLUSIONS: Periodontal therapy significantly reduced levels of CRP, IL-6, fibrinogen, blood pressure, LVM and arterial stiffness, lowering cardiovascular risk in refractory hypertensive patients.
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Limited evidence also suggests that successful periodontal treatment could improve arterial blood pressure.
“Limited evidence also suggests that successful periodontal treatment could improve arterial blood pressure.28,29”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
The effects of non-surgical periodontal therapy on both systolic and diastolic blood pressure in the pilot trial were of greater magnitude than those reported in other intervention studies.
“the effects of non-surgical periodontal therapy on both systolic and diastolic blood pressure were of greater magnitude of those reported in the other intervention studies.”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
The pilot intervention trial had limited sample size and inclusion criteria.
“We urge caution in interpreting these results especially in view of the limited sample size and inclusion criteria adopted by the authors.29”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
The pilot intervention trial by Vidal et al. included only 26 patients with refractory hypertension and periodontitis.
“This study was a pilot intervention trial including only 26 patients with refractory hypertension and periodontitis”
From Periodontitis is associated with hypertension: a systematic review and meta-analysis (2020) · cites this paper as [29]
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- Authors
- Vidal, F., Cordovil, I., Figueredo, C. M. S., & Fischer, R. G.
- Affiliations
- Universidade do Estado do Rio de Janeiro (BR)
- Instituto Nacional de Cardiologia (BR)
- Corresponding author
- Fischer, Ricardo Guimarães
- Venue
- Journal Of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2013-05-03
- Volume
- 40
- Issue
- 7
- Pages
- 681-687
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W1992216876
- Cited by
- 118
- References
- 53
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 14 · 2023: 18 · 2022: 5 · 2021: 18 · 2020: 13 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 6
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal Of Clinical Periodontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- non-surgical periodontal therapy, resistant hypertension, chronic periodontitis, cardiovascular risk, left ventricular mass, arterial stiffness, pulse wave velocity, C-reactive protein, fibrinogen, interleukin-6, systemic inflammation, blood pressure reduction
- MeSH terms
- Arteries, Blood Flow Velocity, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Dental Plaque Index, Fibrinogen, Follow-Up Studies, Gingival Hemorrhage, Humans, Hypertension, Middle Aged, Oral Hygiene, Periodontal Index, Periodontal Pocket, Pilot Projects, Prospective Studies, Risk Factors, Dental Scaling, Cohort Studies, Interleukin-6, Ventricular Function, Left, Periodontal Attachment Loss, Chronic Periodontitis, Periodontal Debridement
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