CoChat
Sign Up
Cited by 201Palliative Care and End-of-Life IssuesPalliative and Oncologic CarePain Management and Opioid Use

The DOI matches its Crossref record; 36 of the 38 references it cites were found in a registry or an index.

Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial

Open access
Farquhar, Morag C, Prevost, A Toby, McCrone, Paul, Brafman-Price, Barbara, Bentley, Allison, Higginson, Irene J, Todd, Chris, Booth, Sara·2014·BMC Medicine
DOI 10.1186/s12916-014-0194-2PMC PMC4222435
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Breathlessness is common in advanced cancer. The Breathlessness Intervention Service (BIS) is a multi-disciplinary complex intervention theoretically underpinned by a palliative care approach, utilising evidence-based non-pharmacological and pharmacological interventions to support patients with advanced disease. We sought to establish whether BIS was more effective, and cost-effective, for patients with advanced cancer and their carers than standard care. METHODS: A single-centre Phase III fast-track single-blind mixed-method randomised controlled trial (RCT) of BIS versus standard care was conducted. Participants were randomised to one of two groups (randomly permuted blocks). A total of 67 patients referred to BIS were randomised (intervention arm n = 35; control arm n = 32 received BIS after a two-week wait); 54 completed to the key outcome measurement. The primary outcome measure was a 0 to 10 numerical rating scale for patient distress due to breathlessness at two-weeks. Secondary outcomes were evaluated using the Chronic Respiratory Questionnaire, Hospital Anxiety and Depression Scale, Client Services Receipt Inventory, EQ-5D and topic-guided interviews. RESULTS: BIS reduced patient distress due to breathlessness (primary outcome: -1.29; 95% CI -2.57 to -0.005; P = 0.049) significantly more than the control group; 94% of respondents reported a positive impact (51/53). BIS reduced fear and worry, and increased confidence in managing breathlessness. Patients and carers consistently identified specific and repeatable aspects of the BIS model and interventions that helped. How interventions were delivered was important. BIS legitimised breathlessness and increased knowledge whilst making patients and carers feel 'not alone'. BIS had a 66% likelihood of better outcomes in terms of reduced distress due to breathlessness at lower health/social care costs than standard care (81% with informal care costs included). CONCLUSIONS: BIS appears to be more effective and cost-effective in advanced cancer than standard care. TRIAL REGISTRATION: RCT registration at ClinicalTrials.gov NCT00678405 (May 2008) and Current Controlled Trials ISRCTN04119516 (December 2008).

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/s12916-014-0194-2

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 CONSORT flow diagram.
Figure 1 CONSORT flow diagram.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 38 references

Research works printed but not linked: 2

  1. Booth S, Moffat C, Burkin J: The Cambridge BIS Manual - Building a Breathlessness Intervention Service. 2012, Cambridge University Hospitals NHS Foundation Trust, Cambridge
  2. Curtis L: Unit Costs of Health and Social Care. 2012, PSSRU, Canterbury

Cited by

Sorted by citations

Items 101–200 of 200

Related

See all

Metadata

Authors
Farquhar, M. C., Prevost, A. T., McCrone, P., Brafman-Price, B., Bentley, A., Higginson, I. J., Todd, C., & Booth, S.
Affiliations
  • University of Cambridge (GB)
  • King's College London (GB)
  • Cambridge University Hospitals NHS Foundation Trust (GB)
  • University of Manchester (GB)
Corresponding author
Farquhar, Morag C
ORCID
Venue
BMC Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-10-31
Volume
12
Issue
1
Pages
194-194
ISSN
1741-7015 (ISSN-L)
DOI
10.1186/s12916-014-0194-2
PMC
PMC4222435
OpenAlex
W2070706399
Cited by
201
References
38
Citations by year
2026: 5 · 2025: 8 · 2024: 12 · 2023: 5 · 2022: 21 · 2021: 16 · 2020: 22 · 2019: 24 · 2018: 19 · 2017: 21 · 2016: 32 · 2015: 14 · 2014: 1
FWCI
22.56
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (acceptedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion, cc-by)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
  • Macmillan Cancer Support
  • National Institute for Health and Care Research (PB-PG-0107-11134, NF-SI-0611-10209)
  • University of Cambridge
  • King's College London
  • Cambridge University Hospitals
  • Research for Patient Benefit Programme
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
dyspnea, advanced cancer, palliative care, caregivers, cost-effectiveness, non-pharmacological treatment, anxiety and depression, informal care costs
MeSH terms
Adult, Aged, Aged, 80 and over, Anxiety, Cost-Benefit Analysis, Dyspnea, Female, Humans, Male, Middle Aged, Neoplasms, Occupational Therapy, Palliative Care, Surveys and Questionnaires, Single-Blind Method, Caregivers, Health Care Costs, Outcome Assessment, Health Care, Physical Therapy Modalities

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review